Article
Infectious Diseases
Qian Liu, Sanwang Li, Feifan Xie
Summary: This study aimed to provide a population PK analysis of linezolid in patients undergoing renal replacement therapy (RRT), and evaluate the target attainment of linezolid standard dosing. The results showed that standard linezolid dosing is adequate for anuric RRT patients with MIC <= 2 mg/L. The probability of target attainment was low for RRT patients with preserved renal function.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
S. Luque, W. Hope, L. Sorli, R. Munoz-Bermudez, N. Campillo, J. Barcelo-Vidal, F. Alvarez-Lerma, J. P. Horcajada, J. R. Masclans-Enviz, M. Neely, S. Grau
Summary: This study aimed to develop a population pharmacokinetic model of linezolid for individualized dosing. Results showed that the recommended dose of linezolid might need to be four times higher than the maximum licensed dose to achieve a PTA >= 90% for all susceptible isolates. The final PK model was used to develop software for dosage individualization, which accurately tracked patients and may be a useful tool for real-time adjustment of linezolid dosages.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Wenqiang Zhou, Wenjuan Nie, Qingfeng Wang, Wenhui Shi, Yang Yang, Qi Li, Hui Zhu, Zhongquan Liu, Yangming Ding, Yu Lu, Naihui Chu
Summary: This study aimed to find the optimal dosing regimen of linezolid in different populations. The results revealed that factors such as body weight and creatinine clearance significantly influenced the pharmacokinetics of linezolid. The study determined the optimal dosage regimens for patients with different body weights and MIC values, and found that single dosing was safer than multiple dosing.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Hitoshi Kawasuji, Yasuhiro Tsuji, Chika Ogami, Makito Kaneda, Yushi Murai, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Yasutaka Fukui, Ippei Sakamaki, Yoshihiro Yamamoto
Summary: The study demonstrated that initially reducing the dose of linezolid in hemodialysis patients can lower the risk of linezolid-induced thrombocytopenia.
Article
Pharmacology & Pharmacy
Laurynas Mockeliunas, Lina Keutzer, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Lotte M. G. Hulskotte, Onno W. Akkerman, Ulrika S. H. Simonsson
Summary: This study developed a population pharmacokinetic model and a model-informed precision dosing (MIPD) algorithm for linezolid to ensure safe and efficacious dosing in patients with multidrug- and extensively drug-resistant tuberculosis. By using information from two or three pharmacokinetic sampling occasions, the proportion of patients reaching the efficacy and safety targets increased compared to flat dosing.
Review
Medicine, General & Internal
Kun-Yan Xu, Dan Li, Zhen-Jie Hu, Cong-Cong Zhao, Jing Bai, Wen-Li Du
Summary: Dosing adjustment of vancomycin in obese patients should be based on total body weight, with monitoring of blood drug concentrations critical to ensure effectiveness and reduce the risk of renal injury.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Psychiatry
Masa Knehtl, Tadej Petreski, Nejc Piko, Robert Ekart, Sebastjan Bevc
Summary: Hemodialysis is a common method for treating chronic kidney failure, but it can lower the quality of life and worsen mental health issues. The aging population and patients with pre-existing mental health conditions are more likely to develop cognitive impairment and require psychotropic medications. These drugs may have altered pharmacokinetics when used during hemodialysis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Yueh-Chun Hsu, Szu-Ying Chen, Yung-Jun Hung, Yu-Wei Huang
Summary: Linezolid usage may increase the risk of thrombocytopenia. This study aimed to identify the risk factors for linezolid-associated thrombocytopenia (LAT), and found that patients receiving renal replacement therapy or concurrent fluconazole were at higher risk of developing LAT.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Karen Woo, Laura Gascue, Keith Norris, Eugene Lin
Summary: This study aimed to investigate the association between frailty and dialysis vascular access failure. The results showed that higher degrees of frailty were associated with longer times to functional use of vascular access. Therefore, frailty may be useful for informing clinical decision-making regarding choice of vascular access.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Psychiatry
Roshan Sutar, Mahendra Kumar Atlani, Pooja Chaudhary
Summary: Antipsychotics play a crucial role in managing behavioral problems in hemodialysis patients, but limited literature is available on their pharmacokinetics in such patients. Manufacturers and guidelines recommend avoiding amisulpride and caution against dosage increase in renal failure. Hemodialysis has complex effects on the distribution volume and blood levels of antipsychotics, making it challenging to predict treatment response reliably.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Fan Wu, Xiao-Shan Zhang, Ying Dai, Zi-Ye Zhou, Chun-Hong Zhang, Lu Han, Fang-Min Xu, Ye-Xuan Wang, Da-Wei Shi, Guan-Yang Lin, Xu-Ben Yu, Fang Chen
Summary: This study aimed to determine the pharmacokinetic/toxicodynamic threshold for linezolid treatment in critically ill patients and propose a dosing strategy for patients with renal insufficiency.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Tjokosela Tikiso, Valentin Fuhrmann, Christina Koenig, Dominik Jarczak, Stefanie Iwersen-Bergmann, Stefan Kluge, Sebastian G. Wicha, Joern Grensemann
Summary: This study investigated the pharmacokinetics of linezolid in critically ill patients with acute-on-chronic liver failure (ACLF) during continuous renal replacement therapy. The results showed that linezolid body clearance was significantly lower in ACLF patients, leading to a higher risk of drug overexposure. Therefore, dose reduction may be necessary in ACLF patients to prevent excessive drug exposure.
ANNALS OF INTENSIVE CARE
(2023)
Article
Chemistry, Medicinal
Sha He, Zeneng Cheng, Feifan Xie
Summary: This study developed a population pharmacokinetic (PK) model of gentamicin in continuous renal replacement therapy (CRRT) patients, and inferred the optimal dosing regimen for gentamicin. The results indicated that a combination of 7 mg/kg gentamicin q24h and 40 mL/kg/h CRRT dose might be considered as a starting treatment option for CRRT patients, and drug monitoring is required to manage toxicity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Microbiology
Michael Thy, Saik Urien, Frantz Foissac, Naim Bouazza, Ines Gana, Emmanuelle Bille, Agathe Beranger, Julie Toubiana, Romain Berthaud, Fabrice Lesage, Sylvain Renolleau, Jean-Marc Treluyer, Sihem Benaboud, Mehdi Oualha
Summary: This study aimed to develop a population pharmacokinetic model for piperacillin in critically ill children receiving continuous renal replacement therapy (CRRT) and optimize dosing regimens. The study found that continuous infusions were appropriate to achieve the target concentration of piperacillin, except for anuric patients who require less frequent intermittent doses. Factors such as body weight, residual diuresis, and minimum inhibitory concentration (MIC) were taken into account to determine the optimal dosing regimen.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Romain Garreau, Benoit Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod, Florent Wallet, Arnaud Friggeri, Jean-Christophe Richard, Sylvain Goutelle
Summary: This study conducted population pharmacokinetic analysis to identify optimal loading and maintenance doses of vancomycin administered by continuous infusion in ICU patients. The model-driven approach suggested loading dose of 27.5 mg/kg of ideal body weight and maintenance dose ranging from 17.5 to 30 mg/kg depending on renal function. Simulations showed that approximately 55.8% of patients would achieve the target exposure with the suggested dosages.
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
