Article
Biochemistry & Molecular Biology
Dariush Haghmorad, Bahman Yousefi, Majid Eslami, Ali Rashidy-Pour, Mahdieh Tarahomi, Maryam Jadid Tavaf, Azita Soltanmohammadi, Simin Zargarani, Aleksandr Kamyshnyi, Valentyn Oksenych
Summary: This study investigated the efficacy of oral administration of Myelin Oligodendrocyte Glycoprotein (MOG) in the treatment of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). The results showed that MOG administration, both before and after EAE induction, efficiently controlled EAE development by modulating T cell proliferation and reducing pro-inflammatory cytokines.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zahra Amiri, Shahla Jalili, Mahdieh Tarahomi, Majid Eslami, Esmaeil Yazdanpanah, Rasoul Baharlou, Seyed-Alireza Esmaeili, Bahman Yousefi, Dariush Haghmorad
Summary: This study investigates the potential benefits of Curcumin in treating experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). The findings reveal that Curcumin can slow disease development and alleviate symptoms in EAE through stimulating Treg and Th2 cell polarization, providing evidence for its therapeutic role in MS.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Clinical Neurology
Jordi Kuehne Escola, Cornelius Deuschl, Andreas Junker, Fabian Dusse, Refik Pul, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: We report a rare case of autoimmune disorder following COVID-19 vaccination, presenting with symptoms similar to bacterial meningomyelitis. The patient showed significant clinical improvement with appropriate treatment.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Editorial Material
Medicine, General & Internal
Sohyeon Kim, Mi-Yeon Eun, Jae-Joon Lee, Hung Youl Seok
Summary: This study highlights the importance of recognizing the potential association between AHEM and MOGAD, especially when distinct MRI patterns are present.
Article
Biochemistry & Molecular Biology
Ana L. Vivinetto, Clara Castanares, Constanza Garcia-Keller, Cristian Falcon, Anabela Palandri, Victoria Rozes-Salvador, Juan I. Rojas, Liliana Patrucco, Clara Monferran, Liliana Cancela, Edgardo Cristiano, Ronald L. Schnaar, Ana Lis Moyano, Pablo H. H. Lopen
Summary: The activation of MAG triggers clearance of Glutamate and induces a protective antioxidant response, safeguarding oligodendrocytes and nearby neurons from damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Immunology
Maryam J. J. Tavaf, Azita Soltanmohammadi, Simin Zargarani, Esmaeil Yazdanpanah, Bizhan Sadighimoghaddam, Bahman Yousefi, Hamid R. R. Sameni, Dariush Haghmorad
Summary: This study utilized an EAE mouse model and found that low-dose and high-dose berberine can decrease the severity of EAE and alleviate its symptoms, possibly through increasing the number and function of Treg and Th2 cells, as well as its anti-inflammatory properties.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Immunology
Yuanhua Cai, Jocelyn A. A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. B. Williams, Shaoyuan Wang, Bonnie N. N. Dittel, Qizhen Shi
Summary: Targeting MOG expression to platelets using genetic engineering can prevent the development of multiple sclerosis and reduce disease severity, showing promise as a potential treatment approach.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Kathrin Schanda, Patrick Peschl, Magdalena Lerch, Barbara Seebacher, Swantje Mindorf, Nora Ritter, Monika Probst, Harald Hegen, Franziska Di Pauli, Eva-Maria Wendel, Christian Lechner, Matthias Baumann, Sara Mariotto, Sergio Ferrari, Albert Saiz, Michael Farrell, Maria Isabel S. Leite, Sarosh R. Irani, Jacqueline Palace, Andreas Lutterotti, Tania Kuempfel, Sandra Vukusic, Romain Marignier, Patrick Waters, Kevin Rostasy, Thomas Berger, Christian Probst, Romana Hoeftberger, Markus Reindl
Summary: The study analyzed different isoforms of MOG and their binding patterns in patients with non-MS demyelinating diseases, identifying three distinct binding patterns. These patterns were found to be associated with non-MS demyelinating diseases and had unique immunologic characteristics without differences in clinical phenotypes or disease course. This novel finding could potentially improve MOG-IgG assays and enhance understanding of the pathophysiologic role of MOG-IgG.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Review
Nanoscience & Nanotechnology
Prashant Sadanandan, Natalie L. Payne, Guizhi Sun, Anusha Ashokan, Siddaramana G. Gowd, Arsha Lal, Madathiparambil Kumaran Satheesh Kumar, Sreeranjini Pulakkat, Shantikumar Nair, Krishnakumar N. Menon, Claude C. A. Bernard, Manzoor Koyakutty
Summary: Targeting nano-conjugated autoantigens to tissue-resident macrophages in lymphoid organs can effectively suppress autoimmunity and restore self-tolerance.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Xin Chen, Xiaoshan Yang, Pingyun Yuan, Ronghua Jin, Lili Bao, Xinyu Qiu, Siying Liu, Tao Liu, John Justin Gooding, WanJun Chen, Guozhen Liu, Yongkang Bai, Shiyu Liu, Yan Jin
Summary: A novel therapeutic approach utilizing immune-homeostatic microparticles (IHMs) was developed to induce apoptosis in activated T cells, reestablish regulatory T cells, and treat multiple mouse models of autoimmunity. This strategy shows promise for efficiently treating autoimmune diseases by promoting immune tolerance.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemical Research Methods
Rina Aharoni, Renana Globerman, Raya Eilam, Ori Brenner, Ruth Arnon
Summary: By titrating the doses of MOG 35-55 peptide, MT H37Ra, and PTx during EAE induction, researchers were able to drastically reduce the amount of reagents used while maintaining similar disease manifestations, high disease incidence, and consistent disease course. This improved protocol may offer a more sensitive and cost-effective model for testing therapeutic modalities for MS.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Medicine, Research & Experimental
Iro Triantafyllakou, Nausicaa Clemente, Ravi Kumar Khetavat, Umberto Dianzani, Theodore Tselios
Summary: This study developed polymeric nanoparticles loaded with myelin peptide analogues to inhibit the development and progression of multiple sclerosis. The results showed that this therapeutic approach effectively reduced clinical scores and CNS inflammation, suggesting it as a promising alternative for treating multiple sclerosis by inducing tolerance against the disease.
MOLECULAR PHARMACEUTICS
(2022)
Article
Neurosciences
Xueshan Dong, Yan Jiang, Ping Yuan, Xiao Fan, Jiannan Ma, Peng Wu, Li Jiang, Xiujuan Li
Summary: This study compared the differences between pediatric patients with acute disseminated encephalomyelitis (ADEM) who tested positive and negative for myelin oligodendrocyte glycoprotein (MOG) antibodies in terms of clinical, radiological, therapeutic, and prognostic factors. The study included 62 patients, with 35 being MOG-seropositive and 27 being MOG-seronegative. MOG-seropositive ADEM children had lower rates of seizures and cranial nerve palsy, and isolated leukocytosis in the blood was more common in these children. The two groups showed no significant differences in MRI lesions and features. MOG-seropositive children were more likely to experience relapses and had slower steroid tapering.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Shin-Young Na, Gurumoorthy Krishnamoorthy
Summary: The study demonstrates that ectopic expression of MOG in immune organs can induce MOG-specific tolerance and long-lasting protection, potentially serving as a therapeutic strategy for specific autoantigen-driven autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Meihui Xu, Chi Ma, Ming Dong, Chunjie Guo, Simin Yang, Yue Liu, Xu Wang
Summary: This study aims to characterize the clinical symptoms, MRI findings, and prognosis of adult cerebral cortical encephalitis (CCE) with anti-MOG antibody. Two adult cases of CCE with anti-MOG antibody were presented and a systematic review of the literature was conducted. The majority of patients had a favorable prognosis after treatment, highlighting the importance of early detection and immunotherapy in improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Samuel D. Dowling, Fernando Macian
Article
Allergy
Deepa Rastogi, John Nico, Andrew D. Johnston, Toni Adrianne M. Tobias, Yurydia Jorge, Fernando Macian, John M. Greally
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Food Science & Technology
Dolores Corella, Oscar Coltell, Fernando Macian, Jose M. Ordovas
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 9
(2018)
Article
Immunology
Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cell Biology
Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo, Fernando Macian
Article
Immunology
Juwen C. DuBois, Alex K. Ray, Ross C. Gruber, Yongwei Zhang, Ranee Aflakpui, Fernando Macian-Juan, Bridget Shafit-Zagardo
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Rut Valdor, David Garcia-Bernal, Dolores Riquelme, Carlos M. Martinez, Jose M. Moraleda, Ana Maria Cuervo, Fernando Macian, Salvador Martinez
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cell Biology
Arsun Bektas, Shepherd H. Schurman, Marta Gonzalez-Freire, Christopher A. Dunn, Amit K. Singh, Fernando Macian, Ana Maria Cuervo, Ranjan Sen, Luigi Ferrucci
Article
Multidisciplinary Sciences
Karin A. Skalina, Saurabh Singh, Claudia Gutierrez Chavez, Fernando Macian, Chandan Guha
SCIENTIFIC REPORTS
(2019)
Review
Cell Biology
Fernando Macian
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Article
Immunology
Tere Williams, Ignacio Guerrero-Ros, Yanfen Ma, Fabiane Matos dos Santos, Philipp E. Scherer, Ruth Gordillo, Aline Horta, Fernando Macian, Louis M. Weiss, Huan Huang
INFECTION AND IMMUNITY
(2020)
Article
Critical Care Medicine
Deepa Rastogi, Andrew D. Johnston, John Nico, Lip Nam Loh, Yurydia Jorge, Masako Suzuki, Fernando Macian, John M. Greally
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Immunology
Erica Moore, Michelle W. Huang, Shweta Jain, Samantha A. Chalmers, Fernando Macian, Chaim Putterman
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Laura Cheney, Hillary Guzik, Frank P. Macaluso, Fernando Macian, Ana Maria Cuervo, Joan W. Berman
Article
Multidisciplinary Sciences
Michael A. Willcockson, Sean E. Healton, Cary N. Weiss, Boris A. Bartholdy, Yair Botbol, Laxmi N. Mishra, Dhruv S. Sidhwani, Tommy J. Wilson, Hugo B. Pinto, Maxim I. Maron, Karin A. Skalina, Laura Norwood Toro, Jie Zhao, Chul-Hwan Lee, Harry Hou, Nevin Yusufova, Cem Meydan, Adewola Osunsade, Yael David, Ethel Cesarman, Ari M. Melnick, Simone Sidoli, Benjamin A. Garcia, Winfried Edelmann, Fernando Macian, Arthur I. Skoultchi
Summary: Histone H1 functions as a critical regulator of gene silencing by controlling chromatin compaction, genome organization, and histone methylation. Experimental evidence using a conditional triple-knockout mouse strain demonstrates that H1 plays a key role in regulating the activity of chromatin domains.