Article
Medicine, General & Internal
Xuhui Li, Hua Fan, Hao Zi, Hankun Hu, Binghui Li, Jiao Huang, Pengcheng Luo, Xiantao Zeng
Summary: This study aimed to estimate the global and regional burden of bacterial antimicrobial resistance (AMR) in urinary tract infections (UTI) in 2019. The results showed that globally, there were approximately 64.89 thousand deaths attributed to and 0.26 million deaths associated with bacterial AMR in UTI. Escherichia coli and Klebsiella pneumoniae had the highest resistance rates, including resistance to fluoroquinolones, carbapenems, and third-generation cephalosporins. Tailored strategies, such as enhanced surveillance and rational use of antibiotics, should be developed for different regions based on their specific pathogen-antibiotic situations and resources.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Bernadette Jones-Freeman, Michelle Chonwerawong, Vanessa R. Marcelino, Aniruddh Deshpande, Samuel C. Forster, Malcolm R. Starkey
Summary: The urinary tract interacts with other mucosal sites and their microbiota, impacting the immune system. Changes in the microbiota may influence the development of urinary tract diseases. There is potential for microbiome-based medicine in treating urinary tract conditions, with emerging technology aiding research in this area.
MUCOSAL IMMUNOLOGY
(2021)
Review
Cell Biology
Vik Ven Eng, Madeleine A. Wemyss, Jaclyn S. Pearson
Summary: RIPKs are cellular signaling molecules crucial for inflammatory and cell death processes. This review discusses their roles in host responses to pathogens and the mechanisms by which pathogens target them for inactivation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Silvia Pavone, Roberto Rinoldo, Elisa Albini, Alessandro Fiorucci, Biagio Caponi, Anna Fratto, Elisabetta Manuali, Paola Papa, Chiara Francesca Magistrali
Summary: This is the first report of C. kerstersii infection in animals (goat), showing severe pyelonephritis and multi-organ vasculitis. The findings suggest C. kerstersii as a possible cause of urinary tract infection from extraintestinal sites.
BMC VETERINARY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hua Wang, Fei-Fei Han, Jian-Xun Wen, Zhi Yan, Yan-Qiu Han, Zhi-De Hu, Wen-Qi Zheng
Summary: This study aimed to investigate the screening performance of the Sysmex UF-5000 analyzer for urinary tract infection (UTI) and its ability to distinguish gram-positive and gram-negative pathogens using the novel parameter Gram flag. The results showed that urine bacteria determined by the Sysmex UF-5000 had higher screening performance and greater benefit than urine white blood cell (WBC). The flag of Gram-negative was a reliable indicator to confirm gram-negative bacteria infection in UTI patients.
Review
Biochemistry & Molecular Biology
Bojana S. Stojanovic, Bojan Stojanovic, Jelena Milovanovic, Aleksandar Arsenijevic, Milica Dimitrijevic Stojanovic, Nebojsa Arsenijevic, Marija Milovanovic
Summary: This comprehensive review discusses the important role of Galectin-3 (Gal-3), a beta-galactoside-binding lectin, in various cellular processes, including immune responses, inflammation, and cancer progression. Gal-3 is crucial for viral entry, immune modulation, and viral pathogenesis, and plays a significant role in viral diseases such as SARS-CoV-2, HIV, and influenza A. Understanding the mechanisms and functions of Gal-3 could lead to innovative treatment and prevention options for viral diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Helle Praetorius
Summary: The local environment in the kidney plays a crucial role in selecting virulent bacteria to invade the urinary tract, with renal function determining the conditions for bacteria-host interaction. The precise composition of urine is influenced by the epithelium lining the microdomain, and the microenvironment in the kidney shows more variation in nutrients, ion composition, osmolality, and pH than any other site of bacteria-host interaction.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Immunology
Abdul Arif Khan, Yasmin Bano
Summary: The study found that Salmonella interacts with multiple human proteins involved in gallbladder carcinoma, with MAPK and RAC1 being the most important based on node degree value among all identified interactors. Functional over-representation analysis reveals that Salmonella can induce adenocarcinoma, which constitutes 85% of gallbladder cancer.
MICROBIAL PATHOGENESIS
(2021)
Article
Multidisciplinary Sciences
Agnes Cottalorda, Sandrine Dahyot, Anais Soares, Kevin Alexandre, Isabelle Zorgniotti, Manuel Etienne, Estelle Jumas-Bilak, Martine Pestel-Caron
Summary: This study assessed the phenotypic and molecular diversity of Pseudomonas aeruginosa isolates responsible for urinary tract infection and asymptomatic bacteriuria. The results showed a high level of diversity in both antimicrobial resistance and genetic background among the isolates.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Virginia Perez-Carrasco, Ana Soriano-Lerma, Miguel Soriano, Jose Gutierrez-Fernandez, Jose A. Garcia-Salcedo
Summary: The application of next generation sequencing techniques has revealed that the urinary tract is not sterile, contrary to previous beliefs. Microbial communities in the urinary tract play a crucial role in maintaining health and are associated with various urinary pathologies. Understanding the urinary microbiome in health and disease could lead to the development of new therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Enrica Pellegrino, Maximiliano G. Gutierrez
Summary: The use of human stem cells in modeling host-pathogen interactions has great potential to overcome current limitations in in vitro research. Genome editing can be utilized in human stem cells to study cellular responses to infection. The combination of human pluripotent stem cells, 3D models, and genome editing technologies can recreate physiological in vitro systems.
CELLULAR MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Elena G. Lara, Isabelle van der Windt, Douwe Molenaar, Marjon G. J. de Vos, Chrats Melkonian
Summary: A computational approach using metabolic gene annotation was used to rapidly predict putative interactions between members of urinary tract infection microbial communities, revealing that Enteroccus spp. were most complemented in its metabolism by other community members. Experimental supplementation of predicted metabolites confirmed the increase in population density of UTI Enterococcus isolates. This method shows promise as a rapid in silico screening tool for predicting metabolic interactions in microbial communities.
Article
Biochemical Research Methods
Abdul Arif Khan, Zakir Khan
Summary: Coronavirus outbreaks, including SARS, MERS and COVID-19, have caused significant global healthcare and economic burdens in the past two decades. Efforts to identify potential viral targets for management of these outbreaks are ongoing, with a focus on common host proteins to prevent current and future outbreaks. Targeting proteins like FURIN and TMPRSS2, which are involved in recent and previous outbreaks, may provide promising results in the development of new therapeutic modalities. However, safety evaluation and risk assessment are crucial considerations when targeting necessary human proteins for the management of coronavirus.
BRIEFINGS IN BIOINFORMATICS
(2021)