Article
Multidisciplinary Sciences
Yue-Mei Hu, Zhao-Feng Bi, Ya Zheng, Li Zhang, Feng-Zhu Zheng, Kai Chu, Ya-Fei Li, Qi Chen, Jia-Li Quan, Xiao-Wen Hu, Xing-Cheng Huang, Kong-Xin Zhu, Ya-Hui Wang-Jiang, Han -Min Jiang, Xia Zang, Dong-Lin Liu, Chang -Lin Yang, Hong-Xing Pan, Qiu-Fen Zhang, Ying-Ying Su, Shou-Jie Huang, Guang Sun, Wei-Jin Huang, Yue Huang, Ting Wu, Jun Zhang, Ning-Shao Xia
Summary: This study evaluated the immunogenicity and safety of the Escherichia coli-produced second-generation nonavalent HPV vaccine (Cecolin 9). The results showed that Cecolin 9 had good immunogenicity against all nine HPV types and was well tolerated.
Review
Oncology
Fausto Petrelli, Gabriella De Santi, Valentina Rampulla, Antonio Ghidini, Paola Mercurio, Marco Mariani, Michele Manara, Emanuele Rausa, Veronica Lonati, Matteo Viti, Andrea Luciani, Andrea Celotti
Summary: The study found that HPV-16/18 can be detected in approximately 1 in 5 cases of ESCC, with varying prevalences worldwide. HPV infection is moderately but significantly associated with a diagnosis of ESCC. Further epidemiological studies are needed to confirm and expand the current knowledge on this topic.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Shreya P. P. Ramkumar, Matthew C. C. Simpson, Eric Adjei Boakye, Aleksandr R. R. Bukatko, Jastin L. L. Antisdel, Sean T. T. Massa, Nosayaba Osazuwa-Peters
Summary: This study aimed to assess the independent prognostic role of human papillomavirus (HPV) status in sinonasal cancer. The results showed that HPV16/18-positive sinonasal cancer had a higher survival rate compared to HPV-negative cases, while other high-risk and low-risk HPV subtypes had similar survival rates to HPV-negative disease. Therefore, HPV status may be an important independent prognostic factor in sinonasal cancer.
Article
Multidisciplinary Sciences
Khalid Al-Shibli, Hiba Abdul Latif Mohammed, Ramona Maurseth, Mikkel Fostervold, Sebastian Werner, Sveinung Wergeland Sorbye
Summary: The study aimed to investigate the detection rate of CIN3+ in women aged 25-39 with normal cytology by using a 3-type HPV mRNA test as a targeted quality assurance measure. Results showed that testing women with normal cytology result using a specific 3-type HPV mRNA test can increase the screening program sensitivity without an excessive additional workload. Women with normal cytology and a negative HPV mRNA test have a very low risk of cervical cancer.
Article
Immunology
Kavita Panwar, Anna Godi, Clementina E. Cocuzza, Nick Andrews, Jo Southern, Paul Turner, Elizabeth Miller, Simon Beddows
Summary: The study evaluated the antibody response of HPV vaccines against different types of human papillomavirus. The findings showed that the vaccines provided long-lasting protection against vaccine types and maintained high antibody levels against related non-vaccine types. This contributes to the evidence base supporting public health intervention.
Article
Health Care Sciences & Services
Kai Chu, Zhao-Feng Bi, Wei-Jin Huang, Ya-Fei Li, Li Zhang, Chang-Lin Yang, Han -Min Jiang, Xia Zang, Qi Chen, Dong-Lin Liu, Hong-Xing Pan, Yue Huang, Feng-Zhu Zheng, Qiu-Fen Zhang, Guang Sun, Ying-Ying Su, Shou-Jie Huang, Hui-Rong Pan, Ting Wu, Yue-Mei Hu, Jun Zhang, Feng-Cai Zhu, Ning-Shao Xia
Summary: This phase 1 clinical trial evaluated the safety and immunogenicity of a second-generation nonavalent HPV vaccine and showed that it was well tolerated and immunogenic, providing encouragement for further studies in larger cohorts and a wider age range.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Immunology
Adolfo Pedroza-Saavedra, Angelica Nallelhy Rodriguez-Ocampo, Azucena Salazar-Pina, Aislinn Citlali Perez-Morales, Lilia Chihu-Amparan, Minerva Maldonado-Gama, Aurelio Cruz-Valdez, Fernando Esquivel-Guadarrama, Lourdes Gutierrez-Xicotencatl
Summary: Antibodies against VLPs-16/18 are effective in detecting HPV-vaccinated women, while antibodies against L1-16 are better at differentiating the CIN3/CC group. Larger population studies are needed to validate these results.
Article
Immunology
Shang-Ying Hu, Sabrina H. Tsang, Feng Chen, Qin-Jing Pan, Wen-Hua Zhang, Ying Hong, Joshua N. Sampson, Allan Hildesheim, Fang-Hui Zhao, Aimee R. Kreimer
Summary: The study found that vaginal infections are associated with incident non-HPV16/18 infections in the cervix, but do not impact the persistence of non-HPV16/18 infections after 6 months among women vaccinated with HPV16/18.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Alexandru Tirziu, Speranta Avram, Leonard Mada, Mihaela Crisan-Vida, Casiana Popovici, Dan Popovici, Cosmin Faur, Corina Duda-Seiman, Virgil Paunescu, Corina Vernic
Summary: Human papillomavirus types 16 and 18 are major causes of cervical cancers worldwide. While prophylactic vaccines based on virus-like particles (VLP) of the major capsid protein (L1) are available, they cannot eliminate existing infections. This study proposes a synthetic long peptide (SLP)-based vaccine as an alternative for infected individuals, including those with precancerous lesions. The SLP vaccine is designed to stimulate both CD8+ and CD4+ T cells, providing a strong and long-lasting immune response.
Article
Immunology
Joske Hoes, Petra J. Woestenberg, Johannes A. Bogaards, Audrey J. King, Hester E. de Melker, Johannes Berkhof, Christian J. P. A. Hoebe, Marianne A. B. van der Sande, Birgit H. B. van Benthem
Summary: This study assessed trends in HPV prevalence over 8 years postvaccination among men and women in the Netherlands. Significant declines were observed in vaccine types HPV-16/18 among women, heterosexual men, and unvaccinated women, while increases were observed for certain HPV types in women and unvaccinated women. The results provide evidence of herd effects against HPV-16/18 among heterosexual men and cross-protective types, as well as herd effects against vaccine types among unvaccinated women.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Lars Sivars, Stefan Holzhauser, Torbjorn Ramqvist, Emma Tham, Kristina Hellman, Tina Dalianis
Summary: The prevalence of HPV16 and 18 in cervical cancer in Stockholm from 2019-2023 was compared to data from 2003-2008. The joint prevalence of HPV16 and 18 in SCC and ADC tended to be slightly lower in 2019-2023, but the difference was not statistically significant.
Article
Infectious Diseases
Anna Loenenbach, Michael Pawlita, Tim Waterboer, Thomas Harder, Christina Poethko-Mueller, Michael Thamm, Raskit Lachmann, Yvonne Delere, Ole Wichmann, Miriam Wiese-Posselt
Summary: This study reports the nationally representative data on HPV antibody reactivity among children and adolescents in Germany before the introduction of HPV vaccination. The study found low seroprevalence for most tested HPV types among children and adolescents in Germany. These data can serve as baseline estimates for evaluating the impact of the current HPV vaccination strategy targeting 9-14-year-old boys and girls.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Gholamreza Haqshenas, Suzanne M. Garland, Prisha Balgovind, Alyssa Cornall, Jennifer Danielewski, Monica Molano, Dorothy A. Machalek, Gerald Murray
Summary: Broad-spectrum droplet digital polymerase chain reaction (ddPCR) assays can accurately quantify human papillomavirus (HPV) types, and the use of touchdown PCR can enhance the sensitivity and specificity of detection. This method has important clinical diagnostic applications for quantification and detection of HPV in anal samples.
MICROBIOLOGY SPECTRUM
(2023)
Article
Neurosciences
Zhaohao Zeng, Yanmei Cen, Lu Wang, Xiaoguang Luo
Summary: The study aimed to explore the association between Parkinson's disease (PD) and dietary inflammatory index (DII) scores in adults over 40 years old in the US. Data from the NHANES conducted from 2003 to 2018 were analyzed, including 21,994 participants. Logistic regression analysis and propensity score matching were used to investigate the relationship between DII and PD. The results showed a positive association between higher DII scores and PD, suggesting the potential use of diet as an intervention strategy for managing PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Virology
Kohsei Tanaka, Gota Kogure, Mamiko Onuki, Koji Matsumoto, Takashi Iwata, Daisuke Aoki, Iwao Kukimoto
Summary: This study analyzed the complete genome sequences of HPV16, HPV18, and HPV58 and found Japan-specific clusters in the phylogenetic analysis. The estimated timeframe suggests that these HPV variants were introduced to Japan at least 25,000 years ago, indicating a co-migration scenario with ancestral Japanese populations during the Upper Paleolithic period.
Article
Chemistry, Multidisciplinary
Wujun Zhao, Taotao Zhu, Rui Cheng, Yufei Liu, Jian He, Hong Qiu, Lianchun Wang, Tamas Nagy, Troy D. Querec, Elizabeth R. Unger, Leidong Mao
ADVANCED FUNCTIONAL MATERIALS
(2016)
Article
Oncology
Nancy M. McClung, Julia W. Gargano, Nancy M. Bennett, Linda M. Niccolai, Nasreen Abdullah, Marie R. Griffin, Ina U. Park, Angela A. Cleveland, Troy D. Querec, Elizabeth R. Unger, Lauri E. Markowitz
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
Article
Multidisciplinary Sciences
Eliana Marcia Wendland, Luisa Lina Villa, Elizabeth R. Unger, Carla Magda Domingues, Adele Schwartz Benzaken
SCIENTIFIC REPORTS
(2020)
Article
Virology
Alexandre Lomsadze, Tengguo Li, Mangalathu S. Rajeevan, Elizabeth R. Unger, Mark Borodovsky
Article
Virology
Mangalathu S. Rajeevan, Sonya Patel, Tengguo Li, Elizabeth R. Unger
Summary: High-throughput HPV typing assays with increased automation, faster turnaround and type-specific digital readout would facilitate studies monitoring the impact of HPV vaccination. The NanoString nCounter platform showed good efficacy in detecting and digitally reading 48 HPV types in a single reaction. Further studies are needed to evaluate the reproducibility and analytic validation of the assay with a larger number of samples.
Article
Oncology
Sharon L. Sauter, Xue Zhang, Lindsey Romick-Rosendale, Susanne I. Wells, Kasiani C. Myers, Marion G. Brusadelli, Charles B. Poff, Darron R. Brown, Gitika Panicker, Elizabeth R. Unger, Parinda A. Mehta, Jack Bleesing, Stella M. Davies, Melinda Butsch Kovacic
Summary: This study found that individuals with Fanconi anemia have a significantly higher oral HPV positivity compared to family and unrelated controls, but respond similarly to HPV vaccination. Unlike unrelated controls, common risk factors associated with HPV in the general population did not predict oral DNA positivity in individuals with FA.
Article
Public, Environmental & Occupational Health
Jacqueline M. Mix, Mona Saraiya, Virginia Senkomago, Elizabeth R. Unger
Summary: This study analyzed the incidence rates of high-grade vulvar, vaginal, and anal precancers among individuals aged 15-39 years using data from select cancer registries in the U.S. The results showed a significant decrease in high-grade vulvar and vaginal precancer rates among females aged 15-29 years after the introduction of the human papillomavirus vaccine, while anal precancer rates stabilized in both females aged 15-29 years and males aged 30-39 years.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Oncology
Jacqueline Mix, Mona Saraiya, Benjamin D. Hallowell, Brian Befano, Li C. Cheung, Elizabeth R. Unger, Julia W. Gargano, Lauri E. Markowitz, Philip E. Castle, Tina Raine-Bennett, Joan Walker, Rosemary Zuna, Mark Schiffman, Nicolas Wentzensen, Julia C. Gage
Summary: Racial and ethnic differences exist in the attribution of cervical precancer and cancer to HPV types. The 9-valent HPV vaccine is effective in preventing most cases of precancers and invasive cancers among major racial and ethnic groups. Adding HPV35 to vaccines could provide additional protection, particularly for Black women.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Medicine, General & Internal
Hannah G. Rosenblum, Rayleen M. Lewis, Julia W. Gargano, Troy D. Querec, Elizabeth R. Unger, Lauri E. Markowitz
Summary: This study estimated the impact and effectiveness of HPV vaccination on sexually experienced females and males in the United States. The results showed significant impact of the vaccine on the prevalence of quadrivalent HPV types, but no significant impact on non-quadrivalent HPV types. Vaccine effectiveness varied across different time periods and genders. The nationally representative data demonstrate the increasing effectiveness of the vaccination program and herd protection.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Trinh Phuong Vo, Gitika Panicker, Kimberly Braz-Gomes, Ashwin C. Parenky, Ira Rajbhandari, Mangalathu S. Rajeevan, Elizabeth R. Unger, Martin J. D'Souza, Mohammad N. Uddin
Summary: This research developed a microparticulate HPV16 vaccine for transdermal administration and evaluated its immunogenicity in a pre-clinical mouse model. The results showed a significant increase in HPV16 IgG antibodies in the microparticle group and expansion of CD4+, CD45R, CD27 and CD62L cell populations in the vaccinated mice group. This suggests the high efficacy of the microparticulate vaccine when administered via transdermal route.
Article
Pathology
Hem R. Thapa, Elizabeth R. Unger, Troy D. Querec
Summary: Prophylactic human papillomavirus (HPV) vaccines are recommended for preventing HPV-associated cancers. However, there is a need for validated typing assays for the detection of HPV in formalin-fixed, paraffin-embedded (FFPE) tissues. The Novaplex II HPV28 Detection assay showed high concordance with the reference method and can be considered as a suitable method for HPV detection in FFPE tissues.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Article
Virology
Laura Teblick, Jade Pattyn, Severien Van Keer, Annemie De Smet, Ilse De Coster, Wiebren A. A. Tjalma, Ira Rajbhandari, Gitika Panicker, Elizabeth R. Unger, Alex Vorsters
Summary: This study explores the potential use of first-void urine as a noninvasive alternative sample for assessing humoral immune responses following HPV vaccination. The results show that first-void urine can detect HPV-specific antibody concentrations, with significant correlations to serum samples at different time points.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Tengguo Li, Elizabeth R. Unger, Mangalathu S. Rajeevan
Summary: This study performed whole-genome sequencing to detect all known and novel HPV types in male genital samples. The results showed that HPV was detected in nearly all samples, with a high number of types per sample. The most frequently detected types were alpha, beta, and gamma, and a novel gamma type and several unclassified types were identified. The study suggests a higher type diversity in males compared to females and calls for further research.
Article
Infectious Diseases
Raiza Amiling, Elissa Meites, Troy D. Querec, Laura Stone, Vidisha Singh, Elizabeth R. Unger, Craig S. Derkay, Lauri E. Markowitz
Summary: This study found that children with JORRP were commonly firstborn, delivered vaginally to young mothers, and most of the mothers reported no HPV vaccination before delivery. Disease severity was associated with younger diagnosis age and detection of HPV type 11.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Immunology
David Mesher, Kate Soldan, Matti Lehtinen, Simon Beddows, Marc Brisson, Julia M. L. Brotherton, Eric P. F. Chow, Teresa Cummings, Melanie Drolet, Christopher K. Fairley, Suzanne M. Garland, Jessica A. Kahn, Kimberley Kavanagh, Lauri Markowitz, Kevin G. Pollock, Anna Soderlund-Strand, Pam Sonnenberg, Sepehr N. Tabrizi, Clare Tanton, Elizabeth Unger, Sara L. Thomas
EMERGING INFECTIOUS DISEASES
(2016)