Article
Immunology
Dmytro Royzman, Darja Andreev, Lena Stich, Katrin Peckert-Maier, Andreas B. Wild, Elisabeth Zinser, Petra Muehl-Zurbes, Evan Jones, Susanne Adam, Silke Frey, Maximilian Fuchs, Meik Kunz, Tobias Baeuerle, Lisa Nagel, Georg Schett, Aline Bozec, Alexander Steinkasserer
Summary: Soluble CD83 induces resolution of inflammation and prevents bone erosion in autoimmune arthritis by reducing joint swelling and expression levels, inhibiting osteoclast formation, and regulating macrophages and metallothionein expression. The signaling cascade downstream to CD83 binding involves the TRIF pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shang Li, Peng Zhang, Ao Li, Jiayu Bao, Zhiqiang Pan, Ying Jie
Summary: Supplementing TIGIT in corneal transplantation can expand and activate Helios(+)Foxp3(+) regulatory T cells, leading to immune tolerance and improved graft survival. TIGIT-Fc treatment increased the expression of TIGIT/CD226, the proportion of Helios(+)Foxp3(+) Treg cells, and the suppressive effect of Treg cells derived from peripheral lymph nodes. Additionally, TIGIT-Fc treatment downregulated CD226 expression and reduced the production of interferon-gamma and VEGF in corneal grafts.
Article
Cell & Tissue Engineering
Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan, Thomas Ritter
Summary: The study showed that low-dose subconjunctival injection of allogeneic MSCs effectively promoted corneal allograft survival, indicating a potential for improving future MSC immunotherapies for preventing corneal allograft rejection.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Liangxing Xiong, Danxin Wang, Shibu Lin, Yubin Wang, Mingwei Luo, Lianghui Gao
Summary: In this study, sCD83 was found to alleviate rejection activities in the early stage of rat liver transplantation, increase the expressions of TGF-beta and IL-10 in peripheral blood, decrease the expressions of MHC-II, CD86, and CD80 in DC cells, and increase the numbers of TGF-beta+CD4+ T cells, Treg cells, and IDO+ DC cells.
TRANSPLANT IMMUNOLOGY
(2021)
Article
Ophthalmology
Raquel Esteves Marques, Ines Leal, Paulo Silva Guerra, Rafael Correia Barao, Ana Miguel Quintas, Walter Rodrigues
Summary: Supplementing topical cyclosporine A to topical corticosteroids shows efficacy in preventing and treating corneal graft rejection post penetrating keratoplasty. The use of CsA 2% is particularly effective in high-risk patients. Further studies are required to confirm these findings.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Munetoyo Toda, Morio Ueno, Jun Yamada, Asako Hiraga, Kazuko Asada, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Summary: This study found that injection of cultured human corneal endothelial cell suspension into the anterior chamber can induce immune tolerance that contributes to the survival of reconstituted endothelium, and no signs of immune rejection were observed during the 5-8 years of postoperative follow-up.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Jin Lee, Yerang Shin, Youjin Kim, Hyeon-Su Im, Hyeyeong Kim, Su Jin Koh, Young Joo Min, Jae-Cheol Jo, Yunsuk Choi
Summary: This study investigated the serum protein profiles of patients who had undergone hematopoietic cell transplantation (HCT) to identify predictive biomarkers of severe acute graft versus host disease (GVHD). The results showed that higher levels of sVCAM-1 at baseline and on day + 14 could be significant predictive biomarkers of severe aGVHD.
Editorial Material
Ophthalmology
Hua-Hsuan Kuo, Elizabeth P. Shen
Summary: The study found that long-term use of 1% topical bevacizumab can effectively treat corneal neovascularization after PK and prevent graft rejections.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Immunology
Yanru Zhao, Xiaoyan Zheng, Miaojing Li, Jing Zhao, Xiaoning Wang, Huachao Zhu
Summary: Th17/Treg imbalance contributes to rejection in allo-HSCT. ADAR1 plays a critical role in regulating Foxp3 expression and improving Treg cell function by suppressing miR-21b production. In aGVHD mouse model, ADAR1 over-expression decreased Th17 proportion, increased Treg proportion, and improved tissue necrosis and reticular structure in liver and lung.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Lambros Kordelas, Ulrike Buttkereit, Falko M. Heinemann, Peter A. Horn, Bernd Giebel, Dietrich W. Beelen, H. Christian Reinhardt, Vera Rebmann
Summary: The study indicates that soluble PD-1 (sPD-1) levels increase significantly after allogeneic hematopoietic stem cell transplantation (HSCT) and are associated with acute GvHD, cGvHD, overall survival, and relapse. Low sPD-1 levels may predict inferior outcomes in HSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Liangmo Lin, Mianhui Hong, Xiangjun Fu
Summary: This retrospective study examined the incidence of MMF-induced diarrhea among allo-HSCT recipients, finding that the incidence rate of diarrhea was higher in the MMF group compared to the non-MMF group.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Ophthalmology
Louis Tong, Elizabeth Wen Ling Lim, Sharon Wan Jie Yeo, Aihua Hou, Yeh Ching Linn, Aloysius Ho, Hein Than, Jeffrey Kim Siang Quek, William Ying Khee Hwang, Francesca Lorraine Wei Inng Lim, Li Lim
Summary: This study aimed to investigate the conjunctival T cell populations in allogeneic hematopoietic stem cell transplant (HSCT) patients after daily instillation of Ikervis eye drops and evaluate patient tolerance. The results showed that compliant patients had stable or decreased proportions of conjunctival CD4 T cells, while non-compliant patients and one patient with ocular graft-versus-host disease (GVHD) had increased CD4 proportions. Most patients tolerated Ikervis well, but 6/19 patients were not compliant. There were no statistically significant changes in clinical variables pre- and post-HSCT, except for one participant who developed ocular GVHD at 9 months post-HSCT.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Cell Biology
Simone Dertschnig, Jakob Passweg, Christoph Bucher, Michael Medinger, Alexandar Tzankov
Summary: The Graft-versus-leukemia (GvL) effects are crucial in preventing relapses after allogeneic hematopoietic cell transplantation (allo-HCT), but the success of this procedure is limited by graft-versus-host disease (GvHD). Both CD4(+) and CD8(+) T cells play a role in GvHD and GvL. This study focused on the role of the sphingosine-1-phosphate receptor (S1PR) signaling and mocravimod, an S1PR modulator, in lymphocyte trafficking and their potential effects on allo-HCT patients.
CELLULAR IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Yun-Xia Xie, Liang-Ming Ma, Rui-Rui Ren, Wei -Wei Tian, Tao Wang
Summary: This study indicates that DLI from a second donor may be an effective treatment for SGF, with the mechanism involving MC-to-CC conversion and activation of Foxp3 and Tregs.
Article
Oncology
Ronak Nalini, Elham Roshandel, Maria Tavakoli Ardakani, Mohammad Hossein Kazemi, Haniyeh Ghaffari-Nazari, Abbas Hajifathali, Masoud Soleimani
Summary: This study identifies a high plasma level of sTIM-3 as a valuable biomarker in predicting the development of acute GVHD, especially severe aGVHD, in patients undergoing allo-HSCT.
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2022)
Article
Ophthalmology
Sarah B. Zwingelberg, Frederike Buescher, Silvia Schrittenlocher, Alexander C. Rokohl, Niklas Loreck, Philomena Wawer-Matos, Anne Fassin, Friederike Schaub, Sigrid Roters, Mario Matthaei, Ludwig M. Heindl, Bjorn O. Bachmann, Claus Cursiefen
Summary: This study compares the long-term outcome of Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK). The results suggest that visual acuity after DMEK is comparable in PBK and FECD patients during long-term follow-up, but corneal edema recurs faster in PBK patients.
Article
Pharmacology & Pharmacy
Daniele La Russa, Domenico Montesano, Daniela Pellegrino, Marialaura Frisina, Giacinto Bagetta, Francesca Fallarino, Diana Amantea
Summary: Sunflower oil, with its high antioxidant potential, has shown promising effects in reducing brain infarct volume and edema, as well as preventing brain lipid peroxidation caused by cerebral ischemic injury in mice. It also helps maintain serum biological antioxidant potential, which is crucial for the prevention and treatment of cerebral ischemia.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Ophthalmology
Lebriz Altay, Julia Lemke, Jutta Schroeder-Braunstein, Caroline Gietzelt, Vasilena Sitnilska, Friederike Schaub, Claus Cursiefen, Philip Enders, Sascha Fauser
Summary: The aim of this study was to investigate the influence of dietary supplementation using Age-Related Eye Disease Study 2 (AREDS2) on complement activation in patients with neovascular age-related macular degeneration (nAMD) under ongoing treatment. The results showed that short-term dietary AREDS2 supplementation leads to a significant increase in systemic zinc levels without any influence on complement activation levels.
Article
Cardiac & Cardiovascular Systems
Jesus Gil-Pulido, Nuria Amezaga, Ivana Jorgacevic, Helga D. Manthey, Melanie Roesch, Theresa Brand, Peter Cidlinsky, Sarah Schafer, Andreas Beilhack, Antoine-Emmanuel Saliba, Kristina Lorenz, Louis Boon, Immo Prinz, Ari Waisman, Thomas Korn, Clement Cochain, Alma Zernecke
Summary: IL-23R(+) gamma delta T cells predominantly found in the aortic root promote early atherosclerotic lesion formation, plaque necrosis, and inflammation at this site. Targeting IL-23R may be explored as a therapeutic approach to mitigate atherosclerotic lesion development.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Medicine, General & Internal
Paolo Puccetti, Francesca Fallarino
Article
Ophthalmology
Verena Schoeneberger, Somaie Eberhardt, Leonie Menghesha, Philip Enders, Claus Cursiefen, Friederike Schaub
Summary: This study investigated the association between anatomical features of rhegmatogenous retinal detachment (RRD) and the extent of blood-aqueous barrier disorder. The results showed that lens status and the extent of retinal detachment can influence the level of objective tyndallometry in RRD.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Hematology
Vincenzo Maria Perriello, Lorenza Falini, Loredana Ruggeri, Alessandra Innocente, Stelvio Ballanti, Cinzia Costa, Massimiliano Di Filippo, Marco Gargaro, Francesca Fallarino, Brunangelo Falini
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Ophthalmology
Verena Schoeneberger, Leonie Menghesha, Stefanie Gerlach, Caroline Gietzelt, Somaie Eberhardt, Claus Cursiefen, Friederike Schaub
Summary: This study investigated the association between lens opacity and flare value in a large cohort of phakic eyes, and found that lens status, degree of lens opacity, and age are correlated with objective tyndallometry measurements.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emilia Nunzi, Letizia Mezzasoma, Ilaria Bellezza, Teresa Zelante, Pierluigi Orvietani, Giuliana Coata, Irene Giardina, Krizia Sagini, Giorgia Manni, Alessandro Di Michele, Marco Gargaro, Vincenzo N. Talesa, Gian Carlo Di Renzo, Francesca Fallarino, Rita Romani
Summary: In this study, researchers investigated the effect of human amniotic fluid extracellular vesicles (HAF-EVs) on inflammasome activation in monocytes. They found that HAF-EVs expressed immunoregulatory molecules and small amounts of endotoxin. Surprisingly, metagenomic analysis revealed the presence of specific bacterial strain variants associated with HAF-EVs as potential sources of endotoxin. These findings suggest that HAF-EVs may play a role in immune modulation and could serve as a source of specific microbiota during early pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Giorgia Manni, Sandra Buratta, Maria Teresa Pallotta, Davide Chiasserini, Alessandro Di Michele, Carla Emiliani, Stefano Giovagnoli, Luisa Pascucci, Rita Romani, Ilaria Bellezza, Lorena Urbanelli, Francesca Fallarino
Summary: Extracellular vesicles (EVs) are membrane-enclosed particles secreted by cells and circulating in body fluids. They not only serve as a tool for waste disposal, but also transmit cell signals. Aging is characterized by genomic instability, telomere erosion, epigenetic alteration, and defective proteostasis. Studies have shown that EVs released in cell models are associated with these aging hallmarks and can spread senescence signals. Furthermore, EVs have great potential as anti-aging tools. Although this is a recent field, altered EV secretion in aging suggests it as an emerging hallmark of aging.
Article
Biology
Thomas Volatier, Bjoern Schumacher, Berbang Meshko, Karina Hadrian, Claus Cursiefen, Maria Notara
Summary: Ultraviolet light from the sun causes DNA damage, especially to the skin and eyes of humans. Two repair enzymes from the kangaroo rat and an anti-bacterial virus show potential in repairing UV-induced lesions. While research and commercial products exist for skin repair, there is little research and no available products for eye protection. Our study aims to offer new options for protecting the eyes, which are particularly sensitive to UV rays and require rapid repair.
Article
Cell Biology
Berbang Meshko, Thomas L. A. Volatier, Karina Hadrian, Shuya Deng, Yanhong Hou, Mark Andreas Kluth, Christoph Ganss, Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Claus Cursiefen, Maria Notara
Summary: The limbal epithelial stem cell (LESC) marker ABCB5 was used to investigate its role in corneal neovascularization. It was found that ABCB5 caused an increase in limbal lymphatic and blood vessel complexity in developing mice, but not in adult mice. Furthermore, in an inflammatory challenge, ABCB5 had a pro-lymphangiogenic effect. In addition, ABCB5-positive cells stimulated blood and lymphatic endothelial cell proliferation and migration, and had both pro-(lymph) angiogenic and anti-inflammatory properties.
Article
Biochemistry & Molecular Biology
Letizia Mezzasoma, Ilaria Bellezza, Pierluigi Orvietani, Giorgia Manni, Marco Gargaro, Krizia Sagini, Alicia Llorente, Paolo Scarpelli, Luisa Pascucci, Barbara Cellini, Vincenzo Nicola Talesa, Francesca Fallarino, Rita Romani
Summary: This study investigated the ability of human amniotic stem cell-derived extracellular vesicles (HASC-EVs) to interfere with inflammasome activation in THP-1 cells. The results showed that HASC-EVs were not internalized or directly interacted with THP-1 cells. HASC-P10 and P100 subsets of HASC-EVs were found to intrinsically produce ATP, which was converted to adenosine by CD73 and CD39 enzymes. Additionally, treatment of THP-1 cells with HASC-EVs prevented the activation of the NLRP3/caspase-1/inflammasome platform, involving the activation of A2a adenosine receptor. These findings suggest that HASC-EVs function as independent metabolic units capable of modulating cellular functions and exerting anti-inflammatory effects in monocytic cells.
Article
Medicine, Research & Experimental
Frank L. van de Veerdonk, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Giuseppe Servillo, Francesca Fallarino, Antonella De Luca, Rossana G. Iannitti, Danilo Piobbico, Marco Gargaro, Giorgia Manni, Fiorella D'Onofrio, Claudia Stincardini, Luigi Sforna, Monica Borghi, Marilena Castelli, Stefania Pieroni, Vasileios Oikonomou, Valeria R. Villella, Matteo Puccetti, Stefano Giovagnoli, Roberta Galarini, Carolina Barola, Luigi Maiuri, Maria Agnese Della Fazia, Barbara Cellini, Vincenzo Nicola Talesa, Charles A. Dinarello, Claudio Costantini, Luigina Romani
Summary: It has been discovered that anakinra can improve protein stability issues in patients with cystic fibrosis by promoting autophagy driven by oxidative stress. By modulating oxidative stress and autophagy processes, anakinra not only restores defective proteostasis but also has anti-inflammatory properties.
JOURNAL OF CLINICAL INVESTIGATION
(2022)