Article
Biochemistry & Molecular Biology
Shaolin Tan, Yuangang Su, Linke Huang, Siyu Deng, Guohua Yan, Xue Yang, Runfeng Chen, Yansi Xian, Jiamin Liang, Qian Liu, Jianwen Cheng
Summary: Cor can inhibit osteoclastogenesis and bone resorption, reduce inflammator- induced bone defects, making it a potential therapeutic agent for osteoclast-mediated osteolytic diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Maria Pelullo, Daniela Savi, Serena Quattrucci, Giuseppe Cimino, Antonio Pizzuti, Isabella Screpanti, Claudio Talora, Samantha Cialfi
Summary: In the physiopathology of cystic fibrosis, oxidative stress implications are recognized and accepted. The present study revealed an association between CFTR, oxidative stress response genes, and miR-125b. The findings suggest that HO-1 and miR-125b may synergistically protect airway cells, serving as potential prognostic markers in CF.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Gi-Sang Bae, Sung-Joo Park
Summary: Guggulsterone (GS) exerts anti-inflammatory effects by inducing heme oxygenase-1 (HO-1) expression through reactive oxygen species (ROS) production. GS inhibits the expression of inflammatory mediators and prolongs survival in an endotoxemia model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Article
Surgery
Rui Mu, Na Li, Jian-bo Yu, Li-rong Gong, Shu-an Dong, Jia Shi, Yuan Zhang, Zi-lei Xie
Summary: EA treatment improves LPS-induced hippocampal injury by regulating HO-1-mediated mitochondrial function. HO-1 plays a critical role in maintaining mitochondrial function and resisting oxidative injury.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sarah E. Machado, Daryll Spangler, Delores A. Stacks, Victor Darley-Usmar, Gloria A. Benavides, Min Xie, Jozsef Balla, Abolfazl Zarjou
Summary: Given the important role of heme proteins in mitochondrial function, this study investigated the significance of myocardial ferritin heavy chain (FtH) in acute myocardial infarction. The results showed that FtH deletion did not impact mitochondrial regulation, bioenergetics, or cardiac function. Furthermore, FtH deletion led to the upregulation of anti-ferroptotic genes, including HO-1 and Slc7a11, suggesting a compensatory mechanism. The induction of HO-1 resulted in increased expression of Slc7a11, ultimately protecting the heart against ischemia-reperfusion-mediated ferroptosis and preserving myocardial and mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Samrat Rakshit, Nisha Sahu, Satendra Kumar Nirala, Monika Bhadauria
Summary: The study found that purpurin has protective potential against acute hepatorenal injury, improving blood and tissue parameters and restoring the normal function of the liver and kidneys.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Krzeptowski, Patryk Chudy, Grzegorz Sokolowski, Monika Zukowska, Anna Kusienicka, Agnieszka Seretny, Agata Kalita, Alicja Czmoczek, Jakub Gubala, Sonia Baran, Damian Kloska, Mateusz Jez, Jacek Stepniewski, Krzysztof Szade, Agata Szade, Anna Grochot-Przeczek, Alicja Jozkowicz, Witold N. Nowak
Summary: G-quadruplexes are nucleic acid structures stabilized by heme, influencing DNA replication and gene transcription. The accumulation of G-quadruplexes is affected by heme oxygenase-1 expression in a cell-type-specific manner. Cellular co-localization of G-quadruplexes with helicases and HMOX1 can be detected using the proximity ligation assay, providing insights into potential roles of HMOX1 in G4 modifications.
Article
Biochemistry & Molecular Biology
Hui Li, Xiaoyu Fan, Xiangmeng Wu, Weiguo Han, Mary Kay Amistadi, Pengfei Liu, Donna Zhang, Jon Chorover, Xinxin Ding, Qing-Yu Zhang
Summary: This study found that exposure to arsenic through drinking water significantly induced high levels of HO-1 in mouse intestinal epithelial cells, but not in the liver. Intestinal epithelial cells were identified as potential preferential targets for arsenic toxicity, highlighting the importance of further research on the functional consequences of intestinal HO-1 induction.
Review
Biochemistry & Molecular Biology
Zhenwei Xia, Wenwei Zhong
Summary: HO-1 plays a crucial immunoregulatory role in asthmatic airway inflammation by regulating various immune cells and exerting anti-inflammatory effects.
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Biochemistry & Molecular Biology
Valeria R. Villella, Andrea Venerando, Giorgio Cozza, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Mara C. Spinella, Vasilis Oikonomou, Giorgia Renga, Antonella Tosco, Federica Rossin, Stefano Guido, Marco Silano, Enrico Garaci, Yu-Kai Chao, Christian Grimm, Alessandro Luciani, Luigina Romani, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri
Article
Cell Biology
Valeria R. Villella, Speranza Esposito, Eleonora Ferrari, Romina Monzani, Antonella Tosco, Federica Rossin, Alice Castaldo, Marco Silano, Gian Luigi Marseglia, Luigina Romani, Nikolai A. Barlev, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri
CELL DEATH & DISEASE
(2019)
Review
Cell Biology
Luigi Maiuri, Valeria R. Villella, Mauro Piacentini, Valeria Raia, Guido Kroemer
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Speranza Esposito, Valeria Rachela Villella, Eleonora Ferrari, Romina Monzani, Antonella Tosco, Federica Rossin, Manuela D'Eletto, Alice Castaldo, Alessandro Luciani, Marco Silano, Gianni Bona, Gian Luigi Marseglia, Luigina Romani, Mauro Piacentini, Valeria Raia, Guido Kroemer, Luigi Maiuri
Review
Pediatrics
Valeria R. Villella, Antonella Tosco, Speranza Esposito, Gianni Bona, Valeria Raia, Luigi Maiuri
MINERVA PEDIATRICA
(2019)
Review
Pediatrics
Valeria R. Villella, Antonella Tosco, Speranza Esposito, Eleonora Ferrari, Gianni Bona, Guido Kroemer, Valeria Raia, Luigi Maiuri
MINERVA PEDIATRICA
(2019)
Review
Pediatrics
Angela Sepe, Valeria R. Villella, Chiara Cimbalo, Alice Castaldo, Francesco Nunziata, Adele Corcione, Gianni Bona, Luigi Maiuri, Valeria Raia
MINERVA PEDIATRICA
(2019)
Article
Nutrition & Dietetics
Eleonora Ferrari, Romina Monzani, Valentina Saverio, Mara Gagliardi, Elzbieta Panczyszyn, Valeria Raia, Valeria Rachela Villella, Gianni Bona, Marco Pane, Angela Amoruso, Marco Corazzari
Summary: Gluten is the major inducer of CD, and the current treatment is limited to a gluten-free diet; studies have shown that dysbiosis of the intestinal microbiota plays a key role in the pathogenesis of CD; probiotics could potentially be a valuable strategy for treating gluten-sensitive patients.
Article
Chemistry, Analytical
Valentina Preziosi, Mario Barra, Valeria Rachela Villella, Speranza Esposito, Pasquale D'Angelo, Simone Luigi Marasso, Matteo Cocuzza, Antonio Cassinese, Stefano Guido
Summary: Transglutaminase 2 (TG2) is a widely expressed member of the transglutaminase family that plays a role in cell growth, differentiation, and apoptosis. It is associated with various pathologies and requires sensitive detection methods. In this study, the researchers used organic electrochemical transistors with gold electrodes functionalized with anti-TG2 antibodies to detect TG2 at attomolar concentrations, offering a rapid and cost-effective alternative to traditional methods.
Article
Pediatrics
Luigi Maiuri, Valeria R. Villella, Valeria Raia, Guido Kroemer
ITALIAN JOURNAL OF PEDIATRICS
(2019)