Article
Pharmacology & Pharmacy
M. Rizwan Siddiqui, Narsa M. Reddy, Hafeez M. Faridi, Mohd Shahid, Thomas P. Shanley
Summary: The study found that metformin can attenuate endothelial hyperpermeability and stress fiber formation by inhibiting the cofilin-1-PP2AC pathway, thus exerting vascular protective and anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Physiology
Chun-Shui Pan, Li Yan, Se-Qi Lin, Ke He, Yuan-Chen Cui, Yu-Ying Liu, Bai-He Hu, Xin Chang, Xin-Rong Zhao, Jing-Yu Fan, Jing-Yan Han
Summary: This study aimed to investigate the protective effect and mechanism of QiShenYiQi Pills (QSYQ) against coronary microvascular hyperpermeability induced by cardiac I/R, showing that QSYQ attenuated microvascular damage and albumin leakage after I/R injury, maintained endothelial junctions, and protected endothelial barrier integrity. QSYQ also regulated various signaling pathways to prevent endothelial damage under hypoxic conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Jingwen Wu, Mingyu Zhang, Suhong Xia, Ping Han, Kai Zhao, Kaixin Peng, Wangdong Zhou, Dean Tian, Jiazhi Liao, Jingmei Liu
Summary: This study demonstrates that hepatic HRC promotes HSCs activation by inducing hepatocyte pyroptosis. HRC overexpression leads to pyroptosis and HMGB1 release in hepatocytes, subsequently activating HSCs. In addition, HRC overexpression enhances the proliferation and migration of HSCs. Inhibitors of NLRP3 and caspase-1 alleviate HRC-mediated hepatocyte pyroptosis and HSCs activation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Yuanyuan Li, Ying Shen, Yudan Zheng, Shundong Ji, Mengru Wang, Beibei Wang, Qingzhen Han, Yufeng Tian, Yiqiang Wang
Summary: FlgE protein interacts with ATP5B to modulate endothelial cell function and permeability, inducing microvascular hyperpermeability in a solid tumor mouse model.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beatrice Anna Brugger, Lena Neuper, Jacqueline Guettler, Desiree Forstner, Stefan Wernitznig, Daniel Kummer, Freya Lyssy, Julia Feichtinger, Julian Krappinger, Amin El-Heliebi, Lilli Bonstingl, Gerit Moser, Giovanny Rodriguez-Blanco, Olaf A. Bachkoenig, Benjamin Gottschalk, Michael Gruber, Olivia Nonn, Florian Herse, Stefan Verlohren, Hans-Georg Frank, Nirav Barapatre, Cornelia Kampfer, Herbert Fluhr, Gernot Desoye, Martin Gauster
Summary: This study investigates the effects of fluidic shear stress on the human trophoblast transcriptome and metabolism. It reveals that shear stress alters the transcriptome and induces a shift from glycolysis to amino acid metabolism in the villous trophoblast. These findings are crucial for understanding intrauterine growth restriction.
CELL AND BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Qun Zhou, Jianjun Jiang, Guanjun Chen, Cheng Qian, Gengyun Sun
Summary: This study investigated the molecular mechanism of endothelial barrier dysfunction induced by inflammatory immune cytokines in acute respiratory distress syndrome (ARDS). The results showed that TNF-alpha induced phosphorylated Ezrin protein via the FAK/RhoA signaling pathway, leading to endothelial hyperpermeability in PMVECs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiyin Wang, Bin Cai, Chenrui Cao, Haining Lv, Yimin Dai, Mingming Zheng, Guangfeng Zhao, Yanfang Peng, Wenjing Gou, Jingmei Wang, Dan Liu, Yali Hu
Summary: The study demonstrated that CD151 is a key regulator of antioxidants in the placenta, and its expression levels are negatively correlated with the expression of antioxidant genes in PE patients. CD151 may be a new target for PE treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tsuyoshi Aoyama, Hiroki Kuriyama, Yuki Sato, Shungo Imai, Hitoshi Kashiwagi, Mitsuru Sugawara, Yoh Takekuma
Summary: Dasatinib is the first-line pharmacotherapeutic treatment for CML, more effective than traditional treatments but may cause adverse effects such as pleural effusion. High concentrations of dasatinib were found to increase vascular permeability in endothelial cells, which could be prevented by cAMP activation.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Makiko Konda, Masahiro Kitabatake, Noriko Ouji-Sageshima, Rei Tonomura, Ryutaro Furukawa, Shota Sonobe, Chiyoko Terada-Ikeda, Maiko Takeda, Masahiko Kawaguchi, Toshihiro Ito
Summary: Acute respiratory distress syndrome (ARDS) lacks specific and effective treatment, making it crucial to understand its pathogenesis. This study reveals that ADAMTS4 plays a role in regulating vascular endothelial cell (VEC) permeability in ARDS and may serve as a significant predictive marker and therapeutic target for ARDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jinfeng Xie, Bingtian Bi, Yunyun Qin, Wenli Dong, Jiahong Zhong, Mengfan Li, Yufang Cheng, Jiangping Xu, Haitao Wang
Summary: Inhibition of phosphodiesterase-4 (PDE4) can reduce depressive symptoms and inflammation in mice, showing potential as antidepressant drugs. The down-regulation of HMGB1/RAGE signaling pathway and suppression of inflammasome may contribute to the antidepressant-like effects of PDE4 inhibitors.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cardiac & Cardiovascular Systems
Weike Liu, Huajing Song, Jing Xu, Yuqi Guo, Chunju Zhang, Yanli Yao, Hua Zhang, Zhendong Liu, Yue-Chun Li
Summary: This study investigates the mechanism underlying the inhibition of endothelial mitophagy by low blood flow shear stress (SS) through the Cav-1/miR-7-5p/SQSTM1 signaling pathway. The results show that low SS suppresses endothelial mitophagy, leading to impaired mitochondrial homeostasis and endothelial dysfunction.
Article
Pharmacology & Pharmacy
Heba M. Hafez, Shaimaa Waz, Nashwa Fathy Gamal El-Tahawy, Mervat Z. Mohamed
Summary: This study found that agomelatine has a protective effect against cadmium-induced toxicity in the heart and testicles of rats, potentially through modulation of the SIRT-1/HMGB1 pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Cell Biology
He Wang, Hiromi Sakata-Haga, Hiroko Masuta, Mitsuhiro Tomosugi, Tsuyoshi Tsukada, Hiroki Shimada, Daisuke Sakai, Hiroki Shoji, Toshihisa Hatta
Summary: Research indicates that LIF indirectly increases placental Pomc expression through the CRH pathway, while directly inducing placental ACTH secretion via the JAK/STAT3 pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Zhao, Jinfan Tian, Yue Liu, Zhishuai Ye, Mingyue Xu, Rongchong Huang, Xiantao Song
Summary: This study investigates the role of toll-like receptor 4-myeloid differentiation factor 88 (TLR4-Myd88) dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and explores the underlying pathogenic mechanisms. The findings suggest that Cav-1, upregulated by TLR4-Myd88, serves as an important modulator of CAS microenvironment establishment in vivo and in vitro, making it a potential pharmacologic target for the treatment of vasospasm via reduced endothelial cell inflammation.
VASCULAR PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xianxian Yao, Danyang Chen, Bin Zhao, Binru Yang, Zhaokui Jin, Mingjian Fan, Geru Tao, Shucun Qin, Wuli Yang, Qianjun He
Summary: The development of stimuli-responsively degradable porous carriers for controlled drug release is important for clinical translation. In this study, a new type of Fe-MOF nanocrystals is engineered as an acid-degradable drug carrier and hydrogen donor. Fe-MOF nanocrystals exhibit acid-responsive degradation for H-2 generation and simultaneous drug release, and can effectively inhibit cancer metastasis and sensitize MDR cancer cells for enhanced chemotherapy. The high anti-MDR/antimetastasis efficacies and biocompatibility make Fe-MOF nanocrystals and Fe-MOF-based nanomedicine highly promising for clinical translation.
Article
Engineering, Biomedical
Yingshuai Wang, Yanxia Zhu, Penghe Zhao, Bin Wei, Mingjian Fan, Danyang Chen, Zhaokui Jin, Qianjun He
Summary: In this study, a new concept of nanoconcrete welding polymer chains is proposed, which significantly enhances the mechanical performances of polymers. The constructed porous membrane, used as a wound dressing, exhibits improved strength, toughness, and anti-fatigue properties. This nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.
BIOACTIVE MATERIALS
(2022)
Article
Biophysics
Danyang Chen, Xiaojun Liu, Yuehua Qi, Xiangbo Ma, Yong Wang, Hongzan Song, Youliang Zhao, Wenjuan Li, Jianglei Qin
Summary: In this study, a novel hemostatic hydrogel with excellent biocompatibility, tissue adhesion, hemostatic performance, and intrinsic antibacterial activity was prepared. It showed the ability to repair cracks when broken and promoted wound repair and tissue regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Computer Science, Artificial Intelligence
Danyang Chen, Xiangyu Wang, Xiu Xu, Cheng Zhong, Jinhui Xu
Summary: In this paper, we propose a novel sparse Non-negative Matrix Factorization (NMF) method for clustering uncertain data. Our method measures data similarity based on shared features and improves efficiency using a divide-and-conquer approach. We introduce a diagonal constraint to determine representatives and provide effective initialization and peeling strategies.
INTELLIGENT DATA ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Xian Bing Hou, Dan Dan Chen, Tong Fei Cheng, Dan Wang, Xiao Jun Dai, Yao Wang, Bi Xian Cui, Yuan Yuan Wang, Hui Xu, Hong Zhou Chen
Summary: This study evaluated the efficacy and safety of rectal administration of oxycodone hydrochloride (OxyContin) in cancer pain patients. The results showed that there were no significant differences in pain control between rectal administration and oral administration, and the rectal administration had lower incidence of adverse reactions.
Article
Chemistry, Physical
Ying Du, Lu Deng, Danping Chen
Summary: In this work, a novel method to improve the scintillation properties of glass-ceramics is reported. By utilizing the plasma enhancement effect and doping Ag ions, the photoluminescence intensity of CsPbBr3 quantum dot glasses was enhanced by 3 times, its radioluminescence intensity increased by 6.25 times, and its decay time was reduced. The mechanism of the enhancements was discussed based on experimental results and simulations.
Article
Multidisciplinary Sciences
Zhicheng Liu, Dongxu Lin, Yi Zhou, Linmeng Zhang, Chen Yang, Bin Guo, Feng Xia, Yan Li, Danyang Chen, Cun Wang, Zhong Chen, Chao Leng, Zhenyu Xiao
Summary: In this study, large-scale genomic profiles from ccRCC cohorts were analyzed to identify synthetic lethality pairs and potential medical targets. BRD4 and PRKDC were identified as novel targets for patients with BAP1 mutations, and two drugs, BI-2536 and PI-103, were found to have therapeutic potential for BAP1 mutant tumors. Overall, this study provides insight into ccRCC mutation patterns and offers new opportunities for personalized cancer treatment.
SCIENTIFIC REPORTS
(2022)
Article
Acoustics
Dandan Chen, Juan Xia, Shurui Xie, Yafeng He, Xiaojing Ma
Summary: This case report highlights the successful diagnosis and treatment of a rare case of unruptured right SOVA using transthoracic echocardiography, contrastive echocardiography, and transesophageal echocardiography.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Medicine, Research & Experimental
Marisa Kujawa, Megan O'Meara, Hainan Li, Liping Xu, Sai Pranathi Meda Venkata, Huong Nguyen, Morgan Minjares, Kezhong Zhang, Jie-Mei Wang
Summary: This study found that miR-200 and miR-466 are upregulated in diabetic endothelial cells, leading to increased cell permeability. These miRNAs suppress the transcription of Claudin-5, a tight junction protein, by binding to its untranslated region. In a mouse model, topical application of miR-200 inhibitor partially improved wound healing, while the combined application of miR-200 and miR-466 inhibitors showed better efficacy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Multidisciplinary Sciences
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Summary: Impaired endothelial cell (EC)-mediated angiogenesis contributes to critical limb ischemia in diabetic patients. The sonic hedgehog (SHH) pathway, which plays a role in angiogenesis, is suppressed in hyperglycemia by obscure mechanisms. This study investigated the involvement of the GPR39 receptor in SHH pathway activation and ischemia-induced angiogenesis. The findings suggest that GPR39 regulates EC migration and proliferation by suppressing SHH effector GLI1 activation through its direct binding with the SUFU inhibitor. In a diabetic animal model, GPR39 knockout mice demonstrated improved revascularization and reduced tissue necrosis compared to wild-type mice. These findings provide insights for developing therapeutic approaches targeting GPR39 for ischemic tissue repair in metabolic stress conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Morgan Minjares, Wendy Wu, Jie-Mei Wang
Summary: Reactive oxygen species (ROS) are important second messengers in signal transduction, but excessive accumulation can lead to oxidative stress and endothelial cell (EC) dysfunction. EC dysfunction causes a pro-coagulative, proinflammatory state in the vascular system, increasing the risk of cardiovascular (CV) diseases and metabolic disorders. MicroRNA treatment has been explored to regulate ROS and reduce CV risk factors. This review discusses ROS pathways and generation, EC physiology and dysfunction induced by ROS, and the connection between common metabolic disorders and oxidative stress. Therapeutic strategies based on microRNAs and their regulatory roles in controlling ROS are also discussed.
Letter
Multidisciplinary Sciences
Jie-Mei Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Jie-Mei Wang, Hainan Li, Liping Xu, Hyunbae Kim, Yining Qiu, Kezhong Zhang
Summary: Enhanced unfolded protein response (UPR) can promote wound repair through stimulating growth factor production and promoting angiogenesis, leading to rapid wound closure and regeneration.
Article
Food Science & Technology
Shijie Shi, Gaoyu Zhang, Lina Li, Dandan Chen, Juan Liu, Cougui Cao, Yang Jiang
Summary: Nitrogen fertilizer application has a direct impact on the eating quality of rice, leading to a decrease in the overall quality. This is attributed to the increased protein content in the outer layer of rice and the changes in starch structure, which result in reduced gelatinization properties of starch and overall rice quality.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Fu Zheng, Dan Tian, Dan Chen, Nana Yao, Hongbo Chen, Xiaohui Hu, Yong Lan, Su Chen
Summary: This study investigates the synchronous signal transmission method of minimally invasive renal failure surgery based on a nano molecular image probe. The nano probe is constructed by loading different signal molecules, photosensitizers, acoustic sensitizers and thermosensitives. Experimental results show that the designed nano molecular image probe has good stability and excellent transmission efficiency when applied to minimally invasive surgery.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)