Review
Medicine, General & Internal
Emilio Bouza, Aristides de Alarcon, Maria Carmen Farinas, Juan Galvez, Miguel Angel Goenaga, Francisco Gutierrez-Diez, Javier Hortal, Jose Lasso, Carlos A. Mestres, Jose M. Miro, Enrique Navas, Mercedes Nieto, Antonio Parra, Enrique Perez de la Sota, Hugo Rodriguez-Abella, Marta Rodriguez-Creixems, Jorge Rodriguez-Roda, Gemma Sanchez Espin, Dolores Sousa, Carlos Velasco Garcia de Sierra, Patricia Munoz, Martha Kestler
Summary: This document, created by a multidisciplinary group of experts from several Spanish societies and research centers, aims to provide guidance on the diagnosis and management of post-surgical mediastinitis infections. The guidance is intended to optimize patient outcomes, minimize adverse effects, and workload.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Daiki Kitano, Hiroaki Takahashi, Tadashi Nomura, Kenji Okada, Hiroto Terashi, Shunsuke Sakakibara
Summary: This study retrospectively analyzed 100 cases of post-sternotomy surgical site infection (SSI) and proposed a new clinical classification and reconstructive strategy. The cases were classified into four categories based on the anatomical invasiveness of the infection and different reconstructive methods were used. The study provided insights into the treatment outcomes for each SSI category.
REGENERATIVE THERAPY
(2022)
Review
Chemistry, Medicinal
Aathira Pradeep, Jayakumar Rangasamy, Praveen Kerala Varma
Summary: Sternal wound infections, classified as superficial or deep, are common complications of cardiac surgery, mostly caused by staphylococcal organisms. Diagnosis involves characteristic symptoms and observation of infection during operation.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander Emil Kaspersen, Susanne J. Nielsen, Andri Wilberg Orrason, Astridur Petursdottir, Martin Ingi Sigurdsson, Anders Jeppsson, Tomas Gudbjartsson
Summary: The study found that DSWI patients have higher short- and long-term mortality risks compared to non-DSWI patients. This highlights the importance of preventing these infections and carefully monitoring DSWI patients postoperatively.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Critical Care Medicine
Geoffroy Hariri, Mathieu Genoud, Vincent Bruckert, Samuel Chosidow, Emmanuel Guerot, Antoine Kimmoun, Nicolas Nesseler, Emmanuel Besnier, Fabrice Daviaud, David Lagier, Julien Imbault, David Grimaldi, Adrien Bougle, Nicolas Mongardon
Summary: This study aimed to investigate the occurrence, characteristics, and outcomes of fungal mediastinitis after cardiac surgery. Among 73,688 cardiac surgery procedures, 40 patients developed fungal mediastinitis. Candida spp. was the most common fungal strain. Survivors were younger, had lower body mass index, and lower severity scores.
Article
Cardiac & Cardiovascular Systems
Ramsey S. Elsayed, Joseph Carey, Robbin G. Cohen, Mark L. Barr, Craig J. Baker, Vaughn A. Starnes, Michael E. Bowdish
Summary: Early diagnosis and aggressive surgical therapy for DSWI following cardiac surgery lead to excellent outcomes, while early diagnosis and failed initial medical management are associated with increased mortality.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Dermatology
Yanbing Zhang, Pengyu Zhang, Han Li, Haitao Chi, Nan Zheng, Xu Pan, Chuzhong Tang
Summary: We conducted a meta-analysis to evaluate the impact of topical vancomycin (TV) application on reducing sternal wound infections (SWIs) following cardiac surgery (CS). The analysis included 23,745 participants who underwent CS, with 8,730 using TV and 15,015 as controls. The results showed that TV significantly reduced the occurrence of SWIs and deep SWIs post-CS compared to the control group.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Agnieszka Zukowska, Maciej Zukowski
Summary: Surgical site infections (SSIs) are a common complication in surgical patients, especially in cardiac surgery patients. Sternum wound and graft harvesting site infections are the most common SSIs. Treatment and prevention strategies include the use of antibiotics, surgical intervention, and reducing preoperative risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Adil A. Isaac
Summary: A study was conducted to identify risk factors for sternal wound infection (SWI) in a cardiac center in Eastern Saudi Arabia. The study found that factors such as hospital stay, graft conduit, transfusion, diabetes markers, BMI, perioperative blood glucose level, and surgery time were associated with infection risk. Therefore, there is an urgent need for multidisciplinary consensus guidelines.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Dermatology
Yixi Tao, Yusui Zhang, Yang Liu, Songjiang Tang
Summary: This study conducted a comprehensive analysis to evaluate the benefits of negative pressure wound therapy (NPWT) versus traditional dressings in preventing surgical site infections in patients undergoing cardiac surgery. The findings revealed that NPWT was more effective in reducing surgical site infections, deep wound infections, and hospital stays compared to conventional dressings. However, the rate of superficial wound infections was not significantly affected by the method of wound care.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Jessica L. Seidelman, Christopher R. Mantyh, Deverick J. Anderson
Summary: Surgical site infections occur in 0.5% to 3% of patients undergoing surgery and are associated with longer hospital stays. Measures such as avoiding razors, maintaining normothermia, using chlorhexidine gluconate plus alcohol-based skin preparation, decolonization with intranasal antistaphylococcal agents, controlling perioperative glucose concentrations, and using negative pressure wound therapy can reduce the rate of surgical site infections.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Roel Henneman, Linda Rouwenhorst, M. Baris Karakullukcu, Ludwig E. Smeele, Peter F. J. M. Lohuis, Michiel W. M. van den Brekel, Olga Hamming-Vrieze, Katarzyna Jozwiak, Alfons J. M. Balm
Summary: This study aims to compare surgical site complications after salvage neck dissection and primary neck dissection. The study found that post-radiotherapy neck dissection, selective neck dissection, and removal of the sternocleidomastoid muscle were significantly associated with more surgical site complications. There was no significant difference in complication frequency between salvage neck dissection and primary neck dissection 10 weeks after radiotherapy/chemoradiotherapy.
Article
Dermatology
Jiang Xie, Yuxuan Du, Zejiu Tan, Hao Tang
Summary: A meta-analysis was conducted to evaluate the relationship between malnutrition and surgical site infection (SSI) after spinal surgery. The results showed that malnutrition significantly increased the incidence of SSI. However, further high-quality studies with larger sample sizes are needed to validate these results.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Cary Jo R. Schlick, Reiping Huang, Brian C. Brajcich, Amy L. Halverson, Anthony D. Yang, Lindsey Kreutzer, Karl Y. Bilimoria, Michael F. McGee
Summary: The implementation of surgical site infection reduction bundles plays an important role in reducing surgical site infections, but different bundle elements have varying associations with infection reduction. Therefore, it is necessary to focus on the specific elements that have an impact on infection reduction during the implementation process.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Dermatology
Thomas Rousseau, Chloe Plomion, Kylie Sandy-Hodgetts
Summary: This study investigated the usefulness of a transparent hydropolymer wound dressing in orthopaedic patients following hip or knee arthroplasty under the ERAS protocol. The results showed that the majority of patients wore the dressing for 14 days without difficulty. The dressing provided sufficient incision site visibility, reducing the need for dressing changes.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Infectious Diseases
Alba Rivera, Belen Vinado, Natividad Benito, Fernando Docobo-Perez, Felipe Fernandez-Cuenca, Javier Fernandez-Dominguez, Jesus Guinea, Antonio Lopez-Navas, Miguel Angel Moreno, Maria Nieves Larrosa, Antonio Oliver, Ferran Navarro
Summary: Disk diffusion is a standardized method used for guiding antimicrobial therapy. Guidelines from EUCAST, which are widely implemented in Spain, have led to the recommendations by COESANT for antimicrobial selection using the disk diffusion technique.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Dermatology
Julia Serrano-Lobo, Ana Gomez, Elena Reigadas, Patricia Munoz, Pilar Escribano, Jesus Guinea
Summary: This study evaluated the performance of gradient diffusion strips (GDSs) in detecting azole resistance in Aspergillus fumigatus. The results showed that GDSs can effectively identify azole-resistant isolates of A. fumigatus sensu stricto, but have poor performance against cryptic species.
Article
Infectious Diseases
Maiken Cavling Arendrup, Sevtap Arikan-Akdagli, Mariana Castanheira, Jesus Guinea, Jeffrey B. Locke, Joseph Meletiadis, Oscar Zaragoza
Summary: The study evaluated the application of a modified EUCAST method in Candida isolates, and the results showed that the method significantly reduced inter-laboratory variation, identified wild-type populations, and separated mutants successfully, except for isolates with weak mutations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Editorial Material
Medicine, General & Internal
Jesus Guinea
Article
Immunology
Sofia de la Villa, Sergio Herrero, Patricia Munoz, Carmen Rodriguez, Maricela Valerio, Elena Reigadas, Ana Alvarez-Uria, Luis Alcala, Mercedes Marin, Maria Olmedo, Martha Kestler, Esther Chamorro, Emilio Bouza
Summary: This study aimed to describe the frequency and effectiveness of Bezlotoxumab (BZX) and fecal microbiota transplantation (FMT) in real-world practice for treating Clostridioides difficile infection (CDI). The results showed that both BZX and FMT had similar effectiveness in preventing CDI recurrence despite their application to different populations.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Pilar Escribano, Aina Mesquida, Sara Lopez-Montesinos, Elena Reigadas, Patricia Munoz, Jesus Guinea
Summary: We compared antifungal susceptibility of 92 Mucorales isolates using visual inspection and spectrophotometric readings following EUCAST testing. Most isolates had Amphotericin B MICs up to 1 mg/l, varying among species except for C. bertholletiae. Posaconazole MICs were up to 1 mg/l against most isolates, but high against M. circinelloides, some R. arrhizus, and R. microsporus. Isavuconazole MICs ranged from 1 to 8 mg/l, but were always >8 mg/l against M. circinelloides and C. bertholletiae. Agreement between MICs obtained by visual inspection or spectrophotometric readings was moderate, but higher when using the >= 90% fungal growth inhibition endpoint. Isavuconazole had higher MICs than posaconazole, regardless of the inhibition endpoint used.
Article
Microbiology
J. J. Aguilera-Correa, B. Salinas, M. Gonzalez-Arjona, D. de Pablo, P. Munoz, E. Bouza, M. J. Fernandez Acenero, J. Esteban, M. Desco, L. Cusso
Summary: This study compared structural and molecular imaging techniques to assess disease progression in a mouse model of osteomyelitis. The results showed that FDG-PET imaging was more sensitive than MRI and CT in differentiating between infection and inflammation at early stages.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Cristina Veintimilla, Ana Alvarez-Uria, Pablo Martin-Rabadan, Maricela Valerio, Marina Machado, Belen Padilla, Roberto Alonso, Cristina Diez, Patricia Munoz, Mercedes Marin
Summary: This study compared the performance of real-time PCR and immunofluorescence assay (IFA) in a large microbiology laboratory. The PCR test showed higher sensitivity, specificity, PPV, and NPV for diagnosing PJP compared to the IFA. Therefore, PCR is a robust and reliable method for diagnosing PJP.
Article
Microbiology
Judith Diaz-Garcia, Marina Machado, Luis Alcala, Elena Reigadas, Ana Perez-Ayala, Elia Gomez-Garcia de la Pedrosa, Fernando Gonzalez-Romo, Maria Soledad Cuetara, Coral Garcia-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, Maria Munoz-Algarra, Maria Teresa Duran-Valle, Aida Sanchez-Garcia, Patricia Munoz, Pilar Escribano, Jesus Guinea, CANDIMAD Study Grp
Summary: A surveillance study on Candida epidemiology and antifungal resistance in Madrid revealed an increase in fluconazole-resistant Candida parapsilosis. Data from isolates collected in 2022 were presented, along with the analysis of epidemiology and antifungal resistance trends throughout the study period. Candida albicans was the most common species found, while Candida auris was not detected. Resistance to antifungal drugs was generally low, except for fluconazole, which showed a resistance rate of 12.0%, mainly due to fluconazole-resistant C. parapsilosis clones.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Pedro Puerta-Alcalde, Patricia Monzo-Gallo, Manuela Aguilar-Guisado, Juan Carlos Ramos, Julia Laporte-Amargos, Marina Machado, Pilar Martin-Davila, Mireia Franch-Sarto, Isabel Sanchez-Romero, Jon Badiola, Lucia Gomez, Isabel Ruiz-Camps, Lucrecia Yanez, Lourdes Vazquez, Mariana Chumbita, Francesc Marco, Alex Soriano, Pedro Gonzalez, Ana Fernandez-Cruz, Montserrat Batlle, Jesus Fortun, Jesus Guinea, Carlota Gudiol, Julio Garcia, Maite Ruiz Perez de Pipaon, Ana Alastruey-Izquierdo, Carolina Garcia-Vidal
Summary: We describe the current epidemiology, causes, and outcomes of breakthrough invasive fungal infections (BtIFI) in patients with haematologic malignancies. Non-fumigatus Aspergillus, non-albicans Candida, Mucorales, and other rare species of mould and yeast are found to be the main causes of BtIFI. Due to the high mortality of BtIFI, an aggressive diagnostic approach and early initiation of broad-spectrum antifungals are warranted.
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Judith Diaz-Garcia, Aina Mesquida, Marina Machado, Carlos Sanchez-Carrillo, Patricia Munoz, Pilar Escribano, Jesus Guinea
Summary: During the COVID-19 pandemic, there was an increase in both fungemia incidence and cases caused by Candida auris or fluconazole-resistant C. parapsilosis. A study conducted from January 2020 to December 2022 analyzed the impact of the pandemic on fungemia incidence, species epidemiology, potential patient-to-patient transmission, and antifungal resistance. The results showed a decrease in fungemia incidence over time and changes in species distribution, but no significant increase in antifungal resistance.
Editorial Material
Medicine, General & Internal
Manuel Martinez-Selles, Patricia Munoz
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Mar Sanchez-Somolinos, Marta Diaz-Navarro, Antonio Benjumea, Jose Matas, Javier Vaquero, Patricia Munoz, Pablo Sanz-Ruiz, Maria Guembe
Summary: By comparing the anti-biofilm activity of dalbavancin and vancomycin over a 3-month period, this study found that dalbavancin showed sustained activity and maintained a higher percentage reduction in cfu/mL counts compared to vancomycin. The concentration of dalbavancin decreased significantly after 2 weeks, while the concentration of vancomycin gradually increased, leading to lower anti-biofilm activity. The study also observed that dalbavancin exhibited stronger anti-biofilm activity against S. epidermidis compared to S. aureus, particularly at the higher concentration of 5% and after 3 months.
Article
Infectious Diseases
Miguel Marquez-Gomez, Marta Diaz-Navarro, Andres Visedo, Rama Hafian, Jose Matas, Patricia Munoz, Javier Vaquero, Maria Guembe, Pablo Sanz-Ruiz
Summary: Irrigation and debridement are crucial steps in the surgical treatment of periprosthetic joint infection, and the choice of irrigation solution and combination remains uncertain. This study investigated the effectiveness of different antiseptic solutions and concluded that a combination of acetic acid, povidone iodine, and hydrogen peroxide yielded the best results for chemical debridement.
Article
Microbiology
Aina Mesquida, Marina Machado, Lorena Davila-Cherres, Teresa Vicente, Carlos Sanchez-Carrillo, Luis Alcala, Elena Reigadas, Patricia Munoz, Jesus Guinea, Pilar Escribano
Summary: This study suggests that the gastrointestinal tract may serve as a potential reservoir for potentially invasive genotypes of Candida spp., as there was a high level of matching between genotypes from rectal swabs and those detected in blood and intra-abdominal samples.