期刊
JOURNAL OF IMMUNOLOGY
卷 192, 期 10, 页码 4483-4486出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1303022
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资金
- Max Planck Society
Mice lacking the lymphocyte-specific transcription factor Bob1 (also called OBF-1 or OCA-B) fail to generate germinal centers and a robust Ig response. We show that peripheral B cells in Bob1(-/-) mice bear characteristics of chronically activated or anergic-like B cells and identify the immunosuppressive microRNA-146a, together with other microRNAs, as novel transcriptional targets of Bob1. The inability to restrict B cell signaling could contribute to the immunodeficient phenotype of these mice and is consistent with an important role for Bob1 in suppressing B cell activation in vivo.
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