Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Theresa Greiner, Markus Kipp
Summary: Multiple sclerosis initially presents with a relapsing-remitting disease course, then progresses to a secondary progressive stage. In both stages, peripheral immune cells are triggered by CNS-intrinsic stimuli to invade the brain parenchyma.
Article
Immunology
Chunlei Feng, Lingyun Li, Qing Li, Kirsten Switzer, Mingyao Liu, Shuhua Han, Biao Zheng
Summary: Research shows that omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (DHA), regulate the functional activities of dendritic cells (DCs) to enhance anti-inflammatory effects in autoimmune diseases. By modulating DCs, DHA reduces proinflammatory cytokine production and increases regulatory T-cell induction capability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kin Man Au, Roland Tisch, Andrew Z. Wang
Summary: Failure to establish immune tolerance can lead to autoimmune diseases. This study demonstrates a potential new strategy for treating autoimmune diseases by bioengineering programmed death-ligand 1 (PD-L1)- and cluster of differentiation 86 (CD86)-functionalized mouse Schwann cells (SCs) to modify disease progression and ameliorate symptoms without inducing systemic immunosuppression.
ADVANCED MATERIALS
(2022)
Article
Medicine, General & Internal
Zhen Jia, Jia Liu, Bin Li, Le Yi, Yanmin Wu, Junna Xing, Liang Wang, Jinli Wang, Li Guo
Summary: This study investigated the effects and mechanisms of FOXP3-EXOs in the development of EAE. FOXP3-EXOs were found to inhibit the production of Th1 and Th17 cells, promote Treg cell production, and improve the development of EAE.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jinwon Park, Quoc-Viet Le, Yina Wu, Jaiwoo Lee, Yu-Kyoung Oh
Summary: A tolerogenic nanovaccine has been developed and tested on an animal model of multiple sclerosis. The nanovaccine delivers a self-antigen to dendritic cells, blocking the interaction between immune cells and reducing interferon gamma secretion. The results show that the nanovaccine has significant preventive and therapeutic effects in the experimental autoimmune encephalomyelitis (EAE) model.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Immunology
Elena Hernandez-Garcia, Francisco J. Cueto, Emma C. L. Cook, Ana Redondo-Urzainqui, Sara Charro-Zanca, Inaki Robles-Vera, Ruth Conde-Garrosa, Ivana Nikolic, Guadalupe Sabio, David Sancho, Salvador Iborra
Summary: Conventional dendritic cells type 1 (cDC1s) play a critical role in adipose tissue homeostasis, with a connection to NK1.1(+) invariant NKT (iNKT) cells, and have an impact on adipose tissue inflammation and overall metabolic health.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Food Science & Technology
Dana Edleman, Clifford Hall
Summary: The study aimed to concentrate the waste product AQF, which can foam like egg whites, by reverse osmosis and then dry it using freeze, tray, or spray drying. AQF products were incorporated into cake mix and sugar cookie formulas. Cakes made with eggs had higher hardness, gumminess, and chewiness, while cookies made with AQF had higher spread factor and lower hardness. Cookies made with AQF also showed higher flavor and overall acceptability scores compared to those made with eggs.
Article
Immunology
Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Summary: Research shows that PINK1 protein plays a crucial role in modulating the immune response during EAE, potentially contributing to the pathogenesis of neuroinflammatory and other associated conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Guan Yang, J. Luke Postoak, Wenqiang Song, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Summary: The study revealed a critical role of PIK3C3 in DC function and the pathogenicity of these cells during EAE, with important implications for the development of immunotherapies for autoimmune diseases such as MS.
Review
Immunology
Xinyu Gu, Qingfei Chu, Xiao Ma, Jing Wang, Chao Chen, Jun Guan, Yanli Ren, Shanshan Wu, Haihong Zhu
Summary: NKT cells play a crucial role in the immune system, particularly in liver diseases. Hepatic iNKT cells interact with other immune cells through direct cell-to-cell contact and cytokine secretion, bridging the innate and adaptive immune systems.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jason M. Zimmerer, Bryce A. Ringwald, Sachi R. Chaudhari, Jing Han, Chelsea M. Peterson, Robert T. Warren, Madison M. Hart, Mahmoud Abdel-Rasoul, Ginny L. Bumgardner
Summary: iNKT cells play a crucial role in modulating CD8-mediated immune responses in the presence or absence of CD4(+) T cells. Lack of iNKT cells decreases CD8-mediated allocytotoxicity, which can be restored by adoptive transfer of iNKT cells. including TNF-alpha and IFN-gamma.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tatjana Bogovic Crncic, Neva Girotto, Maja Ilic Tomas, Ines Kristofic, Sanja Klobucar, Lara Baticic, Bozena Curko-Cofek, Vlatka Sotosek
Summary: Autoimmune thyroid disease (AITD) is a common organ-specific autoimmune disorder, and hormonal changes during pregnancy can worsen the course of AITD. Previous thyroid disorders can also affect pregnancy outcomes. Therefore, maintaining thyroid equilibrium is crucial for pregnant women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Shehla U. Hridi, Mark Barbour, Chelsey Wilson, Aimee Jpm Franssen, Tanith Harte, Trevor J. Bushell, Hui-Rong Jiang
Summary: Interleukin-16 is closely involved in the pathology of multiple sclerosis and other inflammatory diseases in the central nervous system by being produced by glial and infiltrating immune cells, impacting the recruitment and activation of CD4(+) immune cells in neuroinflammation.