Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Yannic C. Bartsch, Carolin Loos, Evan Rossignol, Jesse M. Fajnzylber, Dansu Yuan, Anchalee Avihingsanon, Sasiwimol Ubolyam, Thidarat Jupimai, Bernard Hirschel, Jintanat Ananworanich, Douglas A. Lauffenburger, Jonathan Z. Li, Galit Alter, Boris Julg
Summary: Plasma viremia reoccurs in most HIV-infected individuals once antiretroviral therapy is interrupted, and the kinetics of viral rebound differ significantly between individuals. Antibody features, including Fc functionality and Fc glycosylation, may serve as sensitive indicators of HIV disease activity and could be beneficial for future research.
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Fengqiang Cao, Sha Peng, Yaling An, Kun Xu, Tianyi Zheng, Lianpan Dai, Kenji Ogino, To Ngai, Yufei Xia, Guanghui Ma
Summary: Current vaccine delivery systems aim to replicate the natural dissemination of live pathogens, but fail to consider that pathogens evolve to evade the immune system. A new multi-layered aluminum hydroxide-stabilized emulsion (MASE) has been developed to dictate the delivery sequence of antigens, resulting in enhanced immune responses and decreased viral loads in H1N1 influenza and SARS-CoV-2 vaccines. By reversing the delivery sequence of surface antigen and core antigen, the inside-out strategy may offer major implications for enhanced vaccinations against enveloped RNA viruses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Jiri Brezina, Matous Voboril, Dominik Filipp
Summary: The evolution of the adaptive immune system leads to the generation of self-reactive clones, which must be eliminated to prevent autoimmunity. This process occurs in the thymic medulla, where the interaction between T cell receptor and self-peptide MHC complexes determines the fate of thymocytes. Thymic antigen presenting cells, including medullary thymic epithelial cells and dendritic cells, play a fundamental role in presenting self-antigens in the thymus for the establishment of T cell central tolerance. Recent studies have revealed the heterogeneity of these cell subsets and their roles in T cell selection processes, adding complexity to our understanding. Identification of molecular determinants controlling the presentation of self-antigens would advance our knowledge in this area.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Christian Moebs, Martin Salheiser, Fabian Bleise, Marie Witt, Johannes U. Mayer
Summary: This review aims to highlight the role of basophils in antigen presentation and T cell priming, as well as resolving the debate on whether basophils influence antigen presentation through direct or indirect mechanisms. Tissue-specific differences in basophil phenotypes and their interactions with other antigen-presenting cells will be discussed, along with their implications on immunological and clinical outcomes of disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mirela Kremenovic, Alfred A. Chan, Bing Feng, Lukas Baeriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J. Lee, Mirjam Schenk
Summary: In this study, a novel BCG lysate was developed and formulated into a thermosensitive hydrogel. The BCG lysate exhibited enhanced antitumor efficacy and promoted a proinflammatory tumor microenvironment in vivo. The underlying mechanisms of BCG lysate-mediated tumor immunity relied on macrophages (M phi) and dendritic cells (DCs). The BCG hydrogel treatment induced systemic immunity, suppressed lung metastases, and improved survival in melanoma-bearing mice. Furthermore, BCG hydrogel treatment enhanced antigen processing and presentation, and increased the frequency of melanoma-reactive CD8(+) T cells. In human melanoma patients, intralesional-BCG treatment was associated with enhanced M1 M phi, mature DCs, antigen processing and presentation, and increased patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Chemistry, Inorganic & Nuclear
Dandan Wang, Wenxing Gu, Weiliang Chen, Jin Zhou, Le Yu, Byung Kook Kim, Xuenong Zhang, Jong Seung Kim
Summary: Nanovaccines based on nanomaterials have emerged as an advanced technology for enhancing anti-tumor immunotherapy. They stimulate antigen presenting cells to release signals and activate immune-killing T cells, improving the efficacy of immunotherapy. The positive regulation of nanovaccines enhances antigen presentation and recruits more immune-killing T cells.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Takuya Sakamoto, Terutsugu Koya, Misa Togi, Kenichi Yoshida, Tomohisa Kato, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: This study evaluated the function and preclinical validation of human dendritic cell (DC) dexosomes, small DC-secreted vesicles that contain immune signals, for cancer vaccination. The researchers characterized a potential dexosome model using immature and mature DCs derived from a cell line called MUTZ3, and found that one type of MUTZ3-derived DC dexosomes exhibited potential immunogenicity and higher antigen presentation potency, making them potential resources for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng, Zhenzhong Zhang, Lei Wang
Summary: The physical properties of nanoparticle-based vaccines, such as their shape, play a crucial role in antigen capture, lymphatic delivery, antigen presentation, and immune response in lymph nodes. Star-shaped gold nanoparticles (AuNPs) were found to capture and retain more repetitive antigen epitopes. Rods and star-shaped nanovaccines primarily drained into the lymph node follicles region, while cage-shaped nanovaccines showed stronger paracortex retention. Surprisingly, star-shaped nanovaccines elicited potent humoral immunity, preventing tumor growth in prophylactic studies. Cage-shaped nanovaccines preferentially presented peptide-MHC I complexes and showed the strongest therapeutic efficacy when combined with PD-1 checkpoint inhibitors in established tumor studies.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Oncology
Tim B. Fessenden, Lauren E. Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P. Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Summary: Cytotoxic CD8(+) T cells must recognize tumor-derived antigens to achieve effective tumor elimination. Our study shows that dendritic cells induce cytotoxic CD8(+) T-cell responses by cross-presenting tumor-derived peptides, and the proportion of membrane-derived neoantigens is associated with reduced survival and treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Marko Salmikangas, Maria Laaksonen, Henrik Edgren, Marco Salgado, Anu Suoranta, Pirkko Mattila, Virve Koljonen, Tom Bohling, Harri Sihto
Summary: Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma with distinct genomic and transcriptomic profiles. In this study, transcriptomes of MCC tissue samples were analyzed to identify genes associated with outcome prediction and tumorigenesis. NCAN expression was found to be common in MCC and associated with improved survival. Further research is needed to understand the role of NCAN in MCC tumorigenesis.
Review
Pediatrics
Jon Izquierdo-Pujol, Sara Moron-Lopez, Judith Dalmau, Alba Gonzalez-Aumatell, Clara Carreras-Abad, Maria Mendez, Carlos Rodrigo, Javier Martinez-Picado
Summary: The infection of SARS-CoV-2 has caused a global pandemic with millions of infections and deaths. While persistent sequelae of COVID-19 are less common in children/adolescents compared to adults, evidence suggests that children/adolescents may experience symptoms like fatigue, lack of concentration, and muscle pain. Understanding the pathophysiology and long-term effects of COVID-19 in young people is crucial for their physical, social, and psychological well-being.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Bruna Oriol-Tordera, Anna Esteve-Codina, Maria Berdasco, Miriam Rosas-Umbert, Elena Goncalves, Clara Duran-Castells, Francesc Catala-Moll, Anuska Llano, Samandhy Cedeno, Maria C. Puertas, Martin Tolstrup, Ole S. Sogaard, Bonaventura Clotet, Javier Martinez-Picado, Tomas Hanke, Behazine Combadiere, Roger Paredes, Dennis Hartigan-O'Connor, Manel Esteller, Michael Meulbroek, Maria Luz Calle, Alex Sanchez-Pla, Jose Molto, Beatriz Mothe, Christian Brander, Marta Ruiz-Riol
Summary: This study identifies host DNA methylation profiles and epigenetic cascades that are predictive of subsequent virus control in a kick-and-kill HIV cure strategy.
Review
Biochemistry & Molecular Biology
Dalia Raich-Regue, Patricia Resa-Infante, Marcal Gallemi, Fernando Laguia, Xabier Muniz-Trabudua, Jordana Munoz-Basagoiti, Daniel Perez-Zsolt, Jakub Chojnacki, Susana Benet, Bonaventura Clotet, Javier Martinez-Picado, Nuria Izquierdo-Useros
Summary: Sialic-acid-binding immunoglobulin-like lectins, known as Siglecs, have emerged as important immune regulators that influence the outcome of viral infections. While Siglecs are necessary for effective antiviral immune responses, they can also facilitate viral dissemination within tissues. Recent preclinical findings on the interplay between Siglecs and viruses may lead to promising broad-spectrum therapeutic interventions or serve as key biomarkers to monitor viral infections.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Editorial Material
Cell Biology
Gabriela Sarango, Benedicte Manoury, Arnaud Moris
Article
Virology
Clara Duran-Castells, Anuska Llano, Ai Kawana-Tachikawa, Anna Prats, Ignacio Martinez-Zalacain, Mie Kobayashi-Ishihara, Bruna Oriol-Tordera, Ruth Pena, Cristina Galvez, Sandra Silva-Arrieta, Bonaventura Clotet, Eva Riveira-Munoz, Esther Ballana, Julia. G. Prado, Javier Martinez-Picado, Jorge Sanchez, Beatriz Mothe, Dennis Hartigan-O'Connor, Tony Wyss-Coray, Andreas Meyerhans, Magnus Gisslen, Richard. W. Price, Carles Soriano-Mas, Jose Antonio Munoz-Moreno, Christian Brander, Marta Ruiz-Riol
Summary: High levels of SIRT2 are associated with uncontrolled HIV infection, plasma viral load, and proviral levels. SIRT2 levels are also linked to markers of neurological damage and brain involution, especially in individuals who initiate cART later. Inhibition of SIRT2 could potentially be a therapeutic target for HIV infections and their associated neurological dysfunction.
JOURNAL OF VIROLOGY
(2023)
Review
Virology
Gerard Campos-Gonzalez, Javier Martinez-Picado, Talia Velasco-Hernandez, Maria Salgado
Summary: Chimeric antigen receptor (CAR) technology has had a significant impact on the treatment of blood malignancies, particularly various types of leukemia. However, applying this technology to HIV treatment presents numerous challenges that hinder its widespread adoption.
Article
Multidisciplinary Sciences
Daan K. J. Pieren, Sebastian G. Kuguel, Joel Rosado, Alba G. Robles, Joan Rey-Cano, Cristina Mancebo, Juliana Esperalba, Vicenc Falco, Maria J. Buzon, Meritxell Genesca
Summary: Resident memory T cells at the respiratory tract are important for early SARS-CoV-2 viral clearance. mRNA vaccination induces specific T cell responses in the lung, but the frequency and functionality of these cells are lower compared to convalescent patients.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Enric Gutierrez-Martinez, Susana Benet Garrabe, Nicolas Mateos, Itziar Erkizia, Jon Ander Nieto-Garai, Maier Lorizate, Kyra J. E. Borgman, Carlo Manzo, Felix Campelo, Nuria Izquierdo-Useros, Javier Martinez-Picado, Maria F. Garcia-Parajo
Summary: The immunoglobulin-like lectin receptor CD169 (Siglec-1) on activated dendritic cells (DCs) mediates the capture of HIV-1 through binding to sialylated ligands. Activation of DCs leads to basal nanoclustering of Siglec-1, which enhances the receptor's avidity to gangliosides carrying sialic ligands. This facilitates the accumulation of viral particles in a single compartment.
Review
Cell Biology
Laura Garcia-Gonzalez, Andrea Marti-Sarrias, Maria C. Puertas, Angel Bayon-Gil, Patricia Resa-Infante, Javier Martinez-Picado, Arcadi Navarro, Sandra Acosta
Summary: The acute phase of COVID-19 may have long-term implications, leading to chronic disorders that can last for months or even years. Neurological manifestations can vary in severity and may persist for more than 12 weeks after the initial infection. Brain organoid models provide valuable insights into the neuropathology of acute and long COVID, allowing for a better understanding of the underlying mechanisms.
DISEASE MODELS & MECHANISMS
(2023)
Article
Immunology
Silvia Bernal, Maria C. Puertas, Sara Moron-Lopez, Ross D. Cranston, Victor Urrea, Judith Dalmau, Maria Salgado, Cristina Galvez, Itziar Erkizia, Ian McGowan, Didier Scherrer, Boris Revollo, Guillem Sirera, Jose Ramon Santos, Bonaventura Clotet, Roger Paredes, Javier Martinez-Picado
Summary: This study evaluates the impact of obefazimod, a molecule that interferes with RNA biogenesis, on reducing chronic immune activation and inflammation in people with HIV on suppressive antiretroviral therapy as well as its potential role in virus remission strategies.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Sergi Chumillas, Saurabh Loharch, Manuela Beltran, Mateusz P. Szewczyk, Silvia Bernal, Maria C. Puertas, Javier Martinez-Picado, Jose Alcami, Luis M. Bedoya, Vicente Marchan, Jose Gallego
Summary: This study explored the optimization of the antiretroviral properties of benfluron and found that both the benzo[c] and cyclopentanone components are essential for its activity. The results provide insights for the design of new anti-HIV agents targeting the inhibition of Rev function.
Meeting Abstract
Biochemistry & Molecular Biology
Eliana Molina Moya, Camero Laura Terron, Maria Angeles Pelaez Vico, Maria C. Romero Puertas, Luisa Maria Sandalio Gonzalez
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Nomonde Bengu, Noxolo Mchunu, Sijabulile Mokhethi, Rowena Fillis, Gabriela Cromhout, Jeroen van Lobenstein, Yeney Graza, Constant Kapongo, Kogielambal Chinniah, Roopesh Bhoola, Emily Adland, Mari C. Puertas, Thumbi Ndung'u, Javier Martinez-Picado, Moherndran Archary, Philip J. R. Goulder
Summary: The study evaluated a new Point-of-care (PoC) test for early infant diagnosis (EID) and treatment initiation, showing its potential to improve outcomes. Both PoC tests and the standard treatment test performed well in detecting HIV infection in newborns. The PoC tests had a higher result generation rate than the standard treatment test.
Article
Cell Biology
Edwards Pradenas, Benjamin Trinite, Victor Urrea, Silvia Marfil, Ferran Tarres-Freixas, Raquel Ortiz, Carla Rovirosa, Jordi Rodon, Julia Vergara-Alert, Joaquim Segales, Victor Guallar, Alfonso Valencia, Nuria Izquierdo-Useros, Marc Noguera-Julian, Jorge Carrillo, Roger Paredes, Lourdes Mateu, Anna Chamorro, Ruth Toledo, Marta Massanella, Bonaventura Clotet, Julia Blanco
Summary: This study follows a cohort of 332 COVID-19 patients for over a year to understand the long-term immune responses to SARS-CoV-2. The study finds that long-term neutralizing activity remains stable beyond one year after infection in mild/asymptomatic and hospitalized participants. It also shows that hospitalized individuals generate both short-term and long-term memory B cells, while non-hospitalized individuals have dominant long-term B cells. Vaccination boosts responses to natural infection, but unvaccinated participants show reduced efficacy against the beta variant.
CELL REPORTS MEDICINE
(2022)