Article
Biochemistry & Molecular Biology
Tim Vangansewinkel, Stefanie Lemmens, Assia Tiane, Nathalie Geurts, Dearbhaile Dooley, Tim Vanmierlo, Gunnar Pejler, Sven Hendrix
Summary: In this study, researchers investigated the therapeutic potential of recombinant mMCP6 in improving functional outcomes after spinal cord injury. The findings suggest that mMCP6 can enhance recovery by reducing astrogliosis and promoting (re)myelination in the injured spinal cord.
Article
Biochemistry & Molecular Biology
Adrienn Skopal, Tamas Keki, Peter A. Toth, Balazs Csoka, Balazs Koscso, Zoltan H. Nemeth, Luca Antonioli, Andreas Ivessa, Francisco Ciruela, Laszlo Virag, Gyorgy Hasko, Endre Kokai
Summary: In this study, the researchers identified CtsD as an interacting partner of A(2A)R in macrophages and found that this interaction plays a crucial role in adenosine-mediated macrophage regulation in inflammatory processes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Aoife P. Smith, Emma M. Creagh
Summary: This review discusses the association between inflammatory caspase activity and inflammatory bowel disease (IBD) in both human and murine models. Caspases-4/-5/-11 show increased expression during IBD and are implicated in chronic inflammation. The review also explores the differences in expression and functions of caspases-4, -5, and -11, as well as their activation, function, and regulation mechanisms, and how these mechanisms may contribute to the pathogenesis of IBD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vu Thi Thu Le, Hoang Van Hung, Nguyen Xuan Ha, Cao Hong Le, Pham Thi Hong Minh, Do Tien Lam
Summary: The in silico screening of compounds isolated from Millettia dielsiana against PDE4 proteins showed strong binding affinities, with Millesianin F and D50 exhibiting the highest affinities. Compound D50 displayed strong anti-inflammatory activity and is considered a potential novel anti-inflammatory drug.
Article
Biochemistry & Molecular Biology
David Pericat, Stephen Adonai Leon-Icaza, Marina Sanchez Rico, Christiane Muehle, Iulia Zoicas, Fabian Schumacher, Remi Planes, Raoul Mazars, Germain Gros, Alexander Carpinteiro, Katrin Anne Becker, Jacques Izopet, Nathalie Strub-Wourgaft, Peter Sjoe, Olivier Neyrolles, Burkhard Kleuser, Frederic Limosin, Erich Gulbins, Johannes Kornhuber, Etienne Meunier, Nicolas Hoertel, Celine Cougoule
Summary: This study evaluated the potential antiviral and anti-inflammatory activities of fluoxetine in a SARS-CoV-2 infection model and in vitro. The results showed that fluoxetine significantly reduced lung tissue viral titers and expression of inflammatory markers, and inhibited the replication of all variants of concern. These effects may be attributed to the modulation of the ceramide system in the lung tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pawel Bryniarski, Katarzyna Nazimek, Janusz Marcinkiewicz
Summary: Research shows that the combined use of diuretics with or without captopril affects the function of macrophages, modulating humoral immunity and potentially providing important insights for assessing the safety of antihypertensive therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sarai Rojas-Jimenez, Maria Salud Perez-Gutierrez, Ernesto Sanchez-Mendoza, Rubria Marlen Martinez-Casares, Nimsi Campos-Xolalpa, Maria Guadalupe Valladares-Cisneros, David Osvaldo Salinas-Sanchez
Summary: DHAP, isolated from Ageratina pazcuarensis, exhibits significant anti-inflammatory activity by reducing ear edema, scavenging free radicals, inhibiting the production of inflammatory cytokines, and protecting erythrocyte membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Amreen Naqash, Gabriella Stuart, Roslyn Kemp, Lyn Wise
Summary: This study aimed to produce and characterize recombinant parapoxvirus IL-10s, and quantitatively compare their receptor binding and immunomodulatory activities. The results indicate that IL-10s from different parapoxviruses play similar pathogenic roles during host infection.
Article
Ophthalmology
Jiande Li, Jiangyuan Han, Yongpeng Shi, Minrui Liu
Summary: This study found that rapamycin can inhibit corneal inflammation and neovascularization caused by alkali burns by regulating gene expression and suppressing the infiltration of inflammatory cells. This research provides important insights for the development of new drugs to treat alkali burns.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Natsuki Kubota-Ishida, Takashi Matsuhira, Chizuko Kaji, Chika Kikuchi, Yuji Tabata
Summary: The study compared the effects of a novel PDE4 inhibitor, AA6216, with crisaborole on skin inflammation, showing that AA6216 is a more potent inhibitor of PDE4 and of cytokine production. In mouse models of dermatitis, AA6216 significantly suppressed skin inflammation, suggesting its potential as a novel and effective topical therapeutic agent for the treatment of dermatitis including AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yun Dong, Ling-Qi Kong, Qin-Hua Chen, Bin Li, Xiao-Hua Zeng, Li-Na Ke, Hong-Mei Wang
Summary: A series of gamma-lactone derivatives were efficiently synthesized via a tandem Passerini 3CC/S-N cyclization microwave-assisted one-pot method, using ionic liquid as the reaction medium. The chemical structures of the compounds were confirmed by single crystal X-ray analysis, and one of the compounds showed significant growth inhibition activity against Gibberella zeae.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ling Lv, Mireguli Maimaitiming, Yan Huang, Jichen Yang, Shuxia Chen, Yanfeng Sun, Xuetao Zhang, Xin Li, Changhu Xue, Pingyuan Wang, Chang-Yun Wang, Zhiqing Liu
Summary: A series of quinazolin-4(3H)-one derivatives with cholinesterase inhibition and anti-inflammatory activities were designed and synthesized. The compound MR2938 showed promising inhibitory activity against acetylcholinesterase and suppressed NO production. It also decreased the levels of pro-inflammatory cytokines and suppressed neuroinflammation through blocking certain signaling pathways. These results suggest that MR2938 could be developed as a potential lead compound for anti-AD drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Developmental Biology
Nuria Hernandez, Marta Lopez-Morato, Mario J. Perianes, Soledad Sanchez-Mateos, Vanessa Casas-Rua, Jose Antonio Dominguez-Arroyo, Francisco M. Sanchez-Margallo, Ignacio S. Alvarez
Summary: The study demonstrates that adding 4-OH-E-2 to culture media can improve the quality, implantation rate, and viability of embryos obtained in vitro, as well as enhance their ability to bind EGF. This suggests that 4-OH-E-2 could be a promising candidate for supplementing human IVF culture media to improve embryo implantation outcomes.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Yoko Miura, Shyuntaro Isogai, Shinji Maeda, Satoshi Kanazawa
Summary: CD80 interacts with CD28 and CTLA-4 on antigen-presenting cells to regulate T cell activity. CTLA-4-Ig is used to treat rheumatoid arthritis by blocking co-stimulatory signaling. The study shows that CTLA-4-Ig treatment improves chronic inflammatory polyarthritis and has an effect on the inflamed synovial compartment through the CD80 and PD-L1 axes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyuan Zhang, Jing Tu, Shizhen Ding, Mei Wang, Yanbing Ding, Zhijie Lin, Guotao Lu, Weiming Xiao, Weijuan Gong
Summary: ANGPTL4 plays a protective role in the development of inflammatory bowel disease by downregulating CD8+T cell activities, providing a new therapeutic approach for the prevention and treatment of IBD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Andreas R. Janecke, Xiaoqin Liu, Ruediger Adam, Sumanth Punuru, Arne Viestenz, Valeria Strauss, Martin Laass, Elizabeth Sanchez, Roberto Adachi, Martha P. Schatz, Ujwala S. Saboo, Naveen Mittal, Klaus Rohrschneider, Johanna Escher, Anuradha Ganesh, Sana Al Zuhaibi, Fathiya Al Murshedi, Badr AlSaleem, Majid Alfadhel, Siham Al Sinani, Fowzan S. Alkuraya, Lukas A. Huber, Thomas Mueller, Ruth Heidelberger, Roger Janz
Summary: New STX3 variants have been found to be associated with a syndrome including congenital enteropathy and retinal dystrophy. These variants affect STX3 transcripts, leading to reduced numbers of photoreceptors and thinning of cell layers.
Article
Immunology
Steffie Junius, Adamantios Mavrogiannis, Pierre Lemaitre, Margaux Gerbaux, Frederik Staels, Vanshika Malviya, Oliver Burton, Vaclav Gergelits, Kailash Singh, Raul Yhossef Tito Tadeo, Jeroen Raes, Stephanie Humblet-Baron, Adrian Liston, Susan M. Schlenner
Summary: Regulatory T cells (T-regs) are essential for immune homeostasis and may be used as a cell therapy for autoimmune diseases. A study using mice found that T-reg stability is maintained even in complex microbial/antigenic environments, and that plasticity after transfer to a lymphopenic environment is limited to a subset of T-regs. The unstable T-reg fraction consists of diverse T-regs, with potential implications for improving cell transfer therapy.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Nora Cespedes, Erinn L. Donnelly, Casey Lowder, Gretchen Hansten, Delaney Wagers, Anna M. Briggs, Joseph Schauer, Lori Haapanen, Magnus Abrink, Judy Van de Water, Shirley Luckhart
Summary: Increased mast cells and MC mediators have been observed in malaria-related bacteremia, but their role in malarial immunity is not well understood. Through studying Mcpt4 in malaria-induced bacteremia, it was found that Mcpt4 knockout mice had significantly lower parasitemia but increased intestinal permeability and altered ileal adherens junction E-cadherin. Additionally, differences in immune response were observed between Mcpt4(-/-) and Mcpt4(+/+) mice, suggesting a role for Mcpt4 in host immune response modulation during malaria infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Faruk Dube, Andrea Hinas, Shweta Roy, Frida Martin, Magnus Abrink, Staffan Svard, Eva Tyden
Summary: This study evaluated the use of Caenorhabditis elegans as a model for understanding drug metabolism/resistance in Parascaris univalens. Comparative gene expression analysis identified candidate genes involved in ivermectin metabolism/resistance in P. univalens, but the overlap in gene expression between P. univalens and C. elegans was minimal. This approach shows promise but further studies with a larger number of genes may be needed to identify additional candidate genes.
PARASITES & VECTORS
(2022)
Article
Immunology
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y. F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Summary: The study reveals the contextual influence of IL-2 function and its effects on different cell circuits. Targeted IL-2 production has the potential to fine-tune therapeutic responses, based on the desired clinical outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Correction
Immunology
Carly E. E. Whyte, Kailash Singh, Oliver T. T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y. F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Correction
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Article
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Summary: The lack of T cell infiltrates hinders effective immunotherapy in cancer, while the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs) is associated with a good prognosis. This study reveals that antiangiogenic immune-modulating therapies can induce the transformation of postcapillary venules into inflamed high-endothelial venules (HEVs) through lymphotoxin/lymphotoxin beta receptor (LT/LTbR) signaling. Tumor HEVs enhance intratumoral lymphocyte influx and promote the differentiation of CD8 T cell progenitors into effector cells, contributing to tumor immunotherapy.
Review
Cell Biology
Vanshika Malviya, Lidia Yshii, Steffie Junius, Abhishek D. Garg, Stephanie Humblet-Baron, Susan M. Schlenner
Summary: FOXP3-expressing regulatory T cells (T-reg) play a crucial role in immune homeostasis and tolerance. Tissue-resident T-reg also have tissue-specific functions. To maintain their function during inflammatory disease, T-reg have mechanisms for lineage stability, including a specific DNA demethylation pattern. However, T-reg must also have a level of functional plasticity to regulate the immune response, which can lead to pathogenic ex-T-reg. This review discusses how T-reg epigenetic stability is maintained and the risks of acquiring T-helper cell programs.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Srinivas Akula, Miia Riihimaki, Ida Waern, Magnus Abrink, Amanda Raine, Lars Hellman, Sara Wernersson
Summary: This study provides the first insight into the phenotype of equine MCs in bronchoalveolar lavage fluid (BALF) and their potential role in the airways of asthmatic horses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, Francois Vermeulen, Susan Schlenner, Isabelle Meyts, David Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
Summary: Calcium signaling is crucial for lymphocyte activation, and disruptions of store-operated calcium entry can lead to severe immunodeficiency. In this study, genetic variations of the ITPR3 gene were identified in two Caucasian patients with immunodeficiency, indicating a potential link between these variations and impaired immune responses. The findings demonstrate the functional connection between defective endoplasmic reticulum calcium channels and immunodeficiency, highlighting the importance of IP(3)Rs as diagnostic targets for patients with specific inborn errors of immunity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Correction
Immunology
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, Francois Vermeulen, Susan Schlenner, Isabelle Meyts, David I. Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Genetics & Heredity
Valentina Lykhopiy, Vanshika Malviya, Stephanie Humblet-Baron, Susan M. Schlenner
Summary: FOXP3+ regulatory T cells play a critical role in immune homeostasis and the prevention of autoimmune diseases. IL-2 signalling is important for Treg biology, and dysfunctional IL-2 signalling can lead to autoimmune disorders. Recent studies have shown the potential of IL-2-based approaches in expanding and enhancing the suppressive activity of Treg, with promising results in clinical trials.
GENES AND IMMUNITY
(2023)
Meeting Abstract
Oncology
Gerlanda Vella, Yichao Hua, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Pascal Merchiers, Francesca Bosisio, Giuseppe Floris, Akira Takeda, Sirpa Jalkanen, Maija Hollmen, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
CANCER IMMUNOLOGY RESEARCH
(2022)
Meeting Abstract
Immunology
Acelya Yilmazer Kirgin, Marie Boernert, David Voehringer, Adrian Liston, Susan Schlenner, Karsten Kretschmer
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)