Article
Immunology
Jia Jia, Yunyun Zhang, Hao Zhang, Zhidong Chen, Liwen Chen, Qiang Zhou, Xiongwen Lv, Qin Wang
Summary: This study aimed to investigate the correlation between serum hepcidin levels and the curative effect of interferon-alpha therapy in patients with chronic hepatitis B. The results showed that patients with higher early-on treatment hepcidin levels were more likely to experience a decline in HBsAg and HBV DNA levels. Additionally, changes in serum hepcidin levels could predict the therapeutic effect of interferon-alpha.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Qirong Li, Baozhen Sun, Yue Zhuo, Ziping Jiang, Rong Li, Chao Lin, Ye Jin, Yongjian Gao, Dongxu Wang
Summary: Hepatitis B virus (HBV) is a virus that causes acute and chronic hepatitis, as well as liver cancer and cirrhosis. Interferons (IFNs) are proteins with antiviral properties and play an important role in the immune system. IFNs inhibit HBV replication and transcription by inducing the expression of IFN-stimulated genes (ISGs) in host cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kaiwen Wang, Jiangfeng Zhao, Wanlong Wu, Wenwen Xu, Shuhui Sun, Zhiwei Chen, Yakai Fu, Li Guo, Hui Du, Shuang Ye
Summary: The study found a mechanistic relevance between anti-MDA5 antibody and the type I IFN pathway. Immune complexes formed by MDA5 and anti-MDA5 can induce IFN-alpha via TLR-7 in an RNA-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Chandrika Senthilkumaran, Andrea L. Kroeker, Gregory Smith, Carissa Embury-Hyatt, Brad Collignon, Elizabeth Ramirez-Medina, Paul A. Azzinaro, Bradley S. Pickering, Fayna Diaz-San Segundo, Hana M. Weingartl, Teresa de los Santos
Summary: This study tested the use of a specific viral vector to deliver porcine interferon and limit Ebola virus replication and shedding in pigs. The results showed that treated pigs did not develop clinical symptoms, had reduced viral load and shedding, and displayed an upregulation of immune and inflammatory responses. This treatment approach has the potential to limit the spread of Ebola virus in pigs.
Article
Biochemistry & Molecular Biology
Lishuang Deng, Yue Yin, Zhiwen Xu, Fengqin Li, Jun Zhao, Huidan Deng, Zhijie Jian, Siyuan Lai, Xiangang Sun, Ling Zhu
Summary: IFN-lambda 3 exhibits antiviral activity against porcine rotavirus and may serve as a useful antiviral candidate.
Article
Oncology
Alessandra Fragale, Emilia Stellacci, Giulia Romagnoli, Valerio Licursi, Stefania Parlato, Irene Canini, Giacomo Remedi, Maria Buoncervello, Paola Matarrese, Lucia Pedace, Barbara Ascione, Simone Pizzi, Marco Tartaglia, Stefania D'Atri, Carlo Presutti, Imerio Capone, Lucia Gabriele
Summary: BRAF(V600) mutations are commonly found in melanoma cells and support various oncogenic processes. The combination of romidepsin and IFN-a2b reduces melanoma proliferation, survival, and invasion, and overcomes resistance to vemurafenib. This combination treatment modulates genetic and immune pathways, restores immune signals, induces cell death, and enhances the immunogenic potential of resistant melanoma cells, providing a potential strategy for treating BRAFi-resistant metastatic melanoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Helene Schaefer, Karthikeyan Subbarayan, Chiara Massa, Christoforos Vaxevanis, Anja Mueller, Barbara Seliger
Summary: Using bioinformatics analysis, we found that the expression of ECM protein PRELP is reduced in cutaneous melanoma and is associated with decreased patient survival. High PRELP expression is correlated with low expression of MHC class I antigen processing machinery (APM) and interferon (IFN)-γ pathway, as well as increased expression of TFGB1 and TGFBR1. Transfection of PRELP restores MHC class I surface expression and reduces cell proliferation, migration, and invasion in melanoma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Brendan D. Curti, Mark B. Faries
Summary: Improvements in management have led to increased survival rates for melanoma, with advances such as sentinel-node sampling and targeted therapy reducing morbidity and enhancing treatment outcomes for advanced disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Oncology
Fei Xiong, Qi Wang, Guan-hua Wu, Wen-zheng Liu, Bing Wang, Yong-jun Chen
Summary: IFN-alpha 2b is a highly active cytokine that has antiviral, antitumour, antiparasitic, and immunomodulatory activities. Its antiproliferative effects are mainly mediated through the JAK-STAT pathway. Regulators of IFN-alpha 2b function may help improve its therapeutic efficacy.
BIOMARKER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Veronique Demers-Mathieu
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies specific to self-molecules. Elevated type I interferon signature (IFN- I) in SLE leads to dysregulation of immune function and autoantibodies production. The most common method to determine IFN-I signature is measuring the gene expression of several IFN-a-inducible genes (IFIGs) in blood samples and calculating a score. The understanding of IFN-I signature in SLE can improve diagnosis and monitoring of disease activity.
Editorial Material
Biochemistry & Molecular Biology
Lewis Au, James Larkin, Samra Turajlic
Summary: Combined LAG-3 and PD-1 blockade is a promising strategy in treating melanoma. Two clinical trials evaluating relatlimab and nivolumab as front-line treatment for metastatic and resectable high-risk melanoma with positive lymph nodes, have been reported in The New England Journal of Medicine and Nature respectively.
Review
Medicine, General & Internal
Xinyuan Xu, Wei Dai, Chunying Li
Summary: This article introduces the use of ILs to modulate the immune system in cancer treatment and discusses their application in the treatment of melanoma. It also mentions the potential synergy between ILs and immune checkpoint inhibition for better clinical outcomes.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Deanna M. Santer, Daniel Li, Yanal Ghosheh, Muhammad Atif Zahoor, Dhanvi Prajapati, Bettina E. Hansen, D. Lorne J. Tyrrell, Jordan J. Feld, Adam J. Gehring
Summary: Interferon-lambda is a treatment option for early COVID-19 that enhances innate immunity and accelerates viral clearance without dampening peripheral adaptive immunity. T cell responses are delayed in older adults, but interferon-lambda can overcome this delay.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Stefanie Meyer, Diana Handke, Anja Mueller, Katharina Biehl, Markus Kreuz, Juergen Bukur, Ulrike Koehl, Maria-Filothei Lazaridou, Mark Berneburg, Andre Steven, Chiara Massa, Barbara Seliger
Summary: Limited knowledge exists about the molecular processes controlling HLA class II APM components in melanoma. This study found heterogeneous basal expression of HLA class II antigens and components in melanoma cells is caused by distinct molecular mechanisms and has clinical relevance.
Article
Oncology
Anneloes van Duijn, Karin J. Willemsen, Nathalie O. P. van Uden, Lieke Hoyng, Sterre Erades, Jan Koster, Rosalie M. Luiten, Walbert J. Bakker
Summary: This study aims to explore the hypoxic regulation of PD-L1 expression in human melanoma, and its interaction with IFN gamma-induced PD-L1 expression. The study found that hypoxia can influence PD-L1 expression, especially in response to IFN gamma.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
