期刊
JOURNAL OF INFECTION
卷 68, 期 2, 页码 141-148出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2013.10.010
关键词
Q fever; Coxiella burnetii; Endocarditis; Antibioprophylaxis; Reference center
Objectives: We conducted an observational study to evaluate the impact of our antibioprophylaxis protocols implemented in 2000, on the incidence of Q fever endocarditis diagnosed in our French reference center between 1985 and 2011. Methods: Endocarditis was diagnosed according to modified Duke Criteria, serological and PCR results. Our prophylaxis recommendations consist of a systematic echocardiography and an antibioprophylaxis in patients with acute Q fever and risk factors for developing endocarditis. Results: Over the last 27 years, we diagnosed 4231 acute Q fever and 818 endocarditis. Despite a significantly increased number of acute Q fever diagnoses and the use of systematic PCR testing of valves allowing serendipitous Q fever endocarditis diagnoses, we observed a decline of Q fever endocarditis. The number of cases has decreased from 316, which represents 18% of newly diagnosed cases of Q fever between 1998 and 2004, to 225, which corresponds to 11% of the cases diagnosed between 2005 and 2011. Conclusion: We believe that this decrease was a result of our strategies for prophylaxis. If this assumption is true, we may have prevented more than 150 cases of Q fever endocarditis in France over the past 10 years. (C) 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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