期刊
JOURNAL OF IMMUNOLOGY
卷 193, 期 12, 页码 5914-5923出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1400477
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- Ligue contre le Cancer and the Association pour la Recherche contre le Cancer
- Association pour la Recherche sur le Cancer
CD4 regulatory T cells (Tregs) can be subdivided into two subsets according to Ly-6C expression in the periphery. Phenotypic analysis, imaging, and adoptive-transfer experiments of peripheral Ly-6C and Ly-6C(+) Tregs reveal that the nonexpression of Ly-6C by similar to 70% of peripheral Tregs depends on TCR signaling events. Interestingly, Ly-6C Tregs express higher surface amounts of key immunosuppressive molecules than do Ly-6C(+) Tregs and produce constitutively anti-inflammatory cytokines. In line with their phenotype, Ly6C(+) Tregs exhibit poor suppressive capacities in vitro and in vivo. Finally, although Ly-6C Tregs maintain their numbers with age, Ly-6C(+) Tregs gradually disappear. Altogether, our data strongly suggest that both the survival and suppressive functions of peripheral CD4 Tregs rely on their ability to receive strong TCR signals.
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