Article
Multidisciplinary Sciences
Thaina M. da Costa, Albertus Viljoen, Aisling M. Towell, Yves F. Dufrene, Joan A. Geoghegan
Summary: This study identifies a novel loricrin-binding protein, FnBPB, in Staphylococcus aureus and demonstrates through single-molecule force spectroscopy that FnBPB strengthens the adhesion of S. aureus to human corneocytes through its strong binding to loricrin.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Jelle Vlaeminck, Qiang Lin, Basil Britto Xavier, Sarah De Backer, Matilda Berkell, Henri De Greve, Jean-Pierre Hernalsteens, Samir Kumar-Singh, Herman Goossens, Surbhi Malhotra-Kumar
Summary: There are striking differences in gene expression during biofilm formation by three important pandemic MRSA clones, USA300, HEMRSA-15, and ST239. The clfA gene is the only significantly upregulated gene across all three strains in 24-hour biofilm cultures and represents an important target for disrupting early biofilms. Furthermore, our data indicate the critical role of arginine catabolism pathways in early biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Natalia Salazar, Bruno Bernardi Yamamoto, Matilde Costa Lima de Souza, Ludmila Bezerra da Silva, Ana Paula Mattos Areas, Angela Silva Barbosa
Summary: Staphylococcus aureus has evolved strategies to acquire metals from the host, such as iron, manganese, and zinc, for survival and colonization. The bacteria also utilize adhesins on the bacterial surface and acquire host plasminogen and complement regulatory proteins for colonization and infection. In vitro data shows that the zinc transport protein AdcA interacts with host molecules like plasminogen and factor H, paving the way for future studies on the relevance of these interactions in vivo.
Article
Microbiology
Yi-Tian Ying, Wei-Jia Ren, Xun Tan, Jing Yang, Rui Liu, Ai-Fang Du
Summary: The membrane-binding protein Annexin A2 plays a role in the internalization of Staphylococcus aureus into bovine mammary epithelial cells, with the interaction between ClfB and AnxA2 promoting the invasion of S. aureus. Targeting this interaction may provide protection against S. aureus mastitis.
Article
Immunology
Jyotirmayee Dey, Soumya Ranjan Mahapatra, Pratima Singh, Swadheena Patro, Gajraj Singh Kushwaha, Namrata Misra, Mrutyunjay Suar
Summary: Staphylococcus aureus infection poses a global threat due to its highly debilitating nature and resistance to antimicrobial medicines. The study identified potential vaccine candidates from the Clumping factor surface proteins and designed a multi-epitope vaccine chimera. Molecular dynamics simulations confirmed the stability of the structure for further analysis.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Yanjie Mao, Florent Valour, Nhu T. Q. Nguyen, Thien M. N. Doan, Holly Koelkebeck, Christopher Richardson, Lily Cheng, Bret R. Sellman, Christine Tkaczyk, Binh An Diep
Summary: The study found that prophylaxis targeting specific staphylococcal virulence factors can significantly reduce symptoms such as joint swelling and erythema caused by prosthetic joint infection in a rabbit model.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Alexander M. Tatara, Ronak G. Gandhi, David J. Mooney, Sandra B. Nelson
Summary: Staphylococcus aureus bacteremia remains clinically challenging, but patients treated with ticagrelor may have better infection outcomes. Potential mechanisms of ticagrelor's effects on S. aureus virulence include direct antibacterial activity, boosting platelet-mediated immune responses, and preventing bacterial adhesion to host tissues. Further research is needed to confirm the role of antiplatelet medications in the treatment of S. aureus infection.
Article
Hematology
Hector Martin Merinero, Marta Subias, Amaia Pereda, Elena Gomez-Rubio, Lucia Juana Lopez, Constantino Fernandez, Elena Goicoechea de Jorge, Sonsoles Martin-Santamaria, Francisco Javier Canada, Santiago Rodriguez de Cordoba
Summary: Factor H (FH)-related protein 1 (FHR-1) plays a significant role in diseases like atypical hemolytic uremic syndrome (aHUS) by competing with FH in binding to surface-bound C3b to promote complement activation. Abnormally elevated FHR-1/FH activity ratios perpetuate pathological complement dysregulation at complement-activating surfaces.
Article
Cell Biology
Zubin Zhou, Yuanliang Chen, Hong Sung Min, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Xiaowei Yu
Summary: Merlin deficiency alleviates S. aureus-induced osteomyelitis through the regulation of DCAF1, resulting in the suppression of inflammatory responses in macrophages and BMDMs. This indicates a potential therapeutic target for osteomyelitis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Microbiology
Hasmatbanu Buchad, Mrinalini Nair
Summary: The study revealed that sRNA SprX regulates the pathogenicity of Staphylococcus aureus by modulating the expression of multiple autolysins, which play essential roles in cell wall metabolism and virulence factors. SprX positively regulates the expression of autolysins by regulating WalR, leading to altered phenotype and increased resistance to lysis in S. aureus. These findings point to a novel mechanism in which SprX contributes to S. aureus pathogenesis by controlling autolysins.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Aisling M. Towell, Cecile Feuillie, Pauline Vitry, Thaina M. Costa, Marion Mathelie-Guinlet, Sanja Kezic, Orla M. Fleury, Maeve A. McAleer, Yves F. Dufrene, Alan D. Irvine, Joan A. Geoghegan
Summary: Staphylococcus aureus interacts with the host protein corneodesmosin on atopic dermatitis corneocytes, taking advantage of the aberrant display of corneodesmosin caused by low natural moisturizing factor levels. The bacterial proteins FnBPB and ClfB bind to the N-terminal region of corneodesmosin, facilitating strong adherence of S. aureus to atopic dermatitis corneocytes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Marcus A. Wittekind, Paul Briaud, Jayanna L. Smith, Julia R. Tennant, Ronan K. Carroll
Summary: Staphylococcus aureus is a pathogen that causes potentially life-threatening infections, thanks to its multitude of toxins and virulence factors. This bacterium's ability to cause a wide range of illnesses is due to its complex regulatory network, which controls various virulence factors.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Hao Pei, Chengfeng Zhu, Fang Shu, Zhengfei Lu, Hui Wang, Kai Ma, Jun Wang, Ranxiang Lan, Fei Shang, Ting Xue
Summary: This study reveals the significant role of CodY in environmental stress tolerance of foodborne S. aureus, and suggests that CodY indirectly regulates the temperature tolerance of S. aureus by regulating the expression of heat shock proteins.
Article
Biochemistry & Molecular Biology
Yuan Wei, Jingze Liu, Gongyan Liu, Shuai Gao, Dimeng Wu, Li Yang, Rifang Luo, Fanjun Zhang, Yunbing Wang
Summary: In this work, a self-adaptive anti-inflammatory coating strategy combined with anti-infection and anticoagulant capacity was proposed, which was achieved by using nano-Ag particles and dexamethasone-loaded hydrogel coating. The coating exhibited bactericidal performance and self-adaptive anti-inflammatory properties, effectively resisting infection, thrombosis, and inflammation. This work provides a new perspective for designing clinical complication-conformable coatings on blood-contacting medical devices.
Article
Parasitology
Adalberto Alves Pereira Filho, Alexandre Alves de Sousa Nascimento, Natalia Alvim Araujo Saab, Ricardo Toshio Fugiwara, Grasielle Caldas D'Avila Pessoa, Leonardo Barbosa Koerich, Marcos Horacio Pereira, Ricardo Nascimento Araujo, Mauricio Roberto Viana Sant'Anna, Nelder Figueiredo Gontijo
Summary: Certain pathogens have evolved mechanisms to evade the complement system, such as inactivating C3b molecules through the binding of factor H. Understanding these mechanisms could potentially lead to the development of targeted vaccines for controlling leishmaniasis.