Article
Immunology
Ute V. Solloch, Anette S. Giani, Maria Ignacia Pattillo Garnham, Juergen Sauter, Stefanie N. Bernas, Vinzenz Lange, Francisco Barriga, Marcelo A. Fernandez-Vina, Alexander H. Schmidt
Summary: Hematopoietic stem cell transplantation often requires unrelated stem cell donors matched in HLA genes. The extensive allelic variability of the HLA system complicates donor search, hence the need for large registries. This study analyzed HLA allele and haplotype frequencies of DKMS Chile donors, identifying alleles more abundant in the Chilean subpopulations, particularly in the Mapuche. The study also revealed limited benefits for Chilean patients from non-Chilean donor registries, emphasizing the need for ongoing donor recruitment efforts in Chile.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tiira Johansson, Jukka Partanen, Paeivi Saavalainen
Summary: Varying levels of HLA allele-specific expression are associated with human diseases, and RNA sequencing-based approaches with NGS methodologies have emerged to quantify HLA allele-specific expression and provide important information for predicting immune cell therapy efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Linh Truong, Benedict M. Matern, Naser El-Lagta, Fredrick M. Mobegi, Medhat Askar, Yeliz Ogret, Fatma S. Oguz, Janette Kwok, Lloyd D'Orsogna, Patricia Martinez, Effie Petersdorf, Marcel G. J. Tilanus, Dianne De Santis
Summary: The aim of this study was to characterize extended haplotypes within the HLA-DP region and examine the genetic diversity in different human populations. By analyzing SNPs in 255 subjects from 6 different cohorts, the results validated findings from the initial pilot study. The region showed strong linkage, particularly in the HLA-DPA1 and HLA-DPB1 genes. The study identified multiple haplotypes in the promoter region and highlighted the clinical potential of selecting better-matched donors for patients awaiting stem cell transplants.
Article
Biophysics
Akihisa Kawajiri, Takakazu Kawase, Hidenori Tanaka, Takahiro Fukuda, Junichi Mukae, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Takehiko Mori, Takashi Ashida, Tadakazu Kondo, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Satoko Morishima, Junya Kanda
Summary: Imputing HLA haplotypes using a mathematical approach can help avoid mismatched haplotypes in unrelated allogeneic bone marrow transplantation and improve transplant outcomes.
BONE MARROW TRANSPLANTATION
(2022)
Article
Immunology
Stefano Mocci, Roberto Littera, Stefania Tranquilli, Aldesia Provenzano, Alessia Mascia, Federica Cannas, Sara Lai, Erika Giuressi, Luchino Chessa, Goffredo Angioni, Marcello Campagna, Davide Firinu, Maria Del Zompo, Giorgio La Nasa, Andrea Perra, Sabrina Giglio
Summary: The study found that Sardinian patients carrying the high-risk variant (rs35044562) of the Neanderthal risk locus have an increased risk of developing severe symptoms. However, in the Sardinian population, the extended haplotype of HLA-A*02:01, B*18:01, DRB*03:01 has a protective effect and can counteract the high risk associated with the Neanderthal locus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tran Ngoc Que, Nguyen Ba Khanh, Bach Quoc Khanh, Chu Van Son, Nguyen Thi Van Anh, Tran Thi Thuy Anh, Pham Dinh Tung, Nguyen Dinh Thang
Summary: This study provides critical information on the frequencies and distributions of HLA alleles and haplotypes in the Kinh Vietnamese population, accounting for more than 85% of Vietnamese citizens. It paves the way to establish an umbilical cord blood bank for cord blood transplantation programs in Vietnam.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Chun-Ying Lin, Chia-Ling Chang
Summary: HLA-C*01:143N differs from HLA-C*01:02:01:01 by a nucleotide substitution at position 585 in exon 3.
Article
Medicine, General & Internal
Thanh Thai Van Le, Thanh The Bich Vuong, Thinh Phuc Ong, Minh Duc Do
Summary: This study examined the frequency of HLA-DRB1 and HLA-DQB1 alleles in Vietnamese pemphigus vulgaris (PV) and pemphigus foliaceus (PF) patients, and found that HLA-DRB1*14:54 was the most frequent allele. The distribution of HLA-DQB1 alleles differed between PV and PF patients. HLA-DRB1*04 alleles may be associated with disease severity.
Editorial Material
Cell Biology
Kuo-Liang Yang, Tsung-Chih Chen, Chieh-Lin J. Teng, Py-Yu Lin
Summary: A nucleotide substitution in codon 316 of the HLA-A*24:02:01:01 gene has led to the creation of a novel allele, HLA-A*24:353.
Editorial Material
Cell Biology
Chun-Ying Lin, Chia-Ling Chang
Summary: HLA-C*07:446 differs from HLA-C*07:02:01:01 by a single nucleotide substitution at position 809 (C -> T) in exon 4.
Editorial Material
Cell Biology
Chia-Ling Chang, Chun-Ying Lin
Summary: HLA-A*02:672Q differs from HLA-A*02:06:01:01 by a single nucleotide substitution at position 563 (G -> A) in exon 3.
Article
Immunology
Alejandro Llanes, Luis Ortiz, Juan Moscoso, Gina Gutierrez, Elena Blake, Carlos M. Restrepo, Ricardo Lleonart, Cesar Cuero, Alejandro Vernaza-Kwiers
Summary: This study provides the first report on HLA allele and haplotype frequencies in the modern Panamanian population, offering insights for healthcare strategies and future disease research in the country.
Editorial Material
Cell Biology
Chia-Ling Chang, Chun-Ying Lin
Summary: HLA-C*03:294 differs from HLA-C*03:04:01:01 by a single nucleotide substitution at position 727 in exon 4.
Article
Infectious Diseases
Nandakumar Rangasamy, Rathika Chinniah, Padma-Malini Ravi, Murali Vijayan, Ramgopal Sivanadham, K. Darsa, Sasiharan Pandi, Vandit Sevak, Prabhakaran Krishnan, Balakrishnan Karuppiah
Summary: This study focused on the HLA immunogenetics of South Indian tribes, revealing globally shared haplotypes and their associations with various diseases in the region. The presence of ancestral extended haplotypes not previously reported in Indian populations, as well as the dendrogram-based phylogenetic analyses showing the genetic affinities of different tribal groups, further emphasized the diverse and mosaic immunogenetic fabric of South Indian tribes.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Cell Biology
Antonio Balas, Francisco Sanchez-Gordo, Miguel-Angel Moreno-Hidalgo, Felix Garcia-Sanchez, Jose L. Vicario
Summary: This paper focuses on the sequence and expression analysis of the HLA-DRB1*10:38 allele.
Article
Public, Environmental & Occupational Health
Piraya Bhoomiboonchoo, Ananda Nisalak, Natkamol Chansatiporn, In-Kyu Yoon, Siripen Kalayanarooj, Mathuros Thipayamongkolgul, Timothy Endy, Alan L. Rothman, Sharone Green, Anon Srikiatkhachorn, Darunee Buddhari, Mammen P. Mammen, Robert V. Gibbons
Article
Immunology
E. Townsley, G. O'Connor, C. Cosgrove, M. Woda, M. Co, S. J. Thomas, S. Kalayanarooj, I. -K. Yoon, A. Nisalak, A. Srikiatkhachorn, S. Green, H. A. F. Stephens, E. Gostick, D. A. Price, M. Carrington, G. Alter, D. W. McVicar, A. L. Rothman, A. Mathew
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2016)
Article
Virology
Chonticha Klungthong, Wudtichai Manasatienkij, Thipwipha Phonpakobsin, Piyawan Chinnawirotpisan, Prinyada Rodpradit, Kittinun Hussem, Butsaya Thaisomboonsuk, Prapapun Ong-ajchaowlerd, Ananda Nisalak, Siripen Kalayanarooj, Darunee Buddhari, Robert V. Gibbons, Richard G. Jarman, In-Kyu Yoon, Stefan Fernandez
JOURNAL OF CLINICAL VIROLOGY
(2015)
Article
Virology
Laura L. Hermann, Swati B. Gupta, Susan B. Manoff, Siripen Kalayanarooj, Robert V. Gibbons, Beth-Ann G. Coller
JOURNAL OF CLINICAL VIROLOGY
(2015)
Article
Immunology
Hannah E. Clapham, Isabel Rodriguez-Barraquer, Andrew S. Azman, Benjamin M. Althouse, Henrik Salje, Robert V. Gibbons, Alan L. Rothman, Richard G. Jarman, Ananda Nisalak, Butsaya Thaisomboonsuk, Siripen Kalayanarooj, Suchitra Nimmannitya, David W. Vaughn, Sharone Green, In-Kyu Yoon, Derek A. T. Cummings
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Immunology
Sasijit Vejbaesya, Rungrot Thongpradit, Siripen Kalayanarooj, Komon Luangtrakool, Panpimon Luangtrakool, Robert V. Gibbons, Duangporn Srinak, Somporn Ngammthaworn, Kusuma Apisawes, In-Kyu Yoon, Stephen J. Thomas, Richard G. Jarman, Anon Srikiakthachorn, Sharone Green, Dasnayanee Chandanayingyong, Sangshin Park, Jennifer Friedman, Alan L. Rothman, Henry A. F. Stephens
JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Immunology
Etienne Simon-Loriere, Ren-Jye Lin, Sita Mint Kalayanarooj, Ampaiwan Chuansumrit, Isabelle Casademont, Shyr-Yi Lin, Han-Pang Yu, Worachart Lert-itthiporn, Wathanee Chaiyaratana, Nattaya Tangthawornchaikul, Kanchana Tangnararatchakit, Sirijitt Vasanawathana, Bi-Lan Chang, Prapat Suriyaphol, Sutee Yoksan, Prida Malasit, Philipe Despres, Richard Paul, Yi-Ling Lin, Anavaj Sakuntabhai
JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Medicine, General & Internal
Luis Villar, Gustavo Horacio Dayan, Jose Luis Arredondo-Garcia, Doris Maribel Rivera, Rivaldo Cunha, Carmen Deseda, Humberto Reynales, Maria Selma Costa, Javier Osvaldo Morales-Ramirez, Gabriel Carrasquilla, Luis Carlos Rey, Reynaldo Dietze, Kleber Luz, Enrique Rivas, Maria Consuelo Miranda Montoya, Margarita Cortes Supelano, Betzana Zambrano, Edith Langevin, Mark Boaz, Nadia Tornieporth, Melanie Saville, Fernando Noriega
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Article
Public, Environmental & Occupational Health
Ananda Nisalak, Hannah E. Clapham, Siripen Kalayanarooj, Chonticha Klungthong, Butsaya Thaisomboonsuk, Stefan Fernandez, Julia Reiser, Anon Srikiatkhachorn, Louis R. Macareo, Justin T. Lessler, Derek A. T. Cummings, In-Kyu Yoon
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2016)
Article
Infectious Diseases
Cuong Hoang Quoc, Salje Henrik, Rodriguez-Barraquer Isabel, Yoon In-Kyu, Nguyen Van Vinh Chau, Nguyen Thanh Hung, Ha Manh Tuan, Phan Trong Lan, Bridget Willis, Ananda Nisalak, Siripen Kalayanarooj, Derek A. T. Cummings, Cameron P. Simmons
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Immunology
Siripen Kalayanarooj, Alan L. Rothman, Anon Srikiatkhachorn
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Multidisciplinary Sciences
Henrik Salje, Justin Lessler, Irina Maljkovic Berry, Melanie C. Melendrez, Timothy Endy, Siripen Kalayanarooj, Atchareeya A-Nuegoonpipat, Sumalee Chanama, Somchai Sangkijporn, Chonticha Klungthong, Butsaya Thaisomboonsuk, Ananda Nisalak, Robert V. Gibbons, Sopon Iamsirithaworn, Louis R. Macareo, In-Kyu Yoon, Areerat Sangarsang, Richard G. Jarman, Derek A. T. Cummings
Article
Immunology
Kirk Haltaufderhyde, Anon Srikiatkhachorn, Sharone Green, Louis Macareo, Sangshin Park, Siripen Kalayanarooj, Alan L. Rothman, Anuja Mathew
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
Sangshin Park, Anon Srikiatkhachorn, Siripen Kalayanarooj, Louis Macareo, Sharone Green, Jennifer F. Friedman, Alan L. Rothman
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Immunology
Panpimon Luangtrakool, Sasijit Vejbaesya, Komon Luangtrakool, Somporn Ngamhawornwong, Kusuma Apisawes, Siripen Kalayanarooj, Louis R. Macareo, Stefan Fernandez, Richard G. Jarman, Robert W. M. Collins, Steven T. Cox, Anon Srikiatkhachorn, Alan L. Rothman, Henry A. F. Stephens
JOURNAL OF INFECTIOUS DISEASES
(2020)