Article
Infectious Diseases
Kritsaporn Sujjavorakul, Wasan Katip, Stephen J. Kerr, Noppadol Wacharachaisurapol, Thanyawee Puthanakit
Summary: For the treatment of critically ill patients, it is recommended to achieve the target area under the plasma concentration-time curve/minimum inhibitory concentration (AUC/MIC) early within the first 24 hours. However, accurately calculating the AUC before steady state is a challenge. This study aimed to estimate AUC using two first-order pharmacokinetic equations and compare them to the actual first dose vancomycin AUC. The equation with compensation for the alpha distribution phase using specific time points showed good agreement and low bias, making it reliable for clinical practice settings.
Article
Medical Laboratory Technology
Hyun-Ki Kim, Tae-Dong Jeong
Summary: This study evaluated the need for measuring peak and trough concentrations when using the Bayesian approach for therapeutic drug monitoring. The results showed that using only trough concentration for AUC prediction was more effective than using both peak and trough concentrations. Therefore, the practical value of peak sampling for AUC-guided dosing needs further investigation.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Immunology
Sarah C. J. Jorgensen, Brad Spellberg, Andrew F. Shorr, William F. Wright
Summary: In this analysis, the methodological weaknesses and inconsistencies in the data surrounding therapeutic drug monitoring based on vancomycin 24-hour area under the concentration-time curve are highlighted. It is suggested that alternative strategies, such as antibiotic stewardship and achieving earlier and more complete source control, may be more effective with superior safety and efficacy outcomes. The implementation of AUC(24)-based therapeutic drug monitoring may divert resources away from these more promising alternative solutions, as the supporting data for vancomycin AUC(24) monitoring are insufficient and lack convincing evidence of benefit.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Kazutaka Oda, Yumi Hashiguchi, Toshimi Kimura, Yasuhiro Tsuji, Kensuke Shoji, Yoshiko Takahashi, Kazuaki Matsumoto, Hideki Kawamura, Hideyuki Saito, Yoshio Takesue
Summary: This study validated a newly developed web application, PAT, for estimating AUC of vancomycin. PAT showed the least bias when using two concentrations for estimation, with only 6% of estimations falling outside the acceptable range. Compared to evaluated software, PAT's AUC estimation was unbiased.
PHARMACEUTICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Dario Cattaneo, Deborah J. E. Marriott, Cristina Gervasoni
Summary: This article focuses on linezolid-related hematological toxicity in adult patients requiring prolonged drug treatment. Thrombocytopenia is a major concern with linezolid administration for Gram-positive infections, while anemia is more common in tuberculosis patients. Risk factors for linezolid-related thrombocytopenia include aging, renal dysfunction, low baseline platelet count, duration of treatment, and high linezolid plasma trough concentrations (>8 mg/L). Therapeutic drug monitoring or toxicodynamic predictive models can help optimize linezolid dosing for patients receiving extended treatment or those with altered drug pharmacokinetics.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Article
Infectious Diseases
Helene Thirot, Caroline Briquet, Frederic Frippiat, Frederique Jacobs, Xavier Holemans, Severine Henrard, Paul M. Tulkens, Anne Spinewine, Francoise Van Bambeke
Summary: In Belgium, linezolid is commonly used off-label for pneumonia and skin infections due to its bioavailability and effectiveness against resistant organisms, contributing to a higher prevalence of adverse drug reactions than officially reported. Risk factors for thrombocytopenia with linezolid treatment include duration of over 10 days, decreased kidney function, and higher Charlson index. Prospective detection of these risk factors is crucial in managing the high incidence of adverse drug reactions.
Article
Infectious Diseases
Yuta Ibe, Tomoyuki Ishigo, Satoshi Fujii, Satoshi Takahashi, Masahide Fukudo, Hideki Sato
Summary: This study investigated the factors influencing the achievement of the target area under the concentration-time curve (AUC) of vancomycin in critically ill patients. The results showed that patients in the two-point blood collection group were more likely to achieve the target AUC compared to those in the one-point blood collection group. Multivariate analysis demonstrated that being in the two-point group and having a 20% or more increase (or decrease) in creatinine clearance were significantly associated with the success rate of achieving the target AUC. These findings have important clinical implications.
Article
Health Care Sciences & Services
Hyun-Ki Kim, Tae-Dong Jeong
Summary: With the updated 2020 vancomycin therapeutic drug monitoring guidelines, accurate estimation of AUC(24) has become more critical. This study aimed to compare the AUC(24) using Bayesian dosing software according to various eGFR equations and analyze the clinical impact of eGFR in vancomycin TDM. The results showed that the eGFR formula type had insignificant clinical impact on drug dosing recommendations.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Fan Wu, Xiao-Shan Zhang, Ying Dai, Zi-Ye Zhou, Chun-Hong Zhang, Lu Han, Fang-Min Xu, Ye-Xuan Wang, Da-Wei Shi, Guan-Yang Lin, Xu-Ben Yu, Fang Chen
Summary: This study aimed to determine the pharmacokinetic/toxicodynamic threshold for linezolid treatment in critically ill patients and propose a dosing strategy for patients with renal insufficiency.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nicole M. Ondrush, Rejs Ademovic, Robert W. Seabury, William Darko, Christopher D. Miller, Bryan T. Mogle
Summary: This study compared the AUC(24) estimates from two online, open-access, single-concentration vancomycin calculators with the two-point pharmacokinetic (2PK) method. The results showed that these online calculators had some bias and imprecision compared to the 2PK method.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Review
Infectious Diseases
Hideo Kato, Mao Hagihara, Nobuhiro Asai, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
Summary: The incidence of linezolid-induced myelosuppression in pediatric patients was less than 10%. However, our meta-analysis revealed that administration period of more than 14 days was one of the risk factors associated with linezolid-induced myelosuppression.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Takashi Niwa, Moeka Yasue, Saki Harada, Yuto Yamada, Manami Otsubo, Michi Yamada, Serika Matsuoka, Taishi Yamamoto, Yurika Mizusaki, Akio Suzuki
Summary: This retrospective study aimed to evaluate whether AUC-guided vancomycin monitoring based on a single trough concentration is a better predictor of nephrotoxicity than trough-guided monitoring. The results showed that patients with higher AUC were more likely to develop acute kidney injury (AKI), and AUC had similar sensitivity as trough concentration. Therefore, AUC based on a single trough concentration is a better predictor of nephrotoxicity.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Toshimi Kimura, Kazuaki Matsumoto, Kazutaka Oda, Takeshi Kimura
Summary: AUC-guided vancomycin treatment can reduce nephrotoxicity, and obtaining two samples for AUC estimation is preferable. Significant associations were found between AUC cutoff values and early treatment response as well as nephrotoxicity rate, particularly in patients receiving vancomycin every 12 hours.
Article
Oncology
Toshiaki Komatsu, Miho Nakamura, Katsufumi Uchiyama, Gen Inoue, Kazumi Sakanoue, Atsushi Kawamura, Koki Hiratsuka, Yoko Takayama, Masashi Takaso, Koichiro Atsuda
Summary: This study demonstrates that prospective therapeutic drug monitoring to optimize the therapeutic range can prevent linezolid-induced thrombocytopenia.
JOURNAL OF CHEMOTHERAPY
(2022)
Article
Pediatrics
Abdullah Alsultan, Ahmed A. Albassam, Abdullah Alturki, Abdulrahman Alsultan, Mohammed Essa, Bader Almuzzaini, Salman Alfadhel
Summary: This study aimed to predict the steady state AUC for busulfan using Bayesian pharmacokinetic parameters estimated from the first dose. The results showed that first dose concentrations cannot accurately predict steady state busulfan concentrations, suggesting the need for follow-up therapeutic drug monitoring (TDM).
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Motofumi Maruta, Takanori Miyoshi, Naomi Matsuo, Takuya Yamashina, Kenji Irie, Minako Tsuruta, Hiroko Tsukada, Moeko Tsuruyama, Masahisa Nagano, Yoichi Hiraki
Summary: For hemodialysis patients receiving FOLFOX treatment for advanced gastric cancer, a dose reduction of 30%-50% for L-OHP may be advisable to reduce the risk of hematological toxicities and neuropathy.
JOURNAL OF CHEMOTHERAPY
(2021)
Letter
Pharmacology & Pharmacy
Kentaro Ushijima, Chika Ogami, Yasuhiro Tsuji, Tatsuya Nagano, Akio Fujimura
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Infectious Diseases
Yoshifumi Nishi, Chika Ogami, Yasuhiro Tsuji, Hitoshi Kawasuji, Harumi Yamada, Shin Kawai, Ippei Sakamaki, Hideto To, Yoshihiro Yamamoto
Summary: The study aimed to assess the development of hyponatremia during treatment with linezolid and found that exposure to linezolid, age, and baseline sodium levels were identified as risk factors for linezolid-related hyponatremia, suggesting the importance of regular monitoring of serum sodium levels during treatment with linezolid, especially for elderly patients with low sodium levels.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Medical Laboratory Technology
Chika Ogami, Yasuhiro Tsuji, Yoshifumi Nishi, Hitoshi Kawasuji, Hideto To, Yoshihiro Yamamoto
Summary: This study validated published linezolid population pharmacokinetic and pharmacodynamic models for their transferability and suitability for extrapolation to other hospitals and patients. Model C showed the best predictive accuracy for total linezolid concentration, and an application software based on this model was introduced for therapeutic drug monitoring of linezolid.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Chemistry, Medicinal
Saki Takahashi, Yasuhiro Tsuji, Hidefumi Kasai, Chika Ogami, Hitoshi Kawasuji, Yoshihiro Yamamoto, Hideto To
Summary: Linezolid-induced thrombocytopenia is associated with linezolid exposure, baseline platelet count, and patient background. Machine learning-based CART analysis identified predictive factors and cutoff values for predicting thrombocytopenia. Monitoring linezolid concentration and platelet count change from baseline at an early stage may help prevent thrombocytopenia induced by linezolid.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hitoshi Kawasuji, Yasuhiro Tsuji, Chika Ogami, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Koyomi Kawago, Ippei Sakamaki, Yoshihiro Yamamoto
Summary: This study found that patients with renal impairment are more prone to thrombocytopenia, and the use of therapeutic drug monitoring based on serum linezolid trough concentration may help reduce the rate of treatment failure in these patients, with dose adjustments often necessary. Based on the findings, it is recommended to consider empirical dose reduction to 300 mg every 12 h after the initial fixed dose for 2 days and the use of TDM in patients with renal impairment to improve safety outcomes.
BMC PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chika Ogami, Yasuhiro Tsuji, Hiroto Seki, Hideaki Kawano, Hideto To, Yoshiaki Matsumoto, Hiroyuki Hosono
Summary: This study developed an ANN-PK model to predict time-series pharmacokinetics, with the ability to provide interpretable explanations for model predictions using SHAP. Results showed that the ANN-PK model outperformed the traditional PopPK model in terms of prediction accuracy and handling of time-series data.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Takanori Miyoshi, Hiroo Miyashita, Naomi Matsuo, Miki Odawara, Minako Hori, Yoichi Hiraki, Hirofumi Kawanaka
Summary: The study evaluated the efficacy of palonosetron and granisetron in preventing chemotherapy-induced nausea and vomiting, showing that palonosetron was more effective in the triplet antiemetic therapy compared to granisetron, especially for female patients.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Medicine, General & Internal
Yasuhiro Tsuji, Miki Numajiri, Chika Ogami, Fumihiro Kurosaki, Aoi Miyamoto, Takahiko Aoyama, Hitoshi Kawasuji, Kentaro Nagaoka, Yoshiaki Matsumoto, Hideto To, Yoshihiro Yamamoto
Summary: The study developed a high-performance liquid chromatography-fluorescence detector assay for accurate measurement of TZD concentration in serum, demonstrating high linearity and accuracy, suitable for clinical application.
Editorial Material
Pediatrics
Nobuhiko Nagano, Daichi Katayama, Takayuki Imaizumi, Midori Hijikata, Aya Okahashi, Yasuhiro Tsuji, Ichiro Morioka
PEDIATRICS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Saki Takahashi, Yasuhiro Tsuji, Nick Holford, Chika Ogami, Hidefumi Kasai, Hitoshi Kawasuji, Hideto To, Yoshihiro Yamamoto
Summary: This study developed a population pharmacokinetic model to predict both total and unbound concentrations of daptomycin, which can help clinicians select the appropriate dose regimen and reduce associated adverse effects.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2023)
Review
Infectious Diseases
Hitoshi Kawasuji, Kentaro Nagaoka, Yasuhiro Tsuji, Kou Kimoto, Yusuke Takegoshi, Makito Kaneda, Yushi Murai, Haruka Karaushi, Kotaro Mitsutake, Yoshihiro Yamamoto
Summary: In a systematic review and meta-analysis, the effectiveness and safety of linezolid (LZD) compared to vancomycin (VCM), teicoplanin (TEIC), or daptomycin (DAP) in treating methicillin-resistant Staphylococcus aureus (MRSA) bacteremia were evaluated. The study found that LZD had comparable effectiveness as VCM, TEIC, or DAP and similar rates of adverse events. LZD could be a potential first-line drug against MRSA bacteremia.
Article
Pharmacology & Pharmacy
Shinichi Tsuchiwata, Yasuhiro Tsuji
Summary: Artificial intelligence (AI) is being used in various technological fields, but there have been no reports of AI-designed clinical trials. In this study, a genetic algorithm (GA) was used to develop study designs, applying computational design approach to optimize blood sampling schedule for a pediatric bioequivalence study and allocation of dose groups for a dose-finding study. The GA reduced the number of blood collection points and achieved a reduction in the required subjects for the dose-finding study. The results showed the potential usefulness of computational clinical study design approach in innovative drug development.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Muramori So, Kanae Hatsuyama, Miyuki Tajima, Rie Ueki, Yasuhiro Tsuji, Toyofumi Suzuki
Summary: This study aimed to evaluate the efficacy of ZAH treatment for hypozincemia in elderly inpatients and found that the total zinc dose has a significant impact on the increase of serum zinc levels. It is recommended to measure serum zinc levels once when the total dose reaches 1000 mg for the treatment of zinc deficiency.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Takahiko Aoyama, Toshinori Hirai, Yasuhiro Tsuji, Aoi Miyamoto, Toshimasa Itoh, Takuya Iwamoto, Yoshiaki Matsumoto
Summary: This study evaluated the predictive performance of a kinetic-pharmacodynamic model for warfarin dose requirements in Japanese patients. The study found that the model tended to underpredict, especially in patients over 60 years old, with a body mass index of 25 kg/m(2) or lower, and an estimated glomerular filtration rate of 60 mL/min/1.73 m(2) or lower. However, underprediction was reduced by using Bayesian prediction and more previous observations.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
