Article
Infectious Diseases
Matthaios Papadimitriou-Olivgeris, Damien Jacot, Laurence Senn, Benoit Guery
Summary: This retrospective study compared patients with Staphylococcus aureus bacteraemia (SABA) with or without concomitant bacteriuria (SABU) at Lausanne University Hospital from 2015 to 2021. Out of 448 included bacteraemic patients, 62 (13.8%) had concurrent S. aureus isolated from urine. The study found significant differences in community-onset bacteraemia, malignancy, > 1 pair of positive blood cultures, and persistent bacteraemia for at least 48 h in patients with concurrent SABU. However, there was no difference in mortality. SABU was associated with higher rates of SABA recurrence after antibiotic cessation.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Anthony D. Bai, Carson K. L. Lo, Adam S. Komorowski, Mallika Suresh, Kevin Guo, Akhil Garg, Pranav Tandon, Julien Senecal, Olivier Del Corpo, Isabella Stefanova, Clare Fogarty, Guillaume Butler-Laporte, Emily G. McDonald, Matthew P. Cheng, Andrew M. Morris, Mark Loeb, Todd C. Lee
Summary: The mortality rate of Staphylococcus aureus bacteremia has decreased over the past three decades, but one in four patients still die within three months. Methicillin-resistant Staphylococcus aureus infection is associated with a higher mortality rate, while more recent time periods have shown lower mortality rates.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Itziar Diego-Yague, Alberto Mora-Vargas, Jose Manuel Vazquez-Comendador, Beatriz Santamarina-Alcantud, Ana Fernandez-Cruz, Elena Munez-Rubio, Andrea Gutierrez-Villanueva, Isabel Sanchez-Romero, Victor Moreno-Torres, Antonio Ramos-Martinez, Jorge Calderon-Parra
Summary: Oral sequential therapy (OST) in uncomplicated Staphylococcus aureus bacteraemia (SAB) is found to be safe and effective, reducing mortality and microbiological failure.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Fredrik Kahn, Fredrik Resman, Sissela Bergmark, Peter Filiptsev, Bo Nilson, Patrik Gilje, Magnus Rasmussen
Summary: This study aimed to identify patients with Staphylococcus aureus bacteraemia at risk for infective endocarditis, and found that time to blood culture positivity (TTP) could be used to identify low-risk IE patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Annette C. Westgeest, Felicia Ruffin, Jackson L. Kair, Lawrence P. Park, Rachel E. Korn, Maren E. Webster, Leo G. Visser, Emile F. Schippers, Mark G. J. de Boer, Merel M. C. Lambregts, Vance G. Fowler Jr
Summary: Although there are significant differences in patient characteristics, disease characteristics, and management between women and men with Staphylococcus aureus bacteraemia, they have a similar mortality risk.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Sylvere Bastien, Severien Meyers, Wilmara Salgado-Pabon, Stefano G. Giulieri, Jean-Phillipe Rasigade, Laurens Liesenborghs, Kyle J. Kinney, Florence Couzon, Patricia Martins-Simoes, Vincent Le Moing, Xavier Duval, Natasha E. Holmes, Niels Eske Bruun, Robert Skov, Benjamin P. Howden, Vance G. Fowler, Peter Verhamme, Paal Skytt Andersen, Coralie Bouchiat, Karen Moreau, Francois Vandenesch
Summary: Through a genome-wide association study and experimental animal models, it was found that specific S. aureus strains causing bloodstream infection do not necessarily cause infective endocarditis. Therefore, all S. aureus strains isolated from patients with bloodstream infection should be considered capable of causing this common and deadly infection.
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Malin Hagstrand Aldman, Robert Kavyani, Fredrik Kahn, Lisa Pahlman
Summary: This retrospective study compared the efficacy of penicillin G and cloxacillin in treating penicillin-susceptible Staphylococcus aureus (PSSA) bloodstream infections. The study found that there was no significant difference in mortality rates between the two treatment groups, but patients treated with cloxacillin had a higher odds of experiencing treatment complications.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Immunology
Anita J. Campbell, Laila S. Al Yazidi, Linny K. Phuong, Clare Leung, Emma J. Best, Rachel H. Webb, Lesley Voss, Eugene Athan, Philip N. Britton, Penelope A. Bryant, Coen T. Butters, Jonathan R. Carapetis, Natasha S. Ching, Geoffrey W. Coombs, Denise Daley, Joshua Francis, Te-Yu Hung, Shakeel Mowlaboccus, Clare Nourse, Samar Ojaimi, Alex Tai, Nan Vasilunas, Brendan McMullan, Christopher C. Blyth, Asha C. Bowen
Summary: The ISAIAH study in Australia and New Zealand identified a high incidence of Staphylococcus aureus bacteremia in children hospitalized, with necrotizing pneumonia and multifocal infection being predictors of mortality for the first time in a pediatric setting. Consultation with infectious diseases specialists was found to be protective, highlighting the need to reevaluate pediatric vancomycin trough targets and limit unnecessary empiric vancomycin exposure to reduce poor outcomes and nephrotoxicity.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Rein Willekens, Mireia Puig-Asensio, Paula Suanzes, Nuria Fernandez-Hidalgo, Maria N. Larrosa, Juan J. Gonzalez-Lopez, Dolors Rodriguez-Pardo, Carles Pigrau, Benito Almirante
Summary: Despite good adherence to previously published QIs for the management of Staphylococcus aureus bacteremia, the 30-day mortality remains high. Risk factors such as persistent bacteremia, infective endocarditis, and SAB of unknown source were associated with increased 30-day mortality. Future research should focus on additional factors to further improve outcomes for patients with SAB.
JOURNAL OF INFECTION
(2021)
Article
Immunology
Heather W. Dolby, Sarah A. Clifford, Ian F. Laurenson, Vance G. Fowler, Clark D. Russell
Summary: This study systematically evaluated randomized-controlled trials for Staphylococcus aureus bacteremia and found heterogeneity in cohort characteristics and reporting, introduction of selection bias through exclusion criteria, and difficulties in meta-analysis due to differences in outcome definitions, which complicate the interpretation and application of the results.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Grapsa, Christopher Blauth, Y. S. Chandrashekhar, Bernard Prendergast, Blair Erb, Michael Mack, Valentin Fuster
Summary: This paper presents a clinical case of Staphylococcus aureus infective endocarditis in a 19-year-old female patient and discusses the current evidence on the management and treatment of the disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Infectious Diseases
Andreas Berge, Casper Carlsen, Alexandros Petropoulos, Fredrik Gadler, Magnus Rasmussen
Summary: A study in Sweden examined patients with cardiac implantable electronic devices (CIED) and Staphylococcus aureus bacteremia (SAB), finding that 14% of patients were diagnosed with infective endocarditis (IE). A predictive score for IE was constructed and validated in a separate cohort of patients, showing high sensitivity and negative predictive value.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Critical Care Medicine
Alexis Tabah, Kevin B. Laupland
Summary: This review examines the recent evidence about Staphylococcus aureus bacteremia (SAB). It highlights that S. aureus is the most common pathogen causing co-infections and superinfections in COVID-19 patients. The study also shows an increase in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia ratios during the pandemic. The review suggests that vancomycin remains the first-line treatment for MRSA bacteremia, while cefazolin is a better choice for managing methicillin-susceptible Staphylococcus aureus.
CURRENT OPINION IN CRITICAL CARE
(2022)
Article
Infectious Diseases
Marie Bourget, Marie Pasquie, Helene Charbonneau, Eric Bonnet
Summary: This study compared the morbidity and mortality rates of patients with endocarditis caused by Staphylococcus aureus (E-SA) and endocarditis caused by coagulase-negative staphylococci (E-CNS). The results showed comparable rates of embolic complications, surgical management, and mortality between E-SA and E-CNS.
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Emil L. Fosbol, Thomas A. Gerds, Kasper Iversen, Henning Bundgaard, Niels Eske Bruun, Anders R. Larsen, Andreas Petersen, Paal S. Andersen, Robert L. Skov, Lauge Ostergaard, Eva Havers-Borgersen, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Kober, Jonas B. Olesen
Summary: This study investigated the 1-year risks of Staphylococcus aureus bacteraemia, sepsis, and pneumonia in patients undergoing percutaneous coronary intervention and treated with ticagrelor or clopidogrel. The results showed that treatment with ticagrelor was associated with significantly lower risks of Staphylococcus aureus bacteraemia, sepsis, and pneumonia compared to treatment with clopidogrel.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Michael P. Muehlenbein, Kristina M. Angelo, Patricia Schlagenhauf, Lin Chen, Martin P. Grobusch, Philippe Gautret, Alexandre Duvignaud, Francois Chappuis, Kevin C. Kain, Emmanuel Bottieau, Loic Epelboin, Marc Shaw, Noreen Hynes, Davidson H. Hamer, Henry Wu, Jesse Waggoner, Watcharapong Piyaphanee, Udomsak Silachamroon, Christina Coyle, Eli Schwartz, Lucille Blumberg, Albie de Frey, Hugo Siu, Luis Manuel Valdez, Michael Beadsworth, Nicholas Beeching, Michael Libman, Cedric Yansouni, Anne McCarthy, Mauro Saio, Marta Diaz Menendez, Sabine Jordon, Christof Vinnemeier, Hilmer Asgeirsson, Hedvig Glans, Natasha Hochberg, Federico Gobbi, Andrea Rossanese, Effrossyni Gkrania-Klotsa, Bradley Connor, Perry van Genderen, Susan Anderson, Carmelo Licitra, Ashley Thomas, Poh Lian Lim, Christian Wejse, Sanne Jespersen, Frank Mockenhaupt, Gundel Harms-Zwingenberger, Paul Kelly, Truong Hoang Phu, Jasper Chan, Kwok-Yung Yuen, Johnnie Yates, Victoria Johnston, Vanessa Field, Claudio Viscoli, Federica Toscanini, Prativa Pandey, Bhawana Amatya, Kunjana Mavunda, Dorothy Contiguglia-Akcan, Karin Leder, Joe Torresi, Jonathan Alpern, Bill Stauffer, Frank von Sonnenburg, Camilla Rothe, Stefan Hagmann, Sunil Sood, Ben Wyler, John Cahill, Eric Caumes, Katherine Plewes, Wayne Ghesquiere, Daniel Leung
JOURNAL OF TRAVEL MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Laura Ambra P. Nicolini, Rhett J. Stoney, Andrea Della Vecchia, Martin Grobusch, Philippe Gautret, Kristina M. Angelo, Perry J. J. van Genderen, Emmanuel Bottieau, Karin Leder, Hilmir Asgeirsson, Daniel T. Leung, Bradley Connor, Prativa Pandey, Federica Toscanini, Federico Gobbi, Francesco Castelli, Matteo Bassetti, Davidson H. Hamer
JOURNAL OF TRAVEL MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Pierre Dudouet, Philippe Gautret, Carsten Schade Larsen, Marta Diaz-Menendez, Elena Trigo, Frank von Sonnenburg, Federico Gobbi, Martin P. Grobusch, Denis Malvy, Vanessa Field, Hilmir Asgeirsson, Ines Oliveira Souto, Davidson H. Hamer, Philippe Parola, Emilie Javelle
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2020)
Article
Microbiology
Stefan H. F. Hagmann, Kristina M. Angelo, Ralph Huits, Katherine Plewes, Gilles Eperon, Martin P. Grobusch, Anne McCarthy, Michael Libman, Eric Caumes, Daniel T. Leung, Hilmir Asgeirsson, Mogens Jensenius, Eli Schwartz, Adrian Sanchez-Montalva, Paul Kelly, Prativa Pandey, Karin Leder, Daniel L. Bourque, Yukihiro Yoshimura, Frank P. Mockenhaupt, Perry J. J. van Genderen, Silvia Odolini, Patricia Schlagenhauf, Bradley A. Connor, Davidson H. Hamer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Renata Varnaite, Marina Garcia, Hedvig Glans, Kimia T. Maleki, John Tyler Sandberg, Janne Tynell, Wanda Christ, Nina Lagerqvist, Hilmir Asgeirsson, Hans-Gustaf Ljunggren, Gustaf Ahlen, Lars Frelin, Matti Sallberg, Kim Blom, Jonas Klingstrom, Sara Gredmark-Russ
JOURNAL OF IMMUNOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Johannes Eimer, Calvin Patimeteeporn, Mogens Jensenius, Effrossyni Gkrania-Klotsas, Alexandre Duvignaud, Elizabeth D. Barnett, Natasha S. Hochberg, Lin H. Chen, Elena Trigo-Esteban, Maximilian Gertler, Christina Greenaway, Martin P. Grobusch, Kristina M. Angelo, Davidson H. Hamer, Eric Caumes, Hilmir Asgeirsson
Summary: The study found that MDR-TB is relatively rare among international travelers and migrants, with the majority of cases coming from immigrants from the former Soviet Union. Purposeful medical migration may partly explain differences in time to presentation among different groups.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Medicine, General & Internal
Manu Shankar-Hari, Claire L. Vale, Peter J. Godolphin, David Fisher, Julian P. T. Higgins, Francesca Spiga, Jelena Savovic, Jayne Tierney, Gabriel Baron, Julie S. Benbenishty, Lindsay R. Berry, Niklas Broman, Alexandre Biasi Cavalcanti, Roos Colman, Stefanie L. De Buyser, Lennie P. G. Derde, Pere Domingo, Sharifah Faridah Omar, Ana Fernandez-Cruz, Thijs Feuth, Felipe Garcia, Rosario Garcia-Vicuna, Isidoro Gonzalez-Alvaro, Anthony C. Gordon, Richard Haynes, Olivier Hermine, Peter W. Horby, Nora K. Horick, Kuldeep Kumar, Bart N. Lambrecht, Martin J. Landray, Lorna Leal, David J. Lederer, Elizabeth Lorenzi, Xavier Mariette, Nicolas Merchante, Nor Arisah Misnan, Shalini Mohan, Michael C. Nivens, Jarmo Oksi, Jose A. Perez-Molina, Reuven Pizov, Raphael Porcher, Simone Postma, Reena Rajasuriar, Athimalaipet Ramanan, Philippe Ravaud, Pankti D. Reid, Abraham Rutgers, Aranzazu Sancho-Lopez, Todd B. Seto, Sumathi Sivapalasingam, Arvinder Singh Soin, Natalie Staplin, John H. Stone, Garth W. Strohbehn, Jonas Sunden-Cullberg, Julian Torre-Cisneros, Larry W. Tsai, Hubert van Hoogstraten, Tom van Meerten, Viviane Cordeiro Veiga, Peter E. Westerweel, Srinivas Murthy, Janet Diaz, John C. Marshall, Jonathan A. C. Sterne
Summary: This study identified 27 clinical trials and found that the use of IL-6 antagonists was associated with lower 28-day all-cause mortality in patients hospitalized for COVID-19 compared to usual care or placebo. Different risk effects were observed between tocilizumab and sarilumab, increasing understanding of the treatment with these drugs.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Immunology
Karin A. Ydsten, Urban Hellgren, Hilmir Asgeirsson
Summary: Overall, quinacrine was found to be an effective treatment for nitroimidazole-refractory giardiasis with a high parasitological efficacy rate of 94% and good tolerability. Only a small percentage of patients experienced mild adverse effects during the treatment. Therefore, quinacrine can be recommended as a viable treatment option for this condition.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Oluwafemi Balogun, Ashley Brown, Kristina M. Angelo, Natasha S. Hochberg, Elizabeth D. Barnett, Laura Ambra Nicolini, Hilmir Asgeirsson, Martin P. Grobusch, Karin Leder, Fernando Salvador, Lin Chen, Silvia Odolini, Marta Diaz-Menendez, Federico Gobbi, Bradley A. Connor, Michael Libman, Davidson H. Hamer
Summary: Non-immune international travelers are at risk of acquiring hepatitis A, even when traveling to low-endemicity destinations. Providing pre-departure hepatitis A vaccine to susceptible travelers is crucial to reducing travel-associated hepatitis A.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Immunology
Demi Brownlie, Inga Rodahl, Renata Varnaite, Hilmir Asgeirsson, Hedvig Glans, Sara Falck-Jones, Sindhu Vangeti, Marcus Buggert, Hans-Gustaf Ljunggren, Jakob Michaelsson, Sara Gredmark-Russ, Anna Smed-Sorensen, Nicole Marquardt
Summary: This study compared NK cells and T cells in patients infected with SARS-CoV-2 or influenza virus, focusing on the expression of chemokine receptors involved in lung recruitment. The results suggest a potential role for NK cells and T cells expressing CXCR3(+), CXCR6(+), and/or CCR5(+) in moderate COVID-19 and influenza patients, indicating common targets for therapeutic interventions in respiratory viral infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Public, Environmental & Occupational Health
Marta Diaz-Menendez, Kristina M. Angelo, Rosa de Miguel Buckley, Emmanuel Bottieau, Ralph Huits, Martin P. Grobusch, Federico Giovanni Gobbi, Hilmir Asgeirsson, Alexandre Duvignaud, Francesca F. Norman, Emilie Javelle, Loic Epelboin, Camilla Rothe, Francois Chappuis, Gabriela Equihua Martinez, Corneliu Popescu, Daniel Camprubi-Ferrer, Israel Molina, Silvia Odolini, Sapha Barkati, Susan Kuhn, Stephen Vaughan, Anne McCarthy, Mar Lago, Michael D. Libman, Davidson H. Hamer
Summary: An increasing number of travellers returning from Cuba in June to September 2022 were reported to have dengue virus infection, indicating an ongoing outbreak in the area. This report highlights the significance of travellers as sentinels for arboviral outbreaks and emphasizes the importance of early identification of travel-related dengue.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Watcharapong Piyaphane, Rhett J. Stoney, Hilmir Asgeirsson, Grace D. Appiah, Marta Diaz-Menendez, Elizabeth D. Barnett, Philippe Gautret, Michael Libman, Patricia Schlagenhauf, Karin Leder, Katherine Plewes, Martin P. Grobusch, Ralph Huits, Kunjana Mavunda, Davidson H. Hamer, Lin H. Chen
Summary: International travellers may seek healthcare during their trip or plan healthcare abroad. The study indicates that many travellers encounter health problems during travel that could be prevented and managed through pre-travel consultations.
JOURNAL OF TRAVEL MEDICINE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Ola Blennow, Urban Hellgren, Hilmir Asgeirsson
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Health Care Sciences & Services
Martin P. Grobusch, Leisa Weld, Abraham Goorhuis, Davidson H. Hamer, Mirjam Schunk, Sabine Jordan, Frank P. Mockenhaupt, Francois Chappuis, Hilmir Asgeirsson, Eric Caumes, Mogens Jensenius, Perry J. J. van Genderen, Francesco Castelli, Rogelio Lopez-Velez, Vanessa Field, Emmanuel Bottieau, Israel Molina, Christophe Rapp, Marta Diaz Menendez, Effrossyni Gkrania-Klotsas, Carsten S. Larsen, Denis Malvy, David Lalloo, Federico Gobbi, Simin A. Florescu, Philippe Gautret, Patricia Schlagenhauf
Summary: The study evaluated travel-related illness encountered at EuroTravNet clinics between 1998 and 2018, finding an increase in ill travellers over the years. Despite this, regions of exposure remained stable. Diseases like falciparum malaria, rabies, and influenza showed varying trends over the years.
LANCET REGIONAL HEALTH-EUROPE
(2021)
Article
Immunology
Anna J. Henningsson, Hilmir Asgeirsson, Berit Hammas, Elias Karlsson, Asa Parke, Dieuwertje Hoornstra, Peter Wilhelmsson, Joppe W. Hovius
EMERGING INFECTIOUS DISEASES
(2019)