Article
Oncology
Lu Liu, Jinlan Gao, Xuesha Xing, Meixi Jiang, Qi Liu, Shusen Wang, Yang Luo
Summary: This study found that cyclin G2 is upregulated in macrophages after IFN-gamma treatment. Upregulated cyclin G2 inhibits tumor growth by increasing the secretion of CXCL9, promoting CTL chemotaxis and suppressing angiogenesis. Additionally, cyclin G2 increases CXCL9 mRNA levels by promoting STAT1 signaling pathway activation.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Susana Lopez-Lopez, Maria Jose Romero de Avila, Natalia Carolina Hernandez de Leon, Francisco Ruiz-Marcos, Victoriano Baladron, Maria Luisa Nueda, Jorge Laborda, Jose Javier Garcia-Ramirez, Eva M. Monsalve, Maria Jose M. Diaz-Guerra
Summary: NOTCH4 acts as a negative regulator in macrophage activation by interfering with proinflammatory cytokine expression and signaling pathways such as IFN-gamma and STAT1. It also modulates the balance between STAT1 and STAT3 activation, impacting the transcriptional activity of macrophages. Moreover, NOTCH4 affects NF-kappa B and TLR signaling pathways, revealing new insights into the regulation of macrophage-specific effector functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Can Fang, Tao Weng, Shaojie Hu, Zhiwei Yuan, Hui Xiong, Bing Huang, Yixin Cai, Lequn Li, Xiangning Fu
Summary: IFN-gamma induces protein synthesis and unfolded protein response, leading to impaired autophagy and apoptosis in cancer cells. Inhibition of ER stress prevents IFN-gamma-triggered apoptosis, while CHOP knockdown abrogates IFN-gamma-mediated apoptosis and restores cyclin D1 expression. These findings suggest that ER stress and UPR are novel mechanisms underlying the anticancer effects of IFN-gamma.
Article
Biochemistry & Molecular Biology
Shao-Liang Yang, Hai-Xia Tan, Tian-Tian Niu, Yu-Kai Liu, Chun-Jie Gu, Da-Jin Li, Ming-Qing Li, Hai-Yan Wang
Summary: The study revealed that IFN-gamma promoted autophagy and macrophage phagocytosis in cervical cancer cells. This effect was achieved possibly through the promotion of IDO1 expression and kynurenine metabolism by IFN-gamma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Xianglin Pu, Yangdong Pan, Quanjia Xiang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song
Summary: This study investigated the effects of Eimeria maxima IFN-gamma inhibitory molecules on the immune function of chicken peripheral blood mononuclear cells and T cell subsets. The results showed significant effects of these molecules on cell proliferation and cytokine production.
Article
Biochemistry & Molecular Biology
Shuzhao Zhuang, Aaron Russell, Yifan Guo, Yingying Xu, Weihua Xiao
Summary: Blocking IFN-γ in PD-1 knockout mice may exacerbate skeletal muscle damage and fibrosis, inhibit muscle regeneration, and affect the quantity and phenotype transition of macrophages as well as the infiltration of neutrophils.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Rui Sun, Joyce H. Jang, Anne-Marie Lauzon, James G. Martin
Summary: The study discovered that increased ASM mass in asthmatic airways is mainly attributable to hyperplasia. CD4+ T cells infiltrate asthmatic airways and induce ASMC proliferation via contact-dependent mechanisms. The CXCL10/11-CXCR3 axis enhances the recruitment of CD4+ T cells to ASM in asthmatic airways, amplified by T cell-derived IFN-gamma.
Article
Cell Biology
Ki-Sun Kim, Don-Kyu Kim, Soon-Young Na, Yoon Seok Jung, Sung Jin Cho, Jina Kim, In-Kyu Lee, Young-Hoon Kim, Chul-Ho Lee, Won-Il Jeong, Eun-Kyeong Jo, Hueng-Sik Choi
Summary: ERR gamma expression in macrophages is induced by polyinosinic-polycytidylic acid treatment, and regulates the transcription and secretion of IFN-I genes. The findings suggest that ERR gamma modulates the innate and adaptive immune responses to dsRNA virus replication by binding to conserved ERR response elements in the IFN-alpha and IFN-beta promoters. GSK5182 suppresses IFN-I gene expression and secretion in macrophages.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Oncology
Stefania Angelicola, Francesca Ruzzi, Lorena Landuzzi, Laura Scalambra, Francesco Gelsomino, Andrea Ardizzoni, Patrizia Nanni, Pier-Luigi Lollini, Arianna Palladini
Summary: The mechanisms driving hyperprogressive disease (HPD) are still unknown, but IFN-γ and CD38 are proposed to play important roles in its development by affecting signaling pathways and responses to immune checkpoint inhibitor (ICI) therapy.
Article
Microbiology
Jialei Li, Xintao Gao, Xingjian Liu, Tong Wu, Haozhi Song, Weisong Gao, Hong Jia, Yinue Li, Zhifang Zhang
Summary: In this study, it was found that GETV possesses the ability of viral immune escape, and IFN-? aids in the prevention and control of GETV, implying the potential molecular mechanism of suppression of GETV by IFN-?.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Bin Lang, Meiting Wang, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang
Summary: This study found that during HIV infection, the inhibitory receptor CD47 suppresses NK cell production of IFN-γ by binding to plasma TSP1, activating the JAK/STAT3 pathway. CD47 and its related signaling pathways may be potential therapeutic targets for improving NK cell function in individuals living with HIV.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Angela M. Gocher, Creg J. Workman, Dario A. A. Vignali
Summary: IFN gamma plays pleiotropic roles in the tumor microenvironment, acting as both a 'teammate' to promote antitumor immune responses and an 'opponent' promoting tumor growth and suppressing immune responses.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Immunology
Jedson R. Liggett, Jiman Kang, Suman Ranjit, Olga Rodriguez, Katrina Loh, Digvijay Patil, Yuki Cui, Anju Duttargi, Sang Nguyen, Britney He, Yichien Lee, Kesha Oza, Brett S. Frank, DongHyang Kwon, Heng-Hong Li, Bhaskar Kallakury, Andrew Libby, Moshe Levi, Simon C. Robson, Thomas M. Fishbein, Wanxing Cui, Chris Albanese, Khalid Khan, Alexander Kroemer
Summary: This study investigated the role of Type 1 Natural Killer T-cells (NKT1 cells) in hepatic ischemia-reperfusion injury (IRI) and found that hepatic steatosis exacerbates the damage. Through experiments and analysis, it was observed that a high-fat diet increases the frequency of NKT1 cells and enhances interferon-gamma expression. The study also demonstrated that oral NAC supplementation can improve liver function and glycolysis, while reducing interferon-gamma expression. Lipidomic analysis revealed that NAC downregulates the PPAR-gamma pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Anu Balakrishnan, Sanjukta Majumder, Shivika Guleria, Able Lawrence, Amita Aggarwal
Summary: Macrophage migration inhibitory factor (MIF) and IgA antiCD74 antibodies play important roles in ankylosing spondylitis (AS) and enthesitis-related arthritis (ERA). The study found that serum MIF levels were higher in ERA patients and correlated with disease activity; synovial fluid MIF levels were even higher, indicating a potential role in synovitis seen in ERA. IgA antiCD74 antibodies were rarely detected in ERA patients.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Dilem C. Apaydin, Bhakti Zakarauskas-Seth, Lorenzo Carnevale, Onur Apaydin, Marialuisa Perrotta, Raimondo Carnevale, Maria P. Kotini, Ilan Kotlar-Goldaper, Heinz-Georg Belting, Daniela Carnevale, Alessandro Filosa, Suphansa Sawamiphak
Summary: This study using zebrafish model identified the immune pathways associated with the development of multi-organ dysfunction in response to hypertensive stimulus, and suggested anti-interferon-gamma treatment as a potential intervention strategy.
CARDIOVASCULAR RESEARCH
(2023)
Article
Clinical Neurology
Ming-Kai Hsieh, Mu-Yi Liu, Tsung-Ting Tsai, Po-Liang Lai, Ching-Lung Tai
Summary: Through an in vitro biomechanical study on porcine spines, it was found that placing two cross-links individually at the proximal and distal ends of the center of the construct is the optimal and efficient configuration for long-segment spinal fixation, providing biomechanical stability.
GLOBAL SPINE JOURNAL
(2023)
Article
Emergency Medicine
Chia-Lung Kao, Jui-Yi Tsou, Ming-Yuan Hong, Chih-Jan Chang, Chih-Hsien Chi
Summary: This study compared the quality and safety concerns of one-handed external chest compression (ECC) and two-handed ECC. Results showed that two-handed ECC performed better in terms of depth, depth accuracy, incomplete recoil, maximum force, and ulnar-radial force difference. One-handed ECC resulted in greater ulnar pronation, operator fatigue, and lower quality compared to two-handed ECC. Adjusting training for one-handed ECC could potentially improve the quality of cardiopulmonary resuscitation during transport.
EMERGENCY MEDICINE JOURNAL
(2022)
Letter
Public, Environmental & Occupational Health
Ming-Yuan Hong, Chia-Lung Kao, Chih-Hsien Chi
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ching-Chi Lee, Po-Lin Chen, Yi-Tzu Huang, Ching-Yu Ho, Ming-Yuan Hong, Chih-Chia Hsieh, Chih-Hao Lin, Wen-Chein Ko
Summary: This study investigated the prognostic effects of delayed appropriate antimicrobial therapy (AAT) in older persons with community-onset bacteremia. The results showed that delayed AAT increased mortality rates, with septic patients having shorter delays in treatment and higher mortality rates.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Chemistry, Analytical
Chung-Han Chou, Tse-Hao Huang, Po-Chuan Hsieh, Natalie Yi-Ju Ho, Chung-An Chen, Kan Wu, Tsung-Ting Tsai
Summary: Cerebrospinal fluid (CSF) leakage is a common complication of spine surgery, and its diagnosis and treatment are challenging. A high-sensitivity lateral flow immunoassay (sLFIA) method for quantitatively detecting a specific CSF marker (BTP) was developed. The sLFIA method showed good sensitivity and specificity for diagnosing CSF leakage and assessing the severity of the leakage.
ANALYTICA CHIMICA ACTA
(2022)
Article
Immunology
Hong-Jyun Huang, Martyr Yang, Hsin-Wei Chen, Shuying Wang, Chih-Peng Chang, Tzong-Shiann Ho, Yu-San Kao, Sen-Mao Tien, Hsing-Han Lin, Po-Chun Chang, Yen-Chung Lai, Yu-Peng Hsiao, Yi-Ling Liu, Chiao-Hsuan Chao, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, Shu-Wen Wan
Summary: This study developed a modified DENV vaccine candidate with enhanced features by combining modifications of two DENV proteins. The vaccine candidate showed protective effects against DENV infection in a mouse model, indicating its potential clinical application.
Article
Microbiology
Sen-Mao Tien, Po-Chun Chang, Yen-Chung Lai, Yung-Chun Chuang, Chin-Kai Tseng, Yu-San Kao, Hong-Jyun Huang, Yu-Peng Hsiao, Yi-Ling Liu, Hsing-Han Lin, Chien-Chou Chu, Miao-Huei Cheng, Tzong-Shiann Ho, Chih-Peng Chang, Shu-Fen Ko, Che-Piao Shen, Robert Anderson, Yee-Shin Lin, Shu-Wen Wan, Trai-Ming Yeh
Summary: Dengue virus (DENV) is a global health problem without effective treatment. This study demonstrates the potential of humanized anti-NS1 monoclonal antibodies (mAbs) as a therapeutic tool for DENV infection. The humanized mAbs showed therapeutic benefits in reducing bleeding time and skin hemorrhage, and they also inhibited vascular permeability and enhanced cytolysis of DENV-infected cells.
Article
Immunology
Yen-Chung Lai, Yu-Wei Cheng, Chiao-Hsuan Chao, Yu-Ying Chang, Chi-De Chen, Wei-Jiun Tsai, Shuying Wang, Yee-Shin Lin, Chih-Peng Chang, Woei-Jer Chuang, Li-Yin Chen, Ying-Ren Wang, Sui-Yuan Chang, Wenya Huang, Jen-Ren Wang, Chin-Kai Tseng, Chun-Kuang Lin, Yung-Chun Chuang, Trai-Ming Yeh
Summary: In COVID-19 patients, elevated levels of ACE2 antibodies were found to cross-react with S1-RBD antibodies, suggesting a potential mechanism of immune response induced by SARS-CoV-2 infection. This cross-reactivity highlights the complex interactions between the virus and the host immune system in COVID-19 pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ming-Kai Hsieh, Yun-Da Li, Yun-Ja Hsu, Tsung-Ting Tsai, Po-Liang Lai, De-Mei Lee, Ching-Lung Tai
Summary: The study evaluated a newly designed proximal-conical dual-thread screw and found that it provided fixation strength comparable to that of a traditional screw. These proximal-conical dual-thread screws performed better than single-thread screws and displayed comparable biomechanical performance to traditional dual-thread screws.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Yun-Da Li, Ming-Kai Hsieh, De-Mei Lee, Yi-Jiun Lin, Tsung-Ting Tsai, Po-Liang Lai, Ching-Lung Tai
Summary: This study evaluated the biomechanical properties of screws augmented with four different materials and the effect of different pilot hole sizes and bone densities on screw fixation strength, with bone cement showing the most significant enhancement.
APPLIED SCIENCES-BASEL
(2022)
Article
Immunology
Yi-Ling Cheng, Chiao-Hsuan Chao, Yen-Chung Lai, Kun-Han Hsieh, Jen-Ren Wang, Shu-Wen Wan, Hong-Jyun Huang, Yung-Chun Chuang, Woei-Jer Chuang, Trai-Ming Yeh
Summary: This study confirms the presence of antibodies related to SARS-CoV-2 in dengue virus patients, and these antibodies can cross-react with proteins of the dengue virus. These antibodies can inhibit the pathological reactions caused by dengue virus infection, potentially providing some level of protection against dengue virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Fen Wang, Tsung-Ting Tsai, Yun-Da Li, Ping-Yeh Chiu, Ming-Kai Hsieh, Jen-Chung Liao, Po-Liang Lai, Fu-Cheng Kao
Summary: This study aimed to investigate whether PEIDF could reduce the morbidity rate for patients with infectious spondylodiscitis. The results showed that compared to conventional open surgery, PEIDF significantly reduced surgical blood loss and intraoperative transfusions, with better decline of CRP. Patients undergoing conventional open surgery experienced more postoperative sepsis and prolonged-time for CRP normalization.
Article
Chemistry, Analytical
Chung-An Chen, Ping-Yeh Chiu, Tse-Hao Huang, Natalie Yi-Ju Ho, Fu-Cheng Kao, Tsung-Ting Tsai
Summary: Appropriate follow-up after treatment initiation in patients with osteoporosis is challenging. Serum biomarkers, such as procollagen type I propeptide (PINP), can provide clinically useful information for disease management. However, rapid and cost-effective methods for detecting serum PINP are lacking. In this study, we developed a high-sensitivity lateral flow immunoassay with a stacking pad (sLFIA) for quantitative detection of PINP and found that it can serve as a point-of-care test (POCT) for monitoring medication response and managing osteoporosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Immunology
Chiao-Hsuan Chao, Dayna Cheng, Sheng-Wen Huang, Yung-Chun Chuang, Trai-Ming Yeh, Jen-Ren Wang
Summary: This study collected serum samples from 113 Taiwan participants after receiving different SARS-CoV-2 vaccines and compared the differences in immune responses. The results showed that mRNA vaccines elicited higher levels of antibodies and had higher broadly neutralizing ability compared to AZD1222. Additionally, the study found a significant increase in anti-ACE2 autoantibodies after vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Song-Shu Lin, Steve W. N. Ueng, Kowit-Yu Chong, Yi-Sheng Chan, Tsung-Ting Tsai, Li-Jen Yuan, Shih-Jung Liu, Chuen-Yung Yang, Hui-Yi Hsiao, Yi-Jen Hsueh, Chung-An Chen, Chi-Chien Niu
Summary: MiRNA-107 expression is downregulated while Wnt3a protein and β-catenin are upregulated in degenerated intervertebral disc (IVD). Hyperbaric oxygen (HBO) treatment upregulates miR-107 expression and inhibits the Wnt3a/β-catenin signaling pathway, which may contribute to the protective effect of HBO against IVD degeneration.