Editorial Material
Biochemistry & Molecular Biology
Borja Quiroga
Summary: BPA, a common component of plastics worldwide, has been shown to act as an endocrine disruptor with some hormonal functions. High levels of BPA are related to cardiovascular events and carcinogenesis pathways, and CKD patients have higher serum concentrations of BPA due to impaired renal function. Efforts to reduce BPA levels in these patients include developing BPA-free dialysis filters and other techniques.
Review
Toxicology
Henrique Eloi Costa, Elisa Cairrao
Summary: Bisphenol A (BPA) is a widely produced synthetic compound that can disrupt the endocrine system and have detrimental effects on the neurological system. Exposure to BPA can lead to oxidative stress, changes in gene and protein expression, neuronal damage, and increased risk of neurologic diseases such as stroke, Alzheimer's, and Parkinson's. Epidemiological studies have also shown that BPA exposure during neurodevelopment can contribute to the emergence of disorders such as ADHD, ASD, depression, and cognitive disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhiying Liang, Yafen Guo, Duan Pi, Xiang Li, Bingying Li, Yongsi Huang, Xiaohong Song, Ramji Kumar Bhandari, Xuegeng Wang
Summary: Recent studies have shown that the concentration of bisphenol F (BPF) in water has dramatically increased, raising concerns about its adverse effects on aquatic organisms and humans. This study conducted acute toxic exposure and developmental exposure experiments using Chinese medaka, and found that BPF at a concentration of 2000 ng/L significantly affected the development of Chinese medaka and caused endocrine-related abnormalities in the transcriptional network of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Pieter Vancamp, Lucile Butruille, Anni Herranen, Anita Boelen, Jean -Baptiste Fini, Barbara A. Demeneix, Sylvie Remaud
Summary: Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia throughout adulthood. We previously demonstrated that a postnatal thyroid hormone (TH) peak orchestrates this remodelling, rendering this process vulnerable to endocrine disruption. In this study, we exposed mice to low doses of BPF, a suspected TH-disruptor, and found that it disrupted SVZ remodelling and decreased adult neuron and oligodendroglia output. These findings highlight the potential harm of alternative bisphenol compounds for human fetal brain development.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Eujung Kim, Minjung Song, Adam Gopal Ramu, Dongjin Choi
Summary: Bisphenol A (BPA), a common chemical used in plastic production, has emerged as a serious environmental concern due to its potential toxicity to plants. This study aimed to investigate the mechanism of BPA-induced root cells by examining the effects of BPA on the ultrastructure and function of soybean plant root tip cells. Changes in plant root cell tissues after BPA exposure were observed, and the accumulation of BPA in different plant parts was analyzed. The findings provide insight into how BPA can alter plant root growth.
Review
Environmental Sciences
Tijana Vasiljevic, Tom Harner
Summary: BPA and its analogues are widely used in plastic synthesis, potentially disrupting the hormonal structure of living organisms. Reports on BPA levels in air are limited, mainly due to anthropogenic activities. China reported the highest outdoor air levels of BPA near a low-tech e-waste recycling site, and indoor dust also revealed bisphenol analogues used in BPA-free products.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Chalana M. Sol, Charissa Van Zwol-Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande, Susana Santos
Summary: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be associated with larger fetal head circumference, higher weight, and a lower risk of being small size for gestational age at birth. Other bisphenols were not consistently associated with fetal growth outcomes.
ENVIRONMENTAL HEALTH
(2021)
Article
Endocrinology & Metabolism
Giada Frenzilli, Joan Martorell-Ribera, Margherita Bernardeschi, Vittoria Scarcelli, Elisabeth Jonsson, Nadia Diano, Martina Moggio, Patrizia Guidi, Joachim Sturve, Noomi Asker
Summary: The study shows that both bisphenol A and its alternative bisphenol S can cause endocrine disrupting and genotoxic effects in brown trout, indicating two different mechanisms of damage underlying the activities of bisphenol A and bisphenol S. Bisphenol A primarily increases micronuclei frequency in fish erythrocytes, while bisphenol S may cause damage through other mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Article
Chemistry, Analytical
Anna Raysyan, Rudolf J. Schneider
Summary: Bisphenol A is a crucial chemical in polymer plastics and coatings production. To address concerns about BPA toxicity, a latex microparticle-based lateral flow immunoassay method was developed for rapid on-site screening. The method showed high sensitivity and efficiency in detecting BPA.
Review
Environmental Sciences
Nadeem Ghani Khan, Jacinta Correia, Divya Adiga, Padmalatha Satwadi Rai, Herman Sunil Dsouza, Sanjiban Chakrabarty, Shama Prasada Kabekkodu
Summary: Bisphenol A is a synthetic chemical used for manufacturing plastics and resins, which has been linked to increased susceptibility to diseases, including cancer, at extremely low doses. Studies suggest that BPA may be a probable human carcinogen and exerts toxicological effects at genetic and epigenetic levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Environmental Sciences
Julia de Morais Farias, Natascha Krepsky
Summary: This study reviewed the research on bacterial degradation of bisphenol analogues, finding that bacteria can degrade bisphenol analogues, especially bisphenol A. Sphingomonas, Sphingobium, and Cupriavidus are common degradation strains. The research is important for selecting suitable microorganisms for the bioremediation of bisphenol analogue pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Yiwen Xu, Ailun Hu, Yiren Li, Yan He, Jianming Xu, Zhijiang Lu
Summary: A robust method was developed to accurately and quickly detect bisphenol A and 13 analogs in soil. The method was applied to 29 soil samples from 21 provinces in China, revealing 12 bisphenols with notably high concentrations, particularly bisphenol P which was at least ten times higher than in other environmental matrices. The results indicate hot spots of bisphenol pollution in soil, calling for further investigations.
Article
Dentistry, Oral Surgery & Medicine
Siemon De Nys, Eveline Putzeys, Radu Corneliu Duca, Philippe Vervliet, Adrian Covaci, Imke Boonen, Marc Elskens, Jeroen Vanoirbeek, Lode Godderis, Bart Van Meerbeek, Kirsten L. Van Landuyt
Summary: The study successfully quantified the one-year release of BPA from four commercial materials using an optimized analytical method. Results showed that BPA continuously eluted from all tested composites over a year when ethanol was used as the extraction solvent, while in water, BPA release could be detected for up to a year but levels could not be accurately quantified after several weeks.
Review
Biochemistry & Molecular Biology
Mafalda Presunto, Melissa Mariana, Margarida Lorigo, Elisa Cairrao
Summary: Endocrine disruptor chemicals (EDCs) can harm the endocrine system and negatively impact development, reproduction, neurological functions, cardiovascular health, immune system, and metabolism in both humans and wildlife. Bisphenol A (BPA), a proven EDC, can mimic or block receptors and alter hormone levels and metabolism, even at low doses. Exposure to BPA in humans has been linked to the development of various diseases. This literature review highlights the harmful effects of BPA on human male fertility, including hormonal and semen changes, but more extensive and reproducible scientific studies are needed to strengthen these conclusions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Dylan R. Nieman, Christian G. Peyre, Thomas J. Watson, Wenqing Cao, Michael D. Lunt, Michal J. Lada, Michelle S. Han, Carolyn E. Jones, Jeffrey H. Peters
ANNALS OF THORACIC SURGERY
(2015)
Article
Oncology
Wenqing Cao, Faqian Li, Jorge Yao, Jiangzhou Yu
Article
Oncology
Wenqing Cao, Jeffrey H. Peters, Dylan Nieman, Meenal Sharma, Thomas Watson, JiangZhou Yu
BRITISH JOURNAL OF CANCER
(2015)
Article
Acoustics
Christopher T. Barry, Christopher Hazard, Zaegyoo Hah, Gang Chen, Alexander Partin, Robert A. Mooney, Kuang-Hsiang Chuang, Wenqing Cao, Deborah J. Rubens, Kevin J. Parker
JOURNAL OF ULTRASOUND IN MEDICINE
(2015)
Article
Gastroenterology & Hepatology
Noam Harpaz, Sofia Taboada, Huaibin Mabel Ko, Jiangzhou Yu, Qi Yang, Haodong Xu, Wenqing Cao
INFLAMMATORY BOWEL DISEASES
(2014)
Letter
Pathology
Bing Ren, Wenqing Cao
JOURNAL OF CLINICAL PATHOLOGY
(2014)
Article
Acoustics
Christopher T. Barry, Zaegyoo Hah, Alexander Partin, Robert A. Mooney, Kuang-Hsiang Chuang, Alicia Augustine, Anthony Almudevar, Wenqing Cao, Deborah J. Rubens, Kevin J. Parker
ULTRASOUND IN MEDICINE AND BIOLOGY
(2014)
Article
Pathology
Wenqing Cao, Meenal Sharma, Rami Imam, Jiangzhou Yu
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2019)
Article
Gastroenterology & Hepatology
Eli Stahl, Giulia Roda, Amanda Dobbyn, Jianzhong Hu, Zhongyang Zhang, Helga Westerlind, Ferdinando Bonfiglio, Towfique Raj, Joana Torres, Anli Chen, Robert Petras, Darrell S. Pardi, Alina C. Iuga, Gabriel S. Levi, Wenqing Cao, Prantesh Jain, Florian Rieder, Ilyssa O. Gordon, Judy H. Cho, Mauro D'Amato, Noam Harpaz, Ke Hao, Jean Frederic Colombel, Inga Peter
Article
Pathology
Chaohui Lisa Zhao, Amy Rapkiewicz, Mona Maghsoodi-Deerwester, Mala Gupta, Wenqing Cao, Thomas Palaia, Jianhong Zhou, Bebu Ram, Duc Vo, Zarrin Hossein-Zadeh, Bahram Dabiri, Iman Hanna
Summary: COVID-19 patients exhibit a variety of pathological manifestations in the liver, including platelet-fibrin microthrombi, steatosis, and histiocytic hyperplasia. Abnormal liver-associated enzymes were observed in 12 cases, with most patients showing elevated D-dimer levels.
Article
Oncology
Rami Imam, Qing Chang, Margaret Black, Caroline Yu, Wenqing Cao
Summary: This study revealed that low CD47 expression and high levels of CD163+ TAMs may indicate poor prognosis in pancreatic neuroendocrine tumors.
Article
Medicine, General & Internal
Vivek Sant, Elsa Reich, Lauren Khanna, Wenqing Cao, Susan Kornacki, Alexis Grucela
Article
Medicine, General & Internal
Jasmine Bhinder, Amit Mori, Wenqing Cao, Anju Malieckal
CUREUS JOURNAL OF MEDICAL SCIENCE
(2018)
Article
Pathology
Laura Bratton, Rabih Salloum, Wenqing Cao, Aaron R. Huber
CASE REPORTS IN PATHOLOGY
(2016)
Article
Gastroenterology & Hepatology
Margaret Cho, Weiguo Liu, Sophie Balzora, Yvelisse Suarez, Deepthi Hoskoppal, NeilD. Theise, Wenqing Cao, SuparnaA. Sarkar
Summary: This study focuses on the uncommon gastrointestinal symptoms in COVID-19 patients, particularly hematochezia, and discusses the potential relationship with ischemic injury, especially in elderly patients with significant comorbidities and prolonged hospitalization. The authors suggest that cytokine storm-induced abnormal coagulation may contribute to ischemia and hypoperfusion in COVID-19 cases presenting with lower GI bleeding, emphasizing the importance of prompt consultation and management by gastroenterologists.
CASE REPORTS IN GASTROENTEROLOGY
(2021)