Article
Immunology
Yifan Qu, Xinyi Li, Fengying Xu, Shimin Zhao, Xuemei Wu, Yuzhen Wang, Jiming Xie
Summary: The study demonstrates that kaempferol has significant anti-inflammatory and antioxidant effects in DSS-induced colitis mice, alleviating UC symptoms by modulating the gut microbiota and TLR4-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Li-Jian Chen, Xiu-Wen Li, Yi Liu, Jia-Li Liu, Jian-Zheng Yang, Jia-Hao Li, Clare Hsu, Long Chen, Jia-Hao Zeng, Xiao-Li Xie, Qi Wang
Summary: This study found that propionate supplementation can alleviate liver and intestinal damage caused by METH and improve liver and colon function impairments and inflammation by suppressing the TLR4/MyD88/NF-kappa B pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Reda Juskeviciene, Ann-Kristina Fritz, Margarita Brilkova, Rashid Akbergenov, Karen Schmitt, Hubert Rehrauer, Endre Laczko, Patricia Isnard-Petit, Kader Thiam, Anne Eckert, Jochen Schacht, David P. Wolfer, Erik C. Boettger, Dimitri Shcherbakov
Summary: A point mutation V336Y in mitoribosomal protein Mrps5 (uS5m) has been recently identified as a ribosomal ambiguity (ram) mutation causing error-prone mitochondrial protein synthesis. In transgenic knock-in animals, a homologous mutation V338Y is associated with a specific phenotype including impaired mitochondrial function, behavioral alterations, hearing damage, and accelerated metabolic aging in muscle. However, a homologous G -> R mutation in mitoribosomal Mrps5 did not affect the accuracy of mitochondrial protein synthesis, suggesting a challenge to the postulated link between Mrps5 V338Y-mediated misreading and the in vivo phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jiehong Xie, Peng Tuo, Wei Zhang, Shouping Wang
Summary: This study found that inhibiting the TLR4/NF-κB pathway can promote the polarization of LPS-induced microglia from M1 to M2 phenotype and alleviate excessive cell activation and inflammatory factor release.
Article
Environmental Sciences
Xinwen Dong, Lvfei Deng, Yaguang Su, Xiaofeng Han, Sanqiao Yao, Weidong Wu, Jia Cao, Linqiang Tian, Yichun Bai, Guizhi Wang, Wenjie Ren
Summary: Gas explosions are a common cause of traumatic brain injury in coal miners. This study investigated the effects of curcumin on gas explosion-induced brain injury in rats. The results showed that curcumin treatment improved histological abnormalities, mitochondrial structure, and neuroinflammatory signaling molecules in the brain tissue. Curcumin also reshaped the gut microbiota and reduced serum lipopolysaccharide levels, showing potential therapeutic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Huiting Wang, Xiaoman Zheng, Yongshi Lin, Xirui Zheng, Mingen Yan, Yaoxing Li, Dayou Shi, Shining Guo, Cui Liu
Summary: The study found that the mixture of Radix isatidis, Forsythiae, and Gypsum (RIFG) has a good antipyretic effect on LPS-induced fever in broilers. RIFG can lower body temperature, inhibit the expression of inflammatory genes and proteins, and promote the generation of antipyretic factors.
Article
Agriculture, Dairy & Animal Science
Fujun Miao, Chunlan Shan, Shuxiang Geng, Delu Ning
Summary: This study aimed to investigate the ameliorative effect of oleocanthal (OC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in chickens and its possible mechanisms. The results showed that OC treatment improved the pathological morphology and suppressed apoptosis in LPS-induced ALI chickens. OC supplementation also enhanced antioxidant capacity and inhibited the activation of the toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) pathway in LPS group. Overall, OC supplementation can alleviate LPS-induced ALI in chickens by suppressing apoptosis, enhancing lung antioxidant capacities, and inhibiting TLR4/NF-κB pathway activation.
Article
Chemistry, Medicinal
Shan Han, Siyuan Li, Jilang Li, Jia He, Qin-Qin Wang, Xiang Gao, Shilin Yang, Jingjing Li, Renyikun Yuan, Guoyue Zhong, Hongwei Gao
Summary: Acute kidney injury (AKI) is a common clinical condition with high incidence and mortality rates. This study found that Hederasaponin C (HSC) has a protective effect against lipopolysaccharide (LPS)-induced renal inflammation by inhibiting the expression of TLR4 and the activation of NF-kappa B and PIP2 signaling pathways, as well as suppressing the activation of the NLRP3 inflammasome.
PHYTOTHERAPY RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Shumin Zhang, Jinbiao Zhao, Jinhua Hu, Hengxun He, Yihan Wei, Linbao Ji, Xi Ma
Summary: The offspring of super-multiparous sows face liver inflammation, which can be improved by GABA supplementation through enhancing antioxidant enzyme activity, reducing the expression of pro-inflammatory cytokines, and regulating the TLR4/NF-κB signaling pathway.
Article
Immunology
Yongcan Wu, Demei Huang, Xiaomin Wang, Caixia Pei, Wei Xiao, Fei Wang, Zhenxing Wang
Summary: Pre-treatment with PLD alleviates lung inflammation and injury induced by LPS, reduces inflammatory cytokine levels, modulates oxidative stress-related factors in lung tissue, and inhibits the activation of NLRP3 and NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dandong Fang, Yu Li, Bo He, Daqian Gu, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Ming Tang, Xingbing Li, Donghai Yang, Chunmei Xu, Yijie Hu, Hongyong Wang, Pedro A. Jose, Yu Han, Chunyu Zeng
Summary: Gastrin/CCKBR plays a protective role in sepsis-induced myocardial dysfunction and may serve as a potential therapeutic target for SMD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Immunology
Dongfeng Cai, Jing Zhang, Jin Yang, Qi Lv, Chao Zhong
Summary: This study reveals that FTO is involved in the alleviation of osteoarthritis (OA) through the regulation of the miR-515-5p/TLR4/MyD88/NF-Kappa B axis, which reduces inflammation and cell injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Junqiu Miao, Jing Shen, Chaoqun Yan, Jinhong Ren, Haixin Liu, Yuanbiao Qiao, Qingshan Li
Summary: This study investigated the protective and therapeutic effects of Mai-Luo-Ning injection (MLN) on acute lung injury (ALI) and explored the underlying mechanisms. The results showed that MLN exerted a protective effect on ALI by inhibiting the TLR4/NF-κB signaling pathway and reducing inflammation.
Article
Medicine, Research & Experimental
Xuehai Jia, Ke Zhang, Shushu Feng, Yuyao Li, Dahong Yao, Qiaohui Liu, Dong Liu, Xin Li, Jian Huang, Hangyu Wang, Jinhui Wang
Summary: This study verified the relieving effect of Rhodiola rosea L. total glycosides (RTG) on acute lung injury (ALI) in mice and elucidated its mechanism. RTG significantly improved the pathological structure of lung tissue and reduced inflammatory cell infiltration in LPS-induced ALI mice. RTG decreased the production of proinflammatory cytokines, increased antioxidant activity, and inhibited the TLR4/NF-kappa B pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Dairy & Animal Science
Wenyue Qiu, Xinting Zhang, Xiaoyue Pang, Jianjia Huang, Shuilian Zhou, Ruixia Wu, Rongmei Wang, Zhaoxin Tang, Rongsheng Su
Summary: This study found that tertbutylhydroquinone (TBHQ) can attenuate LPS-induced injury in intestinal porcine epithelial cells by regulating the expression levels of pyroptosis and the HMGB1/TLR4/NF-.B axis.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Allergy
Kentaro Takahashi, Kazuyuki Meguro, Hirotoshi Kawashima, Daisuke Kashiwakuma, Shin-ichiro Kagami, Shoichiro Ohta, Junya Ono, Kenji Izuhara, Itsuo Iwamoto
Article
Multidisciplinary Sciences
Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe
NATURE COMMUNICATIONS
(2019)
Article
Allergy
Junya Ono, Masayuki Takai, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Shoichiro Ohta, Koubun Yasuda, Simon J. Conway, Yasuyuki Yokosaki, Kenji Izuhara
ALLERGOLOGY INTERNATIONAL
(2020)
Article
Immunology
Hiroki Tsukamoto, Kanae Kubota, Ayumi Shichiku, Masamitsu Maekawa, Nariyasu Mano, Hideo Yagita, Shoichiro Ohta, Yoshihisa Tomioka
Article
Biochemical Research Methods
Koshi Nagai, Baasanjav Uranbileg, Zhen Chen, Amane Fujioka, Takahiro Yamazaki, Yotaro Matsumoto, Hiroki Tsukamoto, Hitoshi Ikeda, Yutaka Yatomi, Hitoshi Chiba, Shu-Ping Hui, Toru Nakazawa, Ritsumi Saito, Seizo Koshiba, Junken Aoki, Daisuke Saigusa, Yoshihisa Tomioka
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2020)
Article
Allergy
Jun Tanaka, Akira Hebisawa, Tsuyoshi Oguma, Katsuyoshi Tomomatsu, Junko Suzuki, Hiroshige Shimizu, Yoshinori Kawabata, Takashi Ishiguro, Noboru Takayanagi, Soichiro Ueda, Koichi Fukunaga, Masami Taniguchi, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Koichiro Asano
Article
Multidisciplinary Sciences
Yoshitomi Kanemitsu, Eikan Mishima, Masamitsu Maekawa, Yotaro Matsumoto, Daisuke Saigusa, Hiroaki Yamaguchi, Jiro Ogura, Hiroki Tsukamoto, Yoshihisa Tomioka, Takaaki Abe, Nariyasu Mano
SCIENTIFIC REPORTS
(2019)
Article
Allergy
Chie Morimoto, Hisako Matsumoto, Tomoko Tajiri, Yasuhiro Gon, Reiko Ito, Shu Hashimoto, Maho Suzukawa, Ken Ohta, Kenji Izuhara, Junya Ono, Shoichiro Ohta, Isao Ito, Tsuyoshi Oguma, Yoshihiro Kanemitsu, Tadao Nagasaki, Yumi Izuhara, Akio Niimi, Toyohiro Hirai
Summary: The study aimed to investigate the association between IL-18 and inadequate response to omalizumab treatment in severe allergic asthma patients. It was found that patients with high baseline serum free IL-18 levels may predict reduced efficacy of omalizumab in treating exacerbations.
Article
Biochemistry & Molecular Biology
Hideyuki Ihara, Takahiro Okada, Naoyuki Taniguchi, Yoshitaka Ikeda
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Review
Biochemistry & Molecular Biology
Naoyuki Taniguchi, Yuki Ohkawa, Kento Maeda, Yoichiro Harada, Masamichi Nagae, Yasuhiko Kizuka, Hideyuki Ihara, Yoshitaka Ikeda
Summary: Cancer-related changes in glycans on cell surface proteins are regulated by glycosyltransferases and related genes, which play key roles in cancer metastasis and invasion. The significance of EMT and N-glycan branching glycosyltransferases needs to be reconsidered for potential therapeutic strategies. Specific glycosyltransferases involved in EMT or MET pathways may be difficult to define due to their roles in intermediate states.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Letter
Allergy
Hironobu Sunadome, Hisako Matsumoto, Yuji Tohda, Takahiko Horiguchi, Hideo Kita, Kazunobu Kuwabara, Keisuke Tomii, Kojiro Otsuka, Masaki Fujimura, Noriyuki Ohkura, Takashi Iwanaga, Soichiro Hozawa, Akio Niimi, Yoshihiro Kanemitsu, Tadao Nagasaki, Noriyuki Tashima, Yumi Ishiyama, Chie Morimoto, Tsuyoshi Oguma, Tomoko Tajiri, Isao Ito, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Toyohiro Hirai
ALLERGOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Hideyuki Ihara, Yoshitaka Ikeda
Summary: This review summarizes the biological and physiological characteristics of the core alpha 1,6-fucose structure in asparagine-linked oligosaccharides, with a focus on the importance of the alpha-helical (coiled-coil) and SH3 domains in the function of FUT8 enzyme. The formation of dimers is crucial for the activity, substrate recognition, and other characteristics of this enzyme.
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
(2021)
Letter
Dermatology
Yasuhiro Nanri, Satoshi Nunomura, Tomoya Watanabe, Shoichiro Ohta, Yukie Yamaguchi, Kenji Izuhara
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Medical Laboratory Technology
Masayuki Takai, Junya Ono, Masaki Okamoto, Kiminori Fujimoto, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Shoichiro Ohta, Tomoaki Hoshino, Arata Azuma, Kenji Izuhara
Summary: The formation of an IgA complex affects the measurement of periostin. The EMI and R1 domains of periostin contribute to the formation of the complex with IgA. A novel ELISA system that combines the R3 and R4 domains allows for independent measurement of periostin.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Article
Allergy
Junya Hirayama, Takao Fujisawa, Mizuho Nagao, Yu Kuwabara, Keigo Kainuma, Yoshinori Azuma, Junya Ono, Shoichiro Ohta, Masahiro Hirayama, Kenji Izuhara
Summary: The study found that SCCAs, especially SCCA2, are sensitive biomarkers for detecting AD in children and adolescents, as well as for assessing the severity and response to treatment of severe AD.
ASIA PACIFIC ALLERGY
(2021)