期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 19, 期 11, 页码 1548-1553出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.5b00179
关键词
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资金
- ACS GCI Pharmaceutical Roundtable
- Eli Lilly
- Pfizer
- Merck
- NSF [CHE-9208463]
- NIH [S10 RR08389]
- NSF
An improved Cu/nitroxyl catalyst system for aerobic alcohol Oxidation has been developed for th e Oxidation of functionalized primary and secondary alcohols to aldehydes and ketones, suitable for implementation in batch and flow processes. This catalyst, mhich, has been deinonstratednr a >50 g scale batch reaction, addresses al-lumber of process limitations associated with a previously reported ((MeO)bpy)Crit/MNO/NIVII, catalyst system ((MeO)bpy = 4,4'-Cinnethoxy-2,2'-bipyridine, ABNO = 9-azabicyclo[3.3.1]noriane NMI = N-methylimidazole). Iinportairt catalyst iiodiflcations include the replacement of [Cu(MeCN)4]()Tf with alower-cost Cu source, CriI, reduction of the ABNO loading to 0.05-0.3 mol%, and use of NMI as the only ligand/additive (i.e, without a need for (MeO)bpy). Use of high flash point solvent, N-methylpyrrolidone, enables safe operation in batch reactions with air as the oxidant For continuous-flow applications compatible with elevated gas pressures, better performanCe is observed With acetonitrile as the solvent.
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