Article
Medicine, General & Internal
Xuhui Li, Hua Fan, Hao Zi, Hankun Hu, Binghui Li, Jiao Huang, Pengcheng Luo, Xiantao Zeng
Summary: This study aimed to estimate the global and regional burden of bacterial antimicrobial resistance (AMR) in urinary tract infections (UTI) in 2019. The results showed that globally, there were approximately 64.89 thousand deaths attributed to and 0.26 million deaths associated with bacterial AMR in UTI. Escherichia coli and Klebsiella pneumoniae had the highest resistance rates, including resistance to fluoroquinolones, carbapenems, and third-generation cephalosporins. Tailored strategies, such as enhanced surveillance and rational use of antibiotics, should be developed for different regions based on their specific pathogen-antibiotic situations and resources.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Fergus Allerton, Koen B. Pouwels, Julien Bazelle, Sarah Caddy, Andria Cauvin, Luisa De Risio, James Swann, James Warland, Andrew Kent
Summary: Current research on course lengths for common canine infections is limited. This prospective study aims to determine the shortest course duration for female dogs with lower urinary tract signs, providing guidelines for antimicrobial decision-making in clinical practice.
BMC VETERINARY RESEARCH
(2021)
Article
Infectious Diseases
Guadalupe Miranda-Novales, Karen Flores-Moreno, Yolanda Lopez-Vidal, Samuel Ponce de Leon-Rosales
Summary: This study evaluated the antimicrobial susceptibility patterns of Escherichia coli and Klebsiella pneumoniae, and found that multidrug-resistant bacteria represented 61% of all isolates.
Article
Infectious Diseases
Leah J. Toombs-Ruane, Jonathan C. Marshall, Jackie Benschop, Dragana Drinkovi, Anne C. Midwinter, Patrick J. Biggs, Zoe Grange, Michael G. Baker, Jeroen Douwes, Mick G. Roberts, Nigel P. French, Sara A. Burgess
Summary: This study aimed to assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)-or AmpC β-lactamase (ACBL)-producing Enterobacterales. Through telephone questionnaire and logistic regression analysis, it was found that pet ownership was not associated with ESBL-or ACBL-producing Enterobacterales-related urinary tract infections, while the main risk factors included recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Thijs ten Doesschate, Sander Kuiper, Cees van Nieuwkoop, Robert-Jan Hassing, Tom Ketels, Suzan P. van Mens, Wouter van den Bijllaardt, Akke K. van der Bij, Suzanne E. Geerlings, Ad Koster, Evert L. Koldewijn, Judith Branger, Andy I. M. Hoepelman, Cornelis H. van Werkhoven, Marc J. M. Bonten
Summary: Fosfomycin is noninferior to ciprofloxacin as oral step-down treatment for febrile urinary tract infections (fUTIs) caused by E. coli in women, but its use is associated with more gastrointestinal events.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Kayoko Hayakawa, Yasufumi Matsumura, Kohei Uemura, Shinya Tsuzuki, Aki Sakurai, Ryutaro Tanizaki, Koh Shinohara, Takehiro Hashimoto, Ryota Hase, Takashi Matono, Hideaki Kato, Momoko Mawatari, Hiroshi Hara, Yukihiro Hamada, Sho Saito, Norio Ohmagari, Yohei Doi
Summary: Cefmetazole showed clinical and bacteriological effectiveness comparable to meropenem against invasive urinary tract infection due to ESBLECs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ileana Adela Vacaroiu, Elena Cuiban, Bogdan Florin Geavlete, Valeriu Gheorghita, Cristiana David, Cosmin Victor Ene, Catalin Bulai, Gabriela Elena Lupusoru, Mircea Lupusoru, Andra Elena Balcangiu-Stroescu, Larisa Florina Feier, Ioana Sorina Simion, Daniela Radulescu
Summary: CKD is a significant risk factor for antimicrobial resistance and multi-drug resistance.
Review
Microbiology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Elvira Garza-Gonzalez
Summary: Healthcare-associated infections (HAIs) are a global public health concern and are associated with high mortality and antimicrobial resistance. The hospital environment serves as a potential reservoir for pathogenic microbial strains, which can persist on medical equipment surfaces, patient surroundings, and patient and healthcare worker surfaces. Understanding the hospital microbiota can provide knowledge on the relationship between commensal and pathogenic microorganisms, their role in HAI development, and the environmental conditions that promote their proliferation.
Article
Infectious Diseases
Andreia Silva, Elisabeth Costa, Americo Freitas, Adelaide Almeida
Summary: Urinary tract infections (UTIs) are a common infectious disease in the community. The misuse of antimicrobials has led to an increase in bacterial resistance, which is a global problem. This study aimed to investigate the incidence and pattern of antimicrobial resistance in UTI-causing bacteria in central and northern Portugal. The results showed that UTIs were more prevalent in females and the elderly. Escherichia coli was the most common uropathogen, but other bacteria showed higher resistance rates. Comparison with previous data revealed an increase in bacterial resistance over time. Monitoring microbial resistance is essential for selecting appropriate antibiotic therapy.
Article
Microbiology
Jullia A. S. Nascimento, Fernanda F. Santos, Tiago B. Valiatti, Jose F. Santos-Neto, Ana Carolina M. Santos, Rodrigo Cayo, Ana C. Gales, Tania A. T. Gomes
Summary: This study identified 9 out of 452 UPEC strains (2%) as hybrid strains, with 7 classified as UPEC/EAEC and 2 as UPEC/aEPEC. These hybrid strains displayed specific characteristics in terms of cell adhesion ability and virulence potential.
Review
Biochemistry & Molecular Biology
Maria Maisto, Fortuna Iannuzzo, Ettore Novellino, Elisabetta Schiano, Vincenzo Piccolo, Gian Carlo Tenore
Summary: Urinary tract infections (UTIs) are a common bacterial infection, especially in women. The main etiological agents are E. coli, Pseudomonas aeruginosa, and Proteus mirabilis. Due to the increase in antimicrobial resistance, there is a need for natural alternatives for UTI treatment. This review summarizes the potential therapeutic effects of natural polyphenol-based nutraceuticals and foods through in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Giovanni Autore, Luca Bernardi, Claudio La Scola, Filippo Ghidini, Federico Marchetti, Andrea Pasini, Luca Pierantoni, Claudia Castellini, Claudia Gatti, Cristina Malaventura, Gabriella Pelusi, Francesco Antodaro, Andrea Bergomi, Franco Mazzini, Giovanni Parente, Roberto Pillon, Francesca Cusenza, Giacomo Biasucci, Alessandro De Fanti, Lorenzo Iughetti, Serafina Perrone, Andrea Pession, Mario Lima, Susanna Esposito
Summary: Urinary tract infection (UTI) is a common infectious disease in children, leading to antibiotic consumption and hospitalizations. This study aims to evaluate the agreement on UTI management in pediatric age in Emilia-Romagna Region, Italy, and assess the need to change current recommendations. The consensus provides clear indications based on the most updated literature to guide physicians in UTI management and avoid antibiotic abuse.
Review
Infectious Diseases
Faiza Morado, Darren W. Wong
Summary: Urinary tract infection is a common bacterial infection with challenges in diagnosis. To limit unnecessary testing and antibiotic use, various diagnostic stewardship initiatives involving multidisciplinary approaches and education of healthcare providers are effective in decreasing inappropriate testing and prescribing.
Review
Infectious Diseases
Joanna Marantidis, Rachael Sussman
Summary: While urinary tract infections (UTIs) are common, their management is challenging due to the variety of presentations and severity. The definition of complicated UTIs (cUTIs) lacks consensus, resulting in global differences in management. Patients with cUTIs often have other comorbidities requiring urgent intervention. Antimicrobial resistance (AMR) is a major challenge in treating cUTIs. A multidisciplinary approach, including regulatory frameworks, provider education, and public awareness campaigns, is crucial to limiting unnecessary treatments for asymptomatic bacteriuria (ASB) and uncomplicated UTIs.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Pediatrics
May Albarrak, Mona Al Dabbagh, Hilal Al Hashami, Omar Alzomor, Ghassan Ghatasheh, Nervana Habashy, Ashraf Hassanien, Andres Perez-Lopez
Summary: This study aims to review the published literature on pediatric urinary tract infections (UTIs) in the Gulf Cooperation Council (GCC) countries, including risk factors, etiology, antimicrobial susceptibility, and treatment. UTIs are common bacterial infections in children and can be acquired in healthcare or community settings.
FRONTIERS IN PEDIATRICS
(2023)
Editorial Material
Infectious Diseases
Emilia Cercenado, Jesus Rodriguez-Bano, Jose Luis Alfonso, Esther Calbo, Luis Escosa, Aurora Fernandez-Polo, Julio Garcia-Rodriguez, Jose Garnacho, Maria Victoria Gil-Navarro, Santiago Grau, Carlota Gudiol, Juan Pablo Horcajada, Nieves Larrosa, Carmen Martinez, Jose Molina, Xavier Nuvials, Antonio Oliver, Jose Ramon Pano-Pardo, Maria Teresa Perez-Rodriguez, Paula Ramirez, Pedro Rey-Biel, Pablo Vidal, Pilar Retamar-Gentil
Summary: In 2012, consensus recommendations were published by multiple Spanish societies on the implementation of antimicrobial stewardship (AMS) programs in acute care hospitals. However, there was a need for further guidance on AMS activities for specific patient populations or circumstances. Therefore, a panel of experts was assembled to review available information and provide guidance recommendations on these topics.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Microbiology
Berta Puig-Collderram, Sandra Domene-Ochoa, Maria Salva-Comas, Maria Milagro Montero, Xavier Duran, Juan R. Gonzalez, Santiago Grau, Antonio Oliver, Juan P. Horcajada, Eduardo Padilla, Concepcion Segura, Nuria Prim
Summary: The study validated the use of an ATP assay as an alternative to the conventional colony count method for studying antibiotic combinations. The ATP assay was found to be equivalent to the colony count method in categorizing the effectiveness of antibiotic combinations. This method is less laborious and faster, making it suitable for implementation in clinical laboratory workflow.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
D. Fresan, S. Luque, A. Benitez-Cano, L. Sorli, M. Milagro Montero, M. De-Antonio, N. Prim, V. Vega, J. P. Horcajada, S. Grau
Summary: Administering ceftazidime/avibactam by continuous infusion can achieve the desired drug concentration and therapeutic target in most patients, even at lower doses. The combination of continuous infusion and therapeutic drug monitoring can be a useful tool for reducing antimicrobial-related adverse effects and treatment costs.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Pilar Retamar-Gentil, Rafael Canton, Vicente Abril Lopez de Medrano, Jose Barberan, Andres Canut Blasco, Carlos Duenas Gutierrez, Carolina Garcia-Vidal, Nieves Larrosa Escartin, Jaime Lora-Tamayo, Francisco Javier Martinez Marcos, Carlos Martin Ruiz, Juan Pasquau Liano, Pedro Rascado, Oscar Sanz Pelaez, Genoveva Yague Girao, Juan P. Horcajada
Summary: This work presents the views of a group of experts on resistance to antimicrobial agents in Gram-negative bacilli, including the current epidemiology, its relation to clinical practice, and new therapies based on evidence. After reviewing the most relevant evidence, data on these aspects were presented to experts in infectious diseases, clinical microbiology, internal medicine, intensive care medicine, anaesthesiology, and hospital pharmacy, leading to conclusions on the matter.
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2023)
Article
Multidisciplinary Sciences
Maria Milagro Montero, Max Hardy-Werbin, Soledad Gonzalez-Gallardo, Erica Torres, Rebeca Rueda, Irene Hannet, James T. Kirk, Thomas D. Yager, Krupa Navalkar, Maria del Mar Arenas, Itziar Arietta-Aldea, Silvia Castaneda, Joan Gomez-Junyent, Silvia Gomez-Zorrilla, Roberto Guerri-Fernandez, Francisca Sanchez-Martinez, Immaculada Lopez-Montesinos, Ivan Pelegrin, Elena Sendra, Luisa Sorli, Judith Villar-Garcia, Beatriz Bellosillo, Juan Pablo Horcajada
Summary: Evaluation of SeptiCyte RAPID as a triaging tool for COVID-19 patients found that it can stratify cases according to clinical severity. The tool showed better discrimination than other biomarkers in predicting the need for ICU admission in COVID-19 patients.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Pablo Acin, Sonia Luque, Isaac Subirana, Joan Vila, Xenia Fernandez-Sala, Ana Guelar, Marta de Antonio-Cusco, Itziar Arrieta, Hernando Knobel
Summary: A scoring tool was developed to predict nonadherence in HIV patients starting antiretroviral therapy (ART). Patient-related factors that predict nonadherence, such as prejudice, appointment failures, cultural barriers, alcohol and substance abuse, unstable housing, and mental illness, were identified. The tool showed high sensitivity and specificity in predicting nonadherence, and could be used to optimize resources and achieve treatment goals.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2023)
Review
Infectious Diseases
Daniel Echeverria-Esnal, Luisa Sorli, Maria Eugenia Navarrete-Rouco, Nuria Prim, Jaime Barcelo-Vidal, David Conde-Estevez, Maria Milagro Montero, Clara Martin-Ontiyuelo, Juan Pablo Horcajada, Santiago Grau
Summary: This article reviews the relevant aspects of ampicillin-resistant and vancomycin-susceptible Enterococcus faecium (EfARSV) bacteremia, including microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, and treatment. However, the most appropriate treatment for this infection remains uncertain due to limited data.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Infectious Diseases
Jorge Palacio-Vieira, Sergio Moreno-Fornes, Yesika Diaz, Jordi Aceiton, Andreu K. Bruguera, Daniel M. Nomah, Josep Llibre, Hernando Knobel, Ivan Chivite, Jose M. Miro, Pere Domingo, Paula Suanzes, Francisco Fanjul, Gemma Navarro, Lizza Macorigh, Arantzazu Mera, Jordi Casabona, Arkaitz Imaz, Juliana Reyes-Uruena
Summary: The characteristics of people living with HIV who are lost to follow-up have changed over time. The COVID-19 pandemic has increased the rates of loss to follow-up, but the influencing factors remain similar. Epidemiological trends among people who are lost to follow-up can be utilized to prevent new losses of care and reduce barriers to achieving the Joint United Nations Programme on HIV/AIDS 95-95-95 targets.
Article
Medicine, General & Internal
Diana Badenes Bonet, Oswaldo Antonio Caguana Velez, Xavier Duran Jorda, Merce Comas Serrano, Margarita Posso Rivera, Mireia Admetllo, Anna Herranz Blasco, Elisa Cuadrado Godia, Ester Marco Navarro, Gemma Martin Ezquerra, Zenaida Pineiro Aguin, Maria Cinta Cumpli Gargallo, Jose Gregorio Gonzalez Garcia, Eva Balcells Vilarnau, Diego Rodriguez Chiaradia, Xavier Castells, Joaquim Gea, Juan P. Horcajada, Judit Villar-Garcia
Summary: This study aimed to identify risk factors for the presence of post-acute sequelae of SARS-CoV-2 (PASC) and describe the profile of persistent symptoms in a multidisciplinary Post-Coronavirus Disease-19 (COVID-19) Unit. The results showed that treatment with dexamethasone and remdesivir was associated with shorter duration of symptoms, and female gender, obesity, asthma, and disease severity were identified as risk factors for PASC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Laura Rio-No, Luisa Sorli, Alba Arderiu-Formenti, Marta De Antonio, Lucas Martorell, Isaac Subirana, Lluis Puig, Albert Alier, Joan Gomez-Junyent, Daniel Perez-Prieto, Sonia Luque
Summary: This study aimed to investigate the pharmacokinetic/pharmacodynamic characteristics of vancomycin and identify risk factors associated with failure to achieve optimal PK/PD targets in the first therapeutic drug monitoring. The results showed that over 50% of patients did not achieve optimal PK/PD, and factors such as age, baseline serum creatinine, and body weight influenced drug exposure levels and the occurrence of nephrotoxicity.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Daniel Fresan, Sonia Luque, Adela Benitez-Cano, Luisa Sorli, Maria Milagro Montero, Marta De-Antonio, Victoria Vega, Jason A. Roberts, Juan P. Horcajada, Santiago Grau
Summary: This study describes the use of therapeutic drug monitoring (TDM) and pharmacokinetics/pharmacodynamics (PK/PD) target attainment of ceftaroline administered by intermittent and prolonged infusion in patients with MDR-GP bacterial infections. The results show that patients treated with prolonged infusions achieved the PK/PD target.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Javier Meseguer-Donlo, Jade Soldado-Folgado, Juan Du, Alicia Gonzalez-Mena, Fabiola Blasco-Hernando, Esperanza Canas-Ruano, Xavier Nogues, Hernando Knobel, Natalia Garcia-Giralt, Robert Guerri-Fernandez
Summary: HIV infection leads to chronic inflammation and accelerated aging. This study found that circulating miRNAs in treatment-naive HIV-infected individuals were altered, and these alterations persisted after one year of treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Health Care Sciences & Services
Adela Benitez-Cano, Silvia Bermejo, Sonia Luque, Luisa Sorli, Jesus Carazo, Irene Zaragoza, Isabel Ramos, Jordi Valles, Juan P. Horcajada, Ramon Adalia
Summary: This study evaluated the clinical, microbiological, and treatment characteristics of severe postoperative pneumonia and tracheobronchitis. The findings showed that surgical patients are at high risk for early onset severe pneumonia and tracheobronchitis, with a high proportion of Gram-negative and multi-drug resistant bacteria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)