Article
Infectious Diseases
Toshiki Etani, Shuhei Kondo, Takahiro Yanase, Toshiharu Morikawa, Maria Aoki, Masakazu Gonda, Nami Tomiyama, Takashi Nagai, Keitaro Iida, Shoichiro Iwatsuki, Kazumi Taguchi, Taku Naiki, Shuzo Hamamoto, Atsushi Okada, Noriyasu Kawai, Atsushi Nakamura, Takahiro Yasui
Summary: This study retrospectively analyzed cases of Raoultella ornithinolytica infection detected at our hospital. From September 2019 to July 2021, 62 positive specimens were obtained after removing duplicates. The clinical courses of these cases were investigated based on electronic medical records.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Jing Li, Yan Zhuang, Dingliang Xiao, Haixia Zhang, Fangmei Luo, Jinhua He
Summary: Raoul ornithine-releasing bacteria are widely found in the environment and can cause nosocomial infections. Timely diagnosis and treatment with sensitive antibiotics are crucial for preventing severe consequences. This study retrospectively analyzed clinical data of nine cases of neonatal L. ornithine septicemia to understand its clinical characteristics and treatment options.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Veterinary Sciences
Mathilde L. Pas, Kevin Vanneste, Jade Bokma, Laura Van Driessche, Sigrid C. J. De Keersmaecker, Nancy H. Roosens, Freddy Haesebrouck, Filip Boyen, Bart Pardon
Summary: This report presents a case of sepsis in a calf caused by a multidrug resistant Raoultella ornithinolytica, highlighting the need for rapid and appropriate treatment. Whole genome sequencing confirmed the identification of the pathogen and its drug resistant qualities. The calf recovered with empirical parenteral therapy and ancillary treatment. Further investigation is needed to determine if animals and farms could be reservoirs for such resistant strains.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Xiaonan Chen, Xinjian Zhou, Jun Cao, Ke Ma, Zhijie Xia
Summary: Raoultella ornithinolytica is a Gram-negative bacillus that can cause healthcare-associated infections. This case report describes a 25-year-old patient with R. ornithinolytica infection presenting with fever, rash, and lymph node enlargement. Treatment with meropenem and loratadine was successful in managing the infection and associated allergic reaction.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Meng Wang, Yu Fan, Ping Liu, Yehua Liu, Jianlei Zhang, Yan Jiang, Chunlei Zhou, Lei Yang, Ce Wang, Chengqian Qian, Chao Yuan, Si Zhang, Xiaohang Zhang, Zhiqiu Yin, Hong Mu, Yuhui Du
Summary: Raoultella ornithinolytica is a poorly understood opportunistic pathogen with multidrug resistance mechanisms. The isolate WM1 exhibited resistance to multiple antimicrobials and carried two plasmids with multidrug resistance regions. In addition to virulence-related elements, the strain showed genetic diversity, emphasizing the importance of infection control and antimicrobial stewardship.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Environmental Sciences
Berat Cinar Acar, Zehranur Yuksekdag
Summary: In this study, bioremediation method was used to reduce Cr(VI) to Cr(III). Thirteen chromium resistant bacteria were obtained and their minimum inhibitory concentrations and optimum pH condition were determined. BCA13 strain showed the ability to reduce high concentrations of Cr(VI) and could be used in biodegradation studies.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Environmental Sciences
Dongpeng Li, Xin Kang, Linglong Chu, Yifei Wang, Xinshan Song, Xiaoxiang Zhao, Xin Cao
Summary: Raoultella sp. S1 has been found to have high algicidal efficiency against Microcystis aeruginosa, causing cell death through flocculation and lysis. Its algicidal activity is stable across a range of temperatures and pH levels, and triggers an oxidative stress response to attack the photosynthetic system in algal cells.
ENVIRONMENTAL POLLUTION
(2021)
Review
Immunology
Deniz Yaprak, Mina Misirligil, Ali Dinc Bozat, Belma Saygili Karagol
Summary: This article presents a rare case of community-acquired Raoultella ornithinolytica septicemia in a neonate and reviews the literature on ROS in the neonatal period, emphasizing the importance of early diagnosis and appropriate antibiotics for a good prognosis in neonatal septicemia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Microbiology
Iliana Alejandra Cortes-Ortiz, Edgar Mendieta-Condado, Noe Escobar-Escamilla, Julio Cesar Juarez-Gomez, Fabiola Garces-Ayala, Adnan Araiza Rodriguez, Juan Carlos Bravata-Alcantara, Victor Hugo Gutierrez-Munoz, Juan Manuel Bello-Lopez, Jose Ernesto Ramirez-Gonzalez
Summary: Class D beta-lactamases OXA-232 and OXA-48 were found to hydrolyze penicillin, cephalosporins, and carbapenems, limiting therapeutic options for bacteraemia. The study identified Raoultella ornithinolytica carrying OXA 232 and OXA-48 genes, confirming the results of the beta-lactamases assay. This represents the first report of multidrug resistance R. ornithinolytica in Mexico, highlighting the emergence of OXA producer microorganisms as a significant threat.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Microbiology
Cheng-Zhen Wang, Xun Gao, Qi-Wen Yang, Lu-Chao Lv, Miao Wan, Jun Yang, Zhong-Peng Cai, Jian-Hua Liu
Summary: The study identified a novel mobile gene cluster, tmexCD2-toprJ2, present in Raoultella ornithinolytica, which confers resistance to multiple antimicrobials and may have originated from a Pseudomonas species. The expression of tmexCD2-toprJ2 in Escherichia coli resulted in increased resistance to tigecycline and decreased susceptibility to other antimicrobials. Genetic context analyses demonstrated that tmexCD2-toprJ2 might have been captured and mobilized by a XerD-like tyrosine recombinase system.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Laila Ibrahim Faqe Salih, Rezan Omer Rasheed, Sirwan Muhsin Muhammed
Summary: In this study, metal-resistant Raoultella ornithinolytica was isolated from metal-contaminated samples collected from the Tanjaro River in Sulaymaniyah, Iraq. The bacterium showed high removal rates for various heavy metals and had capabilities to remove metals under different conditions. It can be used as an eco-friendly biological expedient for the remediation and detoxification of metals from contaminated environments.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Jose E. Villacis, Hugo G. Castelan-Sanchez, Jorge Rojas-Vargas, Ulises E. Rodriguez-Cruz, Viviana Alban, Jorge A. Reyes, Pablo M. Meza-Rodriguez, Sonia Davila-Ramos, Fernando Villavicencio, Margarita Galarza, Monica C. Gestal
Summary: This study aimed to investigate the clinical and molecular features of Raoultella ornithinolytica strains isolated from clinical environments in Ecuador, and to compare their genomes with previously published genomes of Raoultella spp. The results revealed the genome plasticity of R. ornithinolytica and its ability to acquire antibiotic resistance genes, highlighting the importance of genomic surveillance and infectious control for these uncommon species.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Juan Camilo Motta, Enrique Ucros, Mariana Reyes Rey, Paula Daniela Gomez, Magda Sanchez
Summary: Raoultella spp. is increasingly isolated in immunocompromised patients with multiple comorbidities, and there is a growing concern about the presence of multi-drug resistant strains.
Article
Environmental Sciences
Nai-Xian Feng, Fei Zhang, Yunchang Xie, Hui Bin, Lei Xiang, Yan-Wen Li, Fantao Zhang, Yunhong Huang, Hai -Ming Zhao, Quan-Ying Cai, Ce-Hui Mo, Qing X. Li
Summary: Genome mining identified bacteria with potential to degrade phthalates (PAEs), which are widely present in soils and food products and pose a high risk to human health. Ribosome engineering was used to activate the expression of key genes involved in PAEs biodegradation, resulting in a mutant strain XF201-G2U5 that showed high activity in degrading di-n butyl phthalate (DBP) and other PAEs. This strategy enables the discovery of novel bacterial resources for the bioremediation of PAEs and other emerging contaminants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Abayomi Tayo, Kwaku Nyame
Summary: Raoultella ornithinolytica is a versatile bacterium that can be found in various habitats, including soil, water, plants, and the human gastrointestinal tract and throat. It was originally thought to cause opportunistic infections, but it is increasingly being implicated in infections in immunocompetent individuals. This bacterium causes infections in different clinical settings, with an increasing incidence of sepsis among humans. There is also a growing concern over multidrug resistance in isolates of Raoultella ornithinolytica.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Yuto Haruki, Hideharu Hagiya, Toshiyuki Hashimoto, Takayoshi Miyake, Tomoko Murase, Akane Matsuo, Tetsuhiro Sugiyama, Sachiyo Kondo
Article
Pharmacology & Pharmacy
Nobutoshi Masuda, Takayoshi Maiguma, Atsushi Komoto, Yuto Haruki, Tetsuhiro Sugiyama, Sachiyo Kondo, Daisuke Teshima
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2015)
Article
Pharmacology & Pharmacy
Yuto Haruki, Hideharu Hagiya, Akiko Sakuma, Mai Haruki, Yasue Oka, Tetsuhiro Sugiyama, Yasuhiro Kawakami, Sachiyo Kondo
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2015)
Article
Medicine, General & Internal
Hideharu Hagiya, Yuto Haruki, Taeko Uchida, Tomoko Wada, Sumiko Shiota, Tomoharu Ishida, Hiroko Ogawa, Tomoko Murase, Fumio Otsuka
Letter
Medicine, General & Internal
Hirotaka Ebara, Hideharu Hagiya, Yuto Haruki, Eisei Kondo, Fumio Otsuka
Article
Medicine, General & Internal
Hirotaka Ebara, Hideharu Hagiya, Yuto Haruki, Eisei Kondo, Fumio Otsuka
Article
Infectious Diseases
Yuto Haruki, Hideharu Hagiya, Yu Takahashi, Hideyuki Yoshida, Kazuki Kobayashi, Tadato Yukiue, Nobushige Tsuboi, Tetsuhiro Sugiyama
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2017)
Article
Infectious Diseases
Yuto Haruki, Hideharu Hagiya, Mai Haruki, Tetsuhiro Sugiyama
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2018)
Article
Medicine, General & Internal
Hideharu Hagiya, Maya Kimura, Toru Miyamoto, Yuto Haruki, Fumio Otsuka
Article
Pharmacology & Pharmacy
Yuto Haruki, Shingo Takatori, Sayo Hattori, Yoshito Zamami, Toshihiro Koyama, Panot Tangsucharit, Hiromu Kawasaki
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2012)
Article
Multidisciplinary Sciences
Atsushi Komoto, Takayoshi Maiguma, Daisuke Teshima, Tetsuhiro Sugiyama, Yuto Haruki
Article
Infectious Diseases
Yuto Haruki, Hideharu Hagiya, Mai Haruki, Yuta Inoue, Tetsuhiro Sugiyama
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2020)
Article
Medicine, General & Internal
Hideharu Hagiya, Yuto Haruki, Fumio Otsuka
ACUTE MEDICINE & SURGERY
(2015)
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)