Article
Oncology
Anthony B. B. El-Khoueiry, James Clarke, Tobias Neff, Tim Crossman, Nirav Ratia, Chetan Rathi, Paul Noto, Aarti Tarkar, Ignacio Garrido-Laguna, Emiliano Calvo, Jordi Rodon, Ben Tran, Peter J. J. O'Dwyer, Adam Cuker, Albiruni R. Abdul R. Razak
Summary: GSK3368715, a reversible inhibitor of type I protein methyltransferases, showed anticancer activity in preclinical studies. This Phase 1 study evaluated its safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy in patients with advanced solid tumors. However, due to a higher-than-expected incidence of thromboembolic events, the study was terminated.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Po-Sheng Chen, Wen-Han Feng, Tzu-Hsien Tsai, Yi-Kai Hong, An-Sheng Lee, Kuan-Cheng Chang, Hsing-Chun Chung, Yen-Wen Liu, Chih-Cheng Hsieh, Yi-Hsian Fang, Pei-Jung Yang, Chawn-Yau Luo, Ping-Yen Liu, Tsung-Lin Cheng, Yi-Heng Li
Summary: TEM1 plays an important role in cardiac remodeling and repair after heart injury by influencing the behavior of cardiac myocytes and activating Erk and Akt pathways through interaction with the PDGF receptor.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Misuzu Hashimoto, Akiyoshi Fukamizu, Tsutomu Nakagawa, Yasuhiko Kizuka
Summary: PRMT1 is crucial for the development of neurons, astrocytes, and oligodendrocytes, requiring further investigation. The relevance of PRMT1 in neurodegenerative diseases will continue to be a hot topic.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Pharmacology & Pharmacy
Vijay Raj, Suganya Natarajan, C. Marimuthu, Suvro Chatterjee, Mohankumar Ramasamy, Ganesh Munuswamy Ramanujam, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ki Choon Choi, Jesu Arockiaraj, Kanchana Karuppiah
Summary: The combination treatment with MET and VD blocked LPS-induced endothelial cell methyltransferase activity, senescence, and dysfunction. The study identified a previously unknown function of the test compounds in inhibiting adverse cellular events through SIRT1 and PRMT1.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Microbiology
Fernanda Sales Coelho, Sandra Grossi Gava, Luiza Freire Andrade, Juliana Assis Geraldo, Naiara Clemente Tavares, Felipe Miguel Nery Lunkes, Renata Heisler Neves, Jose Roberto Machado-Silva, Raymond J. Pierce, Guilherme Oliveira, Marina Moraes Mourao
Summary: This study characterizes the function of the protein arginine methyltransferase SmCARM1 in Schistosoma mansoni and highlights its potential as a drug target.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Seongju Jeong, Minwoo Jeon, Hoyoung Lee, So-Young Kim, Su-Hyung Park, Eui-Cheol Shin
Summary: This study investigates bystander activation of memory CD8(+) T cells in a mouse model of influenza infection and reveals that IL-15 is a critical cytokine for bystander activation. Additionally, the transcriptomic analysis shows that bystander-activated memory CD8(+) T cells have a unique gene signature, with upregulation of IFITM3 as a distinguishing marker.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fang-Zhi Yan, Hui Qian, Fang Liu, Chen-Hong Ding, Shu-Qing Liu, Meng-Chao Xiao, Shi-Jie Chen, Xin Zhang, Cheng Luo, Wei-Fen Xie
Summary: PRMT1 plays a vital role in hepatic fibrogenesis by promoting HSC activation. Inhibition of PRMT1 can mitigate hepatic fibrosis by attenuating HSC activation.
Article
Immunology
Seongju Jeong, Minwoo Jeon, Hoyoung Lee, So-Young Kim, Su-Hyung Park, Eui-Cheol Shin
Summary: In bystander activation, memory CD8(+) T cells unrelated to the infecting microbes are activated without cognate Ags. This study investigates bystander activation of OT-1 memory cells in a mouse model of influenza infection. The findings reveal that IL-15 is critical for bystander activation and upregulation of IFITM3 can be used as a marker for bystander-activated memory CD8(+) T cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Allergy
Jacqueline-Yvonne Cephus, Vivek D. Gandhi, Ruchi Shah, Jordan Brooke Davis, Hubaida Fuseini, Jeffrey A. Yung, Jian Zhang, Hirohito Kita, Vasiliy V. Polosukhin, Weisong Zhou, Dawn C. Newcomb
Summary: In this study, estrogen receptor-alpha signaling was found to increase IL-33 release and ILC2-mediated airway inflammation. Esr1-deficient mice showed significantly reduced IL-5, IL-13 production, BAL eosinophils, and IL-33 release, while PPT and 17β-estradiol increased IL-33 gene expression and release.
Article
Allergy
Shota Toyoshima, Tomomi Sakamoto-Sasaki, Yusuke Kurosawa, Koremasa Hayama, Akira Matsuda, Yasuo Watanabe, Tadashi Terui, Yasuhiro Gon, Kenji Matsumoto, Yoshimichi Okayama
Summary: The study revealed that EVs derived from MCs can activate ILC2s through miR103a-3p, leading to increased production of IL-5 and exacerbating eosinophilic allergic inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Parasitology
Wei-Wei Sun, Xiu-Mei Yan, Ai-Jun Qiao, Yuan-Jiao Zhang, Ling Yang, Hui-Cong Huang, Hong-Fei Shi, Bao-Long Yan
Summary: In this study, the intracellular functions of Acan-Gal-1 were investigated using a surrogate model organism. The results showed that upregulated Acan-Gal-1 plays a defensive role against oxidative stress by reducing fat deposition, which may explain how A. cantonensis L5 worms survive immune attacks in the human central nervous system.
PARASITES & VECTORS
(2022)
Article
Cell Biology
Michele Scuruchi, Angela D'Ascola, Angela Avenoso, Giuseppe Mandraffino, Salvatore Campo, Giuseppe M. Campo
Summary: Endocan is a circulating proteoglycan that may serve as a biomarker for inflammation, increased angiogenesis, and cancer. In vitro studies have shown that expression of endocan can be upregulated by inflammatory cytokines and proangiogenic molecules. Furthermore, the inflammatory response induced by IL-1ss involves activation of the NF-kB pathway leading to increased expression of endocan.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Developmental Biology
Yugo Ishino, Shoko Shimizu, Masaya Tohyama, Shingo Miyata
Summary: Protein arginine methylation, mediated by Carm1, plays a crucial role in regulating cellular events such as cell proliferation and differentiation. In this study, Carm1 was found to be highly expressed in oligodendrocyte lineage cells in the developing brain, and its inhibition resulted in reduced proliferation and impaired differentiation of these cells. Carm1 activity was also found to be necessary for the appropriate formation of myelin processes and myelin sheaths, suggesting its essential role in the development of oligodendrocytes.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhu, Longmei Wang, Rui Liu, Xiurong Ding, Song Yin, Yuankun Chen, Chuanlong Zhu, Zheng Wang, Wenting Li
Summary: This study investigated the potential role of PRMT1 in sepsis-induced acute kidney injury (SI-AKI) and found that inhibition of PRMT1 could alleviate epithelial-mesenchymal transition, apoptosis, and inflammation in renal tissues. Further research revealed that inhibition of PRMT1 suppressed the activation of the TGF-beta 1/Smad3 pathway in the cortex and the IL-6/STAT3 pathway in the medulla. These findings may contribute to the identification of potential therapeutic targets for SI-AKI.
Article
Biochemistry & Molecular Biology
Lu Xue, Lingyu Bao, Julia Roediger, Yijun Su, Bingyin Shi, Yun-Bo Shi
Summary: Adult stem cells are crucial in organ physiology and tissue repair, yet the mechanisms of their development remain unclear. PRMT1, a coactivator of T3 receptor, is highly expressed during intestinal maturation. Knockout of PRMT1 in the intestine surprisingly leads to increased cell proliferation and changes in cell types in the crypt, indicating a potential regulation beyond T3-signaling in intestinal development.
CELL AND BIOSCIENCE
(2021)
Article
Orthopedics
Jian Sun, Zixin Min, Wenxiang Zhao, Safdar Hussain, Yitong Zhao, Dongxian Guo, Fujun Zhang, Yuanxu Guo, Mengyao Sun, Huang Huang, Yan Han, Nannan Zhong, Peng Xu, Shemin Lu
Summary: Both selenium deficiency and mycotoxin T2 can cause chondrocyte necrosis and epiphyseal plate lesions, affecting the extracellular matrix metabolism in rats. These two environmental risk factors intensify the metabolic imbalance of the extracellular matrix, leading to articular cartilage degradation and epiphyseal plate abnormalities in the study model.
Article
Immunology
Sihan Liu, Yanxia Fu, Kunrong Mei, Yinan Jiang, Xiaojun Sun, Yinyin Wang, Fangli Ren, Congshan Jiang, Liesu Meng, Shemin Lu, Zhihai Qin, Chen Dong, Xinquan Wang, Zhijie Chang, Shigao Yang
Summary: The study found that in rheumatoid arthritis, soluble glycosylated interleukin-17 receptor D (sIL-17RD) exacerbates the disease by enhancing the proinflammatory response induced by TNF-alpha. The shedding of IL-17RD is regulated by the proteolytic enzyme TACE and is enhanced by TNF-alpha expression in macrophages, suggesting it may be a new target for the therapy of RA.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Wenhua Zhu, Erik Lonnblom, Michael Forster, Martina Johannesson, Pei Tao, Liesu Meng, Shemin Lu, Rikard Holmdah
Article
Chemistry, Medicinal
Hong-Yi Zhao, Xue-Yan Yang, Hao Lei, Xiao-Xiao Xi, She-Min Lu, Jun-Jie Zhang, Minhang Xin, San-Qi Zhang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Oncology
Xiaowei Li, Fengjie Gao, Wenhua Zhu, Congshan Jiang, Jing Xu, Jing Zhang, Liesu Meng, Shemin Lu
Summary: The study reveals that Pristane-induced arthritis is dependent on macrophages, which undergo metabolic reprogramming in response to pristane. This metabolic shift in macrophages suggests a potential new therapeutic strategy for arthritic disorders.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Weiqi Zhai, Haoming Sun, Zhi Li, Li Li, Ai Jin, Yuwen Li, Jian Chen, Xiaojun Yang, Qingzhu Sun, Shemin Lu, Michael Roth
Summary: PRMT1 acts as a coactivator for STAT1 or RUNX1 in regulating miRNA expression in lung epithelial cells, playing a critical role in the transcription of asthma-related miRNA and their pri-miRNAs.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaozhen Zhang, Li Li, Yuwen Li, Zhi Li, Weiqi Zhai, Qingzhu Sun, Xiaojun Yang, Michael Roth, Shemin Lu
Summary: Fasting reduces miR-21 expression and increases its target PTEN, thereby inhibiting mTOR signaling, p-STAT1, PRMT1, and mitochondrial mass. Downregulation of PRMT1 decreases PPAR-γ expression, leading to decreased mitochondrial mass.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Immunology
Si Wang, Jing Xu, Yuanxu Guo, Yongsong Cai, Xiaoyu Ren, Wenhua Zhu, Manman Geng, Liesu Meng, Congshan Jiang, Shemin Lu
Summary: Mounting evidence suggests that miRNAs, especially the miR-15/107 family, play a role in rheumatoid arthritis (RA). In this study, miR-424 and miR-497 were found to be dysregulated in RA patients, with significant effects on cell proliferation and apoptosis of RASF. A proposed miR-424-DICER1-miR-497 feedback loop offers a novel insight into regulating miRNA expression and controlling RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Congshan Jiang, Xiaowei Li, Changrong Ge, Yuanyuan Ding, Tao Zhang, Shuai Cao, Liesu Meng, Shemin Lu
Summary: This article discusses the mutations of COVID-19, the application of molecular detection techniques, and the impact of viral mutations and asymptomatic infections on diagnosis, providing useful insights into the molecular diagnosis of COVID-19 under the challenges posed by virus mutations and asymptomatic infections.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Jing Li, Qian Chen, Jing Yi, Xi Lan, Kaikai Lu, Xiaojuan Du, Zizhen Guo, Yuanxu Guo, Manman Geng, Dongmin Li, Shemin Lu
Summary: Research suggests that IFN-γ promotes TLR2 transcription and target gene expression through STAT1 beta, leading to a vicious cycle of hepatic inflammation in NASH.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Fei Li, Dan Han, Bo Wang, Wentao Zhang, Yan Zhao, Jing Xu, Liesu Meng, Kuanhou Mou, Shemin Lu, Wenhua Zhu, Yan Zhou
Summary: Colquhounia Root (CR), a Chinese herb with anti-inflammatory properties, can relieve psoriatic lesions and itch by regulating immune and neurogenic inflammation.
MEDIATORS OF INFLAMMATION
(2022)
Review
Pharmacology & Pharmacy
Congshan Jiang, Kaichong Jiang, Xiaowei Li, Ning Zhang, Wenhua Zhu, Liesu Meng, Yanmin Zhang, Shemin Lu
Summary: This study analyzed the rapidly mutating nature of the SARS-CoV-2 genome and summarized the epidemiological diagnostic methods for COVID-19. It emphasized the importance of evaluating immunoprotection conditions and designing pharmaceutical antibody products.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Xiaowei Li, Wenhua Zhu, Meiyang Fan, Jing Zhang, Yizhao Peng, Fumeng Huang, Nan Wang, Langchong He, Lei Zhang, Rikard Holmdahl, Liesu Meng, Shemin Lu
Summary: This study found that SARS-CoV-2 enters human cells through ACE2 and is sensitive to the pH of endosomes/lysosomes in HEK293T cells, with infection dependent on cholesterol-rich lipid rafts instead of other pathways. These findings expand the understanding of the entry mechanism of SARS-CoV-2 and suggest a new strategy for combating the virus.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Dong Liang, Ezra K. Osoro, Shuai Tan, Xi Lan, Wenhua Zhu, Litao Wu, Xiaojuan Du, Dongmin Li, Shemin Lu
CELL BIOCHEMISTRY AND BIOPHYSICS
(2020)