Article
Cell Biology
Nupur Aggarwal, M. Elizabeth Deerhake, Devon DiPalma, Shailesh K. Shahi, Margaret R. Gaggioli, Ashutosh K. Mangalam, Mari L. Shinohara
Summary: This study demonstrates that OPN generated by CD4(+) T cells helps control aGVHD by limiting gastrointestinal pathology and modulating gut microbiota. Secreted OPN (sOPN) is solely responsible for the protective role of OPN.
Article
Oncology
Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan, Priya Ramanathan
Summary: Dendritic cell-based immunotherapy utilizing recombinant human SPAG9 shows promise in stimulating CD4(+) and CD8(+) T cell responses for cervical cancer patients. The study suggests rhSPAG9 as a strong immunogen for DC-based immunotherapy and highlights the potential of a combinatorial regimen with cisplatin for therapeutic intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Gregory S. Whitehead, Seddon Y. Thomas, Keiko Nakano, Derek J. Royer, Catherine G. Burke, Hideki Nakano, Donald N. Cook
Summary: The type of adjuvant used during allergic sensitization has a profound effect on the nature and longevity of the pulmonary inflammation triggered by subsequent reexposure to the same allergen.
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Summary: In this study, the deficiency of CD1d-restricted iNKT cells was found to lead to the expansion of Foxp3(-)CD25(+)CD4(+) T cells in colitis. The MLN dendritic cells in DSS-treated Yeti/CD1d KO mice were shown to promote the differentiation of these cells. Furthermore, Foxp3(-)CD25(+)CD4(+) T cells were found to be pathogenic in DSS-treated Yeti/CD1d KO mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Therese Woodring, Colin N. Dewey, Lucas Dos Santos Dias, Xin He, Hannah E. Dobson, Marcel Wuthrich, Bruce Klein
Summary: Using single cell transcriptome analysis, we identified transcriptionally diverse and distinctive antigen-specific T cells associated with protective vaccine-induced immunity. These cells exhibited a strong type I interferon response and high expression of the natural killer cell marker gene NKG7. We also observed differences in TCR gene use and Th1 and Th17 skewed responses after protective and nonprotective vaccination.
Article
Multidisciplinary Sciences
Louise Malle, Roosheel S. Patel, Marta Martin-Fernandez, O'Jay Stewart, Quentin Philippot, Sofija Buta, Ashley Richardson, Vanessa Barcessat, Justin Taft, Paul Bastard, Julie Samuels, Clotilde Mircher, Anne-Sophie Rebillat, Louise Maillebouis, Marie Vilaire-Meunier, Kevin Tuballes, Brad R. Rosenberg, Rebecca Trachtman, Jean-Laurent Casanova, Luigi D. Notarangelo, Sacha Gnjatic, Douglas Bush, Dusan Bogunovic
Summary: Individuals with Down's syndrome (DS) exhibit multiple impairments such as cardiac, neurocognitive, and growth issues. They are also prone to severe infections and autoimmune disorders. This study reveals an autoimmune-prone state in DS characterized by persistent elevation of cytokines, chronic activation of CD4 T cells, and ongoing B cell activation. Furthermore, auto-antibodies targeting various organs and systems were detected in DS individuals' plasma, suggesting a breach in immune tolerance.
Article
Biochemistry & Molecular Biology
Alessia Furgiuele, Franca Marino, Emanuela Rasini, Massimiliano Legnaro, Alessandra Luini, Maria Giulia Albizzati, Alessia di Flora, Barbara Pacchetti, Marco Cosentino
Summary: This study investigated the effects of CBD on human peripheral blood mononuclear cells (PBMCs) and CD4+ T cells, and found that CBD can affect cytokine production, cell proliferation, and the functional properties of regulatory T cells. However, the effects of CBD on cell proliferation and protein production were inconsistent, suggesting a complex activity that warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Anil Verma, Jesse D. Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L. Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O'Connor, Stephen J. McSorley, John H. Morrison, Nam K. Tran, Graham Simmons, Michael P. Busch, Pamela A. Kozlowski, Koen K. A. Van Rompay, Christopher J. Miller, Smita S. Iyer
Summary: Induction of CD4 T follicular helper (Tfh) cells is crucial for antibody responses to viral infections, as shown in a rhesus macaque model of mild COVID-19 where SARS-CoV-2 infection resulted in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and the generation of germinal center Tfh cells specific for viral proteins.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Jie Lu, Kun Sun, Huiping Yang, Dan Fan, He Huang, Yi Hong, Shuiyan Wu, HuiTing Zhou, Fang Fang, YanHong Li, Lijun Meng, Jie Huang, Zhenjiang Bai
Summary: Sepsis-induced systemic inflammation impairs hematopoietic stem and progenitor cells (HSPCs) in producing dendritic cells (DCs), leading to decreased numbers and functions of DCs. The study found significantly lower levels of pDCs and cDCs in sepsis patients' peripheral blood samples compared to healthy donors, along with increased DC apoptosis and reduced HSPC progenitors. Additionally, sepsis-associated cytokines like G-CSF and IFN-gamma were shown to inhibit DC development from cultured HSPCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huan Xia, Yongmei Wang, Jie Dai, Xin Zhang, Jun Zhou, Zhu Zeng, Yi Jia
Summary: Selenoprotein K is crucial for the migration and phagocytosis of dendritic cells, and its effects are related to endoplasmic reticulum stress levels and calcium ion concentration.
Article
Biochemistry & Molecular Biology
Xianmei Liu, Peng Yu, Yujun Xu, Yun Wang, Jin Chen, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu, Yuannong Ye, Yi Jia, Weijuan Yao, Jinhua Long, Zhu Zeng
Summary: Dendritic cells (DCs) can mediate immune responses or immune tolerance depending on their immunophenotype and functional status. Metformin can induce tolerance in DCs by reprogramming their metabolic patterns, thereby exerting anti-inflammatory effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biology
Ke Jin, Tong Li, Zhiyong Miao, Jingjing Ran, Luyu Chen, Dachao Mou, Chuang Wang, Shasha Wu, Hanshuo Yang, Xin-Yuan Fu
Summary: This study reveals a novel role of Stat5 in regulating tumor-specific Th17 cell differentiation and function in melanoma, providing new possibilities for developing immunotherapies for melanoma patients.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Immunology
Hanna Abberger, Romy Barthel, Jasmin Bahr, Jacqueline Thiel, Sina Luppus, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: The study found that in activated CD4(+) non-Tregs, Nrp-1 expression has an activating role, while in CD4(+) non-Tregs from naive mice, Nrp-1 expression leads to dysfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leng Han, Lulu Bai, Chunjing Qu, Enyong Dai, Jiao Liu, Rui Kang, Di Zhou, Daolin Tang, Yanan Zhao
Summary: The study shows that elevated ferroptosis impairs the maturation and function of dendritic cells (DCs), limiting their role in antitumor immunity. However, genetic depletion of PPARG restores the function of DCs, enhancing their antitumor immune activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marija Drakul, Sergej Tomic, Marina Bekic, Dusan Mihajlovic, Milos Vasiljevic, Sara Rakocevic, Jelena Dokic, Nikola Popovic, Dejan Bokonjic, Miodrag Colic
Summary: Sitagliptin has an effect on the differentiation and maturation of human dendritic cells, with decreased expression of some immune activity molecules and increased expression of some tolerogenic molecules. Sitagliptin-treated cells have lower ability to stimulate T-cells and suppress certain T-cell responses while enhancing immunoregulatory responses. This effect may be achieved through the inhibition of NF-kB and p38MAPK expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Susanna M. Bachle, David F. G. Malone, Marcus Buggert, Annika C. Karlsson, Per-Erik Isberg, Antonio J. Biague, Hans Norrgren, Patrik Medstrand, Markus Moll, Johan K. Sandberg, Marianne Jansson
Article
Immunology
Dominic Paquin-Proulx, Anna Gibbs, Susanna M. Bachle, Antonio Checa, Andrea Introini, Edwin Leeansyah, Craig E. Wheelock, Douglas F. Nixon, Kristina Broliden, Annelie Tjernlund, Markus Moll, Johan K. Sandberg
JOURNAL OF IMMUNOLOGY
(2016)
Article
Cell Biology
Simone P. Sittig, Ghaith Bakdash, Jorieke Weiden, Annette E. Skold, Jurjen Tel, Carl G. Figdor, I. Jolanda M. de Vries, Gerty Schreibelt
MEDIATORS OF INFLAMMATION
(2016)
Article
Chemistry, Multidisciplinary
M. Honcharenko, B. Bestas, M. Jezowska, B. A. Wojtczak, P. M. D. Moreno, J. Romanowska, S. M. Bachle, E. Darzynkiewicz, J. Jemielity, C. I. E. Smith, R. Stromberg
Article
Cell Biology
Kuntal Worah, Till S. M. Mathan, Thien Phong Vu Manh, Shivakumar Keerthikumar, Gerty Schreibelt, Jurjen Tel, Tjitske Duiveman-de Boer, Annette E. Skold, Annemiek B. van Spriel, I. Jolanda M. de Vries, Martijn A. Huynen, Hans J. Wessels, Jolein Gloerich, Marc Dalod, Edwin Lasonder, Carl G. Figdor, Sonja I. Buschow
Article
Oncology
Jasper J. P. van Beek, Mark A. J. Gorris, Annette E. Skold, Ibrahim Hatipoglu, Heleen H. Van Acker, Evelien L. Smits, I. Jolanda M. de Vries, Ghaith Bakdash
Article
Oncology
Till S. M. Mathan, Johannes Textor, Annette E. Skoeld, Inge Reinieren-Beeren, Tom van Oorschot, Mareke Bruening, Carl G. Figdor, Sonja I. Buschow, Ghaith Bakdash, I. Jolanda M. de Vries
Article
Oncology
Annette E. Skold, Till S. M. Mathan, Jasper J. P. van Beek, Georgina Florez-Grau, Michelle D. van den Beukel, Simone P. Sittig, Florian Wimmers, Ghaith Bakdash, Gerty Schreibelt, I. Jolanda M. de Vries
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Multidisciplinary Sciences
Peter Jarver, Aleksandra Dondalska, Candice Poux, AnnSofi Sandberg, Joseph Bergenstrahle, Annette E. Skold, Nathalie Dereuddre-Bosquet, Frederic Martinon, Sandra Palsson, Eman Zaghloul, David Brodin, Birgitta Sander, Kim A. Lennox, Mark A. Behlke, Samir EL-Andaloussi, Janne Lehtio, Joakim Lundeberg, Roger LeGrand, Anna-Lena Spetz
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Lucille Adam, Moises Lopez-Gonzalez, Albin Bjork, Sandra Palsson, Candice Poux, Marie Wahren-Herlenius, Carmen Fernandez, Anna-Lena Spetz
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Kariem Ezzat, Maria Pernemalm, Sandra Palsson, Thomas C. Roberts, Peter Jarver, Aleksandra Dondalska, Burcu Bestas, Michal J. Sobkowiak, Bettina Levanen, Magnus Skold, Elizabeth A. Thompson, Osama Saher, Otto K. Kari, Tatu Lajunen, Eva Sverremark Ekstrom, Caroline Nilsson, Yevheniia Ishchenko, Tarja Malm, Matthew J. A. Wood, Ultan F. Power, Sergej Masich, Anders Linden, Johan K. Sandberg, Janne Lehtio, Anna-Lena Spetz, Samir EL Andaloussi
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Candice Poux, Aleksandra Dondalska, Joseph Bergenstrahle, Sandra Palsson, Vanessa Contreras, Claudia Arasa, Peter Jarver, Jan Albert, David C. Busse, Roger LeGrand, Joakim Lundeberg, John S. Tregoning, Anna-Lena Spetz
FRONTIERS IN IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
Jeanette Linnea Tingstedt, Lasse Toftdal Dynesen, Ria Lassauniere, Hannes Uchtenhagen, Ingrid Karlsson, Guillaume Stewart-Jones, Anna-Lena Spetz, Anders Fomsgaard
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2018)
Meeting Abstract
Immunology
Peter Jarver, Aleksandra Dondalska, Annette Skold, AnnSofi Sandberg, Eman Zaghloul, David Brodin, Candice Poux, Janne Lehtio, Kim Lennox, Mark Behlke, Roger Le Grand, Samir El-Andaloussi, Anna-Lena Spetz
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2017)