Article
Biochemistry & Molecular Biology
Hamidreza Mohammadi, Gholamreza Daryabor, Ali Ghaffarian Bahraman, Majid Keshavarzi, Kurosh Kalantar, Afshin Mohammadi-Bardbori
Summary: Maintaining redox homeostasis is crucial for cell survival and functionality, as redox imbalance can lead to various pathological states. The engagement of AhR during redox alteration may influence the fate of CD4+ T cells, making AhR agonists or antagonists potentially useful in assessing immune responses. Further verification in vitro and in animal models of different diseases is needed to confirm these results.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Immunology
Simin Lu, Kang Zheng, Jianye Wang, Man Xu, Yafeng Xie, Shuai Yuan, Chuan Wang, Yimou Wu
Summary: The study evaluated the response of mice to Treponema pallidum, showing that the pathogen could colonize multiple organs and potentially penetrate the blood-brain barrier in mice. Following infection, bacterial loads were higher in tissues than in blood, and a significant Th1 immune response was recorded.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Miao Qi, Rong Liu, Bing Li, Shuai Wang, Runze Fan, Xinyi Zhao, Dehui Xu
Summary: This study investigated the behavioral effects of terahertz radiation on mice, and the results suggest that terahertz waves may enhance anti-anxiety, anti-depression, and social interaction in mice.
Article
Immunology
Jun Tang, Zhimin Liu, Hua Wu, Xi Deng, Huilong Shen, Jiaofeng Peng, Kang Zheng, Qinghua Xie
Summary: This study investigated the immunogenicity and protective efficacy of Treponema pallidum glycolytic enzyme enolase (Tp Enolase) in mice. Results showed that Tp Enolase induced the production of specific antibodies and splenocyte proliferation, as well as a Th1-biased immune response. In addition, immunization with Tp Enolase inhibited T. pallidum colonization in distal tissues.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Ainsley Lockhart, Aubrey Reed, Tiago Rezende de Castro, Calvin Herman, Maria Cecilia Campos Canesso, Daniel Mucida
Summary: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4(+) T cells. Combining antigenically defined diets with gnotobiotic models, the study shows that both food and microbiota have distinct effects on the profile and T cell receptor repertoire of intestinal CD4(+) T cells. The response of CD4(+) T cells to food is disrupted by inflammatory challenge, but protection against food allergy is associated with Treg clonal expansion and decreased proinflammatory gene expression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Virology
Huan Yang, Xiaoli Wang, Zhao Wang, Guowei Wang, Shihong Fu, Fan Li, Liping Yang, Yanping Yuan, Kaichun Shen, Huanyu Wang, Zhenhai Wang
Summary: This study established a mouse model of JEV infection using JEV GIb NX1889 strain. The model showed general neurological signs on day 3, with motor function deteriorating the most in the 10^5 PFU and 10^6 PFU groups. Microscopy and immunofluorescence staining revealed varying degrees of demyelination and axonal degeneration in the sciatic nerves. Electrophysiological recordings demonstrated peripheral neuropathy with reduced nerve conduction velocity. Increased expression of JEV-E protein and viral RNA in the injured sciatic nerves suggested its role in early stage PNI. Inflammatory cell infiltration and increased inflammatory cytokines indicated neuroinflammation involvement in JEV-induced PNI.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Andres Rojas-Ruiz, Magali Boucher, Rebecka Gill, Louis Gelinas, Fun-Qun Tom, Liah Fereydoonzad, Percival Graham, Jorge Soliz, Ynuk Bosse
Summary: This study compared the lung mechanical properties and lung volumes between C57BL/6 and BALB/c mice and found that the greater lung elastance in C57BL/6 mice is not due to a smaller lung volume but rather a stiffer lung tissue with a higher content of collagen.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sarah Thomas Broome, Alessandro Castorina
Summary: Systemic administration of rotenone in mice replicates various pathogenic and behavioral features of Parkinson's disease, and leads to neurochemical alterations at multiple levels of the central nervous system. This study demonstrates the suitability of this pre-clinical model for studying extra-nigral defects in Parkinson's disease.
Article
Biochemistry & Molecular Biology
Shiying Wu, Wanxin Cui, Qingqing Zhou, Ying Liang, Danli Wu, Yang Xu, Ping Li, Qing Gu
Summary: In this study, researchers found that phenyl lactic acid (PLA) derived from Lactobacillus plantarum ZJ316 can inhibit the growth and urease activity of Helicobacter pylori and cause a morphological transformation in vitro. In mice, PLA administration improved gastric mucosal damage caused by H. pylori and reduced inflammation and increased beneficial gut bacteria. These findings suggest that PLA can ameliorate H. pylori-induced inflammation and support beneficial gut bacteria, providing a new perspective against H. pylori infection.
Article
Immunology
Shihao Xie, Haixia Wei, Anping Peng, Anqi Xie, Jiajie Li, Chao Fang, Feihu Shi, Quan Yang, He Huang, Hongyan Xie, Xingfei Pan, Xu Tian, Jun Huang
Summary: In this study, ICOS+ Th cells were found to play an important role in inducing immune response in the spleen of C57BL/6 mice infected with Schistosoma japonicum. Additionally, Ikzf2 was identified as a key transcription factor that could regulate the expression of ICOS in the spleen of S. japonicum-infected C57BL/6 mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Harrison C. Bergeron, Zachary Beau Reneer, Aakash Arora, Stephen Reynolds, Tamas Nagy, Ralph A. Tripp
Summary: Influenza B viruses primarily infect humans and cause severe respiratory diseases, particularly in young children and the elderly. The immune response to the virus is the major cause of morbidity, mortality, and lung pathology.
Article
Biochemistry & Molecular Biology
Evgenii G. G. Skurikhin, Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Mariia Zhukova, Edgar Pan, Lubov Sandrikina, Darius Widera, Lena Kogai, Nikolai Kushlinskii, Aslan Kubatiev, Sergey G. G. Morozov, Alexander Dygai
Summary: This study demonstrates the potential of using a combination of MEK inhibitor and PD-1 blocker to reprogram human CD8(+) T-cells and target lung cancer cells, resulting in antimetastatic activity, decreased cancer cell and cancer stem cell numbers in the lungs, and increased T-cell numbers in the blood. These findings suggest a new approach to targeted lung cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rinal Sahputra, Krittee Dejyong, Adrian S. Woolf, Matthias Mack, Judith E. Allen, Dominik Ruckerl, Sarah E. Herrick
Summary: Peritoneal adhesions commonly occur after abdominal or pelvic surgery and there are currently no effective treatments available. Peritoneal macrophages have complex and nuanced responses after surgery, and differences in response among specific macrophage subpopulations partially explain the risk of developing peritoneal scars. In a mouse experiment, it was found that monocyte-derived macrophages play an important protective role in reducing adhesion formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Stacey L. P. Scroggs, Danielle K. Offerdahl, Philip E. Stewart, Carl Shaia, Amanda J. Griffin, Marshall E. Bloom
Summary: Powassan infection is caused by two closely related tick-transmitted viruses. Understanding the mechanism of chronic disease caused by these viruses is crucial for developing therapies.
Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Liliana E. Lucca, Benjamin A. Lerner, Calvin Park, Danielle DeBartolo, Brian Harnett, Varun P. Kumar, Gerald Ponath, Khadir Raddassi, Anita Huttner, David A. Hafler, David Pitt
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Article
Medicine, Research & Experimental
Pascal Azar, Jose Enrique Mejia, Claire Cenac, Arnoo Shaiykova, Ali Youness, Sophie Laffont, Asma Essat, Jacques Izopet, Caroline Passaes, Michaela Mueller-Trutwin, Pierre Delobel, Laurence Meyer, Jean-Charles Guery
Review
Biochemistry & Molecular Biology
Ali Youness, Charles-Henry Miquel, Jean-Charles Guery
Summary: Women are more susceptible to autoimmune diseases, not only due to sex hormones, but also because of X-linked genetic factors. X chromosome inactivation in female mammals results in cellular mosaicism and escape of some X-linked genes from inactivation, impacting the functional plasticity of female immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Liliana E. Lucca, Pierre-Paul Axisa, Benjamin Lu, Brian Harnett, Shlomit Jessel, Le Zhang, Khadir Raddassi, Lin Zhang, Kelly Olino, James Clune, Meromit Singer, Harriet M. Kluger, David A. Hafler
Summary: Understanding the relationship between tumor and peripheral immune environments could allow longitudinal immune monitoring in cancer. Analysis of T cells from both tumor and blood in patients with metastatic melanoma revealed that circulating T cells matching clonally expanded tumor-infiltrating T cells show gene signatures of effector functions, while features of exhaustion are predominantly displayed by tumor-exclusive T cells. Circulating TILs have unique transcriptional patterns that may be useful for interrogating T cell function in cancer immunotherapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Clinical Neurology
Heinz Wiendl, Catharina C. Gross, Jan Bauer, Doron Merkler, Alexandre Prat, Roland Liblau
Summary: This review discusses how insights from rare neuroimmunological diseases can provide fundamental understanding of disease mechanisms that can be applied to more complex diseases, and how these insights can be relevant to the study of other neuroimmunological diseases.
NATURE REVIEWS NEUROLOGY
(2021)
Review
Clinical Neurology
Josephina A. Jansen, Antonio Omuro, Liliana E. Lucca
Summary: Purpose of review: Immunotherapies, such as immune checkpoint blockade, have greatly impacted cancer treatment, but have not been as successful in improving outcomes for glioblastoma and other brain tumors. T cell dysfunction is a major barrier in the development of CNS-directed immunotherapy. Recent studies using advanced techniques such as single-cell RNA sequencing have provided insights into the transcriptional state of CNS-resident T cells and revealed differences in T cell function in glioblastoma compared to other solid tumors. Further research is needed to understand the dysfunction of tumor-infiltrating T cells in glioblastoma and explore therapeutic manipulation options.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Immunology
Claire Cenac, Ducatez F. Mariette, Jean-Charles Guery
Summary: The study found that hydroxychloroquine inhibits cleavage of TLR7 protein, leading to accumulation of full-length protein and preventing activation of pDCs in response to TLR7 stimulation. This suggests that hydroxychloroquine may inhibit ssRNA sensing by pDCs through its ability to inhibit endosomal acidification and the functional maturation of TLR7 protein.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Kristen E. Pauken, Kaitlyn A. Lagattuta, Benjamin Y. Lu, Liliana E. Lucca, Adil Daud, David A. Hafler, Harriet M. Kluger, Soumya Raychaudhuri, Arlene H. Sharpe
Summary: The T cell receptor serves as a molecular barcode tracking T cell functions and immune responses. Recent technological advances allow for single-cell TCR sequencing on an unprecedented scale.
TRENDS IN IMMUNOLOGY
(2022)
Article
Immunology
Florent Salvador, Laure Deramoudt, Frederic Lepretre, Martin Figeac, Thomas Guerrier, Julie Boucher, Mathilde Bas, Nathalie Journiac, Anneli Peters, Lennart T. Mars, Helene Zephir
Summary: The key role of B cells in multiple sclerosis is supported by various factors, such as the presence of oligoclonal bands in the cerebrospinal fluid and the efficacy of B lymphocyte depletion. Using an EAE model, this study explores the clonality of B cell response targeting myelin oligodendrocyte glycoprotein (MOG) and demonstrates the pre-clinical mobilization of the MOG-specific B cell response within brain-draining cervical lymph nodes. The study also suggests that MOG antibodies are not a reliable biomarker for disease onset and progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Reinhard Hohlfeld, Roland S. Liblau
Summary: The clinical variability of multiple sclerosis aligns with the diversity of four previously unidentified autoantigens.
Article
Biology
Flora Abbas, Claire Cenac, Ali Youness, Pascal Azar, Pierre Delobel, Jean-Charles Guery
Summary: This study found that pDCs from HIV/ART women exhibited exacerbated production of IFN-alpha and TNF-alpha compared with uninfected controls upon TLR7 activation. The enhanced functional response was associated with higher transcriptional activity of the TLR7 locus from both X chromosomes, rather than differences in the frequency of TLR7 biallelic cells.
LIFE SCIENCE ALLIANCE
(2022)
Article
Immunology
Charles-Henry Miquel, Flora Abbas, Claire Cenac, Charlotte Foret-Lucas, Chang Guo, Mariette Ducatez, Etienne Joly, Baidong Hou, Jean-Charles Guery
Summary: TLR7 plays a crucial role in the recognition of single-stranded RNA and triggering antiviral immune responses. TLR7 loss-of-function mutants are associated with life-threatening pneumonia in severe COVID-19 patients. This study demonstrates that TLR7 is essential for the adaptive B-cell response and the production of specific antibodies to SARS-CoV2.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
Laure Deramoudt, Shin Yi Yu, Nathalie Journiac, Mathilde Bas, Celine Monnet, Jan Bauer, Yann Guerardel, Helene Zephir, Lennart T. Mars
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Juhi R. Kuchroo, David A. Hafler, Arlene H. Sharpe, Liliana E. Lucca
Summary: Immune checkpoint blockade has shown success in cancer treatment but can result in immune-related adverse events. The control of T cell responses by programmed cell death protein 1 (PD-1) is discussed, with a focus on its specific restraint of regulatory T cell function. Strategies to modulate PD-1 blockade to enhance anti-tumor immunity while limiting autoimmunity are reviewed.
SCIENCE IMMUNOLOGY
(2021)
Review
Immunology
Liliana E. Lucca, Margarita Dominguez-Villar
NATURE REVIEWS IMMUNOLOGY
(2020)