期刊
JOURNAL OF INFECTION
卷 62, 期 2, 页码 149-158出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2010.11.005
关键词
Lyme neuroborreliosis; Diagnosis; Chemokine CXCL13; Antibodies; Serology; Cerebrospinal fluid; Serum; Children; Borrelia
资金
- Medical Research Council of Southeast Sweden (FORSS)
Objectives: The aim of this study was to evaluate the chemokine CXCL13 and C6 antibodies separately and in combination in paired serum/cerebrospinal fluid (CSF) samples in the laboratory diagnosis of Lyme neuroborreliosis (LNB). Methods: A large retrospective material with paired serum/CSF samples from 261 patients with clinically suspected LNB was investigated. Patients were divided into three main diagnostic groups based on original results of CSF pleocytosis and intrathecal anti-borrelia antibodies (purified flagellum). Levels of CXCL13, albumin, total IgM and IgG in paired samples and C6 antibodies in CSF were compared across diagnostic groups. Results: A sensitivity of 99% and a specificity of 96% were achieved for CSF-Serum CXCL13 ratio. CSF-C6 antibodies performed with a sensitivity of 99% and a specificity of 88.0%. A combination of CSF-Serum CXCL13 ratio and CSF-C6 antibodies, evaluated in parallel, revealed a sensitivity of 99% and specificity of 98%. Conclusions: This study confirms CSF-CXCL13 as a reliable marker of LNB and suggests improved diagnostic performance especially in children with possible LNB. (C) 2010 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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