Article
Immunology
R. K. Subbarao Malireddi, Ratnakar R. Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma, Amanda R. Burton, Stephane Pelletier, Thirumala-Devi Kanneganti
Summary: This study generated a new line of IL-1 alpha KO mice using CRISPR-Cas9 technology. Compared to the previous model, this new model showed normal induction and activation of IL-1 beta in macrophages and normal response to multiple innate immune triggers. Furthermore, it was found that IL-1 alpha played a critical role in the expression of the neutrophil chemoattractant KC/CXCL1 independent of IL-1 beta.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yufei Luo, Bojun Xiong, Haiping Liu, Zehong Chen, Huihui Huang, Changxi Yu, Jian Yang
Summary: Koumine inhibits NLRP3 inflammasome activation and reduces neutrophil infiltration and IL-1β production, both in vitro and in vivo. The inhibitory effect involves blocking the ROS/NF-kappa B/NLRP3 signal axis, suggesting potential clinical applications for NLRP3 inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Lin Ding, Erica A. Sontz, Milena Saqui-Salces, Juanita L. Merchant
Summary: In the study, it was found that IL1 beta and IFN-gamma have different effects in the gastric antrum, with IL1 beta inducing antral hyperplasia and suppressing gastrin expression, while IFN-gamma increases gastrin and induces antral hyperplasia.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew Menendez, Anna Drozd, Katarzyna Borawska, Joanna J. Chmielewska, Meng-Ling Wu, Courtney T. Griffin
Summary: This study reveals the role of BRG1 in embryonic lymphatic development and highlights the epigenetically regulated crosstalk between macrophages, blood vessels, and lymphatics. The findings suggest that IL-1 beta, produced by omental macrophages, destabilizes adherens junctions in omental blood and lymphatic vessels, leading to erythrocyte extravasation and uptake by lymphatics.
CIRCULATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Summary: PGK1 plays a role in immunometabolism by influencing metabolic status. The inhibitor DC-PGKI can suppress the activity of PGK1 and alleviate symptoms of inflammatory bowel disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Immunology
Bridget Ratitong, Michaela E. Marshall, Morgan A. Dragon, Charissa M. Anunciado, Serena Abbondante, Eric Pearlman
Summary: This study focused on Pseudomonas aeruginosa infections of the cornea and found that IL-1 alpha plays a significant role in impairing bacterial clearance.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Microbiology
Gaofeng Wang, Evan Sweren, Haiyun Liu, Eric Wier, Martin P. Alphonse, Ruosi Chen, Nasif Islam, Ang Li, Yingchao Xue, Junjie Chen, Seungman Park, Yun Chen, Sam Lee, Yu Wang, Saifeng Wang, Nate K. Archer, William Andrews, Maureen A. Kane, Erika Dare, Sashank K. Reddy, Zhiqi Hu, Elizabeth A. Grice, Lloyd S. Miller, Luis A. Garza
Summary: The study evaluated the role of skin bacteria in wound healing and hair follicle regeneration, finding a correlation between bacterial counts and WIHN levels. Reduction of skin microbiota decreased WIHN, while IL-1 beta and IL-1R-MyD88 signaling played crucial roles in bacteria-promoted regeneration.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Josimar Dornelas Moreira, Alexei Iakhiaev, Ramakrishna Vankayalapati, Bock-Gie Jung, Buka Samten
Summary: HDAC1 inhibitor DHOB enhances IL-1β production by increasing NLRP3 expression, promoting cleaved caspase-1, and enhancing ASC oligomerization. DHOB rescues defective IL-1β production and increases NLRP3 expression in dendritic cells infected with Mycobacterium tuberculosis. HDAC2, but not HDAC1, controls IL-1β production through NLRP3 inflammasome activation.
Editorial Material
Chemistry, Multidisciplinary
Hanna S. Schymik, Charlotte Dahlem, Ahmad Barghash, Alexandra K. Kiemer
Summary: This study provides initial insights into the regulation and role of IMP2 in macrophage activation. Differences in the regulation of IMP2 between inflammatory and anti-inflammatory macrophages were observed.
Article
Immunology
Ewa Oleszycka, Eoin C. OBrien, Michael Freeley, Ed C. Lavelle, Aideen Long
Summary: Bile acids, synthesized from cholesterol, play a role in promoting intestinal absorption and have been associated with inflammatory diseases. This study demonstrates that bile acids can induce the secretion of pro-inflammatory cytokines and the recruitment of innate immune cells, suggesting their mechanistic role in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mariane Beatriz Sordi, Layla Panahipour, Zahra Kargarpour, Reinhard Gruber
Summary: The study found that PRF can reduce IL-1β release and partially inhibit pyroptosis-related factors in LPS-challenged macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Summary: IL-1β is regulated by ubiquitination to prevent excessive activity, reducing inflammation and potential immunopathological damage.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Wenxian Yang, Xiaoyuan Bai, Xiaohan Luan, Jie Min, Xiaodong Tian, Heqiao Li, Huizi Li, Wenqiang Sun, Wei Liu, Wenhui Fan, Wenjun Liu, Lei Sun
Summary: The inflammatory response is regulated by complex and delicate mechanisms, with Cyclophilin A (CypA) playing a role in promoting both inflammation activation and resolution by affecting IL-1 beta production and the epithelial-mesenchymal transition (EMT).
Article
Biochemistry & Molecular Biology
Sara Di Carlo, Georg Haecker, Ian E. Gentle
Summary: GM-CSF promotes the ubiquitination and enhanced processing of IL-1 beta through suppression of antioxidant responses, leading to its pro-inflammatory effect.
Article
Multidisciplinary Sciences
Kevin Eislmayr, Annika Bestehorn, Luisa Morelli, Martina Borroni, Lieselotte Vande Walle, Mohamed Lamkanfi, Pavel Kovarik
Summary: IL-1α and IL-1β have distinct functions during infection, with IL-1α governing metabolic pathway reprogramming in the liver for infection tolerance, while IL-1β is essential for pathogen clearance and regulation of the spleen transcriptome.
Article
Obstetrics & Gynecology
Madeline A. Sauer, Shannon Coy, Bradley J. Quade, Marisa R. Nucci
Summary: Teratomas are common benign tumors in the ovary, often containing mature tissues from different embryological germ layers. This report describes a case of a pregnant female with an ovarian mature cystic teratoma that exhibited remarkably well-developed posterior fossa structures.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiucui Ma, David R. Rawnsley, Attila Kovacs, Moydul Islam, John T. Murphy, Chen Zhao, Minu Kumari, Layla Foroughi, Haiyan Liu, Kevin Qi, Aaradhya Diwan, Krzysztof Hyrc, Sarah Evans, Takashi Satoh, Brent A. French, Kenneth B. Margulies, Ali Javaheri, Babak Razani, Douglas L. Mann, Kartik Mani, Abhinav Diwan
Summary: Mitophagy plays a critical role in cardiac myocyte function by removing damaged mitochondria and preventing inflammation and cell death to maintain myocardial homeostasis.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Gordon A. Francis, Babak Razani
CIRCULATION RESEARCH
(2022)
Editorial Material
Medical Laboratory Technology
Madeline A. Sauer, Natalie M. Rizzo, Nicole Tolan
CLINICAL CHEMISTRY
(2022)
Article
Pathology
Madeline A. Sauer, Jing Yang, Raymond A. Isidro, Fei Dong, Deepa T. Patil, Jon O. Wee, Agoston T. Agoston, Vikram Deshpande, Lei Zhao
Summary: This study compared the clinicopathologic and molecular features of esophageal squamous cell carcinoma (SCC) with basaloid features and conventional SCC. The findings suggest that SCC with basaloid features has similar survival and genomic alterations to conventional SCC, and is more commonly associated with diffuse or multifocal squamous dysplasia but not with high-risk HPV infection.
Editorial Material
Public, Environmental & Occupational Health
Mohammad Hossein Taghrir, Hossein Akbarialiabad, Ashkan Abdollahi, Nasrollah Ghahramani, Bahar Bastani, Shahram Paydar, Babak Razani, John Mwangi, Ali A. Asadi-Pooya, Jamshid Roozbeh, Leila Malekmakan, Manasi Kumar
Summary: Since the start of the pandemic, SARS-Cov2 has highlighted the socioeconomic and healthcare disparities at various levels. Long COVID, which affects many patients beyond the acute phase, poses a significant challenge. However, most studies on long COVID have focused on high-income countries, neglecting low and middle-income regions and vulnerable groups. Additionally, there is geographical heterogeneity in investigating Post-Acute Sequelae of COVID-19 (PASC). Recognizing these health disparities is crucial for promoting global health equity.
GLOBAL HEALTH PROMOTION
(2023)
Article
Cell Biology
Xiangyu Zhang, Santosh Kumar Misra, Parikshit Moitra, Xiuli Zhang, Se-Jin Jeong, Jeremiah Stitham, Astrid Rodriguez-Velez, Arick Park, Yu-Sheng Yeh, William E. Gillanders, Daping Fan, Abhinav Diwan, Jaehyung Cho, Slava Epelman, Irfan J. Lodhi, Dipanjan Pan, Babak Razani
Summary: Dysfunction of the macrophage lysosomal system is a characteristic of atherosclerosis, and acidic nanoparticles can be used to rescue this dysfunction and treat the disease.
Article
Orthopedics
Jeffrey J. Frandsen, Joshua P. Rainey, Graham J. DeKeyser, Brenna E. Blackburn, Jeremy M. Gililland
Summary: This study evaluated the differences in outcomes between patients with nondisplaced and displaced geriatric femoral neck fractures (FNFs) who underwent arthroplasty. The results showed that the reoperation rates at 1-year follow-up were similar for patients with nondisplaced and displaced fractures. However, the incidence of heterotopic ossification was higher in displaced fractures, while operative times and blood loss were higher in nondisplaced fractures. Therefore, arthroplasty is an excellent treatment option for both types of FNFs.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Amanda Cao, Elie S. Ghanem, Kyle H. Cichos, Paul Lichstein, Antonia F. Chen
Summary: This study aimed to compare patient characteristics, perioperative management methods, and outcomes for total hip arthroplasty (THA) for femoral neck fracture (FNF) performed by arthroplasty versus trauma trained orthopaedic surgeons. The results showed that patients operated on by arthroplasty-trained surgeons had shorter operative times, higher utilization of tranexamic acid, and lower rates of complications. However, mortality and complications after discharge were similar between both specialties when adjusted for confounding variables.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Multidisciplinary Sciences
Donghua Hu, Min Tan, Dongliang Lu, Brian Kleiboeker, Xuejing Liu, Hongsuk Park, Alexxai V. Kravitz, Kooresh I. Shoghi, Yu-Hua Tseng, Babak Razani, Akihiro Ikeda, Irfan J. Lodhi
Summary: Mitochondrial morphology, regulated by fission and fusion, plays a crucial role in the thermogenic capacity of brown adipocytes. TMEM135 has been identified as a critical mediator in the regulation of mitochondrial fission and thermogenesis, providing a potential target for therapeutic activation of brown adipose tissue.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Mandy M. Chan, Sabine Daemen, Joseph W. Beals, Marina Terekhova, Bin Q. Yang, Christina F. Fu, Li He, Arick C. Park, Gordon I. Smith, Babak Razani, Kathleen Byrnes, Wandy L. Beatty, Shaina R. Eckhouse, J. Christopher Eagon, Daniel Ferguson, Brian N. Finck, Samuel Klein, Maxim N. Artyomov, Joel D. Schilling
Summary: This study revealed the presence of macrophage subsets in the human liver with MAFLD that closely resemble those found in mouse models of fatty liver disease, showing a correlation between recruited myeloid cells and the degree of liver steatosis. MdMs were shown to be involved in lipid uptake during the early stages of MALFD.
Review
Pharmacology & Pharmacy
Cristi L. Galindo, Saifur Khan, Xiangyu Zhang, Yu-Sheng Yeh, Ziyang Liu, Babak Razani
Summary: Lipid-laden foam cells play a crucial role in the development of atherosclerotic plaques, and manipulating their biology has therapeutic potential for treating atherosclerosis.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Biochemical Research Methods
Saifur R. Khan, Andreea Obersterescu, Erica P. Gunderson, Babak Razani, Michael B. Wheeler, Brian J. Cox
Summary: A bioinformatics tool called metGWAS 1.0 has been developed to identify novel disease/trait-specific metabolite-gene associations by integrating independent GWAS data and standalone metabolomics data, with evaluations conducted on two case studies. The tool is implemented in an R pipeline and available on GitHub for use.
Article
Biochemical Research Methods
Xiangyu Zhang, Jeremiah Stitham, Astrid Rodriguez-Velez, Se-Jin Jeong, Arick Park, Yu-Sheng Yeh, Divya Kapoor, Bettina Mittendorfer, Babak Razani
Summary: This study provides a protocol for evaluating diet-induced mTORC1 signaling in plaque macrophages in mice, which can be used to study the atherogenic potential of various mTORC1 modulators.
Article
Pathology
Madeline Sauer, Justine A. Barletta
Summary: DICER1 syndrome is a tumor predisposition syndrome caused by DICER1 gene mutations, which can lead to multinodular goiter and thyroid carcinomas in the thyroid. Somatic DICER1 mutations can occur in follicular-patterned thyroid tumors, especially in pediatric cases and those with a macrofollicular architecture.
HEAD & NECK PATHOLOGY
(2022)