Article
Virology
Xiaohui Zhao, Huijun Yuan, Hang Yang, Yan Liu, Meng Xun, Xiaozhen Li, Tingting Fan, Bo Wu, Shangrui Guo, Hongliang Wang
Summary: EV71 is a common pathogen causing hand, foot, and mouth disease in young children, and it is associated with severe neurological complications. This study found that the ER-resident acetyltransferase NAT8 is a host factor for EV71 infection and promotes viral replication by interacting with viral proteins.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ammar M. Hassanbhai, Meng Chee Phoon, Vincent T. Chow, Bow Ho
Summary: This study investigates the interactions between enterovirus 71 (EV71) and the biofilm formed by Helicobacter pylori. The results show that the H. pylori biofilm can prolong the survival of EV71 and the quantity of biofilm formation affects the viability of the virus. This suggests that the H. pylori biofilm may serve as an additional pathway for EV71 transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Chunchen Wu, Luzhi Zeng, Wenfu Yi, Yuanjiu Miao, Yihan Liu, Qiming Wang, Shi Liu, Guoping Peng, Zhenhua Zheng, Jianbo Xia
Summary: This study demonstrates that echovirus infection can induce autophagy, which promotes viral replication and VP1 expression in host cells. The mechanism involves the regulation of the mTOR/ULK1 signaling pathway, providing insight into the potential role of autophagy in echovirus infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Shanshan Fan, Zihang Xu, Pengfei Liu, Yali Qin, Mingzhou Chen
Summary: Several viruses inhibit the formation of RNA processing bodies, including enterovirus 71, which relies on its 2A protease to block P-body formation and promote viral replication. The interaction between DDX6 and viral RNA also facilitates viral replication.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Jia-Ying Lu, Gary Brewer, Mei-Ling Li, Kai-Zhe Lin, Chien-Chih Huang, Li-Chen Yen, Jing-Yi Lin
Summary: The study investigates the formation of replication organelles by picornaviruses using enterovirus A71 (EV-A71) as a model. SCAMP3, a host protein, associates with viral 3A protein and plays a critical role in viral RNA synthesis and replication. Additionally, the interaction between 3A protein and SCAMP3 positively regulates enterovirus replication and involves the extracellular signal-regulated kinase (ERK) signaling pathway.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Zhihui Ruan, Yicong Liang, Zicong Chen, Jialing Yin, Chengcheng Li, Pan Pan, Qiwei Zhang, Jianguo Wu, Zhen Luo
Summary: This study found that EV71 infection can enhance exosome biogenesis, and EV71 3A protein can promote exosome secretion. Further investigation revealed that VPS25, which is associated with EV71 infection, is located on exosomes and its expression correlates to exosome production. Knock-down of VPS25 decreases exosome biogenesis, thus attenuating viral replication. The exosome inhibitor GW4869 exhibits significant antiviral activity against EV71 replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Rui Zhang, Jing Chen, Ruidong Zi, Lin Ji, Jingping Hu, Zhiwei Wu, Yuxuan Fu
Summary: This study finds that autophagy response contributes to the packaging of EV71 viral genome into exosomes, playing a crucial role in viral spreading. Inhibition of autophagosomes-MVBs fusion can abolish the sorting of viral RNA into exosomes.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Hui Li, Wenqian Li, Shuangling Zhang, Manman Qiu, Zhuoran Li, Yongquan Lin, Juan Tan, Wentao Qiao
Summary: This study reveals the interaction between the upregulated host protein GADD34 and EV71 and provides insights into the mechanisms by which EV71 non-structural precursor protein 3CD regulates host protein expression. GADD34 is important for EV71 replication, and its key functional domains, PEST 1, 2, and 3 regions, promote EV71 replication. Additionally, GADD34 is found to promote viral IRES independently of its eIF2α phosphatase activity.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, Research & Experimental
Xiaoyan Zhang, Jinfang Hao, Chenxi Sun, Jianping Du, Qian Han, Qingshan Li
Summary: Total astragalosides (ASTs) from Astragalus membranaceus have a protective effect against EV71 infection by inhibiting cell apoptosis and pyroptosis, as well as suppressing EV71 replication and release.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemical Research Methods
Guillaume Lingas, Kyle Rosenke, David Safronetz, Jeremie Guedj
Summary: Lassa fever is caused by Lassa virus and currently has no approved vaccine. Recent findings show that the nucleotide analogue favipiravir has a high antiviral efficacy against Lassa virus, but its mechanism of action is not clear and the lack of pharmacokinetic data hinders the translation of these results to humans.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Virology
Ya-Ling Huang, Sheng-Wen Huang, Chun-Yu Shen, Dayna Cheng, Jen-Ren Wang
Summary: Enterovirus genus has a variety of genotypes that can cause severe diseases. Studying the role of conserved residues in the VP1 capsid protein may lead to the development of anti-enteroviral drugs. Highly conserved residues located at the loop and ss-barrel intersections were found to play a role in modulating viral replication.
Article
Microbiology
Bei Wang, Chongyang Zhang, Congci Yu, Yue Zhu, Qing Tang, He Huang, Zhendong Zhao
Summary: The study reveals that EV71 infection leads to cleavage of INF2, a key factor in ER-Mitochondria communication, possibly involved in the formation of viral replication organelles and serves as a positive feedback regulatory mechanism of mitochondrial disorders caused by EV71 infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Jide Tian, Barbara J. J. Dillion, Jill Henley, Lucio Comai, Daniel L. L. Kaufman
Summary: Research has shown the potential of GABA-R agonists for treating COVID-19 by reducing lung damage, death rates, and viral loads. This finding is important for finding treatment methods for diseases induced by new SARS-CoV-2 variants and coronaviruses that evade immune responses and antiviral medications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Subrat Kumar Swain, Ayushman Gadnayak, Jatindra Nath Mohanty, Rachita Sarangi, Jayashankar Das
Summary: This review explores the interaction between enterovirus 71 (EV71) and its host, including how the virus affects the host's immunity and replication, and how it evades the host's immune responses. It also discusses drug targets for EV71 treatment and antiviral drugs and vaccines developed to combat viral outbreaks. The importance of improving existing vaccines is emphasized.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Review
Virology
Subrat Kumar Swain, Subhasmita Panda, Basanta Pravas Sahu, Rachita Sarangi
Summary: This study aims to investigate the interaction between viral ligands and host receptors, the activation of immune-related signaling pathways, and the involvement of cytokines during host-pathogen interaction. The study also examines the roles of viral proteins and interferons.
Article
Pharmacology & Pharmacy
Takuyu Hashiguchi, Sawako Shindo, Shih-Heng Chen, Jau-Shyong Hong, Masahiko Negishi
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Neurosciences
Shih-Heng Chen, Yueh-Feng Sung, Esteban A. Oyarzabal, Yu-Mei Tan, Jeremy Leonard, Mingri Guo, Shuo Li, Qingshan Wang, Chun-Hsien Chu, Shiou-Lan Chen, Ru-Band Lu, Jau-Shyong Hong
MOLECULAR NEUROBIOLOGY
(2018)
Article
Substance Abuse
Tzu-Yun Wang, Sheng-Yu Lee, Yun-Hsuan Chang, Shiou-Lan Chen, Po See Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, I. Hui Lee, Kao Chin Chen, Yen Kuang Yang, Shih-Heng Chen, Jau-Shyong Hong, Ru-Band Lu
DRUG AND ALCOHOL DEPENDENCE
(2018)
Article
Biochemistry & Molecular Biology
Ran Zhou, Shih-Heng Chen, Guorong Li, Hui-Ling Chen, YuXin Liu, Hung-Ming Wu, Yubao Wang, Jing Feng, Jau-Shyong Hong
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Substance Abuse
Ru-Band Lu, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, Shih-Hsien Lin, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, I. Hui Lee, Kao Chin Chen, Yen Kuang Yang, Ping Chen, Shih-Heng Chen, Jau-Shyong Hong
DRUG AND ALCOHOL DEPENDENCE
(2019)
Article
Biochemistry & Molecular Biology
Charles Romeo, Shih-Heng Chen, Eugenia Goulding, Lucas Van Gorder, Maura Schwartz, Mitzie Walker, Gregory Scott, Erica Scappini, Manas Ray, Negin P. Martin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi
CELL COMMUNICATION AND SIGNALING
(2020)
Article
Biochemical Research Methods
Shih-Heng Chen, Amy Papaneri, Mitzie Walker, Erica Scappini, Robert D. Keys, Negin P. Martin
JOURNAL OF VIROLOGICAL METHODS
(2020)
Article
Multidisciplinary Sciences
Alexander C. Y. Foo, Peter M. Thompson, Shih-Heng Chen, Ramesh Jadi, Brianna Lupo, Eugene F. DeRose, Simrat Arora, Victoria C. Placentra, Lakshmanane Premkumar, Lalith Perera, Lars C. Pedersen, Negin Martin, Geoffrey A. Mueller
Summary: The mosquito protein AEG12 has been shown to inhibit replication of enveloped viruses such as Dengue and Zika viruses by selectively delivering unsaturated fatty acids into lipid membranes, demonstrating its potential as a broad-spectrum therapeutic agent.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Chih-Fen Hu, San-Pin Wu, Gu-Jiun Lin, Chi-Chang Shieh, Chih-Sin Hsu, Jing-Wun Chen, Shih-Heng Chen, Jau-Shyong Hong, Shyi-Jou Chen
Summary: The study showed that Nox2 deficiency attenuates neural damage induced by EAE, reduces disease severity, pathogenic immune cells infiltration, demyelination, and oxidative stress in the CNS. It also revealed that microglial Nox2 plays a regulatory role in multiple pathways important for MS/EAE pathogenesis, suggesting that Nox2 inhibition may represent an important therapeutic target for MS.
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Endocrinology & Metabolism
Tzu-Yun Wang, Sheng-Yu Lee, Ming-Chuan Hu, Shiou-Lan Chen, Yun-Hsuan Chang, Chun-Hsien Chu, Shih-Hsien Lin, Chia-Ling Li, Liang-Jen Wang, Po See Chen, Shih-Heng Chen, San-Yuan Huang, Nian-Sheng Tzeng, I. Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shih-Heng Chen, Shuangyu Han, Chih-Fen Hu, Ran Zhou, Yun Gao, Dezhen Tu, Huiming Gao, Jing Feng, Yubao Wang, Ru-Band Lu, Jau-Shyong Hong
Summary: Recent studies have found that improper resolution of acute neuroinflammation can lead to long-lasting low-grade chronic neuroinflammation and progressive neurodegeneration. This study aimed to identify the potential pathways mediating chronic neuroinflammation and resultant neurodegeneration following LPS stimulation. The results showed that TLR-4 activation, which is essential for acute neuroinflammation, is not sufficient for maintaining chronic neuroinflammation. Instead, the MAC1-NOX2-ERK1/2 signaling pathway plays a crucial role in the initiation and maintenance of low-grade chronic neuroinflammation. Continuous activation of ERK1/2 and NOX2 in microglia forms a vicious cycle, sustaining the low-grade neuroinflammation and driving neurodegeneration.
Article
Microbiology
Christopher McGee, Min Shi, John House, Anna Drude, Gladys Gonzalez, Negin Martin, Shih-Heng Chen, Heidi Rogers, Alex Njunge, Xiomara Hodge, Brittany Mosley, Margaret George, Ruhani Agrawal, Catherine Wild, Cynthia Smith, Audrey Brown, Lisa Barber, Stavros Garantziotis
Summary: The COVID-19 pandemic continues to impact societies and healthcare systems worldwide. Vaccination and social distancing behavior are positively correlated. Breakthrough infections are associated with low antibody titers.
MICROBIOLOGY SPECTRUM
(2022)
Article
Neurosciences
Ran Zhou, Shih-Heng Chen, Zhan Zhao, Dezhen Tu, Sheng Song, Yubao Wang, Qingshan Wang, Jing Feng, Jau-Shyong Hong
Summary: Recent studies have found increased expression of complements in neurodegenerative diseases like Alzheimer's and Parkinson's diseases. However, the mechanism and role of complements in neurodegeneration are unclear. This study showed that acute neuroinflammation increased the expression of complement C3, and sustained expression during chronic neuroinflammation required the release of damage-associated molecule patterns (DAMPs). The activation of microglial NADPH oxidase (NOX2) was found to be involved in the sustained expression of C3. The findings suggest a role of C3 in regulating chronic neuroinflammation and driving progressive neurodegeneration.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaoru Inoue, Hamed Bostan, MaKenna R. Browne, Owen F. Bevis, Carl D. Bortner, Steven A. Moore, Aaron A. Stence, Negin P. Martin, Shih-Heng Chen, Adam B. Burkholder, Jian-Liang Li, Natalie D. Shaw
Summary: SMCHD1 mutations cause congenital arhinia and FSHD2. Loss of SMCHD1 activity leads to DUX4 expression and cell death in placode cells derived from hESCs and iPSCs. Herpesvirus infection may amplify DUX4 expression in SMCHD1 KO cells, indicating an environmental disease modifier.