Article
Immunology
Lamine Alaoui, Javiera Villar, Renaud Leclere, Simon Le Gallou, Francis Relouzat, Henri-Alexandre Michaud, Karin Tarte, Natacha Teissier, Benoit Favier, Mikael Roussel, Elodie Segura
Summary: This study characterizes the phenotype, transcriptome, life cycle, and function of human tonsil macrophages, and identifies three subtypes with distinct features. CD36(hi) macrophages are related to monocytes, CD36(lo) macrophages have features of embryonic origin, and CD36(int) macrophages display mixed characteristics. Functionally, CD36(hi) macrophages are specialized in stimulating T follicular helper cells by producing Activin A. Stromal cell-derived TNF-alpha is identified as the inducer of Activin A secretion.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Editorial Material
Environmental Sciences
Seok-Woo Son
Summary: The ozone layer is recovering overall, but the ozone in the tropical lower stratosphere is still declining due to the presence of unregulated very short-lived substances.
NATURE CLIMATE CHANGE
(2023)
Article
Immunology
Caroline L. Ashley, Brian P. McSharry, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Summary: This study reveals that human cytomegalovirus (HCMV) inhibits the MR1 pathway and disrupts the MR1:MAIT cell axis through the viral protein gpUS9. The interaction between this virus and MAIT cells in the context of viral infection is not well characterized.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Karin Broennimann, Inna Ricardo-Lax, Julia Adler, Eleftherios Michailidis, Ype P. de Jong, Nina Reuven, Yosef Shaul
Summary: Research has shown that hepatitis B virus (HBV) can promote RNR-R2 expression by a small conserved region within its transcript when infecting non-dividing cells, leading to an increase in dNTP levels. This demonstrates a non-coding function of HBV transcripts to support its propagation in non-cycling cells.
Article
Biochemistry & Molecular Biology
Rui-Min Qin, Ping Wen, Richard T. Corlett, Yuanye Zhang, Gang Wang, Jin Chen
Summary: Seed dispersal plays a crucial role in the survival of short-lived seeds of Aquilaria sinensis in tropical southwest China. Vespa hornets attract most seeds by consuming elaiosomes and depositing them in damp shade, facilitating germination 166 meters away from the parent tree. Rapid seed dispersal is achieved through the release of volatile compounds that attract hornets and serve as an indirect defense mechanism for the species.
Article
Multidisciplinary Sciences
Alice Rouan, Melanie Pousse, Nadir Djerbi, Barbara Porro, Guillaume Bourdin, Quentin Carradec, Benjamin CC. Hume, Julie Poulain, Julie Le-Hoang, Eric Armstrong, Sylvain Agostini, Guillem Salazar, Hans-Joachim Ruscheweyh, Jean-Marc Aury, David A. Paz-Garcia, Ryan McMinds, Marie-Josephe Giraud-Panis, Romane Deshuraud, Alexandre Ottaviani, Lycia Die Morini, Camille Leone, Lia Wurzer, Jessica Tran, Didier Zoccola, Alexis Pey, Clementine Moulin, Emilie Boissin, Guillaume Iwankow, Sarah Romac, Colomban de Vargas, Bernard Banaigs, Emmanuel Boss, Chris Bowler, Eric Douville, Michel Flores, Stephanie Reynaud, Olivier P. Thomas, Romain Trouble, Rebecca Vega Thurber, Serge Planes, Denis Allemand, Stephane Pesant, Pierre E. Galand, Patrick Wincker, Shinichi Sunagawa, Eric Rottinger, Paola Furla, Christian R. Voolstra, Didier Forcioli, Fabien Lombard, Eric Gilson
Summary: This study uses data from the Tara Pacific expedition to show that the history of water temperature is a key factor in the variation of coral telomere DNA length across the Pacific Ocean. Telomere lengths of short-lived, stress-sensitive Pocillopora colonies are more affected by seasonal temperature variations compared to long-lived and stress-resistant Porites colonies. Telomeres are sensitive to environmental factors, and this research reveals that water thermal regime plays a significant role in the regulation of telomere DNA length in different coral genera.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Ye Jin, Li Fu
Summary: Rationally designed and engineered bacteria have emerged as a unique and promising approach for cancer treatment. Researchers have successfully developed a short-lived bacterium, mp105, which is effective against various types of cancer and safe for intravenous administration. This bacterium combats cancer through direct oncolysis, depletion of tumor-associated macrophages, and elicitation of CD4+ T cell immunity.
CELL REPORTS MEDICINE
(2023)
Article
Chemistry, Medicinal
Yu Gan, Xiaoying Li, Shuangze Han, Li Zhou, Wei Li
Summary: This study confirmed the inhibitory effect of bergenin on colorectal cancer cells both in vivo and in vitro. Bergenin significantly reduced the viability and colony formation of CRC cells, and promoted apoptosis. Bergenin inhibited the Akt/GSK3 beta signaling and promoted the interaction between FBW7 and Mcl-1, resulting in the ubiquitination and degradation of Mcl-1. In vivo studies showed that bergenin reduced tumor size and weight without toxicity to vital organs in mice.
Article
Biochemistry & Molecular Biology
Xu Li, Tianxun Zhang, Lulu Kang, Ruyue Xin, Minli Sun, Qianyue Chen, Jingwen Pei, Qin Chen, Xiang Gao, Zhaoyu Lin
Summary: GSDMB is associated with various inflammatory diseases and is cleaved by GZMA and caspase-7 to regulate pyroptosis. The cleavage of GSDMB is noncell autonomous, and the GSDMB-N domain is important for a novel cell-autonomous function. Inhibition of the caspase-7/GSDMB axis promotes pyroptosis and is a potential target for sepsis therapy.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Medicine, Research & Experimental
Ji Eun Yu, In Jun Yeo, Seung Sik Yoo, Sung-hyun Kim, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong
Summary: CHI3L1, secreted by immune and inflammatory cells, is associated with inflammatory diseases. Overexpression of CHI3L1 leads to increased expression of ER-associated proteins. Depletion of CHI3L1 induces ER stress and apoptosis in cancer cells. SOD1 is identified as a novel target of CHI3L1 and its depletion reduces ER stress and apoptotic cell death caused by CHI3L1.
Article
Chemistry, Analytical
Qiu-Yue Cheng, Ting Wang, Jun Hu, Hong-Yuan Chen, Jing-Juan Xu
Summary: Visible-light-mediated heterogeneous photocatalysis is a promising method for organic transformations. However, accurately detecting and identifying photogenerated species, especially short-lived radical intermediates, remains challenging. In this work, a hybrid ion emitter integrated with a pico-liter heterogeneous photocatalytic reactor was developed for the rapid identification of transient radical intermediates produced under visible-light irradiation. This novel coupling device provides a powerful tool for exploring complex heterogeneous photochemical processes and their ultrafast initial transformations.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Chengcheng Wang, Taiping Zhang, Quan Liao, Menghua Dai, Junchao Guo, Xinyu Yang, Wen Tan, Dongxin Lin, Chen Wu, Yupei Zhao
Summary: In PDAC, overexpression of HNF4G due to SMAD4 deficiency plays a critical oncogenic role in progression and metastasis, but may be a druggable target for Metformin treatment.
Article
Multidisciplinary Sciences
Takashi Nomura, Tetsunari Kimura, Yusuke Kanematsu, Daichi Yamada, Keitaro Yamashita, Kunio Hirata, Go Ueno, Hironori Murakami, Tamao Hisano, Raika Yamagiwa, Hanae Takeda, Chai Gopalasingam, Ryota Kousaka, Sachiko Yanagisawa, Osami Shoji, Takashi Kumasaka, Masaki Yamamoto, Yu Takano, Hiroshi Sugimoto, Takehiko Tosha, Minoru Kubo, Yoshitsugu Shiro
Summary: The study investigated the mechanism of NO reductase catalyzing the generation of N2O. Time-resolved techniques and photolabile-caged NO were used to characterize the structure and formation of the intermediate I in NO reductase. Quantum mechanics/molecular mechanics calculations and experimental results revealed the electronic structure characteristics of the intermediate I.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Keisuke Satoh, Keita Takahashi, Kazuma Noguchi, Yuhki Kobayashi, Ryuichi Majima, Yoshihiko Iwase, Keisuke Yamaguchi, Yukina Masuda, Tetsuo Koshizuka, Naoki Inoue
Summary: This study identified a second apoptosis inhibitor from guinea pig cytomegalovirus (GPCMV) that interacts with BAK, a Bcl-2 family proapoptotic protein. The findings suggest the potential development of BH3 mimetics that can regulate inhibition or induction of apoptosis based on short peptide molecules.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qiongqiong Wan, Kaixiang Chen, Xin Dong, Xianqin Ruan, Hong Yi, Suming Chen
Summary: AC electrolysis is a promising field in synthetic chemistry, but its mechanistic studies face challenges in characterizing elusive intermediate processes. This study develops a new experimental platform and provides direct evidence for the unique reactivities of AC electrosynthesis and controlled kinetics in multistep sequential reactions, which will benefit the rational design of AC electrolysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Virology
Donna Collins-McMillen, Jung Heon Kim, Maciej T. Nogalski, Emily V. Stevenson, Gary C. Chan, Joshua R. Caskey, Stephen J. Cieply, Andrew D. Yurochko
JOURNAL OF VIROLOGY
(2016)
Article
Virology
Donna Collins-McMillen, Emily V. Stevenson, Jung Heon Kim, Byeong-Jae Lee, Stephen J. Cieply, Maciej T. Nogalski, Gary C. Chan, Robert W. Frost, Caroline R. Spohn, Andrew D. Yurochko
JOURNAL OF VIROLOGY
(2017)
Review
Cell Biology
Gary Chan, Maciej T. Nogalski, Emily V. Stevenson, Andrew D. Yurochko
JOURNAL OF LEUKOCYTE BIOLOGY
(2012)
Article
Virology
Maciej T. Nogalski, Gary Chan, Emily V. Stevenson, Scarlet Gray, Andrew D. Yurochko
JOURNAL OF VIROLOGY
(2011)
Article
Virology
Gary Chan, Maciej T. Nogalski, Andrew D. Yurochko
JOURNAL OF VIROLOGY
(2012)
Article
Multidisciplinary Sciences
Gary Chan, Maciej T. Nogalski, Andrew D. Yurochko
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Microbiology
Maciej T. Nogalski, Gary C. T. Chan, Emily V. Stevenson, Donna K. Collins-McMillen, Andrew D. Yurochko
Article
Multidisciplinary Sciences
Maciej T. Nogalski, Gary C. T. Chan, Emily V. Stevenson, Donna K. Collins-McMillen, Andrew D. Yurochko
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2012)
Article
Multidisciplinary Sciences
Maciej T. Nogalski, Alexander Solovyov, Anupriya S. Kulkarni, Niyati Desai, Adam Oberstein, Arnold J. Levine, David T. Tine, Thomas Shenk, Benjamin D. Greenbaum
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Saisai Chen, Thomas Shenk, Maciej T. Nogalski
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Maciej T. Nogalski, Thomas Shenk
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Pooya Naseri-Nosar, Maciej T. Nogalski, Thomas Shenk
Summary: Following human cytomegalovirus (HCMV) infection, the aryl hydrocarbon receptor (AhR) is activated and alters the levels of numerous RNAs, including those related to cell cycle progression. AhR knockdown alleviates the G1/S cell cycle block in HCMV-infected fibroblasts, providing mechanistic insight into the virus-host cell interaction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Maciej T. Nogalski, Jagat P. Podduturi, Ian B. DeMeritt, Liesl E. Milford, Andrew D. Yurochko
JOURNAL OF VIROLOGY
(2007)
Article
Virology
IB DeMeritt, JP Podduturi, AM Tilley, MT Nogalski, AD Yurochko