Article
Multidisciplinary Sciences
Wei-Chun Chou, Zengli Guo, Hao Guo, Liang Chen, Ge Zhang, Kaixin Liang, Ling Xie, Xianming Tan, Sara A. Gibson, Elena Rampanelli, Yan Wang, Stephanie A. Montgomery, W. June Brickey, Meng Deng, Leslie Freeman, Song Zhang, Maureen A. Su, Xian Chen, Yisong Y. Wan, Jenny P. -Y. Ting
Summary: The inflammasome activates inflammatory responses in myeloid cells, while the AIM2 receptor plays an independent role in regulating T-reg cells. AIM2 inhibits AKT phosphorylation, alters immune metabolism to enhance T-reg cell stability, and reduces autoimmune responses independent of the inflammasome.
Article
Immunology
Jing Song, Warren Anderson, Alex Hu, Kazushige Obata-Ninomiya, Steven F. Ziegler, David J. Rawlings, Jane H. Buckner
Summary: This study utilized gene editing to knock out the CBLB gene in human CD4+ T cells, revealing that CBLB knockout resulted in hyperproliferation and excessive IL-2 production in CD4+ T cells. The knockout cells showed resistance to Treg suppression and were able to overcome Treg inhibition by producing high levels of cytokines, promoting the proliferation and activation of T effector cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Tej Pratap Singh, Camila Farias Amorim, Victoria M. Lovins, Charles W. Bradley, Lucas P. Carvalho, Edgar M. Carvalho, Elizabeth A. Grice, Phillip Scott
Summary: Cutaneous leishmaniasis leads to changes in the skin microbiota, resulting in immune responses and delayed healing. This study demonstrates that depletion of regulatory T cells contributes to skin inflammation and impaired immunity against Staphylococcus aureus in mice. Similar findings are observed in Leishmania braziliensis-infected mice and patients, suggesting a critical role of these cells in regulating immune balance and disease progression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Tarun Tyagi, Kanika Jain, Timur O. Yarovinsky, Michael Chiorazzi, Jing Du, Cecilia Castro, Jules Griffin, Asawari Korde, Kathleen A. Martin, Shervin S. Takyar, Richard A. Flavell, Abhijit A. Patel, John Hwa
Summary: This study reveals the immunosuppressive role of platelets in tumor growth and identifies the platelet protein TLT-1 as a key player in suppressing CD8 T cells. Anti-TLT-1 antibody shows potential as a therapeutic option to rescue T cell function and reduce tumor size. Clinically, higher TLT-1 levels are associated with reduced survival in non-small cell lung cancer patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Marco Romano, Monica Sen, Cristiano Scotta, Rowa Y. Alhabbab, Andres Rico-Armada, Robert Lechler, Michael Burch, Giovanna Lombardi
Summary: The study developed a GMP-compatible protocol for expanding Tregs derived from the thymus and found that thymic RA(+)Tregs can be isolated and expanded with stability and similar suppressive effects as adult Tregs. This research provides a basis for clinical application of thymic Tregs to promote tolerance in pediatric heart transplant patients.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Peizhen Lao, Jingyi Chen, Longqian Tang, Jiwen Zhang, Yuxi Chen, Yuyin Fang, Xingliang Fan
Summary: This article introduces the role of Treg cells in pulmonary diseases and lung transplantation, as well as their therapeutic potential. Treg cells can maintain immune homeostasis, prevent inflammatory damage, and have the potential to treat lung diseases and promote lung transplant tolerance.
BIOSCIENCE REPORTS
(2023)
Article
Multidisciplinary Sciences
Mengze Lyu, Hiroaki Suzuki, Lan Kang, Fabrina Gaspal, Wenqing Zhou, Jeremy Goc, Lei Zhou, Jordan Zhou, Wen Zhang, Zeli Shen, James G. Fox, Robbyn E. Sockolow, Terri M. Laufer, Yong Fan, Gerard Eberl, David R. Withers, Gregory F. Sonnenberg
Summary: This study reveals a critical pathway that controls the fate of inflammatory or tolerogenic T cell responses to microbial colonization of the mammalian intestine. By profiling all ROR gamma t(+) immune cells at single-cell resolution, the researchers found a dominant presence of T regulatory cells and ILC3s in the intestine-draining lymph nodes of mice. These ILC3s promote the formation of microbiota-specific ROR gamma t(+) T-reg cells and prevent their expansion as inflammatory T helper 17 cells through antigen presentation, alpha V integrin, and competition for interleukin-2. Single-cell analyses also suggest impaired interactions between ILC3s and ROR gamma t(+) T-reg cells in inflammatory bowel disease.
Review
Immunology
Carsten Riether
Summary: Adult bone marrow hematopoietic stem cells (HSCs) maintain their function through interactions with regulatory T cells (Tregs). In leukemia, these regulatory mechanisms are disrupted, leading to compromised treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Weinian Liao, Chaonan Liu, Ke Yang, Jun Chen, Yiding Wu, Shuzhen Zhang, Kuan Yu, Lisha Wang, Li Ran, Mo Chen, Fang Chen, Yang Xu, Song Wang, Fengchao Wang, Qian Zhang, Jinghong Zhao, Lilin Ye, Changhong Du, Junping Wang
Summary: The accumulation of DNA mutations in aging hematopoietic stem cells (HSCs) increases the expression of MHCII on their surface, allowing them to be recognized by bone marrow regulatory T cells (Tregs). Tregs transfer cAMP to aged HSCs through gap junctions, promoting their survival and preventing apoptosis. Disrupting the interaction between HSCs and Tregs effectively prevents premature/physiological aging of HSCs.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Rheumatology
Antonios G. A. Kolios, George C. Tsokos, David Klatzmann
Summary: Failure of regulatory T (T-reg) cells to properly control immune responses leads to autoimmunity and organ damage. Using low-dose natural IL-2 to restore T-reg cell fitness has shown clinical efficacy, and genetically modified IL-2 with increased selectivity for T-reg cells is being developed for clinical use. Modulating IL-2 signaling and T-reg cell biology may provide novel treatment avenues for autoimmune diseases.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Mei Ding, Rajneesh Malhotra, Tomas Ottosson, Magnus Lundqvist, Aman Mebrahtu, Johan Brengdahl, Ulf Gehrmann, Elisabeth Back, Douglas Ross-Thriepland, Ida Isaksson, Bjorn Magnusson, Kris F. Sachsenmeier, Hanna Tegel, Sophia Hober, Mathias Uhlen, Lorenz M. Mayr, Rick Davies, Johan Rockberg, Lovisa Holmberg Schiavone
Summary: Regulatory T cells (Tregs) play a key role in regulating peripheral autoreactive T lymphocytes by suppressing effector T cells, and secreted proteins can modulate Treg function. This study identified four proteins as positive regulators of FOXP3 and/or CTLA4 expression, which could be potential targets for novel therapies in autoimmune, infectious diseases, and cancer research.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Garam Choi, Young-Jun Park, Minkyoung Cho, Heesu Moon, Daehong Kim, Chang-Yuil Kang, Yeonseok Chung, Byung-Seok Kim
Summary: Research shows that Th17 cells maintain their stability by producing TGF-beta 1, preventing conversion into IFN-gamma producers. Lack of TGF-beta 1 in Th17 cells leads to pathological inflammation in mouse models.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mladen Jergovic, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Zugich
Summary: Infections can lead to the expansion of a subpopulation of long-lived, Ly6C(+) CD8(+) Tn cells with accelerated effector function, depending on the action of IFN-I. This highlights the significant role of infection-driven IFN-I in regulating Tn homeostasis and function, with potential implications for immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Charaix, Alexia Borelli, Jeremy C. Santamaria, Lionel Chasson, Matthieu Giraud, Arnauld Serge, Magali Irla
Summary: This study reveals that Aire regulates the suppressive signature of recirculating T-reg in the thymus. Specifically, Aire controls the suppressive function of recirculating T-reg by regulating the expression of mTEC, which are responsible for restimulating T-reg.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jian Li, Zuojia Chen, Girak Kim, Jialie Luo, Shohei Hori, Chuan Wu
Summary: This study investigates the role of CTSW in regulating the differentiation and function of pTreg cells. The results show that CTSW inhibits IL-2R signaling in pTreg cells, leading to a restraint in pTreg cell generation and maintenance. This finding highlights the important role of CTSW in the mucosal immune quiescence.
Article
Cell Biology
Ruihua Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xinfeng Chen, Pingwei Xu, Degao Chen, Xiaoyu Liang, Xiaonan Yin, Yuying Liu, Jingwei Ma, Ke Tang, Yi Zhang, Yue'e Peng, Jinzhi Lu, Yi Zhang, Xiaofeng Qin, Xuetao Cao, Yonghong Wan, Bo Huang
NATURE CELL BIOLOGY
(2018)
Article
Oncology
Yuying Liu, Xiaoyu Liang, Wenqian Dong, Yi Fang, Jiadi Lv, Tianzhen Zhang, Roland Fiskesund, Jing Xie, Jinyan Liu, Xiaonan Yin, Xun Jin, Degao Chen, Ke Tang, Jingwei Ma, Huafeng Zhang, Jing Yu, Jun Yan, Huaping Liang, Siqi Mo, Feiran Cheng, Yabo Zhou, Haizeng Zhang, Jing Wang, Jingnan Li, Yang Chen, Bing Cui, Zhuo-Wei Hu, Xuetao Cao, F. Xiao-Feng Qin, Bo Huang
Article
Medicine, General & Internal
Yuanyuan Tong, Luyang Zhou, Limin Yang, Panpan Guo, Yanlan Cao, F. Xiao-Feng Qin, Jianghuai Liu
Article
Immunology
Yaqi Li, Jing Liu, Long Gao, Yuan Liu, Fang Meng, Xiaoan Li, F. Xiao-Feng Qin
IMMUNOLOGY LETTERS
(2020)
Article
Microbiology
Xiangwei Wu, Jingfeng Wang, Shanshan Wang, Fei Wu, Zhigao Chen, Chunfeng Li, Genhong Cheng, F. Xiao-Feng Qin
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Immunology
Xiaohong Du, Fang Meng, Di Peng, Zining Wang, Wei Ouyang, Yu Hang, Yayun Gu, Lingbo Fan, Fei Wu, Xiaodong Jiang, Feng Xu, F. Xiao-Feng Qin
JOURNAL OF IMMUNOLOGY
(2019)
Article
Microbiology
Chunfeng Li, Shulong Zu, Yong-Qiang Deng, Dapei Li, Kislay Parvatiyar, Natalie Quanquin, Jingzhe Shang, Nina Sun, Jiaqi Su, Zhenyang Liu, Min Wang, Saba R. Aliyari, Xiao-Feng Li, Aiping Wu, Feng Ma, Yi Shi, Karin Nielsen-Saines, Jae U. Jung, Frank Xiao-Feng Qin, Cheng-Feng Qin, Genhong Cheng
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Biochemical Research Methods
Ziyi Chen, Chengyang Ji, Qin Shen, Wei Liu, F. Xiao-Feng Qin, Aiping Wu
Article
Biochemistry & Molecular Biology
Xiaohong Du, Xiangyang Zuo, Fang Meng, Fei Wu, Xin Zhao, Chunfeng Li, Genhong Cheng, F. Xiao-Feng Qin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Guangyun Tan, Zhaohong Yi, Hongxiao Song, Fengchao Xu, Feng Li, Roghiyh Aliyari, Hong Zhang, Peishuang Du, Yanhua Ding, Junqi Niu, Xiaosong Wang, Lishan Su, F. Xiao-Feng Qin, Genhong Cheng
Article
Cell Biology
Xiaohong Du, Xiangyang Zuo, Fang Meng, Chenfeng Han, Wei Ouyang, Yu Han, Yayun Gu, Xin Zhao, Feng Xu, Frank Xiaofeng Qin
Summary: The study found that azithromycin has effective inhibitory effects against multiple strains of IAV and SARS-CoV-2, preventing viral infection and entry into host cells. Mechanistic studies revealed that this effect is independent of interferon signaling, and azithromycin can alkalize vesicles containing IAV virus particles, preventing pH-dependent membrane fusion.
CELL PROLIFERATION
(2021)
Article
Immunology
Yuying Liu, Nannan Zhou, Li Zhou, Jing Wang, Yabo Zhou, Tianzhen Zhang, Yi Fang, Jinwei Deng, Yunfeng Gao, Xiaoyu Liang, Jiadi Lv, Zhenfeng Wang, Jing Xie, Yuanbo Xue, Huafeng Zhang, Jingwei Ma, Ke Tang, Yiliang Fang, Feiran Cheng, Chengjuan Zhang, Bing Dong, Yuzhou Zhao, Peng Yuan, Quanli Gao, Haizeng Zhang, F. Xiao-Feng Qin, Bo Huang
Summary: IL-2 acts as an environmental cue to induce CD8(+) T cell exhaustion within tumor microenvironments by activating STAT5, inducing tryptophan hydroxylase 1, and subsequently causing T cell dysfunction.
Article
Cell Biology
Long Gao, Yuan Liu, Xiaohong Du, Sai Ma, Minmin Ge, Haijun Tang, Chenfeng Han, Xin Zhao, Yanbin Liu, Yun Shao, Zhao Wu, Lianjun Zhang, Fang Meng, F. Xiao-Feng Qin
Summary: The upregulation of tumor-associated CD38 in lung adenocarcinoma is correlated with poor survival of patients, and facilitates cancer cell migration, proliferation, colony formation, and tumor development. Inhibition of CD38's enzymatic activity may represent an important strategy for preventing tumor progression.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Long Gao, Xiaohong Du, Jiabin Li, F. Xiao-Feng Qin
Summary: This article discusses the progress of CD38 in multiple myeloma and hematological system tumors, as well as its immunologic regulation and evasion in non-hematopoietic solid tumors. The focus is on the bio-function of CD38 enzymatic substrates or metabolites in non-hematopoietic malignancies and the potential therapeutic value of targeting the CD38-NAD(+) or CD38-cADPR/ADPR signal axis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Immunology
Guangyun Tan, Qingfei Xiao, Hongxiao Song, Feng Ma, Fengchao Xu, Di Peng, Na Li, Xiaosong Wang, Junqi Niu, Pujun Gao, F. Xiao-Feng Qin, Genhong Cheng
CELLULAR & MOLECULAR IMMUNOLOGY
(2018)