Article
Cell Biology
Guanyi Liu, Dingyang Li, Liwei Zhang, Qiuping Xu, Dexuan Zhuang, Panpan Liu, Ling Hu, Huiting Deng, Jianfeng Sun, Shuangshuang Wang, Bin Zheng, Jing Guo, Xunwei Wu
Summary: This study demonstrates that phenformin can suppress acute skin inflammatory responses and pro-inflammatory cytokines in keratinocytes, potentially playing an anti-inflammatory role in skin disorders.
Review
Immunology
Shin Morizane, Tomoyuki Mukai, Ko Sunagawa, Kota Tachibana, Yoshio Kawakami, Mamoru Ouchida
Summary: This review aims to provide a foundation of knowledge on the cytokines recognized or produced by epidermal keratinocytes, deepening our understanding of the role of cytokines in inflammatory skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Maysa Alves Rodrigues Brandao-Rangel, Carlos Rocha Oliveira, Fabiana Regina da Silva Olimpio, Flavio Aimbire, Jose Roberto Mateus-Silva, Felipe Augusto Chaluppe, Rodolfo P. Vieira
Summary: This study investigated the effects of collagen peptides on the proliferation and activation of fibroblasts and keratinocytes. The results showed that collagen peptides can promote cell proliferation and reduce inflammatory responses caused by lipopolysaccharide.
Article
Immunology
Sophia Keddache, Caroline Laheurte, Laura Boullerot, Lucie Laurent, Jean-Charles Dalphin, Olivier Adotevi, Thibaud Soumagne
Summary: Inflammatory responses in COPD patients secondary to organic dust exposure differ from those in COPD patients due to tobacco smoking. OD-COPD patients exhibit higher levels of type 2 immunity related cytokines, while T-COPD patients have lower levels of IL-13 after flagellin stimulation.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Shengyuan Zhao, Julia A. Goewey A. Ruiz, Manu Sebastian, Dawit Kidane
Summary: This study reveals that a dRP lyase deficient variant of POLB increases mitotic dysfunction associated genomic instability, leading to a cytosolic DNA mediated inflammatory response. Additionally, inhibiting poly(ADP-ribose) polymerase 1 exacerbates chromosomal instability and enhances the cytosolic DNA mediated inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Giorgos Bamias, Theresa T. Pizarro, Fabio Cominelli
Summary: This review describes the cellular and molecular immunological mechanisms of intestinal fibrosis in IBD, with a particular focus on animal models of intestinal fibrosis. Based on this research, potential future targets for antifibrotic therapies for IBD patients can be identified.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Veterinary Sciences
Diego Piantedosi, Nadia Musco, Anna Teresa Palatucci, Flavia Carriero, Valentina Rubino, Francesco Pizzo, Saad Nasir, Giuseppe Molinaro, Giuseppina Ruggiero, Giuseppe Terrazzano, Pietro Lombardi, Laura Cortese
Summary: Myxomatous mitral valve disease (MMVD) is a common cardiac disease in dogs, leading to congestive heart failure. This study found that inflammation parameters increased with the severity of the disease, suggesting that inflammation activation may play an important role in cardiac remodeling associated with MMVD. Additionally, an increase in Treg cells was observed, indicating their regulatory role in limiting the inflammatory immune response.
VETERINARY SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Immunology
Qigao Chen, Baodan Yu, Yihao Yang, Jiewen Huang, Ying Liang, Jing Zhou, Lianzhong Li, Xuechun Peng, Bolin Cheng, Yongping Lin
Summary: The study found that levels of IP-10, MCP-1, MIG, IL-6, and IL-10 were significantly higher in critically ill/severe COVID-19 patients, while CD8 T cells in these patients showed high levels of cytotoxic granules and hyperactivation. Additionally, there were reductions in the cytotoxic potential of NK cells, as well as in the frequencies of myeloid dendritic cells and plasmacytoid dendritic cells in severe and critical COVID-19 patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Roberto Gramignoli, Aarati R. Ranade, Raman Venkataramanan, Stephen C. Strom
Summary: Pro-inflammatory cytokines can affect liver cell functions, particularly ammonia and drug metabolism, but do not necessarily indicate rejection or loss of cell graft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
G. Bendotti, L. Montefusco, I. Pastore, E. Lazzaroni, M. E. Lunati, P. Fiorina
Summary: This review discusses the anti-inflammatory and immunological properties of SGLT-2 inhibitors and how these properties contribute to their beneficial effects in diabetes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Sakuni Rankothgedera, Inoshi Atukorala, Chandrika Fernando, Duminda Munidasa, Lalith Wijayaratne, Preethi Udagama
Summary: In this study, serum levels of pro-inflammatory cytokines were found to be significantly higher in sKOA patients compared to pKOA patients, with a concurrent decrease in anti-inflammatory cytokine levels. The CombiROC analysis identified specific panels of potential diagnostic markers for differentiating between pKOA and sKOA. This may aid in the development of distinct therapeutic agents for each type of KOA.
Article
Immunology
Natalia Kordulewska, Justyna Topa, Anna Cieslinska, Beata Jarmolowska
Summary: OST was found to suppress inflammatory responses by regulating the secretion of IL-113, TNF-alpha, CCL2/MCP-1, and CCL5/RANTES, as well as the expression of TLR2 and COX-2 during histamine/LPS-induced inflammation in human keratinocytes and fibroblasts. Additionally, it improved cell migration and barrier function.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Yuting Luo, Yafeng Xie, Jiayi Chen, Jiahuan Zhou, Feijun Zhao, Shuangquan Liu, Tiebing Zeng, Man Xu, Yongjian Xiao
Summary: This study found that T. pallidum FlaA2 activates the ERK, p38, and NF-Kappa B signaling pathways through the TLR2 pathway, inducing the production of IL-6 and IL-8, which enhance the understanding of the skin inflammatory response induced by the pathogen in syphilis patients.
MICROBIAL PATHOGENESIS
(2022)
Review
Immunology
Hayder M. Al-Kuraishy, Thabat J. Al-Maiahy, Ali I. Al-Gareeb, Athanasios Alexiou, Marios Papadakis, Omnya Elhussieny, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Progesterone (P4) may play a beneficial role in COVID-19 by modulating inflammatory signaling pathways, inducing the release of anti-inflammatory cytokines, and inhibiting the release of pro-inflammatory cytokines. It may also activate regulatory T cells and reduce the severity of lung and neurological complications.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Hematology
Maria Gluud, Emil M. H. Pallesen, Terkild B. Buus, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Maria R. Kamstrup, Michael Bzorek, Maria Danielsen, Rikke Bech, Madalena N. Monteiro, Edda Blumel, Andreas Willerslev-Olsen, Anders Lykkebo-Valloe, Chella Krishna Vadivel, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Carsten Geisler, Juergen C. Becker, Sergei B. Koralov, Lars Iversen, Thomas Litman, Anders Woetmann, Niels Odum
Summary: Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms and increase the risk of bacterial infection. The study found that malignant T cells secrete cytokines that downregulate the expression of filaggrin and filaggrin-2, leading to compromised skin barrier. Treatment with JAK inhibitors can reverse this effect and increase filaggrin expression in patients with advanced CTCL.
Article
Dermatology
Cathrine Dawn Buttner Elgaard, Lars Iversen, Kasper Fjellhaugen Hjuler
Summary: This study retrospectively analyzed the drug survival and effectiveness of interleukin-23 inhibitors in the treatment of psoriasis and psoriatic arthritis in a real-world setting. The results showed that these drugs have high and similar drug survival and effectiveness in patients with difficult-to-treat psoriasis and PsA.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Letter
Dermatology
Simon Fage, Claus Johansen
Summary: This article reports the convincing and rapid effect of oral roflumilast in a patient with treatment-resistant severe oral erosive lichen planus.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Urology & Nephrology
Simon Kok Jensen, Uffe Heide-Jorgensen, Soren Viborg Vestergaard, Henrik Gammelager, Henrik Birn, Dorothea Nitsch, Christian Fynbo Christiansen
Summary: This study examined the long-term changes in kidney function following acute kidney injury (AKI). It found that AKI had an impact on estimated glomerular filtration rate (eGFR) levels and slopes. The results showed a decrease in eGFR levels and changes in slopes, which depended on the baseline eGFR before AKI.
CLINICAL KIDNEY JOURNAL
(2023)
Editorial Material
Dermatology
Hakim Ben Abdallah, Claus Johansen
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Catalina Hartmann Skovsgard, Trine Bay Laurberg, Anders Dige, Lars Iversen, Kasper Fjellhaugen Hjuler
Summary: The aim of this study was to determine the proportion of psoriasis patients with suspicion of PsA who are diagnosed with PsA or other rheumatologic conditions following referral from a dermatology department. A total of 23.6% of patients with psoriasis with symptoms suggestive of PsA were diagnosed with axial and/or peripheral arthritis following rheumatologic evaluation.
Article
Dermatology
Emil M. H. Pallesen, Maria Gluud, Chella Krishna Vadivel, Terkild B. Buus, Bob de Rooij, Ziao Zeng, Sana Ahmad, Andreas Willerslev-Olsen, Christian Roehrig, Maria R. Kamstrup, Lene Bay, Lise Lindahl, Thorbjorn Krejsgaard, Carsten Geisler, Charlotte M. Bonefeld, Lars Iversen, Anders Woetmann, Sergei B. Koralov, Thomas Bjarnsholt, Johan Frieling, Mathias Schmelcher, Niels Odum
Summary: This study investigates the effect of a recombinant, antibacterial protein, endolysin (XZ.700), on S. aureus skin colonization and malignant T-cell activation in cutaneous T-cell lymphomas. The results show that endolysin strongly inhibits S. aureus proliferation in the skin of lymphoma patients and reduces bacterial cell counts in a dose-dependent manner. Moreover, endolysin also inhibits the colonization of S. aureus on healthy and lesional skin and has a significant inhibitory effect on the activation and proliferation of malignant T cells induced by S. aureus.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Hakim Ben Abdallah, Sabine Seeler, Anne Bregnhoj, Gautam Ghatnekar, Lasse S. Kristensen, Lars Iversen, Claus Johansen
Summary: RGRN-305, an HSP90 inhibitor, exhibits anti-inflammatory effects by suppressing key proinflammatory cytokines and signaling pathways in TPA-induced skin inflammation. This study suggests that HSP90 inhibition may be a novel mechanism of action for treating immune-mediated skin diseases beyond psoriasis, and it may serve as a topical treatment option.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Mette Gyldenlove, Howraman Meteran, Jennifer A. Sorensen, Simon Fage, Yiqiu Yao, Jesper Lindhardsen, Christoffer V. Nissen, Tanja Todberg, Simon F. Thomsen, Lone Skov, Claus Zachariae, Lars Iversen, Mia -Louise Nielsen, Alexander Egeberg
Summary: This study demonstrates the efficacy and safety of oral roflumilast in treating moderate-to-severe psoriasis, suggesting that it may serve as a cost-effective and convenient alternative treatment option.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Dermatology
Mark Lebwohl, Lars Iversen, Liv Eidsmo, James G. Krueger, Mayte Suarez-Farinas, Lewis Tomalin, Frank Kolbinger, Ruquan You, Marina Milutinovic
Summary: A proportion of patients stayed relapse-free following discontinuation of secukinumab, and patients with shorter disease duration remained relapse-free for longer, suggesting that earlier treatment with secukinumab may result in long-term clinical control of moderate-to-severe psoriasis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Virology
Kristoffer Skaalum Hansen, Sofie Eg Jorgensen, Morten Kelder Skouboe, Jane Agergaard, Berit Schiottz-Christensen, Line Khalidan Vibholm, Martin Tolstrup, Lars Ostergaard, Steffen Leth, Trine H. Mogensen
Summary: Long COVID is an emerging global health concern, and its underlying mechanism and pathophysiology are still unclear. This study found that autoantibodies against type 1 interferons in patients with Long COVID do not contribute to the symptoms.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Urology & Nephrology
Philip Vestergaard Munch, Uffe Heide-Jorgensen, Simon Kok Jensen, Henrik Birn, Soren Viborg Vestergaard, Jorgen Frokiaer, Henrik Toft Sorensen, Christian Fynbo Christiansen
Summary: In this study, the CKD-EPI21 equation performed slightly better than the CKD-EPI09-NB equation in Danish patients, especially in the total cohort, cancer patients, and potential living kidney donors. Although the CKD-EPI09-NB equation performed slightly better in patients with mGFR <60 mL/min/1.73 m(2), the differences were considered clinically insignificant.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Ane Emilie Friis Vestergaard, Simon Kok Jensen, Uffe Heide-Jorgensen, Kasper Adelborg, Henrik Birn, Juan-Jesus Carrero, Christian Fynbo Christiansen
Summary: This nationwide cohort study investigated the association between the use of DOACs and the risks of kidney complications in patients with atrial fibrillation compared to VKAs.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hakim Ben Abdallah, Anne Bregnhoj, Lars Iversen, Claus Johansen
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease with limited treatment options. This study used transcriptomic approaches to investigate the underlying inflammatory pathways and cell types in hidradenitis suppurativa, revealing the activation of multiple inflammatory processes and the involvement of lymphoid and myeloid cells. The study also found increased expression of TH1/2/17 signatures in hidradenitis suppurativa. These findings provide molecular insights into the pathomechanisms of hidradenitis suppurativa and suggest potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Azadeh Reyahi, Marie Studahl, Morten K. Skouboe, Stefanie Fruhwurth, Ryo Narita, Fanghui Ren, Moa Bjerhem Viklund, Marie B. Iversen, Mette Christiansen, Alexandra Svensson, Trine H. Mogensen, Kristina Eriksson, Soren R. Paludan
Summary: This study reveals the importance of the IKBKE gene and the cGAS/STING pathway in protecting against recurrent HSV-2 meningitis. A monoallelic variant in the IKBKE gene was identified in a patient with multiple episodes of HSV-2 meningitis, leading to impaired induction of IFN genes and decreased antiviral activity. The patient allele encoded a truncated IKK epsilon protein with loss of kinase activity and dominant-negative activity. Reintroducing wild-type IKBKE into patient cells restored IFN induction and antiviral activity. These findings highlight the nonredundant role of the cGAS/STING pathway in human antiviral immunity.