Article
Biochemistry & Molecular Biology
Nikita G. Nikiforov, Tatiana V. Kirichenko, Marina V. Kubekina, Yegor S. Chegodaev, Alexander D. Zhuravlev, Leonid A. Ilchuk, Marina A. Nikolaeva, Alla S. Arefieva, Mikhail A. Popov, Svetlana S. Verkhova, Mariam Bagheri Ekta, Alexander N. Orekhov
Summary: This study found that macrophages derived from LPS-stimulated monocytes in individuals with subclinical atherosclerosis exhibited increased secretion of IL-6, IL-10, and CCL2, which were associated with atherosclerosis-related measures but not with age. Additionally, individuals with atherosclerotic plaques had impaired tolerance to the second LPS stimulation, indicated by elevated secretion of the chemoattractant CCL2 by macrophages.
Review
Cell Biology
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen
Summary: Liver transplantation is a effective treatment for end-stage liver disease and significantly prolongs the survival time of patients, but acute and chronic rejection still remain major obstacles. Investigating induced immune tolerance is of crucial theoretical significance and socio-economic value. This paper comprehensively summarizes the important roles of Kupffer cells in establishing immune tolerance after transplantation, including phagocytosis, cell polarization, antigen presentation, and cell membrane proteins, providing a theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Olga Sizova, Lisa St. John, Qing Ma, Jeffrey J. Molldrem
Summary: Graft versus host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation (Allo-SCT). GVHD prophylaxis and generalized anti-GVHD medical regimen are commonly used, but current treatment needs improvement. This review highlights the potential therapeutic target of low-density lipoprotein receptor related protein 1 (LRP1) for GVHD prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Miao Li, Yan Yu
Summary: The discovery of receptor clustering on the surfaces of innate immune cells has shed light on the key role these clusters play in pathogen detection and immune response regulation. Despite being a relatively under-explored research topic, pioneering studies have highlighted the importance of understanding the functional role of receptor clustering in innate immune regulation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Tingchen Cai, Lanman Xu, Dingchao Xia, Lujian Zhu, Yanhan Lin, Sijie Yu, Kailu Zhu, Xiaodong Wang, Chenwei Pan, Yongping Chen, Dazhi Chen
Summary: This study investigated the role of MARCO and PolyG in the development and treatment of AIH. The results showed that treatment with PolyG and inhibition of MARCO reduced the expression of inflammatory cytokines and altered the polarization state of macrophages. This suggests that MARCO could be a potential target for the treatment of AIH.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Morgan Towriss, Brian MacVicar, Annie Vogel Ciernia
Summary: Microglia, the resident macrophages of the central nervous system, have two memory states - training and tolerance, which are associated with increased and attenuated expression of inflammatory cytokines, respectively. Aerobic glycolysis triggered by the first stimulation is a critical step in the induction of innate immune tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yu Cao, Florian Kuemmel, Elke Logemann, Jan M. Gebauer, Aaron W. Lawson, Dongli Yu, Matthias Uthoff, Beat Keller, Jan Jirschitzka, Ulrich Baumann, Kenichi Tsuda, Jijie Chai, Paul Schulze-Lefert
Summary: In plants, the coevolution between host and pathogen is reflected in adaptive genetic changes in host immune receptors and pathogen effectors. This study focuses on the RNase-like effector family RALPH in grass powdery mildew fungi and reveals variations in the structures and activities of the RALPH effectors. The findings provide insights into the escape of powdery mildew fungi from host recognition and the acquisition of diverse virulence functions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Huifang Zhu, Yan-Dong Tang, Guoqing Zhan, Chenhe Su, Chunfu Zheng
Summary: PARPs, a family of proteins responsible for transferring ADP-ribose groups, play important roles in regulating various cellular functions and have widespread involvement in mammalian innate immunity. Understanding the roles of PARPs and ADP-ribosylation in regulating innate immune responses can help in discovering and designing new molecular targets for cancers, pathogenic infections, and inflammations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Qianqian Xing, Youxin Feng, Haimei Sun, Shu Yang, Tingyi Sun, Xiaoxia Guo, Fengqing Ji, Bo Wu, Deshan Zhou
Summary: The study demonstrated that MARCO plays an important role in the phagocytosis of tumor cells by macrophages. MARCO expression was correlated with macrophages' ability to carry out phagocytosis.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Eric C. Bredahl, Joan M. Eckerson, Steven M. Tracy, Thomas L. McDonald, Kristen M. Drescher
Summary: The use of dietary supplements has become increasingly common over the past 20 years, extending beyond elite athletes to include recommendations from healthcare professionals to patients. Creatine is a widely used supplement that has been well-studied for its positive effects on performance and health, especially in recovery from exercise. However, limited research exists on the effects of creatine on children and the elderly.
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Immunology
Erica M. Orsini, Apostolos Perelas, Brian D. Southern, Lisa M. Grove, Mitchell A. Olman, Rachel G. Scheraga
Summary: Innate immune cells are able to sense and respond to their physical environment through mechanical signals transmitted via mechanosensitive ion channels and cell adhesion molecules, which then activate intracellular signaling pathways to regulate gene expression and cellular function. Understanding how immune cells interpret mechanical information may provide potential targets for treating human diseases. Areas of future studies include autoimmune, allergic, infectious, and malignant conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chao Wang, Yan Zhang, Wei-Qiang Gao
Summary: Prostate cancer is a common cancer among men in Western countries, and the standard therapy of ADT may lead to resistance and tumor progression. Recent data suggests that immune cells play important roles in the initiation, progression, metastasis, and treatment of prostate cancer.
Review
Engineering, Multidisciplinary
Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu
Summary: This article reviews the role of immune cells in organ transplant rejection and organ transplant tolerance, as well as introduces novel cell therapies currently under clinical trials.
Article
Public, Environmental & Occupational Health
Janine F. Felix, Bonnie R. Joubert, Andrea A. Baccarelli, Gemma C. Sharp, Catarina Almqvist, Isabella Annesi-Maesano, Hasan Arshad, Nour Baiz, Marian J. Bakermans-Kranenburg, Kelly M. Bakulski, Elisabeth B. Binder, Luigi Bouchard, Carrie V. Breton, Bert Brunekreef, Kelly J. Brunst, Esteban G. Burchard, Mariona Bustamante, Leda Chatzi, Monica Cheng Munthe-Kaas, Eva Corpeleijn, Darina Czamara, Dana Dabelea, George Davey Smith, Patrick De Boever, Liesbeth Duijts, Terence Dwyer, Celeste Eng, Brenda Eskenazi, Todd M. Everson, Fahimeh Falahi, M. Daniele Fallin, Sara Farchi, Mariana F. Fernandez, Lu Gao, Tom R. Gaunt, Akram Ghantous, Matthew W. Gillman, Semira Gonseth, Veit Grote, Olena Gruzieva, Siri E. Haberg, Zdenko Herceg, Marie-France Hivert, Nina Holland, John W. Holloway, Cathrine Hoyo, Donglei Hu, Rae-Chi Huang, Karen Huen, Marjo-Riitta Jarvelin, Dereje D. Jima, Allan C. Just, Margaret R. Karagas, Robert Karlsson, Wilfried Karmaus, Katerina J. Kechris, Juha Kere, Manolis Kogevinas, Berthold Koletzko, Gerard H. Koppelman, Leanne K. Kupers, Christine Ladd-Acosta, Jari Lahti, Nathalie Lambrechts, Sabine A. S. Langie, Rolv T. Lie, Andrew H. Liu, Maria C. Magnus, Per Magnus, Rachel L. Maguire, Carmen J. Marsit, Wendy McArdle, Erik Melen, Phillip Melton, Susan K. Murphy, Tim S. Nawrot, Lorenza Nistico, Ellen A. Nohr, Bjorn Nordlund, Wenche Nystad, Sam S. Oh, Emily Oken, Christian M. Page, Patrice Perron, Goran Pershagen, Costanza Pizzi, Michelle Plusquin, Katri Raikkonen, Sarah E. Reese, Eva Reischl, Lorenzo Richiardi, Susan Ring, Ritu P. Roy, Peter Rzehak, Greet Schoeters, David A. Schwartz, Sylvain Sebert, Harold Snieder, Thorkild I. A. Sorensen, Anne P. Starling, Jordi Sunyer, Jack ATaylor, Henning Tiemeier, Vilhelmina Ullemar, Marina Vafeiadi, Marinus H. Van Ijzendoorn, Judith M. Vonk, Annette Vriens, Martine Vrijheid, Pei Wang, Joseph L. Wiemels, Allen J. Wilcox, Rosalind J. Wright, Cheng-Jian Xu, Zongli Xu, Ivana V. Yang, Paul Yousefi, Hongmei Zhang, Weiming Zhang, Shanshan Zhao, Golareh Agha, Caroline L. Relton, Vincent W. V. Jaddoe, Stephanie J. London
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2018)
Letter
Critical Care Medicine
Andrew A. Monte, Hao Sun, Anna Malin Rapp-Olsson, Fahim Mohamed, Indika Gawarammana, Nicholas A. Buckley, Christopher M. Evans, Ivana V. Yang, David A. Schwartz
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Review
Allergy
Elizabeth J. Davidson, Ivana V. Yang
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Endocrinology & Metabolism
I. V. Yang, W. Zhang, E. J. Davidson, T. E. Fingerlin, K. Kechris, D. Dabelea
Article
Respiratory System
Yi-Hsuan Tsai, Joel S. Parker, Ivana V. Yang, Samir N. P. Kelada
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Allergy
Meiqin Wang, Ivana V. Yang, Elizabeth J. Davidson, Anthony Joetham, Katsuyuki Takeda, Brian P. O'Connor, Erwin W. Gelfand
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Kenneth R. Eyring, Brent S. Pedersen, Kenneth N. Maclean, Sally P. Stabler, Ivana V. Yang, David A. Schwartz
Article
Multidisciplinary Sciences
Michael Koeppen, Jae W. Lee, Seong-Wook Seo, Kelley S. Brodsky, Simone Kreth, Ivana V. Yang, Peter M. Buttrick, Tobias Eckle, Holger K. Eltzschig
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
N. M. Grindler, L. Vanderlinden, R. Karthikraj, K. Kannan, S. Teal, A. J. Polotsky, T. L. Powell, I. V. Yang, T. Jansson
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Nancy C. Allen, Naomi H. Philip, Lucy Hui, Xu Zhou, Ruth A. Franklin, Yong Kong, Ruslan Medzhitov
Article
Biochemistry & Molecular Biology
Jay Patel, Dan Xun, Karen Creswell, Daniel K. Kim, Matthew Wu, Jung-Won Hwang, Taylor S. Kim, Shivani Bansal, Sung-Hyeok Hong, Susana Galli, Hyun-Jung Kim, Chuxia Deng, Stephen W. Byers, Mi-Hye Lee
Summary: RARRES1 is commonly methylated in multiple cancers and regulates cell metabolism, stem cell differentiation, and survival. Knockout mouse models revealed that RARRES1 acts as a tumor suppressor in vivo and affects B cell activation, maturation, and differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Meeting Abstract
Medicine, General & Internal
A. C. Schulick, A. M. Estrella, I. Yang, D. A. Schwartz
JOURNAL OF INVESTIGATIVE MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Britney A. Helling, Anthony N. Gerber, Vineela Kadiyala, Sarah K. Sasse, Brent S. Pedersen, Lenore Sparks, Yasushi Nakano, Tsukasa Okamoto, Christopher M. Evans, Ivana V. Yang, David A. Schwartz
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2017)
Meeting Abstract
Critical Care Medicine
R. Blumhagen, I. V. Yang, C. D. Langefeld, D. A. Schwartz, T. E. Fingerlin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Article
Endocrinology & Metabolism
Michael C. Rudolph, Matthew R. Jackman, David M. Presby, Julie A. Houck, Patricia G. Webb, Ginger C. Johnson, Taylor K. Soderborg, Becky A. de la Houssaye, Ivana V. Yang, Jacob E. Friedman, Paul S. MacLean