Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Leonid Olender, Roshina Thapa, Roi Gazit
Summary: In this study, the researchers propose using CD34/CD150 instead of the traditional CD34/Fc gamma R approach to separate sub-populations in the LK compartment. They re-analyzed single-cell RNA-Seq data and confirmed their findings through independent FACS analysis. The newly-obtained LK sub-populations showed comparable differentiation potential to the classical ones.
Article
Biology
Brya G. Matthews, Sanja Novak, Francesca V. Sbrana, Jessica L. Funnell, Ye Cao, Emma J. Buckels, Danka Grcevic, Ivo Kalajzic
Summary: The periosteum is found to be highly enriched with progenitor cells, including alpha SMA-identified osteochondroprogenitors critical for bone formation during fracture healing. Additionally, Col2.3CreER-labeled osteoblast cells contribute to osteoblasts but not chondrocytes in fracture healing, and most periosteal osteochondroprogenitors can be targeted using alpha SMACreER.
Review
Oncology
Anastasia M. Hughes, Vincent Kuek, Rishi S. Kotecha, Laurence C. Cheung
Summary: B cells develop in the bone marrow microenvironment, and this microenvironment plays a crucial role in regulating their development. However, leukemic cells can manipulate the microenvironment to support their growth and resistance to treatment. Understanding the role of the microenvironment in B-ALL pathogenesis and treatment failure will aid in the development of targeted therapies.
Article
Biology
Kazuki Inoue, Yongli Qin, Yuhan Xia, Jie Han, Ruoxi Yuan, Jun Sun, Ren Xu, Jean X. Jiang, Matthew B. Greenblatt, Baohong Zhao
Summary: Adipoq-lineage progenitors in bone marrow are the main cellular source of M-CSF, producing much higher levels than osteoblast lineage cells. Deficiency of M-CSF in these progenitors significantly reduces the generation of bone marrow macrophages and osteoclasts, leading to severe osteopetrosis.
Article
Multidisciplinary Sciences
Abdalla Sheikh, Jennie Jackson, Hanjoo Brian Shim, Clement Yau, Jung Hee Seo, Ninan Abraham
Summary: Interleukin-7 (IL-7) plays an important role in shaping CD8 T cell responses during acute viral infections. IL-7 is required for proper expansion and effector functions of influenza-specific CD8 T cells in the mediastinal lymph node. IL-7 also affects terminal differentiation, degranulation, and cytokine production of specific CD8 T cells. Understanding IL-7's role in respiratory diseases will help expand therapeutic options.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Alexandra R. Dvorscek, Craig McKenzie, Marcus J. Robinson, Zhoujie Ding, Catherine Pitt, Kristy O'Donnell, Dimitra Zotos, Robert Brink, David M. Tarlinton, Isaak Quast
Summary: IL-21 acts as a key regulator in the initial B cell response, accelerating cell cycle progression and fueling cyclic re-entry of B cells, thereby promoting plasma cell differentiation.
Article
Cell & Tissue Engineering
Joshua T. Cohen, Michael Danise, Jason T. Machan, Runping Zhao, Craig T. Lefort
Summary: Transplantation of NPs was found to decrease the expression of inhibitory factors in host neutrophils and reduce proinflammatory cytokines in the lungs after shock, increasing neutrophil migration and enhancing bacterial clearance, indicating the potential of NPs as a cellular therapy for secondary infection following hemorrhagic shock.
Article
Cell Biology
Pijus K. Barman, Juliana E. Shin, Sloan A. Lewis, Seokjo Kang, Di Wu, Yizhou Wang, Xiaoming Yang, Prakash S. Nagarkatti, Mitzi Nagarkatti, Ilhem Messaoudi, Berenice A. Benayoun, Helen S. Goodridge
Summary: Aging is associated with increased monocyte production as well as altered function, with classical monocytes in old mice showing higher expression of DCMo signature genes. This leads to increased production of moDC in old mice. Additionally, higher expression of Aw112010 in old monocytes may be linked to elevated MHCII expression, indicating a potential mechanism for altered monocyte function during aging.
Article
Multidisciplinary Sciences
Greg Holmes, Ana S. Gonzalez-Reiche, Madrikha Saturne, Susan M. Motch Perrine, Xianxiao Zhou, Ana C. Borges, Bhavana Shewale, Joan T. Richtsmeier, Bin Zhang, Harm van Bakel, Ethylin Wang Jabs
Summary: Research found enriched expression of Hhip in the mesenchyme of the murine coronal suture, and sutural dysgenesis in Hhip-/- mutants, indicating the necessity of Hhip for normal development of the coronal suture.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Arshi Khanam, Natarajan Ayithan, Lydia Tang, Bhawna Poonia, Shyam Kottilil
Summary: Chronic Hepatitis B affects over 350 million people worldwide, and current treatments do reduce complications but do not provide a cure. Humoral responses in CHB rely on T-FH cells to support B cell response, with IL-21 playing a key role. However, defective T-FH cells in CHB can efficiently support B cell responses by producing IL-27, which aids in viral clearance and improving antibody production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Baerbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M. Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jaeck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
Summary: This study finds that Irf4(-/-) mice are prone to developing BCP-ALL, and further investigates the impaired differentiation but enhanced proliferation of Irf4(-/-) preB-I cells, possibly due to Jak3 mutations.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Biochemistry & Molecular Biology
Domenico Ribatti, Antonio d'Amati
Summary: Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate into all mature hematopoietic cell types. They are mainly found in the bone marrow and are regulated by a hierarchy of different types of cells. Mast cells, a type of innate immune cell, have a complex developmental process starting from the yolk sac and later originating from HSCs. This review article summarizes the knowledge on mast cell sources and the mechanisms involved in their development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Hyebeen Hong, Jongeun Lee, Guk-Yeol Park, Soeun Kim, Jiho Park, Jong Seok Park, Youngkwon Song, Sujin Lee, Tae Jin Kim, You Jeong Lee, Tae-Young Roh, Seung-Ki Kwok, Sung Won Kim, Qiumin Tan, Yoontae Lee
Summary: CIC is a key transcription factor that limits the population of B-1a cells in the adult stage and balances the formation of B-1 and B-2 cells.
Article
Cell Biology
Lena Batoon, Amy J. Koh, Rahasudha Kannan, Laurie K. McCauley, Hernan Roca
Summary: This study introduced a novel inducible caspase-9 (iCasp9) mouse model that allowed targeted cell apoptosis and further investigation of efferocytosis. The unique feature of this model, controlled by any Cre-expressing mouse lines, holds extensive potential applications and provides more insights into the diversity of mechanisms and cellular effects induced by apoptosis.
CELL DEATH & DISEASE
(2023)