Review
Gastroenterology & Hepatology
Blake Niccum, Oluwatoba Moninuola, Kaia Miller, Hamed Khalili
Summary: In a systematic review and meta-analysis, it was found that 21% of outpatients with IBD (and 62% of hospitalized patients) are opioid users. Opioid use is associated with more severe IBD and increased healthcare use, suggesting urgent interventions are needed to reduce opioid use and improve disease-related outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christian P. Selinger, David J. Gracie, Alexander C. Ford
Summary: The use of opioids in patients with inflammatory bowel disease (IBD) is associated with psychological comorbidity and an increased risk of intestinal resection, particularly with stronger formulations. Future studies should classify the risks of different opioids to develop reliable prescribing algorithms, and evaluate the effectiveness of addressing psychological factors as an opioid avoidance strategy in routine IBD care.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rahul S. Dalal, Sonali Palchaudhuri, Christopher K. Snider, James D. Lewis, Shivan J. Mehta, Gary R. Lichtenstein
Summary: The study found a significant positive correlation between preadmission cannabis use and inpatient opioid exposure among patients with inflammatory bowel disease. Additionally, first patient-reported pain score and preadmission opioid use were also associated with inpatient opioid exposure.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Jessica L. Sheehan, Janson Jacob, Elliot M. Berinstein, LaVana Greene-Higgs, Calen A. Steiner, Sameer K. Berry, Carol Shannon, Shirley A. Cohen-Mekelburg, Peter D. R. Higgins, Jeffrey A. Berinstein
Summary: Pain management in patients with inflammatory bowel disease is challenging due to the potential adverse effects of opioids. This study systematically reviewed the impact of opioid use on healthcare utilization in inflammatory bowel disease patients.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Loren G. Rabinowitz, Haley M. Zylberberg, Jeong Yang, Stephanie Lauren Gold, Jaclyn Chesner, Jiayi Ji, Liangyuan Hu, Marla Dubinsky
Summary: This study identified factors associated with increased outpatient opioid use in IBD patients, including ulcerative colitis, ostomy placement during hospitalization, anxiety, and inpatient opioid exposure. Patients requiring >= 3 opioids had higher rates of unplanned IBD surgery, all-cause repeat hospitalization, and IBD-related repeat hospitalization in the year following hospitalization.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Adam Truong, Lucille Yao, Phillip R. Fleshner, Karen N. Zaghiyan
Summary: This study aimed to explore the possibility of perioperative opioid avoidance in patients undergoing colorectal surgery or those with inflammatory bowel disease (IBD). The research conducted a retrospective analysis of patients from two prospective studies and found that early postoperative opioid avoidance is feasible in a limited number of IBD patients after colorectal surgery.
COLORECTAL DISEASE
(2023)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mika Nakayama, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, Hideshi Ishii
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa. Recent studies have shown the involvement of RNA modifications in the specific pathogenesis of IBD. RNA modification-targeting reagents have shown promising outcomes in treating colitis. Understanding RNA modifications in IBD could contribute to early diagnosis, disease monitoring, and innovative therapeutic approaches.
Article
Rheumatology
Clare Harris, J. R. Fraser Cummings
Summary: Primary non-response and secondary loss of response are still significant issues with current treatment options for inflammatory bowel disease, highlighting the need for new therapeutic choices. As our understanding of IBD pathogenesis advances, new therapeutic targets are being identified.
Review
Medicine, General & Internal
Elizabeth A. A. Spencer, Manasi Agrawal, Tine Jess
Summary: This article reviews the available predictors of outcomes in IBD patient and emphasizes the importance of global collaborative efforts and tools to support the clinical use of these prognostication tools.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Bing Chen, Lauren V. Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J. Lavie, Chayakrit Krittanawong
Summary: This article reviews the association between chronic inflammatory bowel disease and atherosclerotic cardiovascular diseases, heart failure, and atrial fibrillation. The mechanisms underlying this association may involve shared risk factors and pathophysiology. A multidisciplinary team is needed for optimal care.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Cell & Tissue Engineering
Yusuke Wakisaka, Shinya Sugimoto, Toshiro Sato
Summary: This review discusses the application of adult tissue-derived organoids culture technology to elucidate the pathogenesis of IBD and to develop novel therapies, including regenerative treatments.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jill P. Smith, David C. Whitcomb, Gail L. Matters, Randall E. Brand, Jiangang Liao, Yu-Jing Huang, Marsha L. Frazier
Article
Biochemistry & Molecular Biology
Jason W. Hoskins, Abdisamad Ibrahim, Mickey A. Emmanuel, Sarah M. Manmiller, Yinglun Wu, Maura O'Neill, Jinping Jia, Irene Collins, Mingfeng Zhang, Janelle V. Thomas, Lauren M. Rost, Sudipto Das, Hemang Parikh, Jefferson M. Haake, Gail L. Matters, Robert C. Kurtz, William R. Bamlet, Alison Klein, Rachael Stolzenberg-Solomon, Brian M. Wolpin, Ronit Yarden, Zhaoming Wang, Jill Smith, Sara H. Olson, Thorkell Andresson, Gloria M. Petersen, Laufey T. Amundadottir
HUMAN MOLECULAR GENETICS
(2016)
Article
Gastroenterology & Hepatology
Jelal Alsubai, Gail L. Matters, Christopher O. McGovern, Jiangang Liao, Evan L. Gilius, Jill P. Smith
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2016)
Article
Gastroenterology & Hepatology
Mingfeng Zhang, Soren Lykke-Andersen, Bin Zhu, Wenming Xiao, Jason W. Hoskins, Xijun Zhang, Lauren M. Rost, Irene Collins, Martijn van de Bunt, Jinping Jia, Hemang Parikh, Tongwu Zhang, Lei Song, Ashley Jermusyk, Charles C. Chung, Bin Zhu, Weiyin Zhou, Gail L. Matters, Robert C. Kurtz, Meredith Yeager, Torben Heick Jensen, Kevin M. Brown, Halit Ongen, William R. Bamlet, Bradley A. Murray, Mark I. McCarthy, Stephen J. Chanock, Nilanjan Chatterjee, Brian M. Wolpin, Jill P. Smith, Sara H. Olson, Gloria M. Petersen, Jianxin Shi, Laufey Amundadottir
Review
Biotechnology & Applied Microbiology
Xiaomeng Tang, Welley S. Loc, Cheng Dong, Gail L. Matters, Peter J. Butler, Mark Kester, Craig Meyers, Yixing Jiang, James H. Adair
Article
Nanoscience & Nanotechnology
Welley S. Loc, Samuel S. Linton, Zachary R. Wilczynski, Gail L. Matters, Christopher O. McGovern, Thomas Abraham, Todd Fox, Christopher M. Gigliotti, Xiaomeng Tang, Amra Tabakovic, Jo Ann Martin, Gary A. Clawson, Jill P. Smith, Peter J. Butler, Mark Kester, James H. Adair
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Gary A. Clawson, Thomas Abraham, Weihua Pan, Xiaomeng Tang, Samuel S. Linton, Christopher O. McGovern, Welley S. Loc, Jill P. Smith, Peter J. Butler, Mark Kester, James H. Adair, Gail L. Matters
NUCLEIC ACID THERAPEUTICS
(2017)
Article
Gastroenterology & Hepatology
Gail L. Matters, Timothy K. Cooper, Christopher O. McGovern, Evan L. Gilius, Jiangang Liao, Brian M. Barth, Mark Kester, Jill P. Smith
DIGESTIVE DISEASES AND SCIENCES
(2014)
Article
Gastroenterology & Hepatology
Jill P. Smith, Timothy K. Cooper, Christopher O. McGovern, Evan L. Gilius, Qing Zhong, Jiangang Liao, Alfredo A. Molinolo, J. Silvio Gutkind, Gail L. Matters
Article
Multidisciplinary Sciences
Gary A. Clawson, Gail L. Matters, Ping Xin, Yuka Imamura-Kawasawa, Zhen Du, Diane M. Thiboutot, Klaus F. Helm, Rogerio I. Neves, Thomas Abraham
Article
Multidisciplinary Sciences
Gary A. Clawson, Gail L. Matters, Ping Xin, Christopher McGovern, Eric Wafula, Claude dePamphilis, Morgan Meckley, Joyce Wong, Luke Stewart, Christopher D'Jamoos, Naomi Altmann, Yuka Imamura Kawasawa, Zhen Du, Loren Honaas, Thomas Abraham
Article
Gastroenterology & Hepatology
Welley S. Loc, Jill P. Smith, Gail Matters, Mark Kester, James H. Adair
WORLD JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Multidisciplinary Sciences
Samuel S. Linton, Thomas Abraham, Jason Liao, Gary A. Clawson, Peter J. Butler, Todd Fox, Mark Kester, Gail L. Matters
Article
Nanoscience & Nanotechnology
Thomas Abraham, Christopher O. McGovern, Samuel S. Linton, Zachary Wilczynski, James H. Adair, Gail L. Matters
Summary: Aptamer-targeted nanoparticles loaded with imaging agents showed enhanced detection of pancreatic and prostate tumors in vivo and ex vivo. The specific interaction with CCK-B receptors allows for well-distributed distribution of the tumor-targeted nanoparticles in the tumor matrix, improving early cancer detection.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Physiology
Jialing Bao, Renee E. Yura, Gail L. Matters, S. Gaylen Bradley, Pan Shi, Fang Tian, Judith S. Bond
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2013)