Article
Biochemical Research Methods
Raghvendra Mall, Mohamad Saad, Jessica Roelands, Darawan Rinchai, Khalid Kunji, Hossam Almeer, Wouter Hendrickx, Francesco M. Marincola, Michele Ceccarelli, Davide Bedognetti
Summary: An active T-helper 1/cytotoxic response in different tumors is associated with immunotherapy responsiveness and favorable prognosis. However, in some cancers, intratumoral immune activation does not prevent progression or relapse. Defining mechanisms of immune evasion is crucial for refining stratification algorithms, guiding treatment decisions, and identifying candidates for immune-targeted therapy.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Genetics & Heredity
Martha L. Bulyk, Jacques Drouin, Melissa M. Harrison, Jussi Taipale, Kenneth S. Zaret
Summary: This article discusses the important roles of pioneer factors in gene regulation, including their unique ability to bind to chromatin and promote its remodeling for gene expression. It highlights the unique insights that exploring these proteins can offer in understanding gene regulation and cellular identity.
NATURE REVIEWS GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Chengli Fang, Yu Zhang
Summary: MerR family transcription factors modulate gene expression in bacteria, functioning as transcription repressors under normal circumstances but rapidly transforming to transcription activators under cellular triggers. They bind in a unique mechanism in the long spacer of the promoter region, regulating transcription activity.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Maria Teresa Valenti, Luca Dalle Carbonare, Donato Zipeto, Monica Mottes
Summary: Autophagy plays a crucial role in maintaining cartilage homeostasis and preventing premature apoptosis of chondrocytes. Differential expression of autophagomiRNAs has been observed in osteoarthritis and may serve as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Zhong-Yan Cheng, Ting-Ting He, Xiao-Ming Gao, Ying Zhao, Jun Wang
Summary: The development and differentiation of T cells is regulated by various transcription factors, with ZBTB family members playing critical roles in both conventional and unconventional T cell lineages, influencing the development, differentiation, and effector function of these cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Horticulture
Guangwu Zhu, Chongtian Ma, Shuimiao Yu, Xueying Zhang, Jing Jiang, Xin Liu
Summary: Multiple genes related to leaf shape were discovered in the process of leaf development in tomato plants. Transcriptome sequencing and gene silencing experiments revealed that bHLH079, IAA-amino acid hydrolase, Gibberellin2ox7, Gibberellin20ox, WRKY44, and WRKY76 are endogenous regulators influencing tomato compound leaf development. This study provides a promising direction for revealing the molecular regulation mechanism underlying compound leaf development in tomatoes.
Article
Hematology
Nina Germic, Aref Hosseini, Darko Stojkov, Kevin Oberson, Meike Claus, Charaf Benarafa, Sara Calzavarini, Anne Angelillo-Scherrer, Isabelle C. Arnold, Anne Mueller, Carsten Riether, Shida Yousefi, Hans-Uwe Simon
Summary: The study demonstrates that knocking out Atg5 in eosinophils results in a decrease in mature eosinophils, an increase in immature cells, and affects cell proliferation and differentiation. Additionally, Atg5-deficient eosinophils show enhanced degranulation and bacterial killing abilities, leading to better clearance of bacterial infections in vivo models.
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Review
Cell Biology
Jossimar Coronel-Hernandez, Izamary Delgado-Waldo, David Cantu de Leon, Cesar Lopez-Camarillo, Nadia Jacobo-Herrera, Rosalio Ramos-Payan, Carlos Perez-Plasencia
Summary: Hypoxia in cancer is a well-studied phenomenon caused by tumor growth itself. Hypoxic cells are rescued through the accumulation of HIF-1 alpha in the cytoplasm, which regulates different mechanisms through the genes it induces. A group of microRNAs called hypoxaMIRs, regulated by HIF, have been identified.
Article
Immunology
Yayi Gao, Monica Zamisch, Melanie Vacchio, Laura Chopp, Thomas Ciucci, Elliott L. Paine, Gaelyn C. Lyons, Jia Nie, Qi Xiao, Ekaterina Zvezdova, Paul E. Love, Charles R. Vinson, Lisa M. Jenkins, Remy Bosselut
Summary: The NuRD complex is identified as a critical cofactor for Thpok, a BTB-ZF transcription factor that controls T cell development. NuRD is involved in the repression of CD8(+) lineage genes by Thpok, but is dispensable for Cd4 expression. This study reveals the importance of cofactor binding in the functional specificity of BTB-ZF factors.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gauri Deak, Atlanta G. Cook
Summary: Missense variants are alterations to protein coding sequences that can reflect negative selection on protein structure and function. In this study, a set of tools for visualizing missense variants on protein structures was developed and applied to investigate the functional roles of ARID family gene regulators. Comparative analysis of missense depletion patterns among paralogs revealed sub-functionalization.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katri Vaparanta, Anne Jokilammi, Ilkka Paatero, Johannes A. Merilahti, Juho Heliste, Karthik Amudhala Hemanthakumar, Riikka Kivela, Kari Alitalo, Pekka Taimen, Klaus Elenius
Summary: In this study, it is demonstrated that Neuregulin-1 (NRG-1) regulates myocardial growth through the STAT5b pathway. Disruption of the NRG-1/ERBB4 pathway or inhibition of Dynamin-2 reduces STAT5b activation and cardiomyocyte hypertrophy. Activation of Stat5 is also observed in NRG-1-induced myocardial growth in zebrafish embryos, and knockdown of stat5b leads to reduced myocardial growth and cardiac function. Furthermore, the NRG-1/ERBB4/STAT5b pathway is differentially regulated in patients with pathological cardiac hypertrophy.
Review
Immunology
Damian Jacenik, Jakub Fichna, Ewa Malecka-Wojciesko, Anna Mokrowiecka
Summary: This review explores the impact of immune system disorders and colon permeability dysfunction on the pathogenesis of inflammatory bowel diseases, as well as the role of protease-activated receptors in Crohn's disease and ulcerative colitis, highlighting their significance for diagnosis and treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Genetics & Heredity
Bowen Shi, Inzamam Ul Haq, Sajid Fiaz, Badr Alharthi, Ming-Long Xu, Jian-Lin Wang, Wei-Hai Hou, Xi-Bo Feng
Summary: Using a bioinformatics approach, 18 members of the PsZF-HD family were identified in Tibetan pea, belonging to two subgroups. These genes play an important role in food and grass security in Tibet. They showed significant differential expression in different tissues and may have potential functions in response to adversity stress, providing a reference for molecular breeding for stress resistance in peas.
FRONTIERS IN GENETICS
(2023)
Review
Biology
Doryssa Hermans, Lisa van Beers, Bieke Broux
Summary: Immune-cell activation is controlled by co-stimulatory or co-inhibitory signals provided by the cellular environment. The balance between activating and inhibitory receptors regulates immune homeostasis, and an imbalance can lead to chronic inflammation and autoimmunity. This review focuses on the expression pattern of Nectin binding partners as immune-activating and -inhibitory receptors and their role in health and autoimmunity.