Article
Biotechnology & Applied Microbiology
Ai Yan, Ying Zhang, Xiaocong Wang, Yueling Cui, Wei Tan
Summary: IL-35 protects against proliferative diabetic retinopathy by reducing IL-17 levels and inhibiting Th17 cell differentiation.
Article
Pharmacology & Pharmacy
Jianfa Wang, Yayun Xu, Hui Jing, Qimeng Chang, Xubo Wu, Ziping Zhang
Summary: The expression of RORγt was found to be elevated in AP patients, and SR1001 showed therapeutic effects by suppressing IL-17-secreting Th17 and gamma delta T cells in the pancreas.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Rheumatology
Celine Mortier, Eric Gracey, Julie Coudenys, Teddy Manuello, Tine Decruy, Margaux Maelegheer, Flore Stappers, Elisabeth Gilis, Djoere Gaublomme, Luc Van Hoorebeke, Sophie Van Welden, Catherine Ambler, Martin Hegen, Peter Symanowicz, Stefan Steyn, Gabriel Berstein, Dirk Elewaut, Koen Venken
Summary: Inhibiting ROR gamma t can effectively improve skin, joint, and gut inflammation in a preclinical PsA model, with reduction in clinical scores, weight loss, bone density, and surface erosions. ROR gamma t blockade also decreases IL-17 immune responses in PsA-affected tissues. Thus, targeting ROR gamma t may be a potential therapeutic approach for PsA.
Article
Immunology
Shuangpeng Kang, Qiongli Wu, Jun Huang, Binyan Yang, Changyan Liang, Peidong Chi, Changyou Wu
Summary: This study found that γδT cells in the uterus are mainly distributed in the endometrium, with memory cell characteristics and high expression of IL-17 upon activation, promoting the invasion of murine trophocytes. These findings provide a foundation for future research on the role of uterine γδT cells in pregnancy and autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Piotr Konieczny, Yue Xing, Ikjot Sidhu, Ipsita Subudhi, Kody P. Mansfield, Brandon Hsieh, Douglas E. Biancur, Samantha B. Larsen, Michael Cammer, Dongqing Li, Ning Xu Landen, Cynthia Loomis, Adriana Heguy, Anastasia N. Tikhonova, Aristotelis Tsirigos, Shruti Naik
Summary: Mammalian cells activate HIFs to survive in low-oxygen environments, but injury-induced hypoxia is unable to activate HIF1 alpha. However, IL-17A derived from ROR gamma t(+) gamma delta T cells can activate HIF1 alpha. The IL-17A-HIF1 alpha axis promotes glycolysis for wound healing in epithelial cells, and loss of IL-17RC, HIF1 alpha, or blockade of glycolysis disrupts the repair process. These findings highlight the interconnectedness of inflammation, metabolism, and migration programs, as well as the role of immune cell-derived inputs in cellular adaptation to hypoxic stress during repair.
Article
Thermodynamics
Yan Hua, Zhong Wang, Ruina Li, Shuai Liu, Yang Zhao, Lei Qu, Deqing Mei, Hui Lv
Summary: This study investigated the morphology, nanostructure, and oxidation reactivity of particles produced by the combustion of Fischer-Tropsch (F-T) diesel, biodiesel, and regular diesel through techniques such as HRTEM, RS, and TGA. The results showed that F-T diesel particles had smaller fractal dimension and fringe tortuosity, higher graphitization degree, and lower oxidation reactivity compared to regular diesel particles. Biodiesel particles exhibited the opposite characteristics and were more prone to oxidation. The application of exhaust gas recirculation (EGR) increased particle agglomeration, reduced graphitization degree and oxidation characteristic temperature, and enhanced particle oxidation reactivity.
Article
Immunology
Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Summary: This study demonstrates the important immunosuppressive effect of parthenolide (PTL) on autoimmune inflammation. PTL can alleviate clinical symptoms by inhibiting inflammatory cell infiltration, reducing inflammation, and demyelination. It also regulates the immune response by inhibiting the reactivation of specific T cells and the differentiation of CD4(+) T cells into pathogenic Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yana Yang, Wenhui Qi, Yanyan Zhang, Ruining Wang, Mingyue Bao, Mengyuan Tian, Xing Li, Yuan Zhang
Summary: ROR gamma t is a crucial transcription factor for the differentiation of pro-inflammatory Th17 cells. In this study, a natural compound called 2,2',4'-trihydroxychalcone (TDC) was found to directly bind to the ligand binding domain of ROR gamma t and inhibit its transcriptional activation activity. TDC administration effectively alleviated the disease development in three different mouse models of Th17-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jun Yan, Jing Yu, Ke Liu, Yijia Liu, Changchuin Mao, Wenda Gao
Summary: IL-22 plays a dual role in colitis, both protecting gut epithelium and potentially enhancing inflammation. Innate lymphoid cells play a crucial role in IL-22 production and regulation. The transcription factor Musculin has been identified as a key player in the expression of IL-22, which may impact the development of different immune cell subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Farhad Seif, Zahra Torki, Hamidreza Zalpoor, Mehran Habibi, Majid Pornour
Summary: T cells play a crucial role in tumor development and anti-tumor responses in breast cancer patients. The cytokines in the tumor microenvironment can influence the differentiation and function of T cells, thereby affecting breast cancer treatment. This review discusses the factors that affect T cell differentiation in breast cancer, as well as the related clinical trials.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Biochemistry & Molecular Biology
Timothy S. Strutzenberg, Yingmin Zhu, Scott J. Novick, Ruben D. Garcia-Ordonez, Christelle Doebelin, Yuanjun He, Mi Ra Chang, Theodore M. Kamenecka, Dean P. Edwards, Patrick R. Griffin
Summary: ROR gamma, a ligand-dependent transcription factor, plays key roles in metabolic activity, immune function, and cancer progression. Structural studies show that ROR gamma elongates upon DNA recognition, preventing interdomain crosstalk. Coregulatory protein may be able to sense the ligand- and DNA-bound status of ROR gamma, influencing coregulator recruitment. This research sheds light on the regulation of orphan nuclear receptor target genes through DNA-dependent conformational changes.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alexandra M. Riding, Kevin W. Loudon, Andrew Guo, John R. Ferdinand, Laurence S. C. Lok, Nathan Richoz, Andrew Stewart, Tomas Castro-Dopico, Zewen Kelvin Tuong, Remi Fiancette, Georgina S. Bowyer, Aaron Fleming, Eleanor S. Gillman, Ondrej Suchanek, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, David Withers, Gordan Dougan, Simon Clare, Menna R. Clatworthy
Summary: Bladder infection affects a hundred million people annually, but our understanding of bladder immunity is incomplete. Our research found that type 17 immune response genes were highly active in the bladder after exposure to uropathogenic Escherichia coli. Group 3 innate lymphoid cells were identified as the source of cytokines involved in the immune response, and their proliferation post infection contributed to an enhanced immune response in the bladder.
Article
Biochemistry & Molecular Biology
Thamires Rodrigues de-Sousa, Rodrigo Pessoa, Andrezza Nascimento, Beatriz Oliveira Fagundes, Fabio da Ressureicao Sgnotto, Alberto Jose da Silva Duarte, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: Maternal OVA immunization was found to inhibit the frequency of IL-17-producing gamma delta T cells in offspring thymus, possibly through an epigenetic mechanism mediated by miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)