Review
Medicine, General & Internal
Akram I. Ahmad, Colin Wikholm, Ioannis Pothoulakis, Claire Caplan, Arielle Lee, Faith Buchanan, Won Kyoo Cho
Summary: This study reviewed the prevalence, mortality, risk factors, and reasons for hospitalization of patients with Whipple's disease. It found significant differences in age, gender, and hospitalization location among Whipple's disease patients. The most common reason for hospitalization was gastrointestinal disease. The higher hospitalization rates in the Midwest support the influence of environmental and occupational factors in disease transmission.
Article
Immunology
Thamer H. Albekairi, Abdulrahman Alshammari, Metab Alharbi, Amal F. Alshammary, Muhammad Tahir Ul Qamar, Tasneem Anwar, Saba Ismail, Bilal Shaker, Sajjad Ahmad
Summary: This study aimed to design a chimeric peptide vaccine against T. whipplei using computational methods. Four immunodominant epitopes were identified, covering 89.03% of the global population. Further experimental testing is needed to evaluate the vaccine's potential for protective and targeted immunogenicity.
Article
Microbiology
Sylvain Meyer, Xavier Puechal, Gilles Quesne, Isabelle Marques, Anne Jamet, Agnes Ferroni
Summary: This study evaluated the application value of T. whipplei PCR in patients with Whipple disease and carriers. The results showed significant differences in PCR results between WD patients and carriers, with high specificity and moderate sensitivity for the diagnosis of Whipple disease.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Review
Immunology
Nadji Hannachi, Florent Arregle, Hubert Lepidi, Jean-Pierre Baudoin, Frederique Gouriet, Helene Martel, Sandrine Hubert, Benoit Desnues, Alberto Riberi, Jean-Paul Casalta, Gilbert Habib, Laurence Camoin-Jau
Summary: Whipple's disease is a chronic multisystemic infection caused by Tropheryma whipplei. It is often misunderstood due to its intracellular localization and absence of pathognomonic signs, leading to misdiagnosis. This case report highlights a patient initially treated for presumed rheumatoid arthritis who was later diagnosed with Whipple's disease after presenting with infectious endocarditis. The atypical presentation observed might be attributed to the anti-inflammatory treatment given for the initial misdiagnosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Veterinary Sciences
Melissa A. de la Garza, Sara R. Hegge, Jaco Bakker
Summary: This study reviewed the epidemiology, clinical evaluation, and surgical management of inguinal hernias in nonhuman primates. Inguinal hernias are commonly found in male nonhuman primates, and the clinical signs are usually limited to a visible or palpable mass in the groin region. Monitoring is a suitable treatment option, and surgery is necessary for cases with strangulation to avoid tissue necrosis and death. Imaging techniques such as CT, ultrasonography, and MRI can aid in diagnosis and treatment. Surgical repair can be done through open or laparoscopic surgery using mesh or suture. Complication and recurrence rates are generally low, and the presence of hernia does not affect fertility or increase the risk of occurrence, recurrence, or strangulation.
VETERINARY SCIENCES
(2022)
Article
Immunology
Asma Boumaza, Soraya Mezouar, Matthieu Bardou, Didier Raoult, Jean-Louis Mege, Benoit Desnues
Summary: Tropheryma whipplei is the causative agent of Whipple's disease, characterized by macrophage infiltration of the intestinal mucosa. Treatment with TNFI may exacerbate subclinical undiagnosed Whipple's disease by promoting a strong inflammatory response and apoptosis, indicating the need for screening patients for T. whipplei before initiating TNFI therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jianan Sang, Daohua Zhuang, Tao Zhang, Qunfu Wu, Jiangkun Yu, Zhigang Zhang
Summary: This study provides a comprehensive investigation of the gut microbiota's age patterning in four human populations and three nonhuman primates, and identifies Prevotellamassilia, Prevotella, Gemmiger, Coprococcus, Faecalibacterium, and Roseburia as potential common antiaging microbial markers in both humans and nonhuman primates due to their metabolic capabilities for host health benefits. The results also support the use of macaques as animal models for studying the role of the gut microbiome in human aging.
Article
Microbiology
Archana Thomas, Ariel M. Slifka, Sara M. Hendrickson, Ian J. Amanna, Mark K. Slifka
Summary: Diphtheria is rare in the United States and many industrialized nations due to effective vaccines and high vaccination coverage. However, in several European countries, C. ulcerans has become the dominant source of diphtheria cases. This study identified active transmission of toxigenic C. ulcerans among rhesus macaques and provided evidence of potential human transmission. These findings highlight the importance of maintaining high vaccination coverage to reduce the risk of zoonotic infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Davide Scalvini, Patrizia Cambieri, Annalisa Schiepatti, Stiliano Maimaris, Francesca Lusetti, Claudia Vattiato, Piero Marone, Laura Villani, Federico Biagi
Summary: This study aimed to investigate the prevalence of Helicobacter pylori (H. pylori) infection and related disorders in patients with Whipple's disease. The study found that H. pylori infection, H. pylori-related gastritis, and gastric atrophy were significantly more common in patients with Whipple's disease compared to the control group. Interestingly, a higher proportion of patients on long-term trimethoprim-sulfamethoxazole therapy had synchronous occurrence of H. pylori infection and Whipple's disease.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Diyoly Ayona, Sandra Madariaga Zarza, Ludovic Landemarre, Benoit Roubinet, Philippe Decloquement, Didier Raoult, Pierre-Edouard Fournier, Benoit Desnues
Summary: Tropheryma whipplei is an actinobacterium that causes various infections in humans, including Whipple's disease. The bacterium's complex surface glycoproteins contain different sugars, and they interact with Galectin-1 and Galectin-3 to promote infection.
Article
Infectious Diseases
Haiyan Ye, Xiao Hu, Tommy Richard Sun-Wing Tong, Shuang Chen, Tao Li, Fanfan Xing, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Kelvin Hei-Yeung Chiu
Summary: A case of Whipple's disease in a Chinese patient with atypical symptoms was reported. Multiple investigations showed the presence of T. whipplei DNA in the lymph nodes. Prolonged antibiotic treatment was effective in this case, highlighting the need for further research in the Chinese population.
BMC INFECTIOUS DISEASES
(2023)
Article
Allergy
Ali Versi, Fransiskus Xaverius I. Ivan, Mahmoud Abdel-Aziz, Stewart Bates, John Riley, Frederic Baribaud, Nazanin Zounemat Kermani, Paolo Montuschi, Sven-Erik Dahlen, Ratko Djukanovic, Peter H. Sterk, Anke H. Maitland-Van Der Zee, Sanjay Chotirmall, Peter M. Howarth, Ian Adcock, Kian Fan Chung
Summary: The study analyzed the bacterial species in sputum of severe asthma patients and found altered airway microbiome in asthma. Haemophilus influenzae and Moraxella catarrhalis were more abundant in severe neutrophilic asthma, while Haemophilus influenzae and Tropheryma whipplei were highest in current or ex-smokers. The abundance of these bacteria correlated with the presence of inflammatory cells in the airways.
Article
Microbiology
Sumi Yoon, Yoo Jeong Choi, Yong Kwan Lim, Oh Joo Kweon, Hye Ryoun Kim, Tae-Hyoung Kim, Mi-Kyung Lee
Summary: This study estimated the prevalence of T. whipplei in the stools of Korean patients with diarrhea using RT-PCR and compared three RT-PCR targets. T. whipplei was detected in 1.4% of all samples, with no differences in gender and age. The RT-PCRs targeting hsp65 and Dig15 showed reliable performance, suggesting a multiplex PCR including these targets could be useful for T. whipplei detection.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Infectious Diseases
Mihret Tilahun, Mesfin Fiseha, Endris Ebrahim, Seada Ali, Melaku Ashagrie Belete, Abdurahaman Seid, Wondmagegn Demsiss, Alemu Gedefie, Selamyhun Tadesse, Chernet Belayhun
Summary: The study found a relatively low prevalence of Streptococcus pneumoniae nasopharyngeal carriage among preschool children, with high antimicrobial resistance observed in most tested drugs. Younger age groups and passive smokers were identified as being at a higher risk for Streptococcus pneumoniae nasopharyngeal carriage.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Natalia C. C. de Azevedo Fernandes, Juliana M. Guerra, Josue Diaz-Delgado, Mariana S. Cunha, Leila del C. Saad, Silvia D. Iglezias, Rodrigo A. Ressio, Cinthya dos Santos Cirqueira, Cristina T. Kanamura, Isis P. Jesus, Adriana Y. Maeda, Fernanda G. S. Vasami, Julia de Carvalho, Leonardo J. T. de Araujo, Renato Pereira de Souza, Juliana S. Nogueira, Roberta M. F. Spinola, Jose L. Catao-Dias
Summary: The study identified different profiles of yellow fever (YF) among different genera of primates in Brazil, with howler monkeys being the most reliable sentinel; capuchin and titi monkeys having higher viral loads but lower mortality rates; marmosets being the least sensitive, with lower viral loads, mortality rates, and no visible YF virus antigen despite detectable viral RNA. These differences should be taken into consideration in YF surveillance and control measures.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Khouloud Slimene, Allaaeddin El Salabi, Olfa Dziri, Najla Mathlouthi, Seydina M. Diene, Elhussan Ahmed Mohamed, Jadalla M. A. Amhalhal, Mohammed O. Aboalgasem, Jomaa F. Alrjael, Jean-Marc Rolain, Chedly Chouchani
Summary: Antimicrobial resistance, especially to carbapenems, poses a major threat to public health. A study conducted in Ibn Sina Hospital in Libya identified low susceptibility to carbapenems among Gram-negative bacteria. Molecular investigations revealed the presence of New Delhi metallo-beta-lactamases-1 and Verona integron-encoded metallo-beta-lactamase enzymes in Pseudomonas spp. Additionally, a new gene and resistance gene were discovered in Acinetobacter baumannii.
MICROBIAL DRUG RESISTANCE
(2023)
Article
Anatomy & Morphology
Abdourahamane Yacouba, Sara Bellali, Gabriel Haddad, Noelle Mavros, Anthony Fontanini, Gregory Dubourg, Jean-Christophe Lagier, Didier Raoult, Jacques Bou Khalil
Summary: SEM and EDX were used to detect and identify microorganisms and crystals in urine samples, showing promising results for their application in urine sediment analysis.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Microbiology
Sarrah Landolsi, Rachid Selmi, Linda Hadjadj, Asma Ben Haj Yahia, Lilia Messadi, Jean-Marc Rolain
Summary: A study conducted in Tunisia found that rodents can potentially transmit multidrug resistant bacteria, posing a public health problem. The researchers isolated Enterobacteriaceae strains from the intestines of rats captured from various locations and found that rodents may play a role in the spread of antimicrobial resistant E. coli.
VETERINARY MICROBIOLOGY
(2023)
Editorial Material
Microbiology
Ziad Daoud, Jean-Marc Rolain
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Khouloud Slimene, Asrra A. Ali, Elhussan A. Mohamed, Allaaeddin El Salabi, Faraj S. Suliman, Agela A. Elbadri, Fadi F. El-fertas, Ahmed El-awjly, Salah A. Shokri, Jean-Marc Rolain, Chedly Chouchani
Summary: The emergence of carbapenem-resistant bacteria in SARS-CoV-2 patients in eastern Libya highlights the need for increased surveillance and rational use of antibiotics, particularly carbapenems, during the pandemic. Multidrug-resistant strains, including K. pneumoniae, A. baumannii, and colistin-resistant E. coli, were identified, emphasizing the importance of maintaining the efficacy of these antibiotics and minimizing their overuse.
MICROBIOLOGY SPECTRUM
(2023)
Correction
Genetics & Heredity
Sahare Kokcha, Ajay Kumar Mishra, Jean-Christophe Lagier, Matthieu Million, Quentin Leroy, Didier Raoult, Pierre-Edouard Fournier
ENVIRONMENTAL MICROBIOME
(2023)
Letter
Infectious Diseases
May Khoder, Marwan Osman, Issmat I. Kassem, Rayane Rafei, Ahmad Shahin, Seydina M. Diene, Jean-Marc Rolain, Monzer Hamze
NEW MICROBES AND NEW INFECTIONS
(2023)
Article
Infectious Diseases
Anna Barbiero, Tommaso Manciulli, Michele Spinicci, Iacopo Vellere, Maria Grazia Colao, Gian Maria Rossolini, Alessandro Bartoloni, Didier Raoult, Lorenzo Zammarchi
Summary: This study reports ten cases of SENLAT in Tuscany, Italy, with symptoms including scalp eschar and cervical lymphadenopathy. The difficulty of microbiological diagnosis and previous antibiotic treatment administration hindered the identification of the causative agent.
Expression of Concern
Immunology
S. Meconi, C. Capo, M. Remacle-Bonnet, G. Pommier, D. Raoult, J. L. Mege
INFECTION AND IMMUNITY
(2023)
Correction
Infectious Diseases
Thi Loi Dao, Naomie Canard, Van Thuan Hoang, Tran Duc Anh Ly, Tassadit Drali, Laetitia Ninove, Florence Fenollar, Didier Raoult, Philippe Parola, Pierre Marty, Philippe Gautret
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Expression of Concern
Microbiology
T. Adekambi, M. Reynaud-Gaubert, G. Greub, M-J Gevaudan, B. La Scola, D. Raoult, D. Drancourt
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Expression of Concern
Microbiology
W. Xu, D. Raoult
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Immunology
Babacar Mbaye, Reham Magdy Wasfy, Maryam Tidjani Alou, Patrick Borentain, Claudia Andrieu, Aurelia Caputo, Didier Raoult, Rene Gerolami, Matthieu Million
Summary: This study analyzed the microbial composition of NASH patients and controls using 16S rRNA sequencing and qPCR. The results showed an association between Lactobacillus and Lactoccocus with NASH, and an association between Methanobrevibacter, Faecalibacterium, and Romboutsia with controls. At the species level, ethanol-producing species of Lactobacillus and an already associated species of dysbiosis were associated with NASH. This study highlights the potential role of ethanol-producing gut microbes in NASH.
MICROBIAL PATHOGENESIS
(2023)
Correction
Public, Environmental & Occupational Health
Thi Loi Dao, Van Thuan Hoang, Amal Magmoun, Tran Duc Anh Ly, Sophie Alexandra Baron, Linda Hadjadj, Naomie Canard, Tassadit Drali, Frederique Gouriet, Didier Raoult, Philippe Parola, Pierre Marty, Jean-Marc Rolain, Philippe Gautret
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Microbiology
Fatou Samba Diouf, Mamadou Beye, Mapenda Gaye, Babacar Mbaye, Stephane Alibar, Mariema Sarr, Gregory Dubourg, Jean-Christophe Lagier, Cheikh Sokhna, Florence Fenollar, Pierre-Edouard Fournier, Cheikh Ibrahima Lo
Summary: Blood is normally sterile, but bacteria in the bloodstream indicate an anomaly. By performing a blood culture on a patient with thalassemia major, a new strain of Streptococcus was isolated and identified through phenotypic, phylogenetic, and genomic characteristics analysis. Named Streptococcus thalassemiae sp. nov., this strain showed similarity to Streptococcus mitis but had significant differences based on DNA-DNA hybridization and average nucleotide identity analysis. This research demonstrates the importance of studying bacterial strains in blood cultures for accurate diagnosis.
INTERNATIONAL JOURNAL OF MICROBIOLOGY
(2023)