Article
Biochemistry & Molecular Biology
Adham Abuelola Mohamed, Sofia Soler, Julia Wegner, Eva Bartok, Sanda Stankovic, Andrew G. G. Brooks, Martin Schlee
Summary: NK cell activation in response to Influenza A virus infection depends on the cytosolic RNA receptor RIG-I, and activation of RIG-I enhances both the antiviral defense and cytotoxic effector function of NK cells against target cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Zhang Xiangbo, Yuan Zhaofang, Geng Jinjing, Gong Zhuandi, Wei Suocheng
Summary: This study found that bovine coronavirus nucleocapsid (BCoV N) reduces the levels of IFN-beta by inhibiting MDA5, MAVS, TBK1, and IRF3 in the host cells. This discovery reveals a mechanism by which BCoV N protein evades the host's innate immune response by inhibiting the production of type I IFN.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lu Bai, Margaux Vienne, Ling Tang, Yann Kerdiles, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Haiming Wei, Rui Sun, Eric Vivier, Hui Peng, Zhigang Tian
Summary: Research indicates that the adult mouse liver contains lineage-CD122(+)CD49a(+) progenitor cells for liver ILC1s derived from fetal liver. The production of IFN-gamma by liver ILC1s themselves promotes their development in situ, emphasizing the role of extramedullary hematopoiesis in liver immune composition.
Article
Medicine, Research & Experimental
Daxing Gao, Michael J. Ciancanelli, Peng Zhang, Oliver Harschnitz, Vincent Bondet, Mary Hasek, Jie Chen, Xin Mu, Yuval Itan, Aurelie Cobat, Vanessa Sancho-Shimizu, Benedetta Bigio, Lazaro Lorenzo, Gabriele Ciceri, Jessica McAlpine, Esperanza Anguiano, Emmanuelle Jouanguy, Damien Chaussabel, Isabelle Meyts, Michael S. Diamond, Laurent Abel, Sun Hur, Gregory A. Smith, Luigi Notarangelo, Darragh Duffy, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Summary: Human herpes simplex virus 1 encephalitis can be caused by inborn errors of the TLR3 pathway, leading to impaired CNS cell-intrinsic antiviral immunity. Deficiencies in TLR3 pathway impair cell-intrinsic immunity to various viruses, and the mechanism involves impaired IFN-alpha/beta induction. Human TLR3 controls constitutive levels of IFNB mRNA and bioactive IFN-beta protein, as well as the basal levels of ISG mRNA in fibroblasts and cortical neurons.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Kaveh Abdi, Karen Laky, Mehrnoosh Abshari, Elizabeth M. Hill, Larry Lantz, Nevil J. Singh, Eric O. Long
Summary: It has been found that NK cells produce IFN-gamma before the production of IL-12 by DCs in the early stage of immune response. Toll-like Receptor 4 (TLR4) on DCs and soluble factors produced by LPS-activated DCs play important roles in IFN-gamma production by NK cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Zhangchun Guan, Yu Liu, Chenghua Liu, Huiting Wang, Jiannan Feng, Guang Yang
Summary: The study demonstrates that the hemolysin Hlb of S. aureus can upregulate IFN-gamma production in target cells by increasing calcium influx and inducing phosphorylation of ERK1/2. This process is dependent on the sphingomyelinase activity of Hlb.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Qiong Zhang, Xujun Zhang, Xiaobo Lei, Hai Wang, Jingjing Jiang, Yuchong Wang, Kefan Bi, Hongyan Diao
Summary: In this study, it was found that IAV activates host proteins YAP/TAZ to antagonize TLR3 expression, thereby attenuating host innate immune response and promoting virus replication and cell apoptosis. Loss of YAP/TAZ enhances host innate immune response, protecting mice from lung injuries induced by IAV infection. This novel immunomodulatory mechanism provides a potential target for prevention and treatment of IAV infection.
Article
Cell Biology
Wenjie Zuo, Mai Wakimoto, Noriyasu Kozaiwa, Yutaro Shirasaka, Seong-Wook Oh, Shiori Fujiwara, Hitoshi Miyachi, Amane Kogure, Hiroki Kato, Takashi Fujita
Summary: RIG-I-like receptors, protein kinase R, and endosomal Toll-like receptor 3 are important in sensing viral RNA and determining cell fate. Short 5'-triphosphate dsRNA induces slow apoptosis dependent on IRF-3 and IFN-I, while intracellular long dsRNA is sensed by PKR and TLR3, which activate distinct signals and synergistically induce rapid apoptosis.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Iracema Luisa Quintino-de-Carvalho, Marcela Helena Goncalves-Pereira, Michele Faria Ramos, Bruno Henrique Goncalves de Aguiar Milhim, Ultimo Libanio Da Costa, Erika Goncalves Santos, Mauricio Lacerda Nogueira, Helton Da Costa Santiago
Summary: ILCs and NK cells are important sources of inflammatory cytokines during acute dengue infection, with distinct profiles associated with different clinical forms.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Xiao Li, Xinyuan Sun, Zhongyi Yan, Zhenxiang Zhao, Zhaojun Pang, Han Yang, Xiaoxin Ji, Yi Lei, Zixiang Zhu, Xiangqian Guo, Xin Mu
Summary: A study has found that an antibiotic called gramicidin A can enhance MDA5-mediated interferon signaling by increasing the oligomerization of MDA5 and dsRNA.
Article
Infectious Diseases
Chen Liang, Shanshan Li, Jinfeng Yuan, Yanhua Song, Weicong Ren, Wei Wang, Yuanyuan Shang, Shenjie Tang, Yu Pang
Summary: This study aimed to investigate the phenotype, proliferation and functional alterations of cytokine-induced memory-like natural killer (CIML NK) cells from healthy subjects and TB patients, and assessed the efficacy of CIML NK cells in response to H37Rv-infected U937 cells in vitro. CIML NK cells from healthy individuals showed enhanced IFN-gamma secretion and boosted anti-MTB activity in vitro, which from TB patients show impaired IFN-gamma production and no enhanced anti-MTB activity compared to those from healthy donors. These results open up new possibilities for NK cell-based anti-tuberculosis immunotherapeutic strategies.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Allergy
Monika Majewska-Szczepanik, Paulina Kowalczyk, Philip W. Askenase, Marian Szczepanik
Summary: This study aimed to determine whether poly(I:C) injection can induce NK-mediated hapten reactivity in mice. The results showed that poly(I:C) administration increased the response to hapten and only liver poly(I:C)-activated DX5(+) NK cells were able to transfer reactivity to hapten into a naive recipient. This study provides new insights into how poly(I:C) stimulates NK-mediated reactivity to hapten.
CONTACT DERMATITIS
(2023)
Article
Gastroenterology & Hepatology
Chen Cheng, Qian Zhang, Yue Li, Jiali Jiang, Linxi Xie, Haiyuan Shen, Dongqing Wu, Hejiao Zhang, Huiru Zhang, Xuan Wang, Hongyu Wu, Jingjing Xu, Li Gui, Bao Li, Cynthia Ju, Hui Peng, Shi Yin, Long Xu
Summary: This study reveals for the first time that the interaction between liver innate lymphoid cells (ILC1) and natural killer (NK) cells plays an important role in the development of alcoholic steatohepatitis. It was found that NK cells undergo apoptosis upon chronic alcohol consumption, leading to the dominance of ILC1 among group 1 ILC. Depletion of ILC1 or neutralization of IL17A can alleviate liver steatosis, inflammation, and injury, while normalization of the ILC1/NK cells ratio through NK cell transfer or expansion provides significant protection against alcohol-induced steatohepatitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Noriyuki Numao, Shogo Kawaguchi, Jiangli Ding, Takao Karasawa, Kazuhiko Seya, Tomoh Matsumiya, Hidezumi Kikuchi, Hirotake Sakuraba, Shinsaku Fukuda, Tadaatsu Imaizumi
Summary: Upon viral infection, dysregulated immune responses can lead to disease exacerbation and poor prognosis. This study found that tryptanthrin can decrease the activation of STAT1 mediated by Toll-like receptor 3 in macrophages, thereby inhibiting the aberrant immune response caused by viral infection.
IMMUNOLOGIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marije Oosting, Michelle Brouwer, Hedwig D. Vrijmoeth, Rosa Pascual Domingo, Anna Greco, Hadewych ter Hofstede, Ellen H. van den Bogaard, Joost Schalkwijk, Mihai G. Netea, Leo A. B. Joosten
Summary: Natural Killer (NK) cells play an important role in the immune response to Borrelia burgdorferi infection. They produce cytokines and chemokines and are responsible for the early production of interferon-gamma (IFN-gamma) after exposure to B. burgdorferi. CD56(+) (NK + NK-T) cells activate keratinocytes by releasing soluble mediators, highlighting their role in the early defense against B. burgdorferi.
Editorial Material
Oncology
Ignacio Melero, Maria Gato, Tala Shekarian, Angela Aznar, Sandrine Valsesia-Wittmann, Christophe Caux, Inaki Etxeberrria, Alvaro Teijeira, Aurelien Marabelle
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Multidisciplinary Sciences
Gael Boivin, Julien Faget, Pierre-Benoit Ancey, Aspasia Gkasti, Julie Mussard, Camilla Engblom, Christina Pfirschke, Caroline Contat, Justine Pascual, Jessica Vazquez, Nathalie Bendriss-Vermare, Christophe Caux, Marie-Catherine Vozenin, Mikael J. Pittet, Matthias Gunzer, Etienne Meylan
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Margaux Hubert, Elisa Gobbini, Coline Couillault, Thien-Phong Vu Manh, Anne-Claire Doffin, Justine Berthet, Celine Rodriguez, Vincent Ollion, Janice Kielbassa, Christophe Sajous, Isabelle Treilleux, Olivier Tredan, Bertrand Dubois, Marc Dalod, Nathalie Bendriss-Vermare, Christophe Caux, Jenny Valladeau-Guilemond
SCIENCE IMMUNOLOGY
(2020)
Article
Oncology
Lidia Delrieu, Amelie Anota, Olivier Tredan, Damien Freyssenet, Aurelia Maire, Brice Canada, Baptiste Fournier, Olivia Febvey-Combes, Frank Pilleul, Amine Bouhamama, Christophe Caux, Florence Joly, Beatrice Fervers, Vincent Pialoux, David Perol, Olivia Perol
Article
Oncology
Florence Boissiere-Michot, Ghita Chabab, Caroline Mollevi, Severine Guiu, Evelyne Lopez-Crapez, Jeanne Ramos, Nathalie Bonnefoy, Virginie Lafont, William Jacot
Summary: The study revealed that high gamma delta T cell density was significantly associated with younger age, higher tumor grade, adjuvant chemotherapy, BRCA1 promoter methylation, TIL density, and PD-L1/PD-1 expression in triple-negative breast cancer patients, and served as an independent prognostic factor, especially in those with wild-type PIK3CA tumors.
Editorial Material
Immunology
Virginie Lafont, Sophie Lucas, Nathalie Bonnefoy
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yawen Wang, Annie Roussel-Queval, Lionel Chasson, Noel Hanna Kazazian, Laetitia Marcadet, Andrianos Nezos, Michael H. Sieweke, Clio Mavragani, Lena Alexopoulou
Summary: The study reveals that TLR7 signaling plays a crucial role in the development of Sjogren's syndrome (SS), and the SS phenotype in TLR8-deficient mice is primarily dependent on TLR7. Inhibiting TLR7 signaling may have therapeutic value for the treatment of SS.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Julien Faget, Solange Peters, Xavier Quantin, Etienne Meylan, Nathalie Bonnefoy
Summary: Neutrophils in tumors have been highlighted as playing a pivotal role in modulating the tumor microenvironment and antitumor immune response. Research targeting neutrophils could offer new treatment opportunities in the development of immune checkpoint blockade-based immunotherapies. Expanding the study of neutrophil impact on the response to immune checkpoint inhibitors may lead to new translational research avenues for better understanding neutrophil biology and improving patient treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Ivan Vujkovic-Cvijin, Hugh C. Welles, Connie W. Y. Ha, Lutfi Huq, Shreni Mistry, Jason M. Brenchley, Giorgio Trinchieri, Suzanne Devkota, Yasmine Belkaid
Summary: This study reports that certain commensal gut microbiota can translocate across the gut barrier in mice and humans and are associated with heightened systemic immune response. A modified high-throughput approach was developed to quantify systemic immune response against gut commensal bacteria in human serum samples without the need for paired stool samples. Several commensal bacterial species were found to elicit elevated immune response in patients with inflammatory bowel disease (IBD) and exhibited increased transcriptional activity and growth rates in IBD patient gut microbiomes. This approach serves as a complementary tool to understand the interactions between host and gut microbiota and may help identify microbes associated with inflammatory diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Lena Alexopoulou
Summary: This review provides an overview of the pathogenesis of Sjogren's syndrome (SS), focusing on the role of Toll-like receptors (TLRs), particularly TLR7. Studies in mouse models and SS patients confirm the critical role of TLR7 in the development of SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Angelique Bobrie, Oceane Massol, Jeanne Ramos, Caroline Mollevi, Evelyne Lopez-Crapez, Nathalie Bonnefoy, Florence Boissiere-Michot, William Jacot
Summary: This study focused on the immune tumor microenvironment in triple-negative breast cancer (TNBC), specifically investigating the role of macrophages. The findings revealed that a subgroup of TNBCs characterized by CD206 expression in macrophages may have a better prognosis, suggesting potential therapeutic options for this immune TNBC subgroup.
Review
Oncology
Miriam R. Fernandes, Poonam Aggarwal, Raquel G. E. Costa, Alicia M. Cole, Giorgio Trinchieri
Summary: Growing evidence suggests that the gut microbiota plays a crucial role in influencing the effectiveness and toxicity of cancer therapy, particularly immunotherapy and its adverse effects. Recent advances in research have led to a better understanding of the specific microbial species and mechanisms involved.
NATURE REVIEWS CANCER
(2022)
Article
Immunology
Sethuraman Subramanian, Clara Jana-Lui Busch, Kaaweh Molawi, Laufey Geirsdottir, Julien Maurizio, Stephanie Vargas Aguilar, Hassiba Belahbib, Gregory Gimenez, Ridzky Anis Advent Yuda, Michaela Burkon, Jeremy Favret, Sara Gholamhosseinian Najjar, Berengere de Laval, Prashanth Kumar Kandalla, Sandrine Sarrazin, Lena Alexopoulou, Michael H. Sieweke
Summary: Sieweke and colleagues demonstrate that alveolar macrophages maintain their core gene expression program even after long-term culture and regain their full transcriptional and epigenetic identity upon transplantation into the lung. This study shows that culture adaptations observed in ex vivo expanded alveolar macrophages are reversible and do not compromise their cellular identity in vivo. These findings provide new insights into the mechanisms of alveolar macrophages and highlight their therapeutic potential.
Article
Medicine, Research & Experimental
Sylvain Carras, Dimitri Chartoire, Sylvain Mareschal, Mael Heiblig, Antoine Marcais, Remy Robinot, Mirjam Urb, Roxane M. Pommier, Edith Julia, Amel Chebel, Aurelie Verney, Charlotte Bertheau, Emilie Bardel, Caroline Fezelot, Lucien Courtois, Camille Lours, Alyssa Bouska, Sunandini Sharma, Christine Lefebvre, Jean-Pierre Rouault, David Sibon, Anthony Ferrari, Javeed Iqbal, Laurence de Leval, Philippe Gaulard, Alexandra Traverse-Glehen, Pierre Sujobert, Mathieu Blery, Gilles Salles, Thierry Walzer, Emmanuel Bachy, Laurent Genestier
Summary: Chronic TCR stimulation may drive T cell lymphomagenesis, but does not affect PTCL cell survival. NK cell-like reprogramming may occur in PTCL cells, with expression of NK receptors and downstream signaling molecules.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Rodrigo Nalio Ramos, Celine Rodriguez, Margaux Hubert, Maude Ardin, Isabelle Treilleux, Carola H. Ries, Emilie Lavergne, Sylvie Chabaud, Amelie Colombe, Olivier Tredan, Henrique Gomes Guedes, Fabio Laginha, Wilfrid Richer, Eliane Piaggio, Jose Alexandre M. Barbuto, Christophe Caux, Christine Menetrier-Caux, Nathalie Bendriss-Vermare
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2020)