Article
Medicine, Research & Experimental
Jianhua Pan, Meng Ma, Li Qin, Zhongkui Kang, Dickson Adah, Zhu Tao, Xiaofen Li, Linglin Dai, Siting Zhao, Xiaoping Chen, Qin Zhou
Summary: The study found that Plasmodium infection inhibited tumor growth and increased survival rate in a murine triple negative breast cancer model by enhancing CD8+ T cell responses. This suggests a potential novel strategy for the treatment of triple negative breast cancer through induction of antitumor immune responses mediated by CD8+ T cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Yatong Chen, Jing Xu, Xiaodong Wu, Hui Yao, Zhou Yan, Ting Guo, Wenjing Wang, Peixiao Wang, Yu Li, Xiangmin Yang, Hao Li, Huijie Bian, Zhi-Nan Chen
Summary: Deletion of CD147 in T cells limits tumor growth in mouse melanoma and lung cancer. CD147 is upregulated in CD8(+) TILs and coexpressed with immune-checkpoint molecules, leading to increased antitumor responses and potential as a target for cancer immunotherapy.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Mickey V. Patel, Zheng Shen, Marta Rodriguez-Garcia, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira
Summary: Endometrial cancer suppresses host immune function by regulating the cytotoxic capacity of CD8+ T cells. CD103-CD8+ T cells are primarily responsible for killing of allogeneic target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Abhinav Kaushik, Diane Dunham, Xiaorui Han, Evan Do, Sandra Andorf, Sheena Gupta, Andrea Fernandes, Laurie Elizabeth Kost, Sayantani B. Sindher, Wong Yu, Mindy Tsai, Robert Tibshirani, Scott D. Boyd, Manisha Desai, Holden T. Maecker, Stephen J. Galli, R. Sharon Chinthrajah, Rosemarie H. DeKruyff, Monali Manohar, Kari C. Nadeau
Summary: This study analyzed immune cells from participants in a peanut oral immunotherapy (OIT) trial and found that the differentiation status of CD8(+) T cells at baseline may predict the likelihood of achieving sustained unresponsiveness (SU). The study also found that lower frequencies of naïve CD8(+) T cells and terminally differentiated CD57(+)CD8(+) T cell subsets at baseline were associated with SU, while higher frequencies of IL-4(+) and IFN gamma(+) CD4(+) T cells post-OIT were correlated with a lower likelihood of SU.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Chun-Chia Cheng, Hsin-Chi Lin, Ya-Wen Chiang, Jungshan Chang, Zong-Lin Sie, Bi-Ling Yang, Ken-Hong Lim, Cheng-Liang Peng, Ai-Sheng Ho, Yi-Fang Chang
Summary: The mechanism of CD8(+) T cell exhaustion against tumors is not completely clear. Nicotine may exhaust these cells by increasing miR-629-5p to suppress IL2RB. Our findings suggest that smoking disables immune activity and nicotine plays a role in the exhaustion of CD8(+) T cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Haoyi Zhou, Yanpu Wang, Hongchuang Xu, Xiuling Shen, Ting Zhang, Xin Zhou, Yuwen Zeng, Kui Li, Li Zhang, Hua Zhu, Xing Yang, Nan Li, Zhi Yang, Zhaofei Liu
Summary: The noninvasive PET imaging using a granzyme B-targeted radiotracer 68Ga-grazytracer has the potential to predict tumor responses to immunotherapy, supporting early assessment and patient stratification.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Yan Yan, Wei Zhao, Wei Liu, Yan Li, Xu Wang, Jingna Xun, Chantsalmaa Davgadorj
Summary: CCL19 enhances Ag-responsive IFN-γ(+) CD8(+) T cells in patients with HBV infection and promotes rapid clearance of intrahepatic HBV in mice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Cell Biology
Lingjie Luo, Wenhua Liang, Jianfeng Pang, Gang Xu, Yingying Chen, Xinrong Guo, Xin Wang, Yi Zhao, Yangdian Lai, Yang Liu, Bin Li, Bing Su, Shuye Zhang, Michal Baniyash, Lei Shen, Lei Chen, Yun Ling, Ying Wang, Qiming Liang, Hongzhou Lu, Zheng Zhang, Feng Wang
Summary: The study revealed that the diversity of TCR repertoire in discharged COVID-19 patients increased but returned to baseline level about one week after virus clearance, with the dynamics of T cell repertoire correlated with gene signature changes. Top expanded T cell clones displayed key anti-viral features, confirming the critical role of antigen-specific T cells in fighting against SARS-CoV-2.
Article
Immunology
Nicholas G. Ciavattone, Long Wu, Rachel O'Neill, Jingxin Qiu, Eduardo Davila, Xuefang Cao
Summary: Donor-derived lymphocytes can eradicate host tumor cells through the graft-versus-tumor effect, but limited results are often seen in leukemia. By engineering donor CD8(+) T cells to express CD8 alpha:MyD88, the GVT response can be enhanced through increased T cell activation, function, and direct tumor cytotoxicity, although it may also lead to nonlethal graft-versus-host disease. This approach shows promise in improving the effectiveness of allo-HCT.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Giulia Monticone, Zhi Huang, Fred Csibi, Silvana Leit, David Ciccone, Ameya S. Champhekar, Jermaine E. Austin, Deniz A. Ucar, Fokhrul Hossain, Salome V. Ibba, A. Hamid Boulares, Nicholas Carpino, Keli Xu, Samarpan Majumder, Barbara A. Osborne, Christine Loh, Lucio Miele
Summary: This study reveals a novel immunosuppressive pathway by regulating the Cbl-b and Notch1 signaling pathways to enhance the effector functions of CD8+ T cells, thus improving anti-cancer responses and reducing sensitivity to immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhilin Peng, Yiwen Zhang, Xiancai Ma, Mo Zhou, Shiyu Wu, Zheng Song, Yaochang Yuan, Yingshi Chen, Yuzhuang Li, Guanwen Wang, Feng Huang, Yidan Qiao, Baijing Xia, Weiwei Liu, Jun Liu, Xu Zhang, Xin He, Ting Pan, Hanshi Xu, Hui Zhang
Summary: The study highlights the significant role of Brd4 in regulating glucose metabolism and maintaining receptor expression in CD8(+) T cells' homeostasis and immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzman, Gerd Sutter, Reinhold E. Schmidt, Torsten Witte, Ulrich Kalinke
Summary: Rituximab-treated patients and B cell-deficient mice showed reduced expansion of virus-specific CD8(+) T cells after vaccination/infection with different vaccines/pathogens, indicating that B cells can modulate CD8(+) T cell responses. The choice of vaccines for B cell-depleted patients needs to be re-evaluated to effectively induce protective CD8(+) T cell responses.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sekaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Summary: The transcription factor TCF-1 plays a crucial role in regulating the memory properties and expansion capacity of virus-specific CD8(+) T cells, which are important for controlling HIV infection. Increasing TCF-1 levels may enhance the secondary expansion capacity of HIV-specific CD8(+) T cells.
Article
Multidisciplinary Sciences
David O. 'Sullivan, Michal A. Stanczak, Matteo Villa, Franziska M. Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan L. Kyle, Mario Fabri, Jonathan D. Curtis, Michael D. Buck, Annette E. Patterson, Annamaria Regina, Cameron S. Field, Francesc Baixauli, Daniel J. Puleston, Edward J. Pearce, Robert Zeiser, Erika L. Pearce
Summary: Fever can enhance metabolic activity and effector functions of activated CD8* T cells, with limited effects on proliferation or activation marker expression. Exposure to 39 degrees Celsius increases mass and metabolism in T cells, with mitochondrial translation playing a crucial role in the enhanced metabolic activity and function observed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Arianne C. Richard
Summary: The advent of technologies that can characterize individual cells has revealed extensive diversity between cells of the same subset, including CD8(+) T cells. This review focuses on heterogeneity in CD8(+) T cell responses, particularly the impact of TCR stimulation strength and the mechanisms underlying variation between cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Gailen D. Marshall, Donald Y. M. Leung, Anne Ellis, Anna Nowak-Wegrzyn, Marianna Castells, Mitchell Grayson, Matthew Greenhawt, Jay Lieberman, John Oppenheimer, Jonathan Spergel
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2019)
Article
Dermatology
J. I. Silverberg, D. J. Margolis, M. Boguniewicz, L. Fonacier, M. H. Grayson, P. Y. Ong, Z. C. Fuxench, E. L. Simpson
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Allergy
Gailen D. Marshall, Anne Ellis, Mitchell Grayson, Donald Y. M. Leung, Jay Lieberman, Anna Nowak-Wegrzyn, John Oppenheimer
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)
Editorial Material
Allergy
Mitchell H. Grayson, Gailen D. Marshall
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2019)
Meeting Abstract
Dermatology
J. I. Silverberg, D. J. Margolis, M. Boguniewicz, L. Fonacier, M. H. Grayson, P. Y. Ong, Z. C. Fuxench, E. L. Simpson
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Editorial Material
Allergy
Mitchell H. Grayson
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)
Article
Allergy
Deepika Narayanan, Mitchell H. Grayson
Summary: Respiratory syncytial virus (RSV) and rhinovirus (RV) infections are associated with an increased risk of post-viral airway disease and atopy. However, the mechanisms linking these viruses to the development of these diseases appear to be different, suggesting the need for specific treatments targeted at the viral etiology.
Article
Dermatology
Jonathan Ian Silverberg, Zelma Chiesa-Fuxench, David Margolis, Mark Boguniewicz, Luz Fonacier, Mitchell Grayson, Eric Simpson, Peck Ong
Summary: The severity of atopic dermatitis is associated with sleep disturbances, which significantly impact the quality of life and other health outcomes in adult patients with AD.
Review
Allergy
Rob C. Aalberse, Rick Hoekzema, Mitchell H. Grayson
Summary: The hypothesis explaining why most people do not have allergies is based on airborne allergens being weak antigens, obstacles to IgE production, and activated germinal centers preventing IgE-switched B-cell formation. Studies show that the immune response to airborne allergens involves both IgE and IgG antibodies, with low levels of specific IgG in the absence of mature germinal centers.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Article
Immunology
Syed-Rehan A. Hussain, Michelle Rohlfing, Jenny Resiliac, Jennifer Santoro, Mark E. Peeples, Dominique Garcin, Mitchell H. Grayson
Summary: Research has shown that RSV infection in infancy is associated with an increased risk of asthma, except in cases where allergic disease is present at the time of infection. In a mouse model, pre-existing atopy has been found to protect against postviral airway disease, a protection that is dependent on neutrophils. Development of atopy leads to an increase in neutrophil response, potentially interacting with IL-4 to prevent the development of postviral airway disease.
JOURNAL OF IMMUNOLOGY
(2021)
Editorial Material
Allergy
Mitchell H. Grayson
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Meeting Abstract
Allergy
Jenny Resiliac, Michelle Rohlfing, Jennifer Santoro, Syed-Rehan Hussain, Mitchell Grayson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Syed-Rehan Hussain, Michelle Rohlfing, Jennifer Santoro, Mitchell Grayson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
Jenny Resiliac, Michelle Rohlfing, Jennifer Santoro, Syed-Rehan A. Hussain, Mitchell H. Grayson
JOURNAL OF IMMUNOLOGY
(2019)
Article
Allergy
Marcus S. Shaker, John Oppenheimer, Mitchell Grayson, David Stukus, Nicholas Hartog, Elena W. Y. Hsieh, Nicholas Rider, Cullen M. Dutmer, Timothy K. Vander Leek, Harold Kim, Edmond S. Chan, Doug Mack, Anne K. Ellis, David Lang, Jay Lieberman, David Fleischer, David B. K. Golden, Dana Wallace, Jay Portnoy, Giselle Mosnaim, Matthew Greenhawt
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)