Article
Chemistry, Multidisciplinary
Lianyong Han, Verena Haefner, Youjia Yu, Bing Han, Hongyu Ren, Martin Irmler, Johannes Beckers, Qiongliang Liu, Annette Feuchtinger, Ali Oender Yildirim, Heiko Adler, Tobias Stoeger
Summary: In this study, the effects of nanoparticle exposure on lung disease development and herpesvirus reactivation were investigated. The results showed that exposure to nanoparticles can induce lung inflammation and emphysema-like injury, as well as reactivate herpesvirus in lung macrophages. In vitro experiments demonstrated that nanoparticle exposure rapidly activates specific signaling pathways and increases viral gene expression without causing an inflammatory response. Pharmacological inhibition of p38 can effectively prevent nanoparticle-induced virus reactivation. These findings highlight the crucial role of nanoparticle-triggered herpesvirus reactivation in the development of lung diseases.
Article
Engineering, Biomedical
Jiayun Huang, Chunmei Fan, Yangwu Chen, Jinchun Ye, Yuwei Yang, Chenqi Tang, Hong Zhang, Yang Fei, Chengrui An, Yuanhao Xie, Hua Liu, Zi Yin, Weishan Chen, Boon Chin Heng, Hongwei Ouyang, Xiao Chen, Weiliang Shen
Summary: Using single cell RNA-seq, the study analyzed transcriptome profiles of various cell types around the scaffold, revealing tissue-resident macrophages as the major source of biomaterial degradation in situ. The research also found that scaffold architecture can influence the mechanotransduction and catabolic activity of specific macrophage subpopulations, leading to differences in scaffold degradation rate in vivo. This work provides insights into the cellular and molecular basis of biomaterial degradation at the single-cell level and offers a conceptual framework for developing functional tissue engineering scaffolds.
Article
Multidisciplinary Sciences
Therese Woodring, Colin N. Dewey, Lucas Dos Santos Dias, Xin He, Hannah E. Dobson, Marcel Wuthrich, Bruce Klein
Summary: Using single cell transcriptome analysis, we identified transcriptionally diverse and distinctive antigen-specific T cells associated with protective vaccine-induced immunity. These cells exhibited a strong type I interferon response and high expression of the natural killer cell marker gene NKG7. We also observed differences in TCR gene use and Th1 and Th17 skewed responses after protective and nonprotective vaccination.
Article
Immunology
Junjie Ma, Christopher A. Tibbitt, Susanna Kumlien Georen, Murray Christian, Ben Murrell, Lars-Olaf Cardell, Claus Bachert, Jonathan M. Coquet
Summary: The study identified various subsets of T cells in nasal polyps of patients with CRSwNP, including regulatory T cells and T(H)2 cells, expanding the understanding of the complexity of T cell populations in this disease.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Yu Xia, Katalin Sandor, Joy A. Pai, Bence Daniel, Saravanan Raju, Renee Wu, Sunnie Hsiung, Yanyan Qi, Tenzin Yangdon, Mariko Okamoto, Chun Chou, Kamir J. Hiam-Galvez, Robert D. Schreiber, Kenneth M. Murphy, Ansuman T. Satpathy, Takeshi Egawa
Summary: The study reveals the heterogeneity and plasticity of CD4(+) T cells during chronic infection and tumor response, and highlights their population dynamics through a stable, bipotent intermediate state.
Review
Neurosciences
Hugo Balleza-Tapia, Luis Enrique Arroyo-Garcia, Arturo G. Isla, Raul Loera-Valencia, Andre Fisahn
Summary: Gamma oscillations in the hippocampal area CA3 are crucial for memory function. Recent studies have found that pyramidal cells (PCs) in CA3 are organized into different functional subpopulations, which play important roles in cognition-related network dynamics.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Immunology
Aditi Sood, Marie-Eve Lebel, Mengqi Dong, Marilaine Fournier, Suzanne J. Vobecky, Elie Haddad, Jean-Sebastien Delisle, Judith N. Mandl, Nienke Vrisekoop, Heather J. Melichar
Summary: Studies show that CD5 levels correlate with TCR signal strength in human naive CD4(+) T cells, marking functional heterogeneity and dominance of CD5(hi) T cells in the memory compartment. Differences in gene expression and cytokine production between CD5(lo) and CD5(hi) naive human CD4(+) T cells are in line with observations in mice, suggesting potential for improving adoptive cell therapies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinping Zhao, Junqi Song
Summary: The study reveals that the plant immune receptor RB requires self-association via coiled-coil domain for activation, which is differentially affected by pathogen effectors. While IPI-O1 moderately reduces RB self-association, IPI-O4 dramatically impairs the process. Additionally, IPI-O4 disrupts the interaction between RB and IPI-O1, potentially blocking their avirulence function.
PLANT COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Rita Tonin, Selina Wilhelmi, Mehmet Gueltas, Renato Gerdol, Ovidiu Paun, Emiliano Trucchi, Armin Otto Schmitt, Camilla Wellstein
Summary: This study shows significant genetic and phenotypic differences between ice hole populations and nearby subalpine populations. The ice hole populations have developed unique genetic and functional traits under the influence of evolutionary history and ecological factors. These findings suggest that microrefugia populations can contribute to species variability and exhibit intraspecific responses to future environmental changes.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Monica Martinez-Blanco, Daniel Lozano-Ojalvo, Leticia Perez-Rodriguez, Sara Benede, Elena Molina, Rosina Lopez-Fandino
Summary: The study demonstrated that under the influence of IL-2 and TGF-beta, IL-6 can induce the generation of Foxp3(+) and double positive Foxp3(+)ROR gamma t(+) T cells. Furthermore, the presence of RA helps to stabilize the phenotype of these cells and promote the suppressive function of Foxp3(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Evgenii N. Tcyganov, Shino Hanabuchi, Ayumi Hashimoto, David Campbell, Gozde Kar, Timothy W. F. Slidel, Corinne Cayatte, Aimee Landry, Fernanda Pilataxi, Susana Hayes, Brian Dougherty, Kristin C. Hicks, Kathy Mulgrew, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Wei Guo, Sergei Grivennikov, Mohammed-Alkhatim A. Ali, Jean-Christophe Beltra, E. John Wherry, Yulia Nefedova, Dmitry Gabrilovich
Summary: MDSCs play important roles in regulating immune responses in cancer and chronic infections, with different mechanisms controlling the activity of MDSCs in these conditions. Cancer-associated PMN-MDSCs acquire immune-suppressive activity through the IRE1 alpha and ATF6 pathways of the ER stress response, while M-MDSCs in cancer and LCMV infection do not rely on the ER stress response for suppressive activity. The immune-suppressive activity of M-MDSCs in spleens is mediated by IFN-gamma signaling, while IL-6 in tumor tissues retains the suppressive activity of M-MDSCs.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Maryam Hejazi, Congcong Zhang, Sabrina B. Bennstein, Vera Balz, Sarah B. Reusing, Melissa Quadflieg, Keven Hoerster, Stefan Heinrichs, Helmut Hanenberg, Sebastian Oberbeck, Marcus Nitsche, Sophie Cramer, Rita Pfeifer, Pranav Oberoi, Heiko Ruehl, Johannes Oldenburg, Peter Brossart, Peter A. Horn, Florian Babor, Winfried S. Wels, Johannes C. Fischer, Nina Moeker, Markus Uhrberg
Summary: This study reveals a novel functional divergence between NK cell subsets upon in vitro stimulation, marked by CD33 expression. By choosing suitable stimulation protocols, it is possible to preferentially generate CD33(+) NK cells combining efficient target cell killing and cytokine production, or alternatively CD33(-) NK cells, which produce less cytokines but are more efficient in antibody-dependent applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Deming Sun, Nymph Chan, Hui Shao, Willi K. Born, Henry J. Kaplan
Summary: Gamma delta T cells play a significant role in immune regulation, and their activation status and pathway impact their functions. In this study, it was shown that activated gamma delta T cells under different inflammatory conditions differ in functions.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao
Summary: Chronic HCV infection leads to immune activation in CD4(+) T cells with reduced expression of stem cell-like transcription factor T cell factor 1 and telomeric repeat-binding factor 2 (TRF2). Hyperactivation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling on T cell receptor stimulation promotes inflammation and cellular damage, while inhibiting Akt signaling and enhancing TRF2 expression may provide therapeutic strategies.
Article
Engineering, Biomedical
Kwasi Adu-Berchie, Yutong Liu, David K. Y. Zhang, Benjamin R. Freedman, Joshua M. Brockman, Kyle H. Vining, Bryan A. Nerger, Andrea Garmilla, David J. Mooney
Summary: Functionally distinct T-cell populations can be generated by altering the viscoelasticity of the surrounding extracellular matrix. The viscoelasticity of the matrix regulates T-cell phenotype and function through the activator-protein-1 signalling pathway. This finding suggests that matrix viscoelasticity can be utilized in generating T-cell products for therapeutic applications.
NATURE BIOMEDICAL ENGINEERING
(2023)