Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Mengting Li, Caiqin Gan, Runan Zhang, Jiahui Wang, Youwei Wang, Weining Zhu, Lan Liu, Jian Shang, Qiu Zhao
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease. TRAF5 deficiency exacerbates colitis, but its role in regulating CD4(+) T cell immune responses in IBD pathogenesis is unclear.
Article
Nanoscience & Nanotechnology
Yee Huang, Li Nan, Chenwen Xiao, Jie Dong, Ke Li, Jvfen Cheng, Quanan Ji, Qiang Wei, Guolian Bao, Yan Liu
Summary: The study successfully developed GAN-OMV, which can stimulate Th1/Th2/Th17 immune responses against Bb and provide a promising strategy for novel vaccine development against the microbial pathogen. GAN-OMV showed a stable core-shell structure and effectively internalized into macrophages through multiple endocytotic pathways, promoting cell proliferation, cytokine secretion, and M1 polarization. Subcutaneous GAN-OMV vaccination significantly enhanced specific antibody production, lymphocyte proliferation, and the production of Th1/Th2/Th17 cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ritian Lin, Caiyun Ma, Leilei Fang, Chunjin Xu, Cui Zhang, Xiaohan Wu, Wei Wu, Ruixin Zhu, Yingzi Cong, Zhanju Liu
Summary: TOB1 expression is decreased in IBD patients, and overexpression of TOB1 can suppress the differentiation of IBD CD4(+) T cells into Th1/Th17 cells. It inhibits Th1/Th17 cell differentiation through the Smad4/5-ID2 pathway.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Jianya Peng, Hannah G. G. Federman, Christina M. Hernandez, Mark C. C. Siracusa
Summary: Parasitic helminth infections are a global health issue, causing significant morbidity and economic hardships. Host protective responses to helminths involve the initiation of type 2 inflammation and the involvement of various immune cells. Recent studies have also highlighted the importance of neuro-immune interactions in regulating anti-helminth immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ibrahim M. Sayed, Stella-Rita Ibeawuchi, Dominique Lie, Mahitha Shree Anandachar, Rama Pranadinata, Manuela Raffatellu, Soumita Das
Summary: The host engulfment protein ELMO1 interacts with WxxxE effectors like SifA, influencing intestinal inflammation and bacterial pathogenicity. The ELMO1-WxxxE effector interaction plays a crucial role in regulating bacterial colonization, dissemination, and induction of inflammatory cytokines. It has been found that the interaction between ELMO1 and WxxxE motif-containing effectors, such as SifA, not only affects the pathogenicity of enteric pathogens but also plays a role in modulating inflammatory responses and cellular activities.
Article
Chemistry, Multidisciplinary
Xiangke Duan, Zhao Zhi Boo, Song Lin Chua, Kelvin Han Chung Chong, Ziqi Long, Renliang Yang, Yachun Zhou, Baptiste Janela, Sanjay Haresh Chotirmall, Florent Ginhoux, Qinghua Hu, Bin Wu, Liang Yang
Summary: This study reports that Pseudomonas aeruginosa induces innate immune suppression in macrophages through quorum sensing mechanism. It is found that a quorum sensing regulated product, LasB, digests the death domains of innate immune adaptors, mainly MyD88, leading to innate immune suppression.
Article
Neurosciences
Reiss Pal, Barry M. Bradford, Neil A. Mabbott
Summary: Prion diseases are infectious and chronic neurodegenerative diseases with no cure. The activation of microglia in the central nervous system (CNS) is associated with neurodegeneration caused by prion infection. Innate immune tolerance induced by systemic bacterial lipopolysaccharide treatment has been shown to dampen the development of neuritic damage in an Alzheimer's disease mouse model but does not influence the subsequent onset of prion disease-induced neuropathology in mice.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Klare L. Bersch, Kristen E. DeMeester, Rachid Zagani, Shuyuan Chen, Kimberly A. Wodzanowski, Shuzhen Liu, Siavash Mashayekh, Hans-Christian Reinecker, Catherine L. Grimes
Summary: The article discusses the impact of bacterial peptidoglycan (PG) recognition elements on the human innate immune system, as well as immunostimulatory studies using synthesized PG-based disaccharide ligands.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Sutonuka Bhar, Guanqi Zhao, Julia D. Bartel, Heather Sterchele, Alexa Del Mazo, Lisa E. Emerson, Mariola J. Edelmann, Melissa K. Jones
Summary: Human norovirus is a major cause of non-bacterial gastroenteritis worldwide and is the second leading cause of diarrheal deaths in children in developing countries. This study shows that bacterial extracellular vesicles may play a role in controlling murine norovirus infection through modulation of the antiviral immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Dominik Sonanini, Christoph M. Griessinger, Barbara F. Schoerg, Philipp Knopf, Klaus Dittmann, Martin Roecken, Bernd J. Pichler, Manfred Kneilling
Summary: The study demonstrated that low-dose TBI can significantly improve the efficacy of CD4+ T cell-based immunotherapies, leading to increased survival of RIP1-Tag2 mice and enhanced infiltration of CD4+ T cells in tumor tissue. This approach may provide a rationale for combining TBI with immunotherapy for cancer treatment in clinical settings.
Article
Immunology
Xiaoping Ma, Jing Hu, Chengdong Wang, Yu Gu, Sanjie Cao, Xiaobo Huang, Yiping Wen, Qin Zhao, Rui Wu, Zhicai Zuo, Shumin Yu, Liuhong Shen, Zhijun Zhong, Guangneng Peng, Shanshan Ling
Summary: This study evaluated the antifungal immune responses in immunocompetent mice infected with C. cladosporioides. The results showed that skin infection with C. cladosporioides resulted in inflammatory response, with innate and Th17 immune responses playing important roles in the host's antifungal response.
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
Yuena Sun, Lei Zhang, Ling Hong, Weiwei Zheng, Junxia Cui, Xuezhu Liu, Tianjun Xu
Summary: The study identified miR-181b-2 and miR-21-1 from Miichthys miiuy as negative regulators in host immune response, targeting TRIF to suppress inflammatory cytokines and type I IFN production, thus modulating antiviral and antibacterial immunity. These miRNAs act as negative feedback regulators in host immune response, shedding light on the resistance mechanism of lower vertebrates against pathogen invasion and excessive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Xiangyu Fan, Jing Zhang, Yiqin Dai, Kun Shan, Jianjiang Xu
Summary: Blocking P2X7R can significantly alleviate corneal allograft rejection and promote graft survival by reducing inflammatory cell infiltration and Th1/Th17 cell frequencies. Research also showed that its effect on promoting immune responses in corneal allograft rejection relies heavily on activation on the NLRP3/caspase-1/IL-1 beta axis.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alessandra Gurtner, Costanza Borrelli, Ignacio Gonzalez-Perez, Karsten Bach, Ilhan E. Acar, Nicolas G. Nunez, Daniel Crepaz, Kristina Handler, Vivian P. Vu, Atefeh Lafzi, Kristin Stirm, Deeksha Raju, Julia Gschwend, Konrad Basler, Christoph Schneider, Emma Slack, Tomas Valenta, Burkhard Becher, Philippe Krebs, Andreas E. Moor, Isabelle C. Arnold
Summary: In the past decade, single-cell transcriptomics has provided insights into the biology of eosinophils, a difficult-to-sequence cell type, and their roles in intestinal homeostasis, immune regulation, and host defense. The study reveals the heterogeneity of eosinophils and the gene programs that underpin their pleiotropic functions. It also explains the mechanism by which interleukin-33 (IL-33) and interferon-gamma (IFN gamma) induce the accumulation of active eosinophils in the inflamed colon and their association with CD4(+) T cells.
Editorial Material
Biochemistry & Molecular Biology
Tammy Kielian
JOURNAL OF NEUROCHEMISTRY
(2019)
Article
Cell & Tissue Engineering
Wenhai Zhang, Yue Guo, Mitchell Kuss, Wen Shi, Amy L. Aldrich, Jason Untrauer, Tammy Kielian, Bin Duan
TISSUE ENGINEERING PART B-REVIEWS
(2019)
Article
Oncology
Diane L. Costanzo-Garvey, Tyler Keeley, Adam J. Case, Gabrielle F. Watson, Massar Alsamraae, Yangsheng Yu, Kaihong Su, Cortney E. Heim, Tammy Kielian, Colm Morrissey, Jeremy S. Frieling, Leah M. Cook
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Immunology
Casey M. Gries, Trevor Biddle, Jeffrey L. Bose, Tammy Kielian, David D. Lo
INFECTION AND IMMUNITY
(2020)
Article
Microbiology
Kelsey J. Yamada, Cortney E. Heim, Xinyuan Xi, Kuldeep S. Attri, Dezhen Wang, Wenting Zhang, Pankaj K. Singh, Tatiana K. Bronich, Tammy Kielian
Article
Medicine, General & Internal
Cortney E. Heim, Kelsey J. Yamada, Rachel Fallet, Jessica Odvody, Dana M. Schwarz, Elizabeth R. Lyden, Matthew J. Anderson, Roxanne Alter, Debbie Vidlak, Curtis W. Hartman, Beau S. Konigsberg, Chris A. Cornett, Kevin L. Garvin, Naglaa Mohamed, Annaliesa S. Anderson, Tammy Kielian
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Microbiology
Megan E. Bosch, Blake P. Bertrand, Cortney E. Heim, Abdulelah A. Alqarzaee, Sujata S. Chaudhari, Amy L. Aldrich, Paul D. Fey, Vinai C. Thomas, Tammy Kielian
Article
Immunology
Matthew Beaver, Dragana Lagundzin, Ishwor Thapa, Junghyae Lee, Hesham Ali, Tammy Kielian, Gwenn L. Skar
Summary: Cutibacterium acnes is a common cause of CSF shunt infection, often underestimated due to difficulties in culturing. New diagnostic methods are needed to detect C. acnes infection. Research in animal models showed inflammatory responses and alterations in CSF proteome during C. acnes infection, suggesting potential diagnostic strategies.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Amy L. Aldrich, Christopher M. Horn, Cortney E. Heim, Lee E. Korshoj, Tammy Kielian
Summary: The study revealed complex transcriptional heterogeneity of microglia, monocytes, and granulocyte subsets in the brain, scalp, and bone flap of mice with S. aureus craniotomy infection. PMNs played a critical role in S. aureus containment, while MDSCs attenuated PMN antibacterial activity.
JOURNAL OF IMMUNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Lee E. Korshoj, Tammy Kielian
Summary: The rapidly expanding field of immunometabolism has unveiled a complex association between cellular pro-inflammatory and anti-inflammatory activity, showcasing the metabolic profiles of immune cells in neuroinflammation. The review articles in this Special Issue address the roles of different metabolism types in various neurological conditions and discuss potential therapeutic avenues for the future.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Immunology
Lee E. Korshoj, Wen Shi, Bin Duan, Tammy Kielian
Summary: The blood-brain barrier selectively restricts molecule entry into the central nervous system, creating challenges for treating infections. Nanoparticle systems offer promising solutions by crossing the BBB with specific functionality, increasing cellular targeting, controlled release of therapeutic agents, and enhanced bioavailability. These systems can potentially enhance treatment of CNS disorders by modulating immune cell polarization.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Samuel Ruiz, Fei Wang, Lei Liu, Yongfeng Lu, Bin Duan, Lee E. Korshoj, Tammy Kielian, Bai Cui
Summary: Ag nanoparticles were synthesized using a nanosecond pulsed laser ablation process, and their antibacterial properties were studied, showing potential for biomedical applications.
JOURNAL OF LASER APPLICATIONS
(2022)
Review
Immunology
Zachary Van Roy, Tammy Kielian
Summary: Epigenetics focuses on adaptable transcriptional regulation, influencing cell identity and function. During CNS infection, epigenetic mechanisms play a significant role in controlling immune cell maturation and antimicrobial properties. Researchers use epigenetic marks to organize immune cell populations' activation states and inflammatory processes in response to CNS infection.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Blake P. Bertrand, Cortney E. Heim, Sean C. West, Sujata S. Chaudhari, Hesham Ali, Vinai C. Thomas, Tammy Kielian
Summary: Biofilms formed by Staphylococcus aureus on medical devices are a significant healthcare burden, and a type of white blood cell, G-MDSCs, promote biofilm persistence by inhibiting the activity of other immune cells. This study found that S. aureus promotes biofilm formation and survival through formate metabolism.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
Joseph Menousek, Christopher M. Horn, Cortney E. Heim, Zachary Van Roy, Lee E. Korshoj, Tammy Kielian
Summary: This study compares the phagocytic capacity of microglia and leukocytes in vitro and in vivo using a mouse model of craniotomy infection. The results show that microglial uptake of Staphylococcus aureus is limited in vivo, while other leukocyte populations exhibit phagocytic activity. Single-cell RNA sequencing reveals transcriptional differences between phagocytic and nonphagocytic cells, highlighting the importance of reactive oxygen species, lysosome, iron uptake, and transport pathways in phagocytic cells.
JOURNAL OF IMMUNOLOGY
(2022)