期刊
JOURNAL OF IMMUNOLOGY
卷 193, 期 6, 页码 2718-2732出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1303349
关键词
-
类别
资金
- Austrian Science Fund (FWF Fonds zur Forderung der Wissenschaftlichen Forschung) [P22908]
- European Union Framework Program 7 NANOFOL [NMP4-LA-2009-228827]
- Wellcome Trust [GR076558MA]
- European Union Framework Program 7 [EC-FP7-SYBILLA-201106]
- Austrian Science Fund
- Austrian Science Fund (FWF) [P22908] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 22908] Funding Source: researchfish
The spatial and temporal organization of T cell signaling molecules is increasingly accepted as a crucial step in controlling T cell activation. CD222, also known as the cation-independent mannose 6-phosphate/insulin-like growth factor 2 receptor, is the central component of endosomal transport pathways. In this study, we show that CD222 is a key regulator of the early T cell signaling cascade. Knockdown of CD222 hampers the effective progression of TCR-induced signaling and subsequent effector functions, which can be rescued via reconstitution of CD222 expression. We decipher that Lck is retained in the cytosol of CD222-deficient cells, which obstructs the recruitment of Lck to CD45 at the cell surface, resulting in an abundant inhibitory phosphorylation signature on Lck at the steady state. Hence, CD222 specifically controls the balance between active and inactive Lck in resting T cells, which guarantees operative T cell effector functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据