Article
Medicine, Research & Experimental
Chihiro Tsunoda, Kanji Hasegawa, Ryosuke Hiroshige, Takahiro Kasai, Hideshi Yokoyama, Satoru Goto
Summary: This study investigates the effect of cyclodextrin (CD) on the solubility of drugs in the presence of multiple drug interactions. The results show that ss CD has a synergistic effect on increasing solubility in drug-drug combinations and can effectively improve the dissolution rate of drugs.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Siva Ram Munnangi, Ahmed Adel Ali Youssef, Nagarjuna Narala, Preethi Lakkala, Sagar Narala, Sateesh Kumar Vemula, Michael Repka
Summary: Despite numerous research efforts, oral drug delivery remains a major challenge due to the low solubility of more than 40% of new chemical entities in water. Complexation approaches have been widely investigated to improve the bioavailability of these drugs.
PHARMACEUTICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Tatyana V. Volkova, Olga R. Simonova, German L. Perlovich
Summary: The study evaluated the poor solubility of new antifungal drug S-119 and the effectiveness of various excipients in improving its solubility. Pluronic F-127 and 6-O-Maltosyl-beta-CD were identified as the most effective solubilizing agents for S-119, with PVP showing the greatest increase in solubility in pH 7.4 solutions.
Article
Chemistry, Organic
Shuai Zhao, Tanlong Xue, Di Pei, Qiuyan Song, Zhichao Pei, Jun Nie, Yincheng Chang
Summary: A novel photoinitiator based on the macrocyclic molecule pillar[6]arene has been developed, which exhibits lower migration rate and cytotoxicity compared to commercial photoinitiators. This study represents the first time a macrocyclic molecule has been used as a photoinitiator based on the macrocycle fracture mechanism.
Article
Geochemistry & Geophysics
Haylea Nisbet, Artas A. Migdisov, Anthony E. Williams-Jones, Vincent J. van Hinsberg, Hongwu Xu, Robert Roback
Summary: The presence of carbonate ligands in hydrothermal solutions may not promote the transport of Thorium (Th), while SO42- is the primary ligand responsible for the hydrothermal transport of Th.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2022)
Article
Construction & Building Technology
Lina Bouzouaid, Barbara Lothenbach, Alejandro Fernandez-Martinez, Christophe Labbez
Summary: This study investigates the effect of different organic compounds on the solubility of C-S-H, finding that they can form complexes with calcium and hydroxide, with gluconate showing the highest complexation strength. The adsorption order is gluconate > sorbitol > mannitol > galactitol, and a typical adsorption isotherm is found only when buffered with Ca(OH)(2).
CEMENT AND CONCRETE RESEARCH
(2022)
Article
Construction & Building Technology
Bouzouaid Lina, Lothenbach Barbara, Fernandez-Martinez Alejandro, Labbez Christophe
Summary: This study investigated the impact of gluconate, sorbitol, mannitol, and galactitol on calcium speciation at high pH values through solubility measurements and potentiometric titration. The results showed differences in the strength and type of complexes formed by these substances, providing insights into their influence on the hydration of alite and Portland cement.
CEMENT AND CONCRETE RESEARCH
(2021)
Article
Geochemistry & Geophysics
Haylea Nisbet, Artas A. Migdisov, Vitaliy Goncharov, Vincent van Hinsberg, A. E. Williams-Jones, Hongwu Xu, Xiaofeng Guo
Summary: This study investigates the speciation of neodymium in carbonate-bearing fluids and reveals that the major aqueous complexes are NdCO3+ and NdCO3OH0 under acidic and alkaline conditions, respectively. The findings suggest that carbonate species have the potential to play a significant role in the mobilization of rare earth elements in hydrothermal fluids.
Article
Biochemistry & Molecular Biology
Tayel A. Al Hujran, Mousa K. Magharbeh, Almeqdad Y. Habashneh, Rasha S. Al-Dmour, Ashraf Aboelela, Hesham M. Tawfeek
Summary: This study assessed the interaction between fluconazole and sulfonatocalix[4]naphthalene, finding that they formed a stable inclusion complex which significantly enhanced dissolution performance and antimycotic activity.
Article
Engineering, Environmental
Solene Legand, Nathalie Mace, Benoist Muzeau, Philippe Le Tutour, Sandrine Therias, Pascal E. Reiller
Summary: The potential effect of radiolyzed superplasticizers on radionuclide uptake in cement-based materials was studied. The solubility and speciation of Eu with organic ligands resulting from the degradation of superplasticizers were investigated. The study revealed that solubility enhancements observed in artificial cement waters are not representative of real cement pore water interactions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Pitsiree Praphanwittaya, Phennapha Saokham, Phatsawee Jansook, Thorsteinn Loftsson
Summary: Cediranib is a tyrosine kinase inhibitor used to treat ovarian cancer, with its aqueous solubility dependent on ionization and enhanced by cyclodextrin complexation leading to increased stability. The study also identified the degradation pathway of cediranib in acidic aqueous solutions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Thorsteinn Loftsson
Summary: Benzodiazepines are a class of drugs used to treat a variety of conditions such as anxiety, seizures, and insomnia. They are typically poorly soluble in water and require the use of organic solvents or aqueous solutions with organic cosolvents and surfactants. Midazolam is an exception, being soluble and stable in water without the need for additional solvents.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Ptak-Kaczor, Mateusz Banach, Katarzyna Stapor, Piotr Fabian, Leszek Konieczny, Irena Roterman
Summary: Protein solubility relies on the compatibility of protein surface with polar water environment, influenced by the distribution of polar and hydrophobic residues. The fuzzy oil drop model quantifies the compatibility of hydrophobic distribution in proteins and predicts interactions with molecules of different polarity. Analyzing protein solubility helps in understanding protein folding and complex formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Energy & Fuels
Frans G. A. van den Berg
Summary: This article discusses the importance of asphaltenes in the oil industry and the challenges associated with their precipitation and deposition. It provides a historical account of the development of solvent titration techniques for measuring asphaltene stability, highlighting the relevance of dual solvent methods. The article concludes that further improvements are needed to meet the changing demands of the oil business.
Article
Cardiac & Cardiovascular Systems
M. Amin Sharifi, Michael Wierer, Tan An Dang, Jelena Milic, Aldo Moggio, Nadja Sachs, Moritz von Scheidt, Julia Hinterdobler, Philipp Mueller, Julia Werner, Barbara Stiller, Zouhair Aherrahrou, Jeanette Erdmann, Andrea Zaliani, Mira Graettinger, Jeanette Reinshagen, Sheraz Gul, Philip Gribbon, Lars Maegdefessel, Juergen Bernhagen, Hendrik B. Sager, Matthias Mann, Heribert Schunkert, Thorsten Kessler
Summary: ADAMTS-7 plays a role in the development of atherosclerotic plaques by reducing the stability of TIMP-1, which in turn promotes the activity of MMP-9 and the degradation of collagen. Disrupting the interaction between ADAMTS-7 and TIMP-1 may be a strategy to increase plaque stability and reduce the risk of atherosclerosis-related events.
CIRCULATION RESEARCH
(2023)