Review
Immunology
Mikhail Melnikov, Anna Lopatina
Summary: Depression is a common neuropsychological symptom in multiple sclerosis, and it may have a common immune mechanism with the disease. Neuroinflammation, along with disturbances in biogenic amines, is believed to play a significant role in the pathogenesis of depression. Th17 cells are highlighted as critical players in inflammatory diseases of the central nervous system, including multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Paulina Maria Reyes-Mata, Argelia Esperanza Rojas-Mayorquin, Lucrecia Carrera-Quintanar, Celia Gonzalez-Castillo, Mario Alberto Mireles-Ramirez, Jose de Jesus Guerrero-Garcia, Daniel Ortuno-Sahagun
Summary: This study aimed to investigate the serum levels of Pleiotrophin (PTN) in patients with Multiple Sclerosis (MS). The results showed that PTN serum levels were significantly higher in RRMS patients compared to the healthy control group, and were associated with sex, body mass index (BMI), and IFN-beta treatment.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Geosciences, Multidisciplinary
Jonah Bloch-Johnson, Maria Rugenstein, Martin B. Stolpe, Tim Rohrschneider, Yiyu Zheng, Jonathan M. Gregory
Summary: The equilibrium climate sensitivity, or the equilibrium warming per CO2 doubling, increases with CO2 concentration for most coupled general circulation models, with feedback temperature dependence being a key factor driving the sensitivity increase. Feedback temperature dependence is positive in the majority of models, primarily due to the longwave clear-sky feedback, and it raises the risk of extreme or runaway warming.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Clinical Neurology
Nicolas Fissolo, Pascal Benkert, Jaume Sastre-Garriga, Neus Mongay-Ochoa, Andreu Vilaseca-Jolonch, Sara Llufriu, Yolanda Blanco, Harald Hegen, Klaus Berek, Francisco Perez-Miralles, Konrad Rejdak, Luisa M. Villar, Enric Monreal, Roberto Alvarez-Lafuente, Onder K. Soylu, Ahmed Abdelhak, Franziska Bachhuber, Hayrettin Tumani, Sergio Martinez-Yelamos, Antonio J. Sanchez-Lopez, Antonio Garcia-Merino, Lucia Gutierrez, Tamara Castillo-Trivino, Jan Lycke, Igal Rosenstein, Roberto Furlan, Massimo Filippi, Nieves Tellez, Lluis Ramio-Torrenta, Jan D. Lunemann, Heinz Wiendl, Sara Eichau, Michael Khalil, Jens Kuhle, Xavier Montalban, Manuel Comabella
Summary: This study aimed to investigate the potential of serum biomarker levels in predicting disability progression in patients with primary progressive multiple sclerosis (PPMS). The study found that levels of neurofilament light chain (sNfL), glial fibrillar acidic protein (sGFAP), and chitinase 3-like 1 (sCHI3L1) were associated with changes in the Expanded Disability Status Scale (EDSS) over different time periods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Peter G. E. Kennedy, Michael W. Graner, Anthony Fringuello, Wenbo Zhou, Tiffany Pointon, Kinda Alquatli, Sara Bisel, Dianne Langford, Xiaoli Yu
Summary: Increased levels of total IgG and IgG3 antibodies in serum are potential markers for distinguishing multiple sclerosis (MS) from other neurological disorders. These antibodies are not detected in cerebrospinal fluid (CSF), suggesting a systemic source. The role of IgG3 antibodies in MS pathogenesis is supported by their association with disease development and genetic polymorphisms. IgG3 antibodies may serve as a potential candidate for the development of MS blood biomarkers.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Neurosciences
Siying Qu, Shengfeng Hu, Huiting Xu, Yongjian Wu, Siqi Ming, Xiaoxia Zhan, Cheng Wang, Xi Huang
Summary: Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease mediated by pathogenic T helper 17 (Th17) cells. In this study, the key regulator of Th17 differentiation in MS was found to be the triggering receptor expressed on myeloid cells 2 (TREM-2). TREM-2 was highly expressed on pathogenic CD4-positive T lymphocytes in both MS patients and EAE mouse models. Conditional knockout of Trem-2 significantly alleviated disease activity and reduced Th17 cell infiltration, activation, differentiation, and inflammatory cytokine production in EAE mice. The TREM-2/ZAP70/STAT3 signal axis was identified as essential for Th17 activation and differentiation in EAE progression.
NEUROSCIENCE BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Karina Maciak, Sylwia Pietrasik, Angela Dziedzic, Justyna Redlicka, Joanna Saluk-Bijak, Michal Bijak, Tomasz Wlodarczyk, Elzbieta Miller
Summary: Multiple sclerosis (MS) and Devic's disease (NMO) are autoimmune, inflammatory diseases of the central nervous system with unclear etiology. Th17 cells and related cytokines may be useful as discriminatory markers for these diseases, but broader immune response mechanisms must also be considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Mickael Bonnan, Henri Courtade, Stephane Debeugny
Summary: This study describes the natural history of Ig levels in multiple sclerosis (MS) patients. The results show that IgG levels were higher in samples taken before the onset of MS symptoms. Additionally, overall Ig levels remained stable during the first 1 to 20 years after onset.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Neurosciences
Mikhail Melnikov, Anastasiya Sviridova, Vladimir Rogovskii, Vladimir Kudrin, Vladimir Murugin, Alexey Boyko, Mikhail Pashenkov
Summary: Dopamine inhibits the function of Th17 cells in multiple sclerosis (MS) through the activation of D-2-like dopaminergic receptor.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolina Prtenjaca, Matea Rob, Muhammad S. Alam, Andrea Markovinovic, Cristiana Stuani, Emanuele Buratti, Ivana Munitic
Summary: Deficiency of optineurin protein leads to upregulation of TDP-43 protein expression in microglial cells, and this upregulation is not affected by inflammatory stimuli. This finding is important for understanding the pathogenesis of ALS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dhiraj Gurjar, Sananda Kumar Patra, Neelam Bodhale, Nibedita Lenka, Bhaskar Saha
Summary: IFN-gamma plays a critical role in both innate and adaptive immunity, and its responsiveness in infected macrophages determines the efficacy of anti-Leishmania function. Impaired IFN-gamma responsiveness is caused by altered expression and heterodimerization of IFN-gamma receptors, as well as reduced signaling molecule phosphorylation and increased degradation. The parasite load is not only influenced by the production of IFN-gamma but also by its responsiveness.
Article
Genetics & Heredity
Mariusz Kulinczak, Maria Sromek, Grzegorz Panek, Klara Zakrzewska, Renata Lotocka, Lukasz Michal Szafron, Jan Konrad Siwicki
Summary: The study found that the expression levels of certain cancer-promoting genes in tumor-adjacent tissues of endometrial cancer patients were higher than in their primary tumors, suggesting the diagnostic potential and promising role as a target for anticancer therapy of malignant tumor-adjacent tissues.
Article
Clinical Neurology
Manuel Comabella, Jaume Sastre-Garriga, Pere Carbonell-Mirabent, Nicolas Fissolo, Carmen Tur, Sunny Malhotra, Deborah Pareto, Francesc X. Aymerich, Jordi Rio, Alex Rovira, Mar Tintore, Xavier Montalban
Summary: This study found that serum neurofilament light chain (sNfL) levels can be used as a prognostic biomarker for future long-term disability progression in patients with progressive multiple sclerosis (MS).
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Alyssa A. Toorop, Zoe L. E. van Kempen, Maurice Steenhuis, Jessica Nielsen, L. G. F. Sinnige, Gert van Dijk, Christiaan M. Roosendaal, Edo P. J. Arnoldus, Elske Hoitsma, Birgit Lissenberg-Witte, Brigit A. de Jong, Bob W. van Oosten, Eva M. M. Strijbis, Bernard M. J. Uitdehaag, Theo Rispens, Joep Killestein
Summary: The study evaluated the change in natalizumab trough drug levels when switching from intravenous to subcutaneous administration. It was found that the drug levels were on average 55% lower with subcutaneous administration, leading to very low levels in some patients. Monitoring of trough drug levels is advised when switching to subcutaneous administration in patients with low intravenous drug levels, higher body mass index, or extended treatment intervals.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Ahmed Abdelhak, Christian Cordano, W. John Boscardin, Eduardo Caverzasi, Jens Kuhle, Brandon Chan, Jeffrey M. Gelfand, Hao H. Yiu, Frederike C. Oertel, Alexandra Beaudry-Richard, Shivany Condor Montes, Jorge R. Oksenberg, Argentina Lario Lago, Adam Boxer, Julio C. Rojas-Martinez, Fanny M. Elahi, Jonah R. Chan, Ari J. Green
Summary: Treatment with the remyelinating agent clemastine in MS patients with no evidence of disease activity or progression was associated with a reduction of blood NfL, suggesting that neuroprotection is achievable and measurable with therapeutic remyelination.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Clinical Neurology
G. Abbadessa, F. Brigo, M. Clerico, S. De Mercanti, F. Trojsi, G. Tedeschi, S. Bonavita, L. Lavorgna
Summary: Digital therapeutics, defined as evidence-based therapeutic interventions driven by software, can be used independently or in combination with other therapies to optimize patient care and health outcomes, particularly benefiting patients with chronic disabling diseases.
JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Massimiliano Di Filippo, Cinzia Cordioli, Simona Malucchi, Pietro Annovazzi, Paola Cavalla, Valentina Torri Clerici, Paolo Ragonese, Viviana Nociti, Marta Radaelli, Alice Laroni, Fabio Buttari, Lorena Lorefice, Diana Ferraro, Alberto Gajofatto, Luca Prosperini, Roberta Fantozzi, Laura Boffa, Roberta Lanzillo, Marcello Moccia, Marinella Clerico, Giovanna De Luca, Valentina Tomassini, Massimiliano Calabrese, Angela Borrelli, Damiano Paolicelli, Giorgia Teresa Maniscalco, Paola Gazzola, Antonio Gallo, Claudio Solaro, Eleonora Cocco, Claudio Gasperini, Carla Tortorella
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Roberto Furlan, Marco Salvetti
Summary: The study assessed the relationship between disease-modifying therapy (DMT) and the development of anti-SARS-CoV-2 antibodies in patients with multiple sclerosis (MS), finding that patients treated with anti-CD20 drugs had a lower likelihood of developing antibodies.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Luigi Lavorgna, Pietro Iaffaldano, Gianmarco Abbadessa, Roberta Lanzillo, Sabrina Esposito, Domenico Ippolito, Maddalena Sparaco, Simone Cepparulo, Giacomo Lus, Rosa Viterbo, Marinella Clerico, Francesca Trojsi, Paolo Raganose, Giovanna Borriello, Elisabetta Signoriello, Raffaele Palladino, Marcello Moccia, Francesco Brigo, Maria Troiano, Gioacchino Tedeschi, Simona Bonavita
Summary: The study found discrepancies in AS and EDSS assessments between GM (R) and routine clinical methods in 243 patients with multiple sclerosis. Progressive phenotype, worse fatigue, and more severe depression were associated with discrepancies between GM (R) and routine clinical scoring.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Maria Caputo, Elisabetta Zucchi, Ilaria Martinelli, Giulia Gianferrari, Cecilia Simonini, Amedeo Amedei, Elena Niccolai, Cinzia Gellera, Viviana Pensato, Jessica Mandrioli
Summary: Mutations in the MATR3 gene have been linked to ALS, with this case being the first to report duplication in exons 15 and 16. The patient presented with limb-onset ALS and a complex medical history, including autoimmune conditions, suggesting a potential role of MATR3 mutations in this peculiar ALS phenotype.
NEUROLOGICAL SCIENCES
(2022)
Review
Psychology, Multidisciplinary
Marialaura Di Tella, Marinella Clerico, Lorys Castelli
Summary: This scoping review systematically reviews the association between socioemotional alterations and reduced quality of life (QoL) and social functioning in patients with Multiple Sclerosis (MS). Eight studies fulfilling the inclusion criteria were included in the review, and the majority of findings suggest that socioemotional alterations contribute to impaired QoL and social functioning in MS patients. However, more research is needed to replicate and confirm these findings, particularly with standardized and ecological tasks for assessing social cognition skills and diverse samples of MS patients.
CURRENT PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martina Capozza, Rachele Stefania, Valentina Dinatale, Valeria Bitonto, Laura Conti, Cristina Grange, Renata Skovronova, Enzo Terreno
Summary: A PSMA-targeted NIRF dye was developed as an intraoperative tool for improving tumour margin delineation and cancer therapy. The dye exhibited high affinity and specificity towards PCa cells and accurately highlighted tumour margins. In addition, the dye had the capability of PDT to kill residual cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Junbiao Wang, Alessia Lamolinara, Laura Conti, Mara Giangrossi, Lishan Cui, Maria Beatrice Morelli, Consuelo Amantini, Maurizio Falconi, Caterina Bartolacci, Cristina Andreani, Fiorenza Orlando, Mauro Provinciali, Francesco Domenico Del Pizzo, Francesca Russo, Barbara Belletti, Federica Riccardo, Elisabetta Bolli, Elena Quaglino, Federica Cavallo, Augusto Amici, Manuela Iezzi, Cristina Marchini
Summary: This study demonstrates that phage-based HER2 vaccines can delay the onset and progression of breast cancer and generate anti-HER2 antibodies, providing a new approach for the treatment of HER2-positive breast cancer.
Article
Biochemistry & Molecular Biology
Giuseppina Barutello, Antonino Di Lorenzo, Alessandro Gasparetto, Chiara Galiazzi, Elisabetta Bolli, Laura Conti, Federica Cavallo
Summary: Combining xCT immunetargeting with APR-246 treatment shows potential in the management of breast cancer by significantly decreasing cell viability and affecting cancer stem cells' self-renewal. The combination treatment of DNA vaccination against xCT and APR-246 treatment synergistically hinders tumor progression and prevents lung metastasis formation in vivo.
Review
Microbiology
Andrea Piccioni, Elena Niccolai, Gloria Rozzi, Giacomo Spaziani, Christian Zanza, Marcello Candelli, Marcello Covino, Antonio Gasbarrini, Francesco Franceschi, Amedeo Amedei
Summary: Familial hypercholesterolemia is a common genetic disorder that leads to early-onset atherosclerotic cardiovascular disease. The main goal of therapy is to reduce LDL cholesterol through statins, ezetimibe, and PCSK9 inhibitors. However, lowering LDL cholesterol may be challenging due to individual responses to statin therapy and the high cost of some treatments. The gut microbiota has been recently identified as a potential risk factor for CVDs, including familial hypercholesterolemia, and further research is needed to understand its role.
Article
Biochemistry & Molecular Biology
Angela Silvano, Elena Niccolai, Simone Baldi, Viola Seravalli, Noemi Strambi, Giulia Nannini, Marco Pallecchi, Gianluca Bartolucci, Astrid Parenti, Amedeo Amedei, Mariarosaria Di Tommaso
Summary: The composition of gut microbiota in pregnancy undergoes significant changes, influenced by various factors. Dysbiosis during pregnancy has been associated with preterm birth and affects the levels of certain markers in other tissues. This study investigates the impact of cervical length and gestational diabetes mellitus on inflammatory markers and microbial markers in pregnant women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paola Pontecorvi, Simona Ceccarelli, Fabrizio Cece, Simona Camero, Lavinia Vittoria Lotti, Elena Niccolai, Giulia Nannini, Giulia Gerini, Eleni Anastasiadou, Elena Sofia Scialis, Enrico Romano, Mary Anna Venneri, Amedeo Amedei, Antonio Angeloni, Francesca Megiorni, Cinzia Marchese
Summary: The global rise of single-use throw-away plastic products has led to an increase in nano/microplastics exposure burden in humans. Recently, it has been discovered that disposable period products may release nano/microplastics, which poses a potential threat to women's health. The exposure to polyethylene (PE) particles induced cell toxicity in vaginal keratinocytes, affecting gene expression, cellular structure, and potentially leading to cell ageing, inflammation, or malignant transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Serena Martinelli, Ingrid Lamminpaa, Eda Nur Dubus, Dilara Sarikaya, Elena Niccolai
Summary: GI cancers are highly prevalent malignant tumors affecting the gastrointestinal tract, accounting for one in four cancer cases and one in three cancer deaths globally. They can cause severe malnutrition and alter digestive functions, worsening the prognosis of patients. Therefore, nutritional intervention and monitoring are crucial for managing metabolic alterations, cancer symptoms, and minimizing side effects of chemotherapy.
Article
Oncology
Enza Di Gregorio, Chiara Romiti, Antonino Di Lorenzo, Federica Cavallo, Giuseppe Ferrauto, Laura Conti
Summary: Breast cancer is the most common cancer in women and the leading cause of cancer-related death. Systemic chemotherapy is the primary choice for treatment, but it causes side effects and requires high drug doses. Nanosystems for drug delivery offer a promising solution to these drawbacks.
Article
Computer Science, Interdisciplinary Applications
Simone Pernice, Alessandro Maglione, Dora Tortarolo, Roberta Sirovich, Marinella Clerico, Simona Rolla, Marco Beccuti, Francesca Cordero
Summary: GreatNector workflow is a valuable tool for analyzing and clustering patient-derived longitudinal data, as well as simulating the resulting model of patient-specific disease dynamics. The analysis was able to stratify individual patients into three model meta-patients, providing insight into patient-tailored interventions. The results showed that T-cell dynamics after alemtuzumab treatment separate non-responders versus responders patients, with non-responders group characterized by an increase of the Th17 concentration around 36 months.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)