Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Sara Akalay, Sarah A. Hosgood
Summary: Although machine perfusion is gradually being applied in clinical practice, the improvement of organ reconditioning therapies is still at the experimental stage, showing a translational gap. This review discusses the biological processes and current strategies and interventions for preventing ischemia-reperfusion injury, treating its deleterious consequences, or supporting the reparative response of the kidney, and explores prospects to improve the clinical translation of these therapies by addressing multiple aspects of ischemia-reperfusion injury to achieve robust and long-lasting protective effects on the kidney graft.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Man Guo, Jiarui Xu, Shuan Zhao, Daoqi Shen, Wuhua Jiang, Lin Zhang, Xiaoqiang Ding, Xialian Xu
Summary: This study investigated the role of SDC-1 shedding in ischemia/reperfusion-induced acute kidney injury (AKI) and found that inhibiting SDC-1 shedding can protect against renal injury by restoring cell polarity and reducing apoptosis in tubular epithelial cells.
Article
Urology & Nephrology
Karla Johanna Ruth Hoyer-Allo, Martin Richard Spath, Susanne Brodesser, Yiyi Zhu, Julia Binz-Lotter, Martin Hohne, Hella Bronneke, Katrin Bohl, Marc Johnsen, Torsten Kubacki, Katharina Kiefer, Lisa Seufert, Felix Carlo Koehler, Franziska Grundmann, Matthias J. Hackl, Bernhard Schermer, Jens Bruning, Thomas Benzing, Volker Burst, Roman-Ulrich Muller
Summary: Caloric restriction provides protective effects against kidney injury in male mice by downregulating Cyp4a12a and reducing 20-HETE concentrations. However, supplementation of 20-HETE can partially undermine the protective potential of caloric restriction by reversing changes in protein expression.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Khaled Dastagir, Jaba Gamrekelashvili, Nadjib Dastagir, Anne Limbourg, Dustin Kijas, Tamar Kapanadze, Peter M. Vogt, Florian P. Limbourg
Summary: In this study, the researchers found that the Notch ligand Delta-like 1 (Dll1), expressed in vascular endothelial cells, regulates flap arteriogenesis, inflammation, and survival. The loss of Dll1 impaired collateral vessel formation and led to aberrant vascularization and necrosis of the tissue. Furthermore, Dll1 deficiency also resulted in severe inflammation in the flap dominated by monocytes and macrophages. These findings demonstrate the importance of Dll1 in vascular adaptation to flap surgery and provide insights into the molecular and cellular regulators of flap healing and survival.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Shaobo Wang, Yin Chen, Songling Hang, Yong Liu, Jining Gao, Yinghui Huang, Wei Sun, Junping Wang, Cheng Wang, Jinghong Zhao
Summary: This study demonstrates an effective therapeutic option by using Se@BSA nanoparticles to treat IRI-induced AKI. By correcting selenium deficiency and inhibiting inflammatory responses, Se@BSA nanoparticles show promising results in mitigating AKI and preventing fibrosis formation.
Article
Biochemistry & Molecular Biology
Ha Nee Jang, Jin Hyun Kim, Myeong Hee Jung, Taekil Tak, Jung Hwa Jung, Seunghye Lee, Sehyun Jung, Se-Ho Chang, Hyun-Jung Kim
Summary: This study demonstrates that inflammasome-mediated inflammation accompanied by immune modulation and fibrosis is a potential target for EPCs as a treatment for IRI-induced AKI and prevention of progression to CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chiara Bellini, Salvatore Antonucci, Lucia Morillas-Becerril, Sara Scarpa, Regina Tavano, Fabrizio Mancin, Fabio Di Lisa, Emanuele Papini
Summary: The study demonstrated the effectiveness of utilizing two formulations of poly(lipoic acid)-based nanoparticles (NPs) in combating radical damage and ROS formation in various cell types. Results indicate that NPs could effectively protect against myocardial cell damage induced by ischemic reperfusion injury.
Article
Biochemistry & Molecular Biology
Stephanie M. Mutchler, Mahpara Hasan, Donald E. Kohan, Thomas R. Kleyman, Roderick J. Tan
Summary: Our study demonstrates that deletion of the gamma subunit of ENaC, while allowing for greater activation of eNOS, is not sufficient to prevent IRI. This suggests that the protective effects of alpha subunit deletion may be due, in part, to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Jizong Jiang, Lingyan Ni, Xinxin Zhang, Hongyun Wang, Li Liu, Meng Wei, Guoping Li, Yihua Bei
Summary: This study constructs a biomimetic delivery system of platelet membrane-fused extracellular vesicles (P-hEV) for targeted delivery to protect against myocardial ischemia/reperfusion injury (I/RI). Results show that P-hEV enhances cellular uptake and exhibits beneficial effects on endothelial cell survival and function under stress. In vivo, P-hEV effectively targets and accumulates at injury sites in the heart and provides significant protection against acute I/RI and cardiac remodeling. This innovative delivery system presents a promising approach for treating ischemic heart diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Felix Becker, Linus Kebschull, Constantin Rieger, Annika Mohr, Barbara Heitplatz, Veerle Van Marck, Uwe Hansen, Junaid Ansari, Stefan Reuter, Benjamin Struecker, Andreas Pascher, Jens G. Brockmann, Trevor Castor, J. Steve Alexander, Felicity N. E. Gavins
Summary: This study demonstrates that Bryostatin-1 shows promise as a pharmacological candidate for graft-specific treatment in kidney transplantation, as it provides protection by blocking neutrophil infiltration and attenuating functional graft injury.
Article
Cell Biology
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima
Summary: In this study, the expression and localization of follistatin in normal and ischemic rat kidneys were examined, and urinary follistatin levels were measured to assess its potential as a biomarker for acute kidney injury. The results showed that follistatin was mainly localized in the distal tubules of the cortex in normal kidneys, while it was also present in the distal tubules of both the cortex and outer medulla in ischemic kidneys. Urinary follistatin levels were significantly increased in ischemic rats and correlated with the duration of ischemia, the follistatin-positive area, and the acute tubular damage area.
Article
Biochemistry & Molecular Biology
Beata Roka, Pal Tod, Tamas Kaucsar, Eva Nora Bukosza, Imre Voros, Zoltan V. Varga, Balazs Petrovich, Bence Agg, Peter Ferdinandy, Gabor Szenasi, Peter Hamar
Summary: Delayed contralateral nephrectomy improved kidney function after IR and decreased fibrosis progression. miRNAs play a crucial role in this process.
Article
Endocrinology & Metabolism
Marie Boutant, Magali Joffraud, Sameer S. Kulkarni, Ester Garcia-Casarrubios, Pablo M. Garcia-Roves, Joanna Ratajczak, Pablo J. Fernandez-Marcos, Angela M. Valverde, Manuel Serrano, Carles Canto
MOLECULAR METABOLISM
(2015)
Article
Endocrinology & Metabolism
Sameer S. Kulkarni, Magali Joffraud, Marie Boutant, Joanna Ratajczak, Arwen W. Gao, Catherine Maclachlan, Maria Isabel Hernandez-Alvarez, Frederic Raymond, Sylviane Metairon, Patrick Descombes, Riekelt H. Houtkooper, Antonio Zorzano, Caries Canto
Article
Multidisciplinary Sciences
Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Nuria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Canto
NATURE COMMUNICATIONS
(2016)
Article
Cell Biology
Daniel Mauvoisin, Florian Atger, Loic Dayon, Antonio Nunez Galindo, Jingkui Wang, Eva Martin, Laetitia Da Silva, Ivan Montoliu, Sebastiano Collino, Francois-Pierre Martin, Joanna Ratajczak, Carles Canto, Martin Kussmann, Felix Naef, Frederic Gachon
Article
Endocrinology & Metabolism
Rachel S. Fletcher, Joanna Ratajczak, Craig L. Doig, Lucy A. Oakey, Rebecca Callingham, Gabriella Da Silva Xavier, Antje Garten, Yasir S. Elhassan, Philip Redpath, Marie E. Migaud, Andrew Philp, Charles Brenner, Carles Canto, Gareth G. Lavery
MOLECULAR METABOLISM
(2017)
Article
Biochemistry & Molecular Biology
Marie Boutant, Sameer S. Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera-Alberni, Roy Combe, Antonio Zorzano, Carles Canto