Article
Immunology
Hung D. Nguyen, Sidhartha Chaudhury, Adam T. Waickman, Heather Friberg, Jeffrey R. Currier, Anders Wallqvist
Summary: The study revealed that overproduction of specific antibodies during primary dengue infection can lead to an increase in cross-reactive antibodies during secondary infection, ultimately exacerbating disease severity. The dynamics of immune response were found to correlate with disease severity, depending on lymphocyte levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Adrian Kuipery, Juan Diego Sanchez Vasquez, Aman Mehrotra, Jordan J. Feld, Harry L. A. Janssen, Adam J. Gehring
Summary: CD8 T cells play a crucial role in controlling HBV infection by recognizing and lysing infected hepatocytes. Innate immunomodulators and RNA interference may alter HBV antigen presentation and impact CD8 T-cell recognition, in addition to their primary mechanisms of action.
Review
Biochemistry & Molecular Biology
Athanasios Ziogas, Mihai G. Netea
Summary: The innate immune system is capable of developing memory-like features through trained immunity, which leads to enhanced immune responses and heterologous protection upon (re) infection. The cellular and molecular mechanisms underlying trained immunity provide insights for developing novel vaccine strategies against new pandemics in the future.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Taryn E. Murray, Tyler J. Wenzel, Svetlana Simtchouk, Bridget K. Greuel, Julien Gibon, Andis Klegeris
Summary: The study reveals that cardiolipin (CL) can modulate the secretion and phagocytic activity of astrocytes, potentially through interaction with TLR 4, expanding our understanding of CL's role in neuroimmune responses.
MEDIATORS OF INFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Dannielle Wellington, Zixi Yin, Zhanru Yu, Raphael Heilig, Simon Davis, Roman Fischer, Suet Ling Felce, Elie Antoun, Philip Hublitz, Ryan Beveridge, Danning Dong, Guihai Liu, Xuan Yao, Yanchun Peng, Benedikt M. Kessler, Tao Dong
Summary: This study reveals that mutations in flanking regions of SARS-CoV-2 epitopes can affect proteasomal processing and T cell activation, leading to immune escape or enhancement. These findings have important implications for the design of COVID-19 vaccines.
Article
Immunology
Lyudmila Belenska-Todorova, Ralitsa Zhivkova, Maya Markova, Nina Ivanovska
Summary: This study aimed to investigate the effects of 17 beta-estradiol (ED) and follicle stimulating hormone (FSH) on bone marrow cell differentiation in arthritic mice. The results showed that FSH favored osteoclast formation, while ED favored osteoblast accumulation. Both hormones influenced cellular differentiation processes in osteoarthritis, with FSH promoting cartilage degradation and ED inhibiting it.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Steven J. Campbell, Battist Utinger, Alexandre Barth, Suzanne E. Paulson, Markus Kalberer
Summary: This study presents a novel approach using two online instruments to quantitatively measure the oxidative potential (OP) of particulate matter. It investigates the influence of Fe(II) and Cu(II) on secondary organic aerosol (SOA) and reveals a range of synergistic and antagonistic interactions. The results provide new insights into the influence of metal and SOA interactions on particle OP.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Steven J. Campbell, Battist Utinger, Alexandre Barth, Suzanne E. Paulson, Markus Kalberer
Summary: The oxidative potential (OP) of particulate matter is a key metric for assessing atmospheric particle toxicity. This study used two novel online instruments to quantify particle OP and investigated the influence of Fe(II) and Cu(II) on the OP of secondary organic aerosol (SOA). Synergistic and antagonistic interactions were observed when Fe(II) and Cu(II) were mixed with representative biogenic and anthropogenic SOA. A kinetic model revealed important reactions among SOA components, transition metals, and ascorbate, impacting the OP.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Immunology
Karolina Kuczborska, Ewelina Krzeminska, Piotr Buda, Edyta Heropolitanska-Pliszka, Barbara Piatosa, Janusz Ksiazyk
Summary: The study compared the seroconversion rates and changes of lymphocyte subsets during COVID-19 in immunocompetent children and those with secondary immunodeficiencies. The results showed that both groups had similar seroconversion rates, but the immunocompromised group had lower titers of anti-S antibodies. The immunocompetent group had a decrease in NK cells, while immunocompromised children had reduced CD4 + /CD 8 + T cell ratios, which may be a protective factor against severe COVID-19.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Breanna Noffsinger, Alexandra Witter, Natasha Sheybani, Aizhen Xiao, Laryssa Manigat, Qing Zhong, Suchet Taori, Tajie Harris, Tim Bullock, Richard Price, Benjamin Purow
Summary: The study compared immune responses in GL261 and CT2A models, finding that CT2A-Luc significantly increased the number of T cells in the brain and altered response to anti-PD-1 therapy. A larger cell inoculum size in GL261 model increased T cell response at day 28 post-injection. Both models peak in T cell immune response at day 21 post-injection.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Biology
Felipe Alves Rubio, Hyun Mo Yang
Summary: A mathematical model was proposed to investigate the ADE phenomenon during secondary dengue infection, involving an ODE system that describes the interaction of the dengue virus with macrophages and memory B and T cells. The analysis of the model was based on memory B and T cell cloning parameters and the basic reproduction number R-0. It was found that memory B and T cells play essential roles in determining the possibility of dengue infection and ADE occurrence when R-0 is less than 1.
JOURNAL OF THEORETICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yibing Wang, Peng Jin, Xia Wang
Summary: The study finds that YTHDF1, a reader protein of m(6)A, promotes immune escape in prostate cancer (PCa) cells by enhancing the transcriptional stability of PD-L1, inhibiting the killing activity of CD8 + T cells, and mitigating ferroptosis. These findings provide a new perspective for PCa immunotherapy.
Article
Multidisciplinary Sciences
Chih-Hsuan Tsai, Yi-Chi Chuang, Yun-Heng Lu, Chia-Yang Lin, Cheng-Kang Tang, Sung-Chan Wei, Yueh-Lung Wu
Summary: Our study reveals that the alteration of the host's carbohydrate metabolism is a crucial factor determining the host specificity of baculoviruses, in addition to viral factors. After infection of nonpermissive hosts, stored carbohydrates are rapidly transformed into glucose, upregulating enzymes involved in glycolysis and the TCA cycle to produce more ATP. This stimulation of energy production supports the immune response against infection by increasing phagocytosis in cellular immunity and the expression of genes involved in humoral immunity.
Article
Immunology
Vianney Tricou, Raphael Gottardo, Michael A. Egan, Frederic Clement, Geert Leroux-Roels, Xavier Saez-Llorens, Astrid Borkowski, Derek Wallace, Hansi J. Dean
Summary: This study assessed the cell-mediated immune responses to a dengue tetravalent vaccine candidate, TAK-003, in adolescents. The results showed that TAK-003 elicited cross-reactive and multi-functional CD4+ and CD8+ T-cell responses.
Review
Immunology
Liyana Ahmad
Summary: This article discusses the pressures leading to the emergence of new SARS-CoV-2 variants and key mutations that promote immune escape mechanisms, highlighting the potential threats to the efficacy of current COVID-19 vaccines. It cautions on the risks of reinfection, vaccine breakthrough infections, and therapeutic values.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Awadalkareem Adam, Marcia Woda, Sonia Kounlavouth, Alan L. Rothman, Richard G. Jarman, Josephine H. Cox, Julie E. Ledgerwood, Gregory D. Gromowski, Jeffrey R. Currier, Heather Friberg, Anuja Mathew
JOURNAL OF IMMUNOLOGY
(2018)
Article
Infectious Diseases
Heather Friberg, Coreen M. Beaumier, Sangshin Park, Pamela Pazoles, Timothy P. Endy, Anuja Mathew, Jeffrey R. Currier, Richard G. Jarman, Kathryn B. Anderson, Steven Hatch, Stephen J. Thomas, Alan L. Rothman
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Infectious Diseases
Sangshin Park, Anon Srikiatkhachorn, Siripen Kalayanarooj, Louis Macareo, Sharone Green, Jennifer F. Friedman, Alan L. Rothman
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Review
Virology
Luis A. Sanchez-Vargas, Anuja Mathew
Article
Immunology
Aviva Geretz, Lauryn Cofer, Philip K. Ehrenberg, Jeffrey R. Currier, In-Kyu Yoon, Maria T. P. Alera, Richard Jarman, Alan L. Rothman, Rasmi Thomas
Article
Virology
Luis Alberto Sanchez Vargas, Anuja Mathew, Alan L. Rothman
CURRENT OPINION IN VIROLOGY
(2020)
Article
Biochemical Research Methods
Kathryn L. Schaber, T. Alex Perkins, Alun L. Lloyd, Lance A. Waller, Uriel Kitron, Valerie A. Paz-Soldan, John P. Elder, Alan L. Rothman, David J. Civitello, William H. Elson, Amy C. Morrison, Thomas W. Scott, Gonzalo M. Vazquez-Prokopec
Summary: The study shows the significant impact of different population behavior responses and activity reductions on the transmission and outbreak of DENV, leading to changes in transmission methods at the individual level and reducing the importance of transmission from the activity space outside symptomatic cases.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Christian K. Fung, Tao Li, Simon Pollett, Maria Theresa Alera, In-Kyu Yoon, Jun Hang, Louis Macareo, Anon Srikiatkhachorn, Damon Ellison, Alan L. Rothman, Stefan Fernandez, Richard G. Jarman, Irina Maljkovic Berry
Summary: This study investigated the consensus and iSNV frequency differences between DENV sequenced directly from clinical samples and their corresponding low-passage isolates. The results showed that low-passage DENV isolate consensus genomes are largely representative of their direct sample parental viruses, and that high frequency within-host variants are often preserved between clinical samples and isolates.
JOURNAL OF GENERAL VIROLOGY
(2021)
Review
Microbiology
Darshika J. Udawatte, Alan L. Rothman
Summary: RIPK1 serves as a key regulator of cell death and inflammation, affecting the outcome of virus infections through activation of different signaling pathways. Viruses manipulate host immune responses by targeting RIPK1, highlighting potential directions for future research.
Article
Infectious Diseases
Darunee Buddhari, Kathryn B. Anderson, Gregory D. Gromowski, Richard G. Jarman, Sopon Iamsirithaworn, Butsaya Thaisomboonsuk, Taweewun Hunsawong, Anon Srikiatkhachorn, Alan L. Rothman, Anthony R. Jones, Stefan Fernandez, Stephen J. Thomas, Timothy P. Endy
Summary: The study conducted in a dengue-endemic area in Thailand found that self-reported dengue illness history had low sensitivity and limited specificity compared to serological testing. This highlights the importance of a highly sensitive and specific test prior to Dengvaxia vaccination.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Thanyalak Fansiri, Darunee Buddhari, Nattaphol Pathawong, Arissara Pongsiri, Chonticha Klungthong, Sopon Iamsirithaworn, Anthony R. Jones, Stefan Fernandez, Anon Srikiatkhachorn, Alan L. Rothman, Kathryn B. Anderson, Stephen J. Thomas, Timothy P. Endy, Alongkot Ponlawat
Summary: Individual houses with high risks of Dengue virus transmission may serve as a source of virus transmission in the neighborhood. Through entomological risk assessment at the household level, a higher DENV infection rate was detected in mosquito vectors, indicating a considerable risk of Dengue transmission within the community.
Article
Multidisciplinary Sciences
Angkana T. Huang, Saki Takahashi, Henrik Salje, Lin Wang, Bernardo Garcia-Carreras, Kathryn Anderson, Timothy Endy, Stephen Thomas, Alan L. Rothman, Chonticha Klungthong, Anthony R. Jones, Stefan Fernandez, Sopon Iamsirithaworn, Pawinee Doung-Ngern, Isabel Rodriguez-Barraquer, Derek A. T. Cummings
Summary: The mean age of dengue hemorrhagic fever (DHF) cases in Thailand has increased significantly from 1981 to 2017. This trend can be explained by various factors such as changes in population demographics, reduction in infection hazards, and heterogeneous reporting rates. The demographic transition plays a major role in this change, affecting both the age structure of susceptibility and the number of infectious individuals, leading to a continuing increase in the age of DHF cases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Luis Vargas, Anuja Mathew, Katie Anderson, Damon Ellison, Timothy Endy, Alan Rothman
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)
Meeting Abstract
Public, Environmental & Occupational Health
Heather Friberg, Anuja Mathew, Morgan Becker, Kristin Hatch, Amanda Kong, Kaitlin Victor, Richard Jarman, Robert Paris, Alexander Schmidt, Stephen Thomas, Philippe Moris, Jeffrey Currier
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)
Meeting Abstract
Public, Environmental & Occupational Health
Heather Friberg, Anuja Mathew, Kathryn Anderson, Damon Ellison, Louis Macareo, Timothy Endy, Richard Jarman, Alan Rothman, Jeffrey Currier
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)