Article
Medicine, Research & Experimental
Jing Chang, Bin Zhou, Zhu Wei, Yongqi Luo
Summary: This study identifies the mechanism by which IL-32 affects atopic dermatitis through the JAK1/miR-155 axis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Biochemistry & Molecular Biology
Yi-Chun Chen, Yu-Show Fu, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Wei-Ming Chen, Cheng-Fong Chen
Summary: MSCs derived from bone marrow, adipose tissue, and Wharton's jelly have the potential to promote angiogenesis in tissue regeneration. This study compares the angiogenic effects of secretomes from different sources of MSCs and identifies IL-1b as a key factor in angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Xinmei Huang, Yue Li, Xiaoxu Tong, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Zaoping Chen, Tiange Sun, Fang Wang, Qian Yang, Zhangyan Li, Cuijun Gao, Ling Ma, Heyuan Ding, Shufei Zang, Ni Yang, Tie-Ning Zhang, Jun Liu
Summary: Increased circulating IL-32 throughout pregnancy is closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Yang Si, Jiwei Zhang, Shisan Bao, Steven G. G. Wise, Yuli Wang, Yanfang Zhang, Yuhong Tang
Summary: Hepatocellular carcinoma (HCC) has a high mortality and morbidity rate, and its development is influenced by multiple factors such as viral infection, alcoholism, and non-alcoholic fatty liver disease. Dysregulated host immunity plays a significant role in tumorigenesis among susceptible individuals. IL-32 and IL-34, key cytokines involved in chronic inflammatory conditions, also contribute to the development of HCC by influencing inflammation. This review provides insights into the latest research on IL-32 and IL-34 in HCC, highlighting their potential as therapeutic targets in precision medicine.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Dan Li, Jiaping Tang, Ruifang Gao, Jinxin Lan, Wenzhi Shen, Yanhua Liu, Yanan Chen, Hongwei Sun, Jie Yan, Yongwei Nie, Na Luo
Summary: Breast cancer is a major global health concern, and the process of angiogenesis and metastasis plays a crucial role in its progression. This study investigates the role of PFKFB4 in breast cancer angiogenesis and provides evidence that PFKFB4 regulates IL-6 expression and lactate secretion to promote angiogenesis. Furthermore, a specific PFKFB4 inhibitor, 5-MPN, is found to suppress angiogenesis, suggesting its potential as a therapeutic strategy for breast cancer patients.
Article
Immunology
Grazzielle Guimaraes de Matos, Ana Marina Barroso de Figueiredo, Pedro Hugo Diniz Goncalves, Lucas Luiz de Lima Silva, Aline Carvalho Bastista, Clayton Luiz Borges, Celia Maria de Almeida Soares, Leo A. B. Joosten, Fatima Ribeiro-Dias
Summary: IL-32 is highly detected in PCM lesions, its production in PBMCs is dependent on the Dectin-1 receptor, IL-15 can induce IL-32, and together IL-15 and IL-32 can increase fungicidal activity of PBMCs.
MICROBIAL PATHOGENESIS
(2021)
Article
Oncology
Junmei Zhang, Xuyuan Sun, Lingling Zhong, Bei Shen
Summary: IL-32 may play a role in the progression of AH by promoting inflammation, and the potential mechanism may involve NLRP3-mediated pyroptosis. IL-32 concentration-dependently affected cell proliferation, apoptosis, GSDMD activation, and inflammatory cytokine release in HNEpCs.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Shuai Song, Yahui Zhang, Xinchun Duan, Chunquan Liu, Yanlin Du, Xiaoran Wang, Yi Luo, Yong Cui
Summary: In this study, the influence of hypoxia-treated tumor-associated macrophages (TAMs) on the malignant phenotypes of esophageal cancer (EC) cells was examined. It was found that hypoxic macrophages contributed to the proliferation, cell cycle progression, and metastasis of EC cells. Additionally, hypoxia treatment accelerated the transformation of macrophages into M2 polarization. The upregulation of interleukin-8 (IL-8) secretion by macrophages after hypoxia treatment was found to be mediated by hypoxia-inducible factor-1 alpha (HIF-1 alpha). IL-8 secreted by hypoxic macrophages further facilitated EC cell proliferation, cell cycle progression, and metastasis by elevating programmed death 1 ligand (PD-L1) expression. The study suggests that the HIF-1 alpha/IL-8 axis in hypoxic macrophages could enhance EC advancement through upregulating PD-L1 expression, providing a novel potential target for EC treatment.
CANCER GENE THERAPY
(2023)
Article
Oncology
Yixuan Sun, Yuzhen Qian, Chunxia Chen, Hongfei Wang, Xiuman Zhou, Wenjie Zhai, Lu Qiu, Xiaowen Zhou, Haoming Ning, Yumiao Zhao, Chao Shi, Lu Han, Yuanming Qi, Yahong Wu, Yanfeng Gao
Summary: We found that IL-32 was overexpressed and positively correlated to lymph node metastasis in ESCC. EV-IL-32 derived from ESCC cells could promote the polarization of M2 macrophages via the FAK-STAT3 pathway, thus promoting ESCC metastasis. These findings suggest that IL-32 could serve as a potential therapeutic target in patients with ESCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Medicine, Research & Experimental
Valerio Ciccone, Erika Terzuoli, Emma Ristori, Arianna Filippelli, Marina Ziche, Lucia Morbidelli, Sandra Donnini
Summary: This study found a correlation between the overexpression of ALDH1A1 in melanoma cells and the modification of EC Notch signaling, resulting in a pro-angiogenic phenotype. ALDH1A1 plays a crucial role in controlling the tumor microenvironment in melanoma, making it a promising target for the development of novel drugs that can disrupt the interaction between cancer (stem) cells and endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Jing Lei, Feng Xu, Chao Deng, Xubiao Nie, Li Zhong, Zhixuan Wu, Juan Li, Xiaoling Wu, Song He, Yongyu Chen
Summary: Previous studies have shown an association between gastrointestinal microbiome and esophageal cancer. This study investigated the relationship and molecular mechanism between esophageal microbiota and the early development of esophageal cancer. The findings suggest that Fusobacterium nucleatum (Fn) may play a role in promoting the early development of esophageal squamous cell carcinoma (ESCC) by upregulating the expression of IL-32/PRTN3 and activating the PI3K/AKT signaling pathway.
Article
Pharmacology & Pharmacy
Kang Wu, Jun Zeng, Xulian Shi, Jiajia Xie, Yuqing Li, Haoxiang Zheng, Guoyu Peng, Guanghui Zhu, Dongdong Tang, Song Wu
Summary: The study identified a subset of Treg cells with high expression of TIGIT and IL-32 using single-cell sequencing. This subset of Treg cells suppressed the antitumor immune response and promoted bladder cancer metastasis. However, targeting TIGIT reversed immunosuppression, inhibited IL-32 secretion, and suppressed bladder cancer cell metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Jacob T. Hough, Lei Zhao, Marco Lequio, Aidan J. Heslin, Huaping Xiao, Cade C. Lewis, Justin Zhang, Qian Bai, Mark R. Wakefield, Yujiang Fang
Summary: IL-32 is an interleukin cytokine that is associated with inflammation. It has been found to have both pro- and anti-tumor effects, making its role in cancer formation complex. Considering the role of IL-32 in various cancers and protein pathways is crucial when exploring potential therapeutic options for tumor treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biology
Siroon Bekkering, Krishan Singh, Hui Lu, Albert P. Limawan, Claudia A. Nold-Petry, Megan J. Wallace, Nigel Curtis, Salvatore Pepe, Michael Cheung, David P. Burgner, Timothy Moss
Summary: The study found that BCG vaccination can reduce the occurrence of atherosclerosis and therefore lower the risk of developing cardiovascular diseases. This research is of great significance for exploring the effects of BCG on human health.
Review
Biochemistry & Molecular Biology
Elys A. Green, Steven P. Garrick, Briana Peterson, Philip J. Berger, Robert Galinsky, Rod W. Hunt, Steven X. Cho, Jane E. Bourke, Marcel F. Nold, Claudia A. Nold-Petry
Summary: Preterm birth is a major cause of neonatal morbidity and mortality, with complications such as BPD, BPD-PH, WMI, ROP, NEC, and sepsis. Inflammation, particularly the imbalance of pro- and anti-inflammatory mediators, plays a key role in the pathophysiology of these diseases. This review focuses on the involvement of the IL-1 family in perinatal inflammation and its clinical implications, highlighting the potential of these cytokines as therapeutic targets for early life inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Sharmony B. Kelly, Elys Green, Rod W. Hunt, Claudia A. Nold-Petry, Alistair J. Gunn, Marcel F. Nold, Robert Galinsky
Summary: Perinatal inflammation is linked to lifelong neurodevelopmental impairments, and the pro-inflammatory cytokine interleukin-1 plays a critical role in this process. Inhibiting interleukin-1 with the antagonist anakinra can mitigate neuroinflammation and tissue damage. Clinical translation of interleukin-1 receptor antagonist shows promise for protecting infants at risk of perinatal inflammation and impaired neurodevelopment.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell Biology
Sara K. Di Simone, Ina Rudloff, Claudia A. Nold-Petry, Samuel C. Forster, Marcel F. Nold
Summary: Interactions between the developing microbiome and maturing immune system in early life play a critical role in establishing a beneficial homeostasis for both the host and commensals. The lung is home to a diverse community of microbes, which can be associated with health, as well as local or systemic diseases. This article discusses how the colonization and changes in the microbial community during early life correlate with immune development, health, and disease from infancy to adulthood. The authors also highlight the advances in microbiology, immunology, and computational biology that enable the investigation of the functional relevance of interactions between the respiratory microbiome and the host immune system, potentially leading to microbiome-based therapeutics.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Madison C. B. Paton, Megan Finch-Edmondson, Russell C. Dale, Michael C. Fahey, Claudia A. Nold-Petry, Marcel F. Nold, Alexandra R. Griffin, Iona Novak
Summary: Research has shown that inflammation plays a role in brain injury and the development of cerebral palsy (CP). It is believed that inflammation may persist as a comorbidity in CP, contributing to ongoing functional impairments. Studies have found significant differences in inflammatory markers between CP patients and controls, particularly cytokines such as tumor necrosis factor, Interleukin (IL)-6, and IL-10. These differences in inflammation may also vary among different subgroups of CP. Further research is needed to fully understand the complexity of inflammation and its long-term effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A. A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas
Summary: Pulmonary arterial hypertension (PAH) is characterized by pathogenic and abnormal endothelial cells (ECs), potentially resulting from clonal selection. This study explores the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) through regulation of bone morphogenetic protein (BMPR2) signaling. The findings suggest that a p53/TLR3/IRF3 axis regulates BMPR2 expression and signaling in ECs, offering a potential therapeutic target for PH.
Article
Biochemistry & Molecular Biology
Claudia Sirbe, Medeea Badii, Tania O. Crisan, Gabriel Benta, Alina Grama, Leo A. B. Joosten, Simona Rednic, Tudor Lucian Pop
Summary: Autoimmune hepatitis (AIH) is an immune-mediated liver disease that causes inflammation, liver failure, and fibrosis. This study analyzed the proteomic profiling data of pediatric AIH patients and controls and identified 16 proteins with significantly different abundance in AIH patients, which could potentially serve as biomarkers for AIH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Hadewych ter Hofstede, Jeroen Haex, Michael Belias, Marije Oosting, Leo A. B. Joosten, Foekje F. Stelma
Summary: Little is known about the dynamics of immune responses to Borrelia spp. and the development of serological markers over time after repeated exposure to tick bites. In this study, we followed 106 forestry service workers for 8 years and found that antibody levels were positively correlated with the number of tick bites, and active smoking was associated with antibody seroconversion. Overall, we rated the importance of this study as 8 out of 10.
Article
Pharmacology & Pharmacy
William R. Studley, Emma Lamanna, Katherine A. Martin, Claudia A. Nold-Petry, Simon G. Royce, Owen L. Woodman, Rebecca H. Ritchie, Cheng Xue Qin, Jane E. Bourke
Summary: The study found that the agonist 17b can maintain vasodilation under inflammatory conditions and inhibit the release of cytokines related to pulmonary arterial hypertension.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Neville J. Fields, Kirsten R. Palmer, Daniel L. Rolnik, Jennifer Yo, Marcel F. Nold, Michelle L. Giles, Sushena Krishnaswamy, Ary Serpa Neto, Ryan J. Hodges, Sarah A. Marshall, Bruce W. Hollis
Summary: This study aims to evaluate the effects of using a broccoli sprout supplement on the duration of symptoms, maternal and neonatal outcomes, and biomarkers in pregnant women with COVID-19 infection. By conducting a pilot, double-blinded, placebo-controlled randomized trial, researchers plan to enroll 60 pregnant women with COVID-19 and treat them for 14 days, assessing the feasibility and safety of the broccoli sprout supplement.
Review
Gastroenterology & Hepatology
Ralley E. Prentice, Emily K. Wright, Emma Flanagan, Rod W. Hunt, Gregory T. Moore, Claudia A. Nold-Petry, Sally J. Bell, Marcel F. Nold, Rimma Goldberg
Summary: Autoimmune and inflammatory disorders in women of childbearing age may affect the development of the neonatal immune system, potentially increasing the risk of disease. Maternal inflammation, IBD-associated intestinal dysbiosis, and the use of immunomodulatory drugs may all have an impact on infant immune system development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexander Bujotzek, Georg Tiefenthaler, Laurent Lariviere, Laura D'Andrea, Elsa A. Marquez, Ina Rudloff, Steven X. Cho, Nadia S. Deen, Wolfgang Richter, Franziska Regenass-Lechner, Alexander Poehler, James C. Whisstock, Jasmin Sydow-Andersen, Xaver Reiser, Sabine Schuster, Jeannette Neubauer, Sebastian Hoepfl, Kirsten Richter, Marcel F. Nold, Claudia A. Nold-Petry, Felix Schumacher, Andrew M. Ellisdon
Summary: This article presents the engineering of the unstable cytokine IL-37 into an anti-inflammatory molecule with excellent therapeutic properties. The use of site-directed mutagenesis, the addition of a non-native disulfide bond, and the engineering of IL-37 as an Fc-fusion protein overcame its poor pharmacokinetic and manufacturing profile. These findings provide a platform for preclinical testing of IL-37 Fc-fusion proteins and can be applied to convert similar short-acting cytokines into therapeutics.
CELL CHEMICAL BIOLOGY
(2022)